Antigen Information

General Information of This Antigen
Antigen ID
TAR0MIBZW
Antigen Name
Tumor-associated calcium signal transducer 2 (TACSTD2)
Gene Name
TACSTD2
Gene ID
4070
Synonym
GA733-1; M1S1; TROP2; Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1
Sequence
MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGS
GMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCN
QTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLF
RERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRG
GLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVITNR
RKSGKYKKVEIKELGELRKEPSL

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Family
EPCAM family
Function
May function as a growth factor receptor.

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Uniprot Entry
TACD2_HUMAN
HGNC ID
HGNC:11530
KEGG ID
hsa:4070
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Name Payload Target Linker ADC Info
BR112024020733A2ADC1 [1]
Monomethyl auristatin E
Microtubule (MT)
BR112024020733A2 ADC1 Linker
 ADC Info 
BR112024020733A2ADC2 [1]
BR112024020733A2 ADC2 Payload
Undisclosed
BR112024020733A2 ADC2 Linker
 ADC Info 
BR112024020733A2ADC3 [1]
BR112024020733A2 ADC3 Payload
Undisclosed
BR112024020733A2 ADC3 Linker
 ADC Info 
BR112024020733A2ADC4 [1]
BR112024020733A2 ADC2 Payload
Undisclosed
BR112024020733A2 ADC4 Linker
 ADC Info 
JP2025004232A ADC1 1-20 [2]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC2 1-20 [2]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC3 1-20 [2]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC4 1-20 [2]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
AcLys-vc0101 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AcLys-vc0101 [3]
AcLys-vc0101 payload
Undisclosed
AcLys-vc0101 linker
 ADC Info 
AcLys-vcMMAD antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AcLys-vcMMAD [3]
AcLys-vcMMAD payload
Undisclosed
AcLys-vcMMAD linker
 ADC Info 
Anti-Trop
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US20230256114A1 ADC (DAR3.5) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR5.1) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR7) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR2.8) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR3.9) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR3.6) 1 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR4.9) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR7.1) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR3.6) 2 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR4.5) 1 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR3.4) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR4.5) 2 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR3.0) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR4.3) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR6.2) [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20230256114A1 ADC (DAR4) 1 [4]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
US20230256114A1 ADC (DAR4) 2 [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-Trop-2 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
FDA018
SN-38
DNA topoisomerase 1 (TOP1)
An acid-cleavable linker
 ADC Info 
Anti-Trop2 - (MSG1-N3) 2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7615189B2 ADC50 [5]
JP7615189B2+ADC40+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
Anti-TROP2 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MK-6837
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ASP2998
Undisclosed
Stimulator of interferon genes protein (STING1)+DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
BIO-106
TAMTM
Microtubule (MT)
A non-cleavable linker
 ADC Info 
Sacituzumab drozuntecan
P1021
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
MHB036C
MH30010008
DNA topoisomerase 1 (TOP1)
Stable cleavable linker
 ADC Info 
9MW2921 [6]
Mtoxin
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
GQ1010
Camptothecin analog
DNA topoisomerase 1 (TOP1)
A cleavable open-ring linker
 ADC Info 
BAT8008
Exatecan
DNA topoisomerase 1 (TOP1)
Maleimide tetrapeptide-based cleavable linker
 ADC Info 
FZ-AD004
DXd
DNA topoisomerase 1 (TOP1)
Mc-Val-Ala-PABC double self-immolative linker
 ADC Info 
BL-M08D1
Ed-04
DNA topoisomerase 1 (TOP1)
Gly-Mal-Gly-Gly-Phe-Gly
 ADC Info 
DXC1002
CPT113
DNA topoisomerase 1 (TOP1)
CrossConju linker
 ADC Info 
DAC-002
Tubulysin 196
Microtubule (MT)
2,3-disubstituted long side-chain hydrolysis-resistant linker
 ADC Info 
BAT8003
Batansine
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
XYD-9668-198 [7]
Undisclosed
Undisclosed
A cleavable linker
 ADC Info 
IBI130 [8]
NT1
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
HS-20105
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
anti-TROP2 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AU2023281032A1 ADC-3 [9]
AU2023281032A1 ADC-3 Payload
Undisclosed
AU2023281032A1 ADC-3 Linker
 ADC Info 
AU2023281032A1 ADC-5 [9]
Monomethyl auristatin E
Microtubule (MT)
AU2023281032A1 ADC-1 linker
 ADC Info 
AU2023281032A1 ADC-2 [9]
AU2023281032A1 ADC-3 Payload
Undisclosed
AU2023281032A1 ADC-3 Linker
 ADC Info 
anti-TROP2 antibody-ADC [10]
anti-TROP2 antibody-ADC Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
DS-1062 [11]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
anti-TROP2 antibody mAb-2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2023232144A1ADC-3 [12]
WO2023232144A1, ADC-2, Payload
DNA topoisomerase I (TOP1)
WO2023232144A1, ADC-2, linker
 ADC Info 
WO2023232144A1ADC-4 [12]
WO2023232144A1, ADC-1, Payload
Microtubule (MT)
WO2023232144A1, ADC-1, linker
 ADC Info 
WO2023232144A1ADC-5 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
anti-TROP2 HCAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
KJ-103 [13]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-TROP2 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ESG401
SN-38
DNA topoisomerase 1 (TOP1)
A proprietary stable-cleavable linker
 ADC Info 
Anti-TROP2 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ADC2192 [14]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
OBI-902 [15]
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
ZA202500114A-ADC-3 [16]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ZA202500114A-ADC-4 [16]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
ZA202500114A-ADC-5 [16]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
ESG406
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-TROP2 mAb T6-16
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TROP2-IR700 [17]
IRDye 700DX
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
LN488-04-2 [18]
Exatecan
DNA topoisomerase 1 (TOP1)
US20240269308A1 LN488-04-2 Linker
 ADC Info 
LN488-01-1 [18]
Exatecan
DNA topoisomerase 1 (TOP1)
US20240269308A1 LN488-01-1 Linker
 ADC Info 
LN488-02-2 [18]
Exatecan
DNA topoisomerase 1 (TOP1)
US20240269308A1 LN488-02-2 Linker
 ADC Info 
LN488-05-2 [18]
Exatecan
DNA topoisomerase 1 (TOP1)
US20240269308A1 LN488-05-2 Linker
 ADC Info 
LN488-01-2 [18]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
LN437-99 [19]
Monomethyl auristatin E
Microtubule (MT)
CN118079014A-linker-2
 ADC Info 
C6vc0101 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
C6vc0101 [3]
C6vc0101 payload
Undisclosed
C6vc0101 linker
 ADC Info 
C6vcMMAD antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
C6vcMMAD [3]
C6vcMMAD payload
Undisclosed
C6vcMMAD linker
 ADC Info 
CN106795203B_ADC-12 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-12 [3]
CN106795203B_ADC-12 payload
Undisclosed
CN106795203B_ADC-12 linker
 ADC Info 
CN106795203B_ADC-13 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-13 [3]
CN106795203B_ADC-13 payload
Undisclosed
CN106795203B_ADC-13 linker
 ADC Info 
CN106795203B_ADC-14 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-14 [3]
CN106795203B_ADC-14 payload
Undisclosed
CN106795203B_ADC-14 linker
 ADC Info 
CN106795203B_ADC-15 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-15 [3]
CN106795203B_ADC-15 payload
Undisclosed
CN106795203B_ADC-15 linker
 ADC Info 
CN106795203B_ADC-16 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-16 [3]
CN106795203B_ADC-16 payload
Undisclosed
CN106795203B_ADC-16 linker
 ADC Info 
CN106795203B_ADC-17 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-17 [3]
CN106795203B_ADC-17 payload
Undisclosed
CN106795203B_ADC-17 linker
 ADC Info 
CN106795203B_ADC-18 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-18 [3]
CN106795203B_ADC-18 payload
Undisclosed
CN106795203B_ADC-18 linker
 ADC Info 
CN106795203B_ADC-19 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-19 [3]
CN106795203B_ADC-19 payload
Undisclosed
CN106795203B_ADC-19 linker
 ADC Info 
CN106795203B_ADC-49 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-49 [3]
CN106795203B_ADC-49 payload
Undisclosed
CN106795203B_ADC-49 linker
 ADC Info 
CN106795203B_ADC-50 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-50 [3]
CN106795203B_ADC-50 payload
Undisclosed
CN106795203B_ADC-50 linker
 ADC Info 
CN106795203B_ADC-51 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-51 [3]
CN106795203B_ADC-51 payload
Undisclosed
CN106795203B_ADC-51 linker
 ADC Info 
CN106795203B_ADC-52 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-52 [3]
CN106795203B_ADC-52 payload
Undisclosed
CN106795203B_ADC-52 linker
 ADC Info 
CN106795203B_ADC-53 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-53 [3]
CN106795203B_ADC-53 payload
Undisclosed
CN106795203B_ADC-53 linker
 ADC Info 
CN106795203B_ADC-54 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-54 [3]
CN106795203B_ADC-54 payload
Undisclosed
CN106795203B_ADC-54 linker
 ADC Info 
CN106795203B_ADC-55 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-55 [3]
CN106795203B_ADC-55 payload
Undisclosed
CN106795203B_ADC-55 linker
 ADC Info 
CN106795203B_ADC-56 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-56 [3]
CN106795203B_ADC-56 payload
Undisclosed
CN106795203B_ADC-56 linker
 ADC Info 
CN106795203B_ADC-57 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-57 [3]
CN106795203B_ADC-57 payload
Undisclosed
CN106795203B_ADC-57 linker
 ADC Info 
CN106795203B_ADC-58 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-58 [3]
CN106795203B_ADC-58 payload
Undisclosed
CN106795203B_ADC-58 linker
 ADC Info 
CN106795203B_ADC-59 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-59 [3]
CN106795203B_ADC-59 payload
Undisclosed
CN106795203B_ADC-59 linker
 ADC Info 
CN106795203B_ADC-60 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-60 [3]
CN106795203B_ADC-60 payload
Undisclosed
CN106795203B_ADC-60 linker
 ADC Info 
CN106795203B_ADC-61 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-61 [3]
CN106795203B_ADC-61 payload
Undisclosed
CN106795203B_ADC-61 linker
 ADC Info 
CN106795203B_ADC-62 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-62 [3]
CN106795203B_ADC-62 payload
Undisclosed
CN106795203B_ADC-62 linker
 ADC Info 
CN106795203B_ADC-63 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-63 [3]
CN106795203B_ADC-63 payload
Undisclosed
CN106795203B_ADC-63 linker
 ADC Info 
CN106795203B_ADC-64 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-64 [3]
CN106795203B_ADC-64 payload
Undisclosed
CN106795203B_ADC-64 linker
 ADC Info 
CN106795203B_ADC-65 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-65 [3]
CN106795203B_ADC-65 payload
Undisclosed
CN106795203B_ADC-65 linker
 ADC Info 
CN106795203B_ADC-66 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-66 [3]
CN106795203B_ADC-66 payload
Undisclosed
CN106795203B_ADC-66 linker
 ADC Info 
CN106795203B_ADC-67 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-67 [3]
CN106795203B_ADC-67 payload
Undisclosed
CN106795203B_ADC-67 linker
 ADC Info 
CN106795203B_ADC-68 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-68 [3]
CN106795203B_ADC-68 payload
Undisclosed
CN106795203B_ADC-68 linker
 ADC Info 
CN106795203B_ADC-69 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-69 [3]
CN106795203B_ADC-69 payload
Undisclosed
CN106795203B_ADC-69 linker
 ADC Info 
CN106795203B_ADC-70 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-70 [3]
CN106795203B_ADC-70 payload
Undisclosed
CN106795203B_ADC-70 linker
 ADC Info 
CN106795203B_ADC-71 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106795203B ADC-71 [3]
CN106795203B_ADC-71 payload
Undisclosed
CN106795203B_ADC-71 linker
 ADC Info 
Cys-mutant sacituzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cys-mutant sacituzumab-biotin [20]
Biotin
Undisclosed
Undisclosed
 ADC Info 
Cys-mutant sacituzumab-vinblastine [20]
Vinblastine
Undisclosed
Undisclosed
 ADC Info 
Datopotamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Datopotamab deruxtecan
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Datopotamab-ADC-Tb2-1 [21]
Datopotamab-ADC-Tb2-1 payload
Undisclosed
Datopotamab-ADC-Tb2-1 linker
 ADC Info 
Datopotamab-ADC-Tb2-2 [21]
Datopotamab-ADC-Tb2-2 payload
Undisclosed
Datopotamab-ADC-Tb2-2 linker
 ADC Info 
Datopotamab-ADC-Tb2-3 [21]
Datopotamab-ADC-Tb2-3 payload
Undisclosed
Datopotamab-ADC-Tb2-3 linker
 ADC Info 
Datopotamab-ADC-Tb2-4 [21]
Datopotamab-ADC-Tb2-4 payload
Undisclosed
Datopotamab-ADC-Tb2-4 linker
 ADC Info 
Datopotamab-ADC-Tb2-5 [21]
Datopotamab-ADC-Tb2-5 payload
Undisclosed
Datopotamab-ADC-Tb2-5 linker
 ADC Info 
Datopotamab-ADC-Tb2-6 [21]
Datopotamab-ADC-Tb2-6 payload
Undisclosed
Datopotamab-ADC-Tb2-6 linker
 ADC Info 
Datopotamab-ADC-Tb2-7 [21]
Datopotamab-ADC-Tb2-7 payload
Undisclosed
Datopotamab-ADC-Tb2-7 linker
 ADC Info 
Datopotamab-ADC-Tb2-8 [21]
Datopotamab-ADC-Tb2-8 payload
Undisclosed
Datopotamab-ADC-Tb2-8 linker
 ADC Info 
Datopotamab-ADC-Tb2-9 [21]
Datopotamab-ADC-Tb2-9 payload
Undisclosed
Datopotamab-ADC-Tb2-9 linker
 ADC Info 
Datopotamab-ADC-Tb2-10 [21]
Datopotamab-ADC-Tb2-10 payload
Undisclosed
Datopotamab-ADC-Tb2-10 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
hIMB1636-MMAE [22]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hIMB1636-LDP-AE [23]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
KH-815 [24]
Exatecan+Triptolide
Undisclosed
DBCO-PEG4-GGFG linker
 ADC Info 
WO2021147993A1 ADC-6 [25]
WO2021147993A1 ADC-6 payload
Undisclosed
WO2021147993A1 ADC-6 linker
 ADC Info 
WO2021147993A1 ADC-7 [25]
WO2021147993A1 ADC-7 payload
Undisclosed
WO2021147993A1 ADC-7 linker
 ADC Info 
WO2021147993A1 ADC-8 [25]
WO2021147993A1 ADC-8 payload
Undisclosed
WO2021147993A1 ADC-8 linker
 ADC Info 
RS7-DL 1 [26]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
RS7-DL 2 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG4-Val-Cit-PABC
 ADC Info 
RS7-DL 3 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG8-Val-Cit-PAB
 ADC Info 
RS7-DL 4 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG24-Val-Cit-PAB
 ADC Info 
RS7-DL 5 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG8-Val-Cit-PEG8-PAB
 ADC Info 
RS7-DL 6 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG4-Lys (PEG24)-Cit-PAB
 ADC Info 
RS7-DL 7 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG8-Val-Lys (PEG8)-Cit-PAB
 ADC Info 
RS7-DL 8 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG4-Val-Lys (PEG12)-Cit-PAB
 ADC Info 
RS7-DL 9 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG4-Val-Lys (PEG16)-Cit-PAB
 ADC Info 
RS7-DL 10 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG4-Val-Lys (PEG24)-Cit-PAB
 ADC Info 
RS7-DL 11 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-Val-Lys (PEG24)-Cit-PAB
 ADC Info 
RS7-DL 12 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-Val-Lys-PAB
 ADC Info 
RS7-DL 13 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-PEG4-Lys (PEG24)-Cit-PAB
 ADC Info 
RS7-DL 14 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-Gly (glucose)-Val-Cit-PAB
 ADC Info 
RS7-DL 15 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-Val-Lys (Ser-PEG4-glucose)-PAB
 ADC Info 
RS7-DL 16 [26]
Monomethyl auristatin E
Microtubule (MT)
Mal-Val-Lys (Ser-PEG4-glucose)-PAB
 ADC Info 
hRS7 ATAC 1 [27]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mal-Val-Ala-PAB
 ADC Info 
hRS7 ATAC 2 [27]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimide-noncleavable-C6-linker
 ADC Info 
CN115515644A ADC-1-a [28]
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-1-a Linker
 ADC Info 
CN115515644A ADC-2-a [28]
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-2-a Linker
 ADC Info 
CN115515644A ADC-3-a [28]
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-3-a Linker
 ADC Info 
CN115515644A ADC-4-a [28]
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-4-a Linker
 ADC Info 
CN115515644A ADC-5-a [28]
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-5-a Linker
 ADC Info 
CN115515644A ADC-6-a [28]
CN115515644A ADC-1-a Payload
Undisclosed
CN115515644A ADC-6-a Linker
 ADC Info 
US20240245795A1 Antibody Conjugate 13 [29]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
US20240245795A1 Antibody Conjugate 14 [29]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
US20240245795A1 Antibody Conjugate 15 [29]
Antibody Conjugate 7 +Payload
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound12 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115429893A ADC4 [31]
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
 ADC Info 
CN115429893A ADC5 [31]
CN115429893A ADC2 Payload
Undisclosed
CB07 linker
 ADC Info 
CN115429893A ADC6 [31]
CN115429893A ADC3 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
CN115429893A ADC7 [31]
CN115429893A ADC7 Payload
Undisclosed
CN115429893A ADC7
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound1 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound11 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound2 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
LCB84
Monomethyl auristatin E
Microtubule (MT)
β-glucuronide linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound3 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound4 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
BL-M02D1
Ed-04
DNA topoisomerase 1 (TOP1)
Cathepsin B cleavable linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound5 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound6 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound10 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound7 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound8 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN115298220B Compound9 [30]
CN115298220B+Compound1+payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Humanized Anti-Trop-2 hIgG1 Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
RN927C [32]
Auristatin 0101
Microtubule (MT)
AcLys-Val-Cit-PABC
 ADC Info 
HuNb (TROP2-HSA)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuNb (TROP2-HSA)-MMAE [33]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2021147993A1 ADC-1 [25]
WO2021147993A1 ADC-1 payload
Undisclosed
WO2021147993A1 ADC-1 linker
 ADC Info 
WO2021147993A1 ADC-2 [25]
WO2021147993A1 ADC-2 payload
Undisclosed
WO2021147993A1 ADC-2 linker
 ADC Info 
WO2021147993A1 ADC-3 [25]
WO2021147993A1 ADC-3 payload
Undisclosed
WO2021147993A1 ADC-3 linker
 ADC Info 
WO2021147993A1 ADC-5 [25]
WO2021147993A1 ADC-5 payload
Undisclosed
WO2021147993A1 ADC-5 linker
 ADC Info 
PF-06478924
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PF-06664178
Auristatin 0101 (Aur0101)
Microtubule (MT)
AcLys-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
OBI-992
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-PEG24-Val-Ala-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
GsADC 3b [34]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
GsADC 5d [34]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
KsADC 7a [34]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
38981219 ADC 10a [34]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
38981219 ADC 10b [34]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
38981219 ADC 12a [34]
Monomethyl auristatin E
Microtubule (MT)
NHS-VC-PAB
 ADC Info 
38981219 ADC 12b [34]
Monomethyl auristatin E
Microtubule (MT)
NHS-VC-PAB
 ADC Info 
Sacituzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Sacituzumab govitecan [35]
SN-38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Sacituzumab tirumotecan
KL610023
DNA topoisomerase 1 (TOP1)
Pyrimidine CL2A carbonate linker
 ADC Info 
PBX-001 [36]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Trop2-ADC-01 (DAR8) [21]
Trop2-ADC-01(DAR8) payload
Undisclosed
Trop2-ADC-01(DAR8) linker
 ADC Info 
Trop2-ADC-02 (DAR8) [21]
Trop2-ADC-02(DAR8) payload
Undisclosed
Trop2-ADC-02(DAR8) linker
 ADC Info 
Trop2-ADC-03 (DAR8) [21]
Trop2-ADC-03(DAR8) payload
Undisclosed
Trop2-ADC-03(DAR8) linker
 ADC Info 
Trop2-ADC-04 (DAR8) [21]
Trop2-ADC-04(DAR8) payload
Undisclosed
Trop2-ADC-04(DAR8) linker
 ADC Info 
Trop2-ADC-05 (DAR8) [21]
Trop2-ADC-05(DAR8) payload
Undisclosed
Trop2-ADC-05(DAR8) linker
 ADC Info 
Trop2-ADC-06 (DAR8) [21]
Trop2-ADC-06(DAR8) payload
Undisclosed
Trop2-ADC-06(DAR8) linker
 ADC Info 
Trop2-ADC-07 (DAR8) [21]
Trop2-ADC-07(DAR8) payload
Undisclosed
Trop2-ADC-07(DAR8) linker
 ADC Info 
Trop2-ADC-08 (DAR8) [21]
Trop2-ADC-08(DAR8) payload
Undisclosed
Trop2-ADC-08(DAR8) linker
 ADC Info 
Trop2-ADC-09 (DAR8) [21]
Trop2-ADC-09(DAR8) payload
Undisclosed
Trop2-ADC-09(DAR8) linker
 ADC Info 
Trop2-ADC-10 (DAR8) [21]
Trop2-ADC-10(DAR8) payload
Undisclosed
Trop2-ADC-10(DAR8) linker
 ADC Info 
Sacituzumab-Compound (Ia) [37]
NeoDegrader P1
Protein cereblon (CRBN)
Sacituzumab-Compound (Ia) linker
 ADC Info 
ADC-II-3 [38]
ADC-II-3 payload
Undisclosed
ADC-II-3 linker
 ADC Info 
ADC-II-7 [38]
ADC-II-7 payload
Undisclosed
ADC-II-7 linker
 ADC Info 
ADC-II-11-a [38]
ADC-II-11-a payload
Undisclosed
ADC-II-11-a linker
 ADC Info 
ADC-II-15 [38]
ADC-II-15 payload
Undisclosed
ADC-II-15 linker
 ADC Info 
ADC-III-3 [38]
ADC-III-3 payload
Undisclosed
ADC-III-3 linker
 ADC Info 
ADC-III-11 [38]
ADC-III-11 payload
Undisclosed
ADC-III-11 linker
 ADC Info 
ADC-II-11-b [38]
ADC-II-11-b payload
Undisclosed
ADC-II-11-b linker
 ADC Info 
ADC-II-53 [38]
ADC-II-53 payload
Undisclosed
ADC-II-53 linker
 ADC Info 
ADC-II-57 [38]
ADC-II-57 payload
Undisclosed
ADC-II-57 linker
 ADC Info 
ADC-III-28 [38]
ADC-III-28 payload
Undisclosed
ADC-III-28 linker
 ADC Info 
ADC-III-33 [38]
ADC-III-33 payload
Undisclosed
ADC-III-33 linker
 ADC Info 
Sacituzumab-Deruxtecan [38]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2022228495A1 ADC-76 [39]
WO2022228495A1 ADC-76 payload
Undisclosed
WO2022228495A1 ADC-76 linker
 ADC Info 
WO2022228495A1 ADC-77 [39]
WO2022228495A1 ADC-77 payload
Undisclosed
WO2022228495A1 ADC-77 linker
 ADC Info 
WO2022228495A1 ADC-78 [39]
WO2022228495A1 ADC-78 payload
Undisclosed
WO2022228495A1 ADC-78 linker
 ADC Info 
Sacituzumab-SN-38 [40]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Sacituzumab-Compound 9 [41]
Mertansine DM1
Microtubule (MT)
Sacituzumab-Compound 9 linker
 ADC Info 
Sacituzumab-Compound 17 [41]
Mertansine DM4
Microtubule (MT)
Sacituzumab-Compound 17 linker
 ADC Info 
Sacituzumab-Compound 25 [41]
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 25 linker
 ADC Info 
Sacituzumab-Compound 31 [41]
Auristatin 0101
Microtubule (MT)
Sacituzumab-Compound 31 linker
 ADC Info 
Sacituzumab-Compound 36 [41]
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 36 linker
 ADC Info 
Sacituzumab-Compound 43 [41]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Sacituzumab-Compound 43 linker
 ADC Info 
Sacituzumab-Compound 49 [41]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Sacituzumab-Compound 49 linker
 ADC Info 
Sacituzumab-Compound 55 [41]
Mertansine DM1
Microtubule (MT)
Sacituzumab-Compound 55 linker
 ADC Info 
Sacituzumab-Compound 59 [41]
Mertansine DM4
Microtubule (MT)
Sacituzumab-Compound 59 linker
 ADC Info 
Sacituzumab-Compound 64 [41]
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 64 linker
 ADC Info 
Sacituzumab-Compound 69 [41]
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 69 linker
 ADC Info 
Sacituzumab-Compound 74 [41]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Sacituzumab-Compound 74 linker
 ADC Info 
Sacituzumab-Compound 75 [41]
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 75 linker
 ADC Info 
Sacituzumab-Compound 76 [41]
Monomethyl auristatin E
Microtubule (MT)
Sacituzumab-Compound 76 linker
 ADC Info 
Sacituzumab-Compound 77 [41]
Mertansine DM1
Microtubule (MT)
Sacituzumab-Compound 77 linker
 ADC Info 
Sacituzumab-Compound 78 [41]
Auristatin 0101
Microtubule (MT)
Sacituzumab-Compound 78 linker
 ADC Info 
Sacituzumab-Compound 79 [41]
Auristatin 0101
Microtubule (MT)
Sacituzumab-Compound 79 linker
 ADC Info 
Sacituzumab-Compound 80 [41]
Mertansine DM4
Microtubule (MT)
Sacituzumab-Compound 80 linker
 ADC Info 
SA-7-49 [42]
Exatecan
DNA topoisomerase 1 (TOP1)
BVP-PEG-VC-PABC
 ADC Info 
40151029 ADC 1 [43]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
40151029 ADC 2 [43]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Sac-CL2A-FL118 (10) [44]
Undisclosed
Undisclosed
CL2A
 ADC Info 
KH815 [45]
Exatecan+Triptolide
DNA topoisomerase 1 (TOP1)+RNA polymerase II
Mc-PEG2-VA-PAB+DBCO-PEG4-GGFG
 ADC Info 
Saxituzumab-chemical compound21 ADC [46]
US20240325556A1 Saxituzumab-chemical compound21 ADC Payload
Undisclosed
US20240325556A1 Saxituzumab-chemical compound21 ADC Linker
 ADC Info 
BT001021 [47]
US11970506B2 BT001021 Payload
Undisclosed
US11970506B2 BT001021 Linker
 ADC Info 
BT001002 [47]
US11970506B2 BT001002 Payload
Undisclosed
US11970506B2 BT001002 Linker
 ADC Info 
BT001004 [47]
T01-1
Undisclosed
US11970506B2 BT001021 Linker
 ADC Info 
BT001012 [47]
T01-1
Undisclosed
US11970506B2 BT001021 Linker
 ADC Info 
BT001013 [47]
US11970506B2 BT001021 Payload
Undisclosed
US11970506B2 BT001013 Linker
 ADC Info 
BT001018 [47]
T01-1
Undisclosed
US11970506B2 BT001018 Linker
 ADC Info 
BT001023 [47]
US11970506B2 BT001023 Payload
Undisclosed
US11970506B2 BT001013 Linker
 ADC Info 
BT001040 [47]
T01-1
Undisclosed
US11970506B2 BT001040 Linker
 ADC Info 
BT001041 [47]
T01-1
Undisclosed
US11970506B2 BT001041 Linker
 ADC Info 
BT001042 [47]
US11970506B2 BT001042 Payload
Undisclosed
US11970506B2 BT001042 Linker
 ADC Info 
BT001043 [47]
US11970506B2 BT001043 Payload
Undisclosed
US11970506B2 BT001043 Linker
 ADC Info 
BT001044 [47]
US11970506B2 BT001044 Payload
Undisclosed
US11970506B2 BT001043 Linker
 ADC Info 
BT001046 [47]
T01-1
Undisclosed
US11970506B2 BT001046 Linker
 ADC Info 
BT001047 [47]
US11970506B2 BT001047 Payload
Undisclosed
US11970506B2 BT001047 Linker
 ADC Info 
ZA202500415A-ADC Example 3 [48]
NMT inhibitor 1
N-Myristoyltransferase (NMT)
ZA202500415A-ADC-Example-1-Linker
 ADC Info 
CN118873678A ADC-15 [49]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN118873678A ADC-16 [49]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
Sacituzumab-RTX-5007 [50]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
sacituzumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2021147993A1 ADC-4 [25]
WO2021147993A1 ADC-4 payload
Undisclosed
WO2021147993A1 ADC-4 linker
 ADC Info 
WO2021147993A1 ADC-9 [25]
WO2021147993A1 ADC-9 payload
Undisclosed
WO2021147993A1 ADC-9 linker
 ADC Info 
Tizetatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Tizetatug rezetecan
SHR9265
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Trastuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-Trop2- (Q295-mcValCitPABC-A6)- (mcMMAF) [51]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-Trop2- (Q295-mcA6)- (mcMMMAF) [51]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-Trop2- (Q295-mcMMAF)- (mcValCitPABC-A6) [51]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-Trop2- (0295-mcMMAF)- (mc-A6) [51]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-Trop2- (Q295-mcMMAE)- (mc-A6) [51]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
Trop2-Saci- (mc-MMAF)- (McAsnAsn-A6) [51]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
Trop2-Saci- (mc-MMAF)- (mc-A6) [51]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
TROP2 (L328C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
anti-TROP2 Ab (L328C)-vcMMAE [52]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TROP2 Ab (L234A, L235A, L328C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
anti-TROP2 Ab (L234A, L235A, L328C)-vcMMAE [52]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BI0106
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Humanized anti-TROP2-SN38 antibody conjugate [53]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
R4702 [54]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-TROP2 ADC (Lanier) [55]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
DXC-003 [56]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
GQ-1003 [57]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
DpADC [58]
Topo1 inhibitor+immune agonist
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
Anti-TROP2 ADC (XDCExplorer) [59]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Recombinant humanized anti-Trop2 antibody [60]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-Trop2_AsnAsnPABC_MMAE 7.6 [61]
Monomethyl auristatin E
Microtubule (MT)
AsnAsnPABC
 ADC Info 
Antl-Trop2_AsnAlaPABC_MMAE [61]
Monomethyl auristatin E
Microtubule (MT)
AsnAlaPABC
 ADC Info 
Antl-Trop2_ValAlaPABC_MMAE [61]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Ala-PABC
 ADC Info 
Anti-Trop2_AsnAsnPABC_MMAE 4.5 [61]
Monomethyl auristatin E
Microtubule (MT)
AsnAsnPABC
 ADC Info 
Anti-Trop2_ValCitPABC_MMAE [61]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
SM002 [62]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
alphaTROP2-MMAE [63]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
PARPi ADC [64]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
antiTROP2 MF6 [65]
MF6
Undisclosed
Undisclosed
 ADC Info 
CAT-10-106 [46]
Maytansine
Microtubule (MT)
Undisclosed
 ADC Info 
WO2019126691A1 Conjugate No.10A [66]
Conjugate No.10 Payload
Undisclosed
Conjugate No.5 Linker
 ADC Info 
WO2019126691A1 Conjugate No.61 [66]
Conjugate No.60 Payload
Undisclosed
Conjugate No.5 Linker
 ADC Info 
Ab-TROP2-CIDE-BRM1-20
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab-TROF2-CIDE-BRM1-19
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab-TROF2-CIDE-BRM1-15
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2023124963A1 ADC-1 [67]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2023124963A1 ADC-2 [67]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2023124963A1 ADC-3 [67]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2023124963A1 ADC-4 [67]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2023124963A1 ADC-5 [67]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2023124963A1 ADC-6 [67]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN113813399A ADC:LN401-34-3 [68]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CN113813399A-ADC:LN401-34-3-linker
 ADC Info 
Production of the antibody-drug conjugate (3) [69]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Conjugate antibody-drug comprising human trop2 antibody and use of the same
Ref 2 Antibody-drug conjugates comprising an antibody against human TROP2 and uses thereof
Ref 3 Stability modulating linkers for antibody drug conjugates.
Ref 4 Novel maytansinoids as ADC payloads and their use for the treatment of cancer
Ref 5 Antibody-pyrrolobenzodiazepine derivative conjugates
Ref 6 Mabwell biopharmaceutical company product pipeline
Ref 7 ADC drug XYD-9668-198 antibody conjugating agent for injection passed the review of the State Drug Administration Drug Review Center and was granted implied permission for clinical trials.
Ref 8 Innoventbio 2022 Annual Performance Report.
Ref 9 Oligosaccharide linker, linker-payload comprising the same and glycan chain-remodeled antibody-drug conjugate, preparation methods and uses thereof
Ref 10 Combination of antibody-drug conjugate and ATR inhibitor
Ref 11 Combination of antibody-drug conjugate and PARP1 selective inhibitor
Ref 12 Oligosaccharide linkers, linker-payloads comprising the linkers, and glycan chain-remodeled antibody-drug conjugates, preparation methods and uses thereof
Ref 13 KJ-103: First-in-class naked anti-TROP2 HCAb with immune modulatory mechanisms and tumor regression potential in clinical trials
Ref 14 Introduction to basic information on ADC drug ADC2192
Ref 15 OBI-902, a novel TROP2 targeted antibody-drug conjugate via GlycOBI® platform, has favorable pharmacokinetics and sustained antitumor activities in challenging solid tumors
Ref 16 Oligosaccharide linker, linker-payload comprising the same and glycan chain-remodeled antibody-drug conjugate, preparation methods and uses thereof
Ref 17 Photoimmunotherapy targeting biliary-pancreatic cancer with humanized anti-TROP2 antibody. Cancer Med. 2019 Dec;8(18):7781-7792. doi: 10.1002/cam4.2658. Epub 2019 Nov 1.
Ref 18 Antibody-drug conjugate intermediates carrying irinotecan and C-lock site-specific conjugation groups, conjugation methods and antibody-drug conjugates
Ref 19 Antibody-drug conjugate intermediate SET0562, and its preparation and uses
Ref 20 Nickel-Catalyzed Antibody Bioconjugation
Ref 21 Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.
Ref 22 hIMB1636-MMAE, a Novel TROP2-Targeting Antibody-Drug Conjugate Exerting Potent Antitumor Efficacy in Pancreatic Cancer
Ref 23 A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers
Ref 24 Abstract 1586: KH815, a novel dual-payload TROP2-directed antibody-drug conjugate, shows potent antitumor efficacy in pre-clinical tumor model
Ref 25 Anti-trop-2 antidody-exatecan analog conjugate and medical use thereof; 2021-07-29.
Ref 26 PEGylation of Dipeptide Linker Improves Therapeutic Index and Pharmacokinetics of Antibody-Drug Conjugates
Ref 27 Novel Amanitin-Based Antibody-Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
Ref 28 An antibody-drug conjugate, its preparation method and applications
Ref 29 Preparation method and application of antibody drug conjugate
Ref 30 Antibody-drug conjugates and medical uses thereof
Ref 31 Drug conjugates and uses thereof
Ref 32 RN927C, a Site-Specific Trop-2 Antibody-Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models. Mol Cancer Ther. 2016 Nov;15(11):2698-2708. doi: 10.1158/1535-7163.MCT-16-0431. Epub 2016 Aug 31.
Ref 33 TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer
Ref 34 Design and synthesis of novel site-specific antibody-drug conjugates that target TROP2
Ref 35 Sacituzumab govitecan (IMMU-132), an anti-Trop-2-SN-38 antibody-drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics
Ref 36 Pinotbio biotechnology company product pipeline
Ref 37 Neodegrader conjugates; 2021-10-07.
Ref 38 Antitumor compound, and preparation method therefor and use thereof; 2022-04-07.
Ref 39 Preparation method for antibody-drug conjugate, and application; 2022-11-03.
Ref 40 Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34. doi: 10.1158/1535-7163.MCT-11-0632. Epub 2011 Oct 28.
Ref 41 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 42 Exploiting synthetic lethality in PDAC with antibody drug conjugates and ATR inhibition
Ref 43 Direct Preparation of Site-Specific Antibody-Drug Conjugates with Unpurified Antibodies in Culture Medium
Ref 44 Design, synthesis and biological evaluation of camptothecin analogue FL118 as a payload for antibody-drug conjugates in targeted cancer therapy
Ref 45 KH815, a novel dual-payload TROP2-directed antibody-drug conjugate, shows potent antitumor efficacy in pre-clinical tumor model
Ref 46 Methods of using antibody-drug conjugates
Ref 47 Bioactive molecule conjugate, preparation method and use thereof
Ref 48 Antibody drug conjugate comprising NMT inhibitor and its use
Ref 49 Antibody-drug conjugates and uses thereof
Ref 50 Oxazaphosphorine antibody drug conjugates and methods of use
Ref 51 Targeted delivery of dual payloads of MMAF or MMAE and TLR7 agonists for the treatment of cancer
Ref 52 Antibody compositions comprising Fc mutations and site-specific conjugation properties for use in treating cancer, immunological disorders, and methods thereof
Ref 53 Sorrento Announces That Its Subsidiary Levena and Its Partner Escugen Have Received Clearance to Begin Clinical Trials With Anti-TROP-2 Antibody Drug Conjugate For Multiple Solid Tumors; 21 Jul 2021.
Ref 54 Introduction to basic information on ADC drug R4702.
Ref 55 Introduction to basic information on anti TROP2 antibody drug conjugate (Lanier Biotherapeutics).
Ref 56 DAC biotechnology company product pipeline
Ref 57 ADC review: basic information about GQ1003.
Ref 58 An innovative site-specific dual-payload antibody drug conjugate (dpADC) combining a novel Topo1 inhibitor and an immune agonist delivers a strong immunogenic cell death (ICD) and antitumor response in vitro and in vivo. Cancer Res (2023) 83 (7_Supplement): 2640.
Ref 59 Introduction to basic information on ADC drug anti-TROP2 antibody-drug conjugate(XDCExplorer).
Ref 60 Introduction to basic information on ADC drug recombinant humanized anti-Trop2 antibody.
Ref 61 A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers
Ref 62 Development of an ELISA with acidification treatment for an antibody conjugate incorporating Exatecans
Ref 63 Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer
Ref 64 Therapeutic potential of antibody-drug conjugate with PARP1 selective inhibitor as a payload: A promising therapeutic approach for potent antitumor efficacy with reduced toxicity
Ref 65 Design and synthesis of the novel camptothecin analog MF-6 for application into site-specific antibody-drug conjugate
Ref 66 Pyrrolobenzodiazepine antibody conjugates
Ref 67 Antibody-drug conjugates with reduced reversible reactions, and their preparation and applications
Ref 68 Camptothecin compounds, their antibody-drug conjugates and uses thereof
Ref 69 Combination of antibody-drug conjugate with anti-SIRPα antibody