Antibody Information
General Information of This Antibody
| Antibody ID | ANI0NAAJB |
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| Antibody Name | Anti-GPC3 mAb A43 |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG1 |
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| Antigen Name | Glypican-3 (GPC3) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
A43-PE24 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 50.00% (Day 48) | Positive GPC3 expression (GPC3+++/++) | ||
| Method Description |
A43-PE24 induces efficient tumor cell killing in cell line-derived models of immunotherapy of hepatocellular carcinoma cells.
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| In Vivo Model | Hepatocellular carcinoma CDX model | ||||
| In Vitro Model | Hepatocellular carcinoma | Hepatocellular carcinoma cells | Homo sapiens | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Inhibitory Concentration 5% (IC5) |
110.00 ng/mL
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Positive GPC3 expression (GPC3+++/++) | ||
| Method Description |
Ten thousand cells were seeded in a 96-well cell culture plate (200 l per well), supplemented with purified immunotoxins at the indicated final concentrations, and incubated at 37°C for 3 days. Cell viability was determined by quantifying the enzymatic activity of the intracellular luciferase that was released by two rounds of freezing-thawing.
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| In Vitro Model | Hepatocellular carcinoma | G1LG cells | Homo sapiens | ||
References
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