Antibody Information

General Information of This Antibody

Antibody ID	ANI0BUNQH
Antibody Name	Anti-TROP2 mAb T6-16
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Tumor-associated calcium signal transducer 2 (TACSTD2)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

TROP2-IR700 [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 49.50% (Day 14)	Positive TROP2 expression (TROP2+++/++)
Method Description	Five million of PK59 or TFK1 cells were injected subcutaneously into the right dorsum of the mice. Five million of 3T3/HER2 cells were injected subcutaneously into the left dorsum of the mice as negative control. The dose of ADC was 200 ug TROP2-IR700.
In Vivo Model	PK59 CDX model
In Vitro Model	Pancreatic carcinoma	PK-59 cells		CVCL_4897

References

Ref 1	Photoimmunotherapy targeting biliary-pancreatic cancer with humanized anti-TROP2 antibody. Cancer Med. 2019 Dec;8(18):7781-7792. doi: 10.1002/cam4.2658. Epub 2019 Nov 1.

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