Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0HCSHN
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| ADC Name |
WO2021147993A1 ADC-7
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| Synonyms |
WO2021147993A1 ADC 7
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| Organization |
Jiangsu Hengrui Pharmaceuticals Co., Ltd.
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| Drug Status |
Investigative
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| Indication |
In total 2 Indication(s)
Gastric cancer [ICD11:2B72]
Investigative
Pancreatic cancer [ICD11:2C10]
Investigative
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| Drug-to-Antibody Ratio |
3.72
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| Structure |
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| Antibody Name |
hRS7
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Antibody Info | ||||
| Antigen Name |
Tumor-associated calcium signal transducer 2 (TACSTD2)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Linker Name |
WO2021147993A1 ADC-7 linker
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General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
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| Tumor Growth Inhibition value (TGI) |
≈ 100
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%
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COLO 205 cells
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Colon adenocarcinoma
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Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 100.00% (Day 28) | Moderate TROP2 expression (TROP2 ++) | ||
| Method Description |
Conjugates of the exemplary anti-TROP2 antibodies were tested using an established xenograft model of NUGC4 cells implanted subcutaneous into SCID mice. Mice were randomized by body weight into treatment groups and treated once post cell inoculation with 10 mg/kg of one of the conjugates listed above or with PBS only.
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| In Vivo Model | Colo205 CDX model | ||||
| In Vitro Model | Colon adenocarcinoma | COLO 205 cells | CVCL_0218 | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.18 nM | High TROP2 expression (TROP2 +++) | ||
| Method Description |
Conjugate in various concentrations was added to TROP2-expressing cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
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| In Vitro Model | Lung adenocarcinoma | HCC827 cells | CVCL_2063 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.31 nM | High TROP2 expression (TROP2 +++) | ||
| Method Description |
Conjugate in various concentrations was added to TROP2-expressing cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
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| In Vitro Model | Hypopharyngeal squamous cell carcinoma | FaDu cells | CVCL_1218 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 50.00 nM | Positive TROP2 expression (TROP2 +++/++) | ||
| Method Description |
Conjugate in various concentrations was added to TROP2-expressing cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
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| In Vitro Model | Ovarian serous cystadenocarcinoma | SK-OV-3 cells | CVCL_0532 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 52.75 nM | Moderate TROP2 expression (TROP2 ++) | ||
| Method Description |
Conjugate in various concentrations was added to TROP2-expressing cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
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| In Vitro Model | Colon adenocarcinoma | COLO 205 cells | CVCL_0218 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 72.92 nM | Moderate TROP2 expression (TROP2 ++) | ||
| Method Description |
Conjugate in various concentrations was added to TROP2-expressing cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
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| In Vitro Model | Lung small cell carcinoma | DMS 53 cells | CVCL_1177 | ||
| Experiment 6 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 100 nM | Negative TROP2 expression (TROP2 -) | ||
| Method Description |
Conjugate in various concentrations was added to TROP2-expressing cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
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| In Vitro Model | Normal | CHO-K1 cells | CVCL_0214 | ||
References
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