Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0BDGKC
ADC Name	Trop2-ADC-05 (DAR8)
Synonyms	Trop2 ADC 05 (DAR8) Click to Show/Hide
Organization	Suzhou Medilink Therapeutics Ltd.
Drug Status	Investigative
Indication	In total 1 Indication(s) Breast cancer [ICD11:2C60-2C65] Investigative
Drug-to-Antibody Ratio	7.8
Structure
	3D MOL	2D MOL
Antibody Name	Sacituzumab		Antibody Info
Antigen Name	Tumor-associated calcium signal transducer 2 (TACSTD2)		Antigen Info
Payload Name	Undisclosed
Linker Name	Trop2-ADC-05(DAR8) linker

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Effective Concentration (EC50)	3.4	nM	HCC1806 cells	Breast squamous cell carcinoma
Half Maximal Effective Concentration (EC50)	10000	nM	NCI-H23 cells	Lung adenocarcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Effective Concentration (EC50)	3.40 nM	Positive TROP2 expression (TROP2 +++/++)
Method Description	Conjugate in various concentrations was added to cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
In Vitro Model	Breast squamous cell carcinoma	HCC1806 cells		CVCL_1258
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Effective Concentration (EC50)	10000 nM	Negative TROP2 expression (TROP2 -)
Method Description	Conjugate in various concentrations was added to cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
In Vitro Model	Lung adenocarcinoma	NCI-H23 cells		CVCL_1547

References

Ref 1	Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.