General Information of This Antigen
Antigen ID
TAR0MIBZW
Antigen Name
Tumor-associated calcium signal transducer 2 (TACSTD2)
Gene Name
TACSTD2
Gene ID
4070
Synonym
GA733-1; M1S1; TROP2; Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1
Sequence
MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGS
GMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCN
QTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLF
RERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRG
GLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVITNR
RKSGKYKKVEIKELGELRKEPSL

    Click to Show/Hide
Family
EPCAM family
Function
May function as a growth factor receptor.

    Click to Show/Hide
Uniprot Entry
TACD2_HUMAN
HGNC ID
HGNC:11530
KEGG ID
hsa:4070
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
AcLys-vc0101 antibody
ADC Info ADC Name Payload Target Linker Ref
AcLys-vc0101
AcLys-vc0101 payload
Undisclosed
AcLys-vc0101 linker
[1]
AcLys-vcMMAD antibody
ADC Info ADC Name Payload Target Linker Ref
AcLys-vcMMAD
AcLys-vcMMAD payload
Undisclosed
AcLys-vcMMAD linker
[1]
Anti-TROP2 mAb
ADC Info ADC Name Payload Target Linker Ref
ADC2192
Undisclosed
Undisclosed
Undisclosed
[2]
Anti-TROP2 mAb T6-16
ADC Info ADC Name Payload Target Linker Ref
TROP2-IR700
IRDye 700DX
Undisclosed
Undisclosed
[3]
C6vc0101 antibody
ADC Info ADC Name Payload Target Linker Ref
C6vc0101
C6vc0101 payload
Undisclosed
C6vc0101 linker
[1]
C6vcMMAD antibody
ADC Info ADC Name Payload Target Linker Ref
C6vcMMAD
C6vcMMAD payload
Undisclosed
C6vcMMAD linker
[1]
CN106795203B_ADC-12 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-12
CN106795203B_ADC-12 payload
Undisclosed
CN106795203B_ADC-12 linker
[1]
CN106795203B_ADC-13 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-13
CN106795203B_ADC-13 payload
Undisclosed
CN106795203B_ADC-13 linker
[1]
CN106795203B_ADC-14 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-14
CN106795203B_ADC-14 payload
Undisclosed
CN106795203B_ADC-14 linker
[1]
CN106795203B_ADC-15 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-15
CN106795203B_ADC-15 payload
Undisclosed
CN106795203B_ADC-15 linker
[1]
CN106795203B_ADC-16 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-16
CN106795203B_ADC-16 payload
Undisclosed
CN106795203B_ADC-16 linker
[1]
CN106795203B_ADC-17 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-17
CN106795203B_ADC-17 payload
Undisclosed
CN106795203B_ADC-17 linker
[1]
CN106795203B_ADC-18 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-18
CN106795203B_ADC-18 payload
Undisclosed
CN106795203B_ADC-18 linker
[1]
CN106795203B_ADC-19 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-19
CN106795203B_ADC-19 payload
Undisclosed
CN106795203B_ADC-19 linker
[1]
CN106795203B_ADC-49 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-49
CN106795203B_ADC-49 payload
Undisclosed
CN106795203B_ADC-49 linker
[1]
CN106795203B_ADC-50 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-50
CN106795203B_ADC-50 payload
Undisclosed
CN106795203B_ADC-50 linker
[1]
CN106795203B_ADC-51 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-51
CN106795203B_ADC-51 payload
Undisclosed
CN106795203B_ADC-51 linker
[1]
CN106795203B_ADC-52 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-52
CN106795203B_ADC-52 payload
Undisclosed
CN106795203B_ADC-52 linker
[1]
CN106795203B_ADC-53 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-53
CN106795203B_ADC-53 payload
Undisclosed
CN106795203B_ADC-53 linker
[1]
CN106795203B_ADC-54 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-54
CN106795203B_ADC-54 payload
Undisclosed
CN106795203B_ADC-54 linker
[1]
CN106795203B_ADC-55 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-55
CN106795203B_ADC-55 payload
Undisclosed
CN106795203B_ADC-55 linker
[1]
CN106795203B_ADC-56 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-56
CN106795203B_ADC-56 payload
Undisclosed
CN106795203B_ADC-56 linker
[1]
CN106795203B_ADC-57 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-57
CN106795203B_ADC-57 payload
Undisclosed
CN106795203B_ADC-57 linker
[1]
CN106795203B_ADC-58 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-58
CN106795203B_ADC-58 payload
Undisclosed
CN106795203B_ADC-58 linker
[1]
CN106795203B_ADC-59 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-59
CN106795203B_ADC-59 payload
Undisclosed
CN106795203B_ADC-59 linker
[1]
CN106795203B_ADC-60 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-60
CN106795203B_ADC-60 payload
Undisclosed
CN106795203B_ADC-60 linker
[1]
CN106795203B_ADC-61 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-61
CN106795203B_ADC-61 payload
Undisclosed
CN106795203B_ADC-61 linker
[1]
CN106795203B_ADC-62 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-62
CN106795203B_ADC-62 payload
Undisclosed
CN106795203B_ADC-62 linker
[1]
CN106795203B_ADC-63 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-63
CN106795203B_ADC-63 payload
Undisclosed
CN106795203B_ADC-63 linker
[1]
CN106795203B_ADC-64 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-64
CN106795203B_ADC-64 payload
Undisclosed
CN106795203B_ADC-64 linker
[1]
CN106795203B_ADC-65 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-65
CN106795203B_ADC-65 payload
Undisclosed
CN106795203B_ADC-65 linker
[1]
CN106795203B_ADC-66 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-66
CN106795203B_ADC-66 payload
Undisclosed
CN106795203B_ADC-66 linker
[1]
CN106795203B_ADC-67 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-67
CN106795203B_ADC-67 payload
Undisclosed
CN106795203B_ADC-67 linker
[1]
CN106795203B_ADC-68 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-68
CN106795203B_ADC-68 payload
Undisclosed
CN106795203B_ADC-68 linker
[1]
CN106795203B_ADC-69 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-69
CN106795203B_ADC-69 payload
Undisclosed
CN106795203B_ADC-69 linker
[1]
CN106795203B_ADC-70 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-70
CN106795203B_ADC-70 payload
Undisclosed
CN106795203B_ADC-70 linker
[1]
CN106795203B_ADC-71 antibody
ADC Info ADC Name Payload Target Linker Ref
CN106795203B ADC-71
CN106795203B_ADC-71 payload
Undisclosed
CN106795203B_ADC-71 linker
[1]
Datopotamab
ADC Info ADC Name Payload Target Linker Ref
Datopotamab deruxtecan
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[4]
Datopotamab-ADC-Tb2-1
Datopotamab-ADC-Tb2-1 payload
Undisclosed
Datopotamab-ADC-Tb2-1 linker
[5]
Datopotamab-ADC-Tb2-2
Datopotamab-ADC-Tb2-2 payload
Undisclosed
Datopotamab-ADC-Tb2-2 linker
[5]
Datopotamab-ADC-Tb2-3
Datopotamab-ADC-Tb2-3 payload
Undisclosed
Datopotamab-ADC-Tb2-3 linker
[5]
Datopotamab-ADC-Tb2-4
Datopotamab-ADC-Tb2-4 payload
Undisclosed
Datopotamab-ADC-Tb2-4 linker
[5]
Datopotamab-ADC-Tb2-5
Datopotamab-ADC-Tb2-5 payload
Undisclosed
Datopotamab-ADC-Tb2-5 linker
[5]
Datopotamab-ADC-Tb2-6
Datopotamab-ADC-Tb2-6 payload
Undisclosed
Datopotamab-ADC-Tb2-6 linker
[5]
Datopotamab-ADC-Tb2-7
Datopotamab-ADC-Tb2-7 payload
Undisclosed
Datopotamab-ADC-Tb2-7 linker
[5]
Datopotamab-ADC-Tb2-8
Datopotamab-ADC-Tb2-8 payload
Undisclosed
Datopotamab-ADC-Tb2-8 linker
[5]
Datopotamab-ADC-Tb2-9
Datopotamab-ADC-Tb2-9 payload
Undisclosed
Datopotamab-ADC-Tb2-9 linker
[5]
Datopotamab-ADC-Tb2-10
Datopotamab-ADC-Tb2-10 payload
Undisclosed
Datopotamab-ADC-Tb2-10 linker
[5]
ADC Info ADC Name Payload Target Linker Ref
WO2021147993A1 ADC-6
WO2021147993A1 ADC-6 payload
Undisclosed
WO2021147993A1 ADC-6 linker
[6]
WO2021147993A1 ADC-7
WO2021147993A1 ADC-7 payload
Undisclosed
WO2021147993A1 ADC-7 linker
[6]
WO2021147993A1 ADC-8
WO2021147993A1 ADC-8 payload
Undisclosed
WO2021147993A1 ADC-8 linker
[6]
Humanized Anti-Trop-2 hIgG1 Anti-ody
ADC Info ADC Name Payload Target Linker Ref
RN927C
Auristatin 0101
Microtubule (MT)
AcLys-Val-Cit-PABC
[7]
ADC Info ADC Name Payload Target Linker Ref
WO2021147993A1 ADC-1
WO2021147993A1 ADC-1 payload
Undisclosed
WO2021147993A1 ADC-1 linker
[6]
WO2021147993A1 ADC-2
WO2021147993A1 ADC-2 payload
Undisclosed
WO2021147993A1 ADC-2 linker
[6]
WO2021147993A1 ADC-3
WO2021147993A1 ADC-3 payload
Undisclosed
WO2021147993A1 ADC-3 linker
[6]
WO2021147993A1 ADC-5
WO2021147993A1 ADC-5 payload
Undisclosed
WO2021147993A1 ADC-5 linker
[6]
PF-06478924
ADC Info ADC Name Payload Target Linker Ref
PF-06664178
Auristatin 0101
Microtubule (MT)
AcLys-Val-Cit-PABC
[8]
Sacituzumab
ADC Info ADC Name Payload Target Linker Ref
Sacituzumab govitecan
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
[9]
SKB-264
KL610023
DNA topoisomerase 1 (TOP1)
Pyrimidine-CL2A-carbonate
[10]
ESG-401
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Undisclosed
[11]
PBX-001
Undisclosed
Undisclosed
Undisclosed
[12]
Trop2-ADC-01 (DAR8)
Trop2-ADC-01(DAR8) payload
Undisclosed
Trop2-ADC-01(DAR8) linker
[5]
Trop2-ADC-02 (DAR8)
Trop2-ADC-02(DAR8) payload
Undisclosed
Trop2-ADC-02(DAR8) linker
[5]
Trop2-ADC-03 (DAR8)
Trop2-ADC-03(DAR8) payload
Undisclosed
Trop2-ADC-03(DAR8) linker
[5]
Trop2-ADC-04 (DAR8)
Trop2-ADC-04(DAR8) payload
Undisclosed
Trop2-ADC-04(DAR8) linker
[5]
Trop2-ADC-05 (DAR8)
Trop2-ADC-05(DAR8) payload
Undisclosed
Trop2-ADC-05(DAR8) linker
[5]
Trop2-ADC-06 (DAR8)
Trop2-ADC-06(DAR8) payload
Undisclosed
Trop2-ADC-06(DAR8) linker
[5]
Trop2-ADC-08 (DAR8)
Trop2-ADC-08(DAR8) payload
Undisclosed
Trop2-ADC-08(DAR8) linker
[5]
Trop2-ADC-09 (DAR8)
Trop2-ADC-09(DAR8) payload
Undisclosed
Trop2-ADC-09(DAR8) linker
[5]
Trop2-ADC-10 (DAR8)
Trop2-ADC-10(DAR8) payload
Undisclosed
Trop2-ADC-10(DAR8) linker
[5]
Sacituzumab-Compound (Ia)
NeoDegrader P1
Protein cereblon (CRBN)
Sacituzumab-Compound (Ia) linker
[13]
ADC-II-3
ADC-II-3 payload
Undisclosed
ADC-II-3 linker
[14]
ADC-II-7
ADC-II-7 payload
Undisclosed
ADC-II-7 linker
[14]
ADC-II-11-a
ADC-II-11-a payload
Undisclosed
ADC-II-11-a linker
[14]
ADC-II-15
ADC-II-15 payload
Undisclosed
ADC-II-15 linker
[14]
ADC-III-3
ADC-III-3 payload
Undisclosed
ADC-III-3 linker
[14]
ADC-III-11
ADC-III-11 payload
Undisclosed
ADC-III-11 linker
[14]
ADC-II-11-b
ADC-II-11-b payload
Undisclosed
ADC-II-11-b linker
[14]
ADC-II-53
ADC-II-53 payload
Undisclosed
ADC-II-53 linker
[14]
ADC-II-57
ADC-II-57 payload
Undisclosed
ADC-II-57 linker
[14]
ADC-III-28
ADC-III-28 payload
Undisclosed
ADC-III-28 linker
[14]
ADC-III-33
ADC-III-33 payload
Undisclosed
ADC-III-33 linker
[14]
Sacituzumab-Deruxtecan
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[14]
Trop2-ADC-07 (DAR8)
Trop2-ADC-07(DAR8) payload
Undisclosed
Trop2-ADC-07(DAR8) linker
[5]
WO2022228495A1 ADC-76
WO2022228495A1 ADC-76 payload
Undisclosed
WO2022228495A1 ADC-76 linker
[15]
WO2022228495A1 ADC-77
WO2022228495A1 ADC-77 payload
Undisclosed
WO2022228495A1 ADC-77 linker
[15]
WO2022228495A1 ADC-78
WO2022228495A1 ADC-78 payload
Undisclosed
WO2022228495A1 ADC-78 linker
[15]
Sacituzumab-SN-38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
[16]
Sacituzumab-Compound 9
Mertansine DM1
Microtubule (MT)
Sacituzumab-Compound 9 linker
[17]
Sacituzumab-Compound 17
Mertansine DM4
Microtubule (MT)
Sacituzumab-Compound 17 linker
[17]
Sacituzumab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 25 linker
[17]
Sacituzumab-Compound 31
Auristatin 0101
Microtubule (MT)
Sacituzumab-Compound 31 linker
[17]
Sacituzumab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 36 linker
[17]
Sacituzumab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Sacituzumab-Compound 43 linker
[17]
Sacituzumab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Sacituzumab-Compound 49 linker
[17]
Sacituzumab-Compound 55
Mertansine DM1
Microtubule (MT)
Sacituzumab-Compound 55 linker
[17]
Sacituzumab-Compound 59
Mertansine DM4
Microtubule (MT)
Sacituzumab-Compound 59 linker
[17]
Sacituzumab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 64 linker
[17]
Sacituzumab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 69 linker
[17]
Sacituzumab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Sacituzumab-Compound 74 linker
[17]
Sacituzumab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 75 linker
[17]
Sacituzumab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 76 linker
[17]
Sacituzumab-Compound 77
Mertansine DM1
Microtubule (MT)
Sacituzumab-Compound 77 linker
[17]
Sacituzumab-Compound 78
Auristatin 0101
Microtubule (MT)
Sacituzumab-Compound 78 linker
[17]
Sacituzumab-Compound 79
Auristatin 0101
Microtubule (MT)
Sacituzumab-Compound 79 linker
[17]
Sacituzumab-Compound 80
Mertansine DM4
Microtubule (MT)
Sacituzumab-Compound 80 linker
[17]
ADC Info ADC Name Payload Target Linker Ref
WO2021147993A1 ADC-4
WO2021147993A1 ADC-4 payload
Undisclosed
WO2021147993A1 ADC-4 linker
[6]
WO2021147993A1 ADC-9
WO2021147993A1 ADC-9 payload
Undisclosed
WO2021147993A1 ADC-9 linker
[6]
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
DB-1305
P1003
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[18]
SHR-A1921
SHR9265
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[19]
BIO-106
Undisclosed
Undisclosed
Undisclosed
[20]
MHB036C
Topoisomerase I inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
[21]
BAT-8008
Undisclosed
Undisclosed
Undisclosed
[22]
BL-M02D1
Undisclosed
Undisclosed
Undisclosed
[23]
DAC-002
Undisclosed
Undisclosed
Undisclosed
[24]
FDA-018
Undisclosed
Undisclosed
Undisclosed
[25]
Recombinant humanized anti-Trop2 antibody
Undisclosed
Undisclosed
Undisclosed
[26]
YL202
Undisclosed
Undisclosed
Undisclosed
[27]
9MW-2921
Topoisomerase I inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
[28]
FZ-AD004
Undisclosed
Undisclosed
Undisclosed
[29]
Humanized anti-TROP2-SN38 antibody conjugate
Undisclosed
Undisclosed
Undisclosed
[30]
R4702
Undisclosed
Undisclosed
Undisclosed
[31]
DXC-003
Undisclosed
Undisclosed
Undisclosed
[24]
GQ-1003
Undisclosed
Undisclosed
Undisclosed
[32]
BSI-04702
Undisclosed
Undisclosed
Undisclosed
[33]
DpADC
Topo1 inhibitor+immune agonist
DNA topoisomerase 1 (TOP1)
Undisclosed
[34]
LCB-84
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[35]
Anti-TROP2 ADC (Lanier)
Undisclosed
Undisclosed
Undisclosed
[36]
BAT-8003
Maytansinoid derivative
Microtubule (MT)
Uncleavable linker
[37]
Anti-TROP2 ADC (XDCExplorer)
Undisclosed
Undisclosed
Undisclosed
[38]
Tissue/Disease specific Abundances of This Antigen
Tissue specific Abundances of This Antigen
ICD Disease Classification 01
Click to Show/Hide the 1 Disease of This Class
Bacterial infection [ICD-11: 1A00-1C4Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Bacterial infection of gingival
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.646003732; Fold-change: 0.02005813; Z-score: 0.104342136
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 02
Click to Show/Hide the 22 Disease of This Class
Brain cancer [ICD-11: 2A00]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Brainstem
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.860929017; Fold-change: -0.121771864; Z-score: -0.248138211
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue White matter
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000246098; Fold-change: -0.757520251; Z-score: -2.034875933
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Brainstem
The Specific Disease Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.02147792; Fold-change: -0.177238287; Z-score: -1.182758318
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Nervous
The Specific Disease Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 5.31E-20; Fold-change: -0.120295595; Z-score: -0.607883179
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic myeloid leukemia [ICD-11: 2A20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Polycythemia vera
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.045121825; Fold-change: 0.0769918; Z-score: 0.577978813
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Whole blood
The Specific Disease Myelofibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.786287453; Fold-change: -0.019383026; Z-score: -0.156995689
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
MyeloDysplastic syndromes [ICD-11: 2A37]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myelodysplastic syndromes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.153912727; Fold-change: 0.069573148; Z-score: 0.311027408
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.02344139; Fold-change: 0.099187066; Z-score: 1.295646269
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lymphoma [ICD-11: 2A90- 2A85]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Tonsil
The Specific Disease Lymphoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.747715931; Fold-change: -0.064636806; Z-score: -0.532557963
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Gastric cancer [ICD-11: 2B72]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Gastric
The Specific Disease Gastric cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.860965989; Fold-change: -0.031569624; Z-score: -0.363157552
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.983354219; Fold-change: 0.012789259; Z-score: 0.05877818
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Colon cancer [ICD-11: 2B90]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Colon
The Specific Disease Colon cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.16E-19; Fold-change: 0.234394083; Z-score: 0.976617871
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.454131877; Fold-change: 0.017840273; Z-score: 0.060252076
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pancreatic cancer [ICD-11: 2C10]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Pancreas
The Specific Disease Pancreatic cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.032162447; Fold-change: -0.191004657; Z-score: -0.863191043
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 9.44E-05; Fold-change: -0.245019937; Z-score: -0.731956798
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver cancer [ICD-11: 2C12]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.87E-18; Fold-change: -0.608712001; Z-score: -2.505996726
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 4.06E-88; Fold-change: -0.610862193; Z-score: -2.858492514
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.00528615; Fold-change: -0.570033126; Z-score: -3.96108538
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lung cancer [ICD-11: 2C25]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Lung cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.00055185; Fold-change: 0.060675065; Z-score: 0.31092763
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.904195475; Fold-change: -0.00021585; Z-score: -0.000945757
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Melanoma [ICD-11: 2C30]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Melanoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.00155708; Fold-change: -0.400040853; Z-score: -0.820529974
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sarcoma [ICD-11: 2C35]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Sarcoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000261883; Fold-change: 0.058912068; Z-score: 0.261989945
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.566217999; Fold-change: -0.033960636; Z-score: -0.278110988
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Breast cancer [ICD-11: 2C60]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Breast
The Specific Disease Breast cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.848801339; Fold-change: 0.01049881; Z-score: 0.041504994
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.430283007; Fold-change: -0.043752942; Z-score: -0.155416008
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ovarian cancer [ICD-11: 2C73]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Ovarian
The Specific Disease Ovarian cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.599278238; Fold-change: 0.03145742; Z-score: 0.093963239
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.000895596; Fold-change: 0.142403641; Z-score: 1.187750535
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cervical cancer [ICD-11: 2C77]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Cervical
The Specific Disease Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.01257321; Fold-change: -0.121305273; Z-score: -0.820775723
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Uterine cancer [ICD-11: 2C78]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Uterine cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.47E-11; Fold-change: 0.197743186; Z-score: 0.81638737
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.063727968; Fold-change: 0.145029655; Z-score: 1.059202896
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Prostate cancer [ICD-11: 2C82]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Prostate
The Specific Disease Prostate cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.22E-08; Fold-change: 0.826805512; Z-score: 1.72169731
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Bladder cancer [ICD-11: 2C94]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Bladder cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.017547574; Fold-change: 0.177486888; Z-score: 1.415257041
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Retina cancer [ICD-11: 2D02]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Uvea
The Specific Disease Retinoblastoma tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.525036887; Fold-change: -0.080833151; Z-score: -0.616793808
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thyroid cancer [ICD-11: 2D10]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Thyroid
The Specific Disease Thyroid cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000655815; Fold-change: 0.062278488; Z-score: 0.294286473
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.118167386; Fold-change: 0.112127674; Z-score: 0.445768548
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Adrenal cancer [ICD-11: 2D11]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Adrenal cortex
The Specific Disease Adrenocortical carcinoma
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.001281225; Fold-change: -0.099728738; Z-score: -0.468852749
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Head and neck cancer [ICD-11: 2D42]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Head and neck
The Specific Disease Head and neck cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.033873507; Fold-change: -0.043109712; Z-score: -0.187280283
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pituitary cancer [ICD-11: 2F37]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Pituitary
The Specific Disease Pituitary gonadotrope tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.937995389; Fold-change: 0.020318056; Z-score: 0.2198227
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Pituitary
The Specific Disease Pituitary cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.089959363; Fold-change: 0.062078978; Z-score: 0.486864118
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 03
Click to Show/Hide the 1 Disease of This Class
Thrombocytopenia [ICD-11: 3B64]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.466524531; Fold-change: 0.135191888; Z-score: 0.99910311
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 04
Click to Show/Hide the 2 Disease of This Class
Lupus erythematosus [ICD-11: 4A40]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Lupus erythematosus
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.4657422; Fold-change: -0.091897705; Z-score: -0.234721636
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autoimmune disease [ICD-11: 4A4Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral monocyte
The Specific Disease Autoimmune uveitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.009963869; Fold-change: -0.201762636; Z-score: -1.098354132
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 05
Click to Show/Hide the 1 Disease of This Class
Hyperlipoproteinaemia [ICD-11: 5C80]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Familial hypercholesterolemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.959433282; Fold-change: -0.018777131; Z-score: -0.060103424
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 06
Click to Show/Hide the 1 Disease of This Class
Schizophrenia [ICD-11: 6A20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Superior temporal cortex
The Specific Disease Schizophrenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.205354038; Fold-change: -0.05651575; Z-score: -0.537465229
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 08
Click to Show/Hide the 3 Disease of This Class
Multiple sclerosis [ICD-11: 8A40]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Spinal cord
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.874623063; Fold-change: -0.123054734; Z-score: -1.181671231
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Plasmacytoid dendritic cells
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.619291188; Fold-change: 0.020810969; Z-score: 0.09683439
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Epilepsy [ICD-11: 8A60]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peritumoral cortex
The Specific Disease Epilepsy
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.235364418; Fold-change: -0.01802855; Z-score: -0.103354409
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cerebral ischaemic stroke [ICD-11: 8B11]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Cardioembolic Stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.015177009; Fold-change: 0.231597676; Z-score: 0.721031236
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Ischemic stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.13507681; Fold-change: 0.053476596; Z-score: 0.18935571
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 1
Click to Show/Hide the 6 Disease of This Class
HIV [ICD-11: 1C60-1C62]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue White matter
The Specific Disease HIV
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.183644388; Fold-change: -0.011078298; Z-score: -0.048035772
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Influenza [ICD-11: 1E30]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Influenza
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.68302535; Fold-change: 0.166100001; Z-score: 0.612290876
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic hepatitis C [ICD-11: 1E51.1]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Chronic hepatitis C
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.592682113; Fold-change: 0.017226339; Z-score: 0.181984871
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sepsis [ICD-11: 1G40-1G41]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Sepsis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.23E-08; Fold-change: 0.158915165; Z-score: 0.683076848
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Septic shock [ICD-11: 1G41]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Septic shock
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 9.68E-25; Fold-change: 0.358246066; Z-score: 1.397439169
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pediatric respiratory syncytial virus infection [ICD-11: CA40.11]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Pediatric respiratory syncytial virus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.19488862; Fold-change: 0.158527747; Z-score: 0.798212051
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 11
Click to Show/Hide the 6 Disease of This Class
Essential hypertension [ICD-11: BA00]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Essential hypertension
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.967678461; Fold-change: 0.113411252; Z-score: 3.521072561
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myocardial infarction [ICD-11: BA41]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Myocardial infarction
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.020199876; Fold-change: 0.220375809; Z-score: 0.474346434
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Coronary artery disease [ICD-11: BA8Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Coronary artery disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.211195737; Fold-change: -0.052552312; Z-score: -0.505916764
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aortic stenosis [ICD-11: BB70]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Calcified aortic valve
The Specific Disease Aortic stenosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.548670066; Fold-change: -0.149540921; Z-score: -0.478661794
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arteriosclerosis [ICD-11: BD40]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arteriosclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.864890603; Fold-change: -0.019731596; Z-score: -0.076530094
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aneurysm [ICD-11: BD50]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Intracranial artery
The Specific Disease Aneurysm
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.20242167; Fold-change: -0.072310084; Z-score: -0.68167151
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 12
Click to Show/Hide the 8 Disease of This Class
Immunodeficiency [ICD-11: 4A00-4A20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Immunodeficiency
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.031816868; Fold-change: 0.106330694; Z-score: 1.158559696
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Apnea [ICD-11: 7A40]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Hyperplastic tonsil
The Specific Disease Apnea
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.90178899; Fold-change: -0.263636723; Z-score: -1.23697409
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Olive pollen allergy [ICD-11: CA08.00]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Olive pollen allergy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.34853716; Fold-change: 0.10169276; Z-score: 0.407916442
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic rhinosinusitis [ICD-11: CA0A]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Sinus mucosa
The Specific Disease Chronic rhinosinusitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.097056368; Fold-change: 0.120899246; Z-score: 0.788816175
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic obstructive pulmonary disease [ICD-11: CA22]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.461457902; Fold-change: -0.01082863; Z-score: -0.054646571
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Small airway epithelium
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000786034; Fold-change: 0.146735236; Z-score: 0.849639215
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Asthma [ICD-11: CA23]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Nasal and bronchial airway
The Specific Disease Asthma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.070361966; Fold-change: 0.382843432; Z-score: 0.430802637
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Human rhinovirus infection [ICD-11: CA42]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Nasal Epithelium
The Specific Disease Human rhinovirus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.480486248; Fold-change: -0.017291686; Z-score: -0.119182819
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Idiopathic pulmonary fibrosis [ICD-11: CB03.4]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Idiopathic pulmonary fibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.066611112; Fold-change: -0.157101714; Z-score: -1.183812052
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 13
Click to Show/Hide the 5 Disease of This Class
Periodontal disease [ICD-11: DA0C]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Periodontal disease
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.443421089; Fold-change: -0.027619194; Z-score: -0.145580093
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Eosinophilic gastritis [ICD-11: DA42.2]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Gastric antrum
The Specific Disease Eosinophilic gastritis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.170953924; Fold-change: 0.116475104; Z-score: 1.094063062
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver failure [ICD-11: DB99.7-DB99.8]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver failure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.421809104; Fold-change: 0.002833709; Z-score: 0.0175548
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ulcerative colitis [ICD-11: DD71]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Colon mucosal
The Specific Disease Ulcerative colitis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.635855799; Fold-change: 0.065278367; Z-score: 0.242126494
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Irritable bowel syndrome [ICD-11: DD91.0]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Irritable bowel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.259773766; Fold-change: -0.037337221; Z-score: -0.181666724
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 14
Click to Show/Hide the 5 Disease of This Class
Atopic dermatitis [ICD-11: EA80]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Atopic dermatitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000623516; Fold-change: -0.116117804; Z-score: -1.288980192
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Psoriasis [ICD-11: EA90]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Psoriasis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 9.62E-08; Fold-change: 0.293996088; Z-score: 0.801657998
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.75268022; Fold-change: -0.01739102; Z-score: -0.042207256
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Vitiligo [ICD-11: ED63.0]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Vitiligo
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.488409745; Fold-change: -0.013237104; Z-score: -0.073336526
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alopecia [ICD-11: ED70]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin from scalp
The Specific Disease Alopecia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.003007082; Fold-change: -0.168749204; Z-score: -0.506585611
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sensitive skin [ICD-11: EK0Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Sensitive skin
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.134101564; Fold-change: 0.094520679; Z-score: 0.77941183
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 15
Click to Show/Hide the 6 Disease of This Class
Osteoarthritis [ICD-11: FA00-FA0Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Osteoarthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.178042747; Fold-change: -0.084085503; Z-score: -0.383245002
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthropathy [ICD-11: FA00-FA5Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthropathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.521321498; Fold-change: 0.129542698; Z-score: 0.416118973
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthritis [ICD-11: FA20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.852167133; Fold-change: -0.073314329; Z-score: -0.273773561
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rheumatoid arthritis [ICD-11: FA20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Rheumatoid arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001154467; Fold-change: -0.403906279; Z-score: -2.428000076
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ankylosing spondylitis [ICD-11: FA92.0Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Pheripheral blood
The Specific Disease Ankylosing spondylitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.121041237; Fold-change: -0.048218715; Z-score: -0.448595181
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Osteoporosis [ICD-11: FB83]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Osteoporosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.582699634; Fold-change: -0.152244985; Z-score: -0.560662269
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 16
Click to Show/Hide the 2 Disease of This Class
Endometriosis [ICD-11: GA10]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Endometriosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.237972269; Fold-change: 0.103723969; Z-score: 0.390020876
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Interstitial cystitis [ICD-11: GC00.3]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Interstitial cystitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.449841987; Fold-change: -0.078865333; Z-score: -1.092104911
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 19
Click to Show/Hide the 1 Disease of This Class
Preterm birth [ICD-11: KA21.4Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Myometrium
The Specific Disease Preterm birth
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.755964768; Fold-change: -0.051468298; Z-score: -0.251055381
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 2
Click to Show/Hide the 8 Disease of This Class
Acute myelocytic leukemia [ICD-11: 2A60]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Acute myelocytic leukemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.035929484; Fold-change: -0.017973558; Z-score: -0.075712205
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myeloma [ICD-11: 2A83]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.754692186; Fold-change: -0.029477216; Z-score: -0.339215688
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.331931739; Fold-change: -0.04968298; Z-score: -0.269897304
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Oral cancer [ICD-11: 2B6E]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Oral
The Specific Disease Oral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.63E-06; Fold-change: -0.296823023; Z-score: -1.275806007
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.002042436; Fold-change: -0.084873377; Z-score: -0.294510313
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Esophagal cancer [ICD-11: 2B70]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Esophagus
The Specific Disease Esophagal cancer
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.001701951; Fold-change: -0.463484352; Z-score: -2.814378182
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rectal cancer [ICD-11: 2B92]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Rectal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.207515955; Fold-change: 0.198736903; Z-score: 0.96681527
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.914503668; Fold-change: 0.024889823; Z-score: 0.080401531
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Skin cancer [ICD-11: 2C30-2C3Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Skin cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 3.55E-31; Fold-change: -0.537265817; Z-score: -1.432572789
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.11E-23; Fold-change: -0.627952675; Z-score: -1.132475425
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Renal cancer [ICD-11: 2C90-2C91]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Kidney
The Specific Disease Renal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.00483207; Fold-change: -0.309130357; Z-score: -1.532039343
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 7.19E-28; Fold-change: -0.453385437; Z-score: -2.020541088
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ureter cancer [ICD-11: 2C92]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Urothelium
The Specific Disease Ureter cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.685295868; Fold-change: 0.011574557; Z-score: 0.08755066
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 20
Click to Show/Hide the 2 Disease of This Class
Simpson golabi behmel syndrome [ICD-11: LD2C]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Adipose
The Specific Disease Simpson golabi behmel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.12293909; Fold-change: 0.071545773; Z-score: 0.880288148
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Tuberous sclerosis complex [ICD-11: LD2D.2]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Perituberal
The Specific Disease Tuberous sclerosis complex
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.16344363; Fold-change: 0.251185468; Z-score: 1.167433398
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 3
Click to Show/Hide the 3 Disease of This Class
Anemia [ICD-11: 3A00-3A9Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Anemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.713856233; Fold-change: 0.046770081; Z-score: 0.226070042
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sickle cell disease [ICD-11: 3A51.0-3A51.3]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Sickle cell disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.481139088; Fold-change: 0.070283558; Z-score: 0.356491361
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thrombocythemia [ICD-11: 3B63]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocythemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.685824948; Fold-change: -0.030142767; Z-score: -0.23211535
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 4
Click to Show/Hide the 4 Disease of This Class
Scleroderma [ICD-11: 4A42.Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Scleroderma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.727161659; Fold-change: -0.075131185; Z-score: -0.156485899
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sjogren syndrome [ICD-11: 4A43]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Salivary gland
The Specific Disease Sjogren syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.205944381; Fold-change: -0.321823967; Z-score: -1.238248636
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.0360331; Fold-change: -0.293650716; Z-score: -2.280971814
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Behcet disease [ICD-11: 4A62]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Behcet disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.977293134; Fold-change: 0.02692613; Z-score: 0.084008119
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autosomal dominant monocytopenia [ICD-11: 4B04]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autosomal dominant monocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.686444908; Fold-change: 0.010956123; Z-score: 0.077316942
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 5
Click to Show/Hide the 5 Disease of This Class
Type 2 diabetes [ICD-11: 5A11]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Type 2 diabetes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.312088257; Fold-change: -0.025965167; Z-score: -0.256695555
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Polycystic ovary syndrome [ICD-11: 5A80.1]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Vastus lateralis muscle
The Specific Disease Polycystic ovary syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.352269551; Fold-change: 0.080417634; Z-score: 0.693726536
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Obesity [ICD-11: 5B81]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Subcutaneous Adipose
The Specific Disease Obesity
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.371508991; Fold-change: -0.000305341; Z-score: -0.001936737
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pompe disease [ICD-11: 5C51.3]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Biceps muscle
The Specific Disease Pompe disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.374784036; Fold-change: -0.012090491; Z-score: -0.151685242
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Batten disease [ICD-11: 5C56.1]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Batten disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.096807504; Fold-change: 0.646134778; Z-score: 1.37762977
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 6
Click to Show/Hide the 2 Disease of This Class
Autism [ICD-11: 6A02]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autism
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.186814943; Fold-change: 0.083428594; Z-score: 0.298093773
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Anxiety disorder [ICD-11: 6B00-6B0Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Anxiety disorder
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.030404127; Fold-change: 0.309518825; Z-score: 0.796949303
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 8
Click to Show/Hide the 7 Disease of This Class
Parkinson disease [ICD-11: 8A00]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Substantia nigra
The Specific Disease Parkinson disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.412309285; Fold-change: 0.149830631; Z-score: 0.954388748
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Huntington disease [ICD-11: 8A01]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Huntington disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.253668926; Fold-change: 0.080115972; Z-score: 0.290992463
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alzheimer disease [ICD-11: 8A20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Entorhinal cortex
The Specific Disease Alzheimer disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 9.46E-05; Fold-change: -0.049002687; Z-score: -0.275235133
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Seizure [ICD-11: 8A60-8A6Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Seizure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.182658001; Fold-change: -0.008784825; Z-score: -0.029543633
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lateral sclerosis [ICD-11: 8B60.4]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.908428841; Fold-change: 0.038060892; Z-score: 0.146849167
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Cervical spinal cord
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.046919751; Fold-change: 0.112954517; Z-score: 1.09880085
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Muscular atrophy [ICD-11: 8C70]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Muscular atrophy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.297465848; Fold-change: -0.14429818; Z-score: -0.54405598
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myopathy [ICD-11: 8C70.6]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Myopathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.069433026; Fold-change: 0.125000643; Z-score: 1.145116703
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
References
Ref 1 Stability modulating linkers for antibody drug conjugates.
Ref 2 Introduction to basic information on ADC drug ADC2192
Ref 3 Photoimmunotherapy targeting biliary-pancreatic cancer with humanized anti-TROP2 antibody. Cancer Med. 2019 Dec;8(18):7781-7792. doi: 10.1002/cam4.2658. Epub 2019 Nov 1.
Ref 4 Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Dec;20(12):2329-2340.
Ref 5 Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.
Ref 6 Anti-trop-2 antidody-exatecan analog conjugate and medical use thereof; 2021-07-29.
Ref 7 RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models. Mol Cancer Ther. 2016 Nov;15(11):2698-2708. doi: 10.1158/1535-7163.MCT-16-0431. Epub 2016 Aug 31.
Ref 8 A phase 1, dose-escalation study of PF-06664178, an anti-Trop-2/Aur0101 antibody-drug conjugate in patients with advanced or metastatic solid tumors. Invest New Drugs. 2018 Oct;36(5):836-847.
Ref 9 FDA approves sacituzumab govitecan-hziy for HR-positive breast cancer; 3 Feb 2023.
Ref 10 Preclinical profiles of SKB264, a novel anti-TROP2 antibody conjugated to topoisomerase inhibitor, demonstrated promising antitumor efficacy compared to IMMU-132. Front Oncol. 2022 Dec 23;12:951589.
Ref 11 Study of ESG401 in Adults With Solid Tumors; NCT04892342.
Ref 12 Pinotbio biotechnology company product pipeline
Ref 13 Neodegrader conjugates; 2021-10-07.
Ref 14 Antitumor compound, and preparation method therefor and use thereof; 2022-04-07.
Ref 15 Preparation method for antibody-drug conjugate, and application; 2022-11-03.
Ref 16 Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34. doi: 10.1158/1535-7163.MCT-11-0632. Epub 2011 Oct 28.
Ref 17 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 18 First in human trial of DB1305 in patients with advanced malignant solid tumors. Cancer Res (2023) 83 (8_Supplement): CT248.
Ref 19 SHR-A1921, a novel TROP-2 ADC with an optimized design and well-balanced profile between efficacy and safety. Cancer Res (2023) 83 (8_Supplement): LB030.
Ref 20 A Study in Patients With Advanced Cancers; NCT05320588.
Ref 21 Study of MHB036C in Participants With Advanced or Metastatic Solid Tumors
Ref 22 BAT8008, a novel Trop-2 ADC with strong bystander effect, for the treatment of Trop-2 positive cancer. Cancer Res (2023) 83 (5_Supplement): P4-01-32.
Ref 23 BL-M02D1, a novel Trop2-targeting ADC, demonstrates robust anti-tumor efficacy in preclinical evaluation. Cancer Res (2023) 83 (7_Supplement): 2644.
Ref 24 DAC biotechnology company product pipeline
Ref 25 A Study of FDA018-ADC in Patients With Advanced Solid Tumors; NCT05174637.
Ref 26 Introduction to basic information on ADC drug recombinant humanized anti-Trop2 antibody.
Ref 27 Preclinical development of YL202, a novel HER3-targeting antibody-drug conjugate (ADC) with novel DNA topoisomerase I inhibitor for treatment of solid tumors. Cancer Res (2023) 83 (7_Supplement): 563.
Ref 28 Accelerating Development of Mabwell's ADC Plateform: Clinical Trial Application for an Innovative Drug (9MW2921) Accepted by NMPA; 5 Feb 2023.
Ref 29 FZ-AD004 antibody drug conjugate for injection for the treatment of advanced solid tumors received the acceptance notice for the investigational new drug application; 18 Jan 2023.
Ref 30 Sorrento Announces That Its Subsidiary Levena and Its Partner Escugen Have Received Clearance to Begin Clinical Trials With Anti-TROP-2 Antibody Drug Conjugate For Multiple Solid Tumors; 21 Jul 2021.
Ref 31 Introduction to basic information on ADC drug R4702.
Ref 32 ADC review: basic information about GQ1003.
Ref 33 Biosion biotechnology company product pipeline
Ref 34 An innovative site-specific dual-payload antibody drug conjugate (dpADC) combining a novel Topo1 inhibitor and an immune agonist delivers a strong immunogenic cell death (ICD) and antitumor response in vitro and in vivo. Cancer Res (2023) 83 (7_Supplement): 2640.
Ref 35 Legochem biosciences biopharmaceutical company product pipeline
Ref 36 Introduction to basic information on anti TROP2 antibody drug conjugate (Lanier Biotherapeutics).
Ref 37 Development of a potent Trop-2 antibody-drug conjugate, BAT8003, for the treatment of Trop-2 positive gastric tumors. Cancer Res (2019) 79 (13_Supplement): 4821.
Ref 38 Introduction to basic information on ADC drug anti-TROP2 antibody-drug conjugate(XDCExplorer).

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.