Antibody Information

General Information of This Antibody
Antibody ID
ANI0KPQVQ
Antibody Name
Adnectins scaffold protein
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG scFv
Antigen Name
Glypican-3 (GPC3)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Glypican 3 ADC [Terminated in phase 1]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI)
100.00%
Positive GPC3 expression (GPC3+++/++)
Method Description
Female NOD/SCID mice were inoculated subcutaneously in the right flank with 500,000 Hep3B cells. Three weekly administration of A2-tub at 0.12 mol/kg.
In Vivo Model Hep3B CDX model
In Vitro Model Childhood hepatocellular carcinoma Hep 3B2.1-7 cells CVCL_0326
References
Ref 1 Adnectin-drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors. Protein Eng Des Sel. 2018 May 1;31(5):159-171. doi: 10.1093/protein/gzy013.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.