Antigen Information

General Information of This Antigen
Antigen ID
TAR0ZHRFU
Antigen Name
Glutamate carboxypeptidase 2 (FOLH1)
Gene Name
FOLH1
Gene ID
2346
Synonym
Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; Prostate-specific membrane antigen; Pteroylpoly-gamma-glutamate carboxypeptidase
Sequence
MWNLLHETDSAVA.RPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKAFL
DELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNK
THPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYART
EDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSY
PDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDA
QKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTL
RGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWD
AEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKELK
SPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWE
TNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAV
VLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLR
MMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPS
KAWGEVKRQIYVAAFTVQAAAETLSEVA

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Family
Peptidase M28 family
Function
Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.; Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

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Uniprot Entry
FOLH1_HUMAN
HGNC ID
HGNC:3788
KEGG ID
hsa:2346
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Name Payload Target Linker ADC Info
38751786 5D3 (CC-MLB8237)3.2 ATC [1]
MLN8237
Undisclosed
NHS-PEG-TCO-Tz
 ADC Info 
5D3 mAb-AF488
 Antibody Info 
ADC Name Payload Target Linker ADC Info
38751786 5D3 (CC-MLB8237)3.2-AF488 [1]
MLN8237
Undisclosed
NHS-PEG-TCO-Tz
 ADC Info 
5D3 mAb-AF555
 Antibody Info 
ADC Name Payload Target Linker ADC Info
38751786 5D3 (CC-MLB8237)3.2-AF555 [1]
MLN8237
Undisclosed
NHS-PEG-TCO-Tz
 ADC Info 
5D3 mAb-CF750
 Antibody Info 
ADC Name Payload Target Linker ADC Info
38751786 5D3 (CC-MLB8237)3.2-CF750 [1]
MLN8237
Undisclosed
NHS-PEG-TCO-Tz
 ADC Info 
ADC Name Payload Target Linker ADC Info
Monoclonal antibody 7E11 C5-selenocystamine conjugate [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
H8-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD7 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD8 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA -LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA -LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA -LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA -LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA -LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MHB048C [4]
MH30010008
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
Anti-PSMA IgG1 mAb D2B
 Antibody Info 
ADC Name Payload Target Linker ADC Info
111In-DTPA-D2B-DAR2-MMAE [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
111In-DTPA-D2B-DAR4-MMAE [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-PSMA IgG1k mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JNJ-95298177
Amberstatin 269 (AS269)
Microtubule (MT)
Oxime-PEG3
 ADC Info 
Anti-PSMA mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-15 [6]
DM1 derivative 15
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
PSMA-16 [6]
DM1 derivative 16
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
SHR-4394
SHR9265
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-PSMA mAb 5D3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
111In-DOTA-5D3 [7]
Indium-111
Human Deoxyribonucleic acid (hDNA)
Tetraxetan
 ADC Info 
Anti-PSMA mAb D2B
 Antibody Info 
ADC Name Payload Target Linker ADC Info
D2B-DCM [8]
Duocarmycin A
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Cit-PABC
 ADC Info 
Anti-PSMA mAb h3/F11-Var16
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H3/F11-Var16 (Anti-PSMA)-30.2060 [9]
Amanitin 30.206
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
H3/F11-Var16 (Anti-PSMA)-30.2867 [9]
Amanitin 30.2867
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb hD7-1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HD7-1 (VL-VH)-PE40 [10]
Pseudomonas exotoxin PE40
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
HD7-1 (VL-VH)-PE24 [10]
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
HD7-1 (VL-VH)-PE24mut [10]
Pseudomonas exotoxin PE24 mut
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
Anti-PSMA mAb wt
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYD998 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-wt-vcMMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2015177360A1 ADC-wt-mcMMAF [11]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb wt HC A339C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC339 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC D376C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC376 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC E152C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC152 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC G236C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC236 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC P153C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC153 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC P247C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC247 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC S375C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC375 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC S41C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYD1091 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-HC41-vcMMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2015177360A1 ADC-HC41-mcMMAF [11]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb wt HC S41C/S375C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC41-375 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC S41C/T120C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC41-120 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC T120C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYD1035 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC E165C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC205 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC G157C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC157 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC G41C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC41 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-LC41-vcMMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2015177360A1 ADC-LC41-mcMMAF [11]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb wt LC L154C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC165 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC P40C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC154 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-LC40-vcMMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2015177360A1 ADC-LC40-mcMMAF [11]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb wt LC T109C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC109 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC V205C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC40 [11]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA scFv
 Antibody Info 
ADC Name Payload Target Linker ADC Info
124I-scFvD2B [12]
Iodine I-124
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA-D265C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-PSMA-D265C-30.2060 [9]
Amanitin 30.206
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.2115 [9]
Amanitin 30.2115
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.2347 [9]
Amanitin 30.2347
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.1699 [9]
Amanitin 30.1699
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.2371 [9]
Amanitin 30.2371
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.0880 [9]
Amanitin 30.088
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimido-caproyl
 ADC Info 
Anti-PSMA-D265C-30.2867 [9]
Amanitin 30.2867
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimido-caproyl
 ADC Info 
Anti-PSMA-HC1205
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-HC1205-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC1205-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC1205-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC1205-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC1205-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA-HC41
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-HC41-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD7 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD8 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD9 [3]
Undisclosed
Undisclosed
PSMA-HC41-LD9 LINKER
 ADC Info 
PSMA-HC41-LD10 [3]
Undisclosed
Undisclosed
Trastuzumab-LD1-LINKER
 ADC Info 
PSMA-HC41-LD36 [3]
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
PSMA-HC41-LD36 LINKER
 ADC Info 
PSMA-HC41-LD64 [3]
PSMA-HC41-LD64 payload
Undisclosed
PSMA-HC41-LD64 LINKER
 ADC Info 
Anti-PSMA-LC40
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-LC40-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC40-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC40-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC40-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC40-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA-LC41
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-LC41-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC41-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC41-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC41-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC41-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA1 -LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA 1-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA 1-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA 1-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA 1-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Chimeric Anti-PSMA Antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EP4461318A2 anti-PSMA ADC11 [13]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC12 [13]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC13 [13]
Monomethyl auristatin F
Microtubule (MT)
CLeavable (Val-Citruline-PEG1) linker
 ADC Info 
EP4461318A2 anti-PSMA ADC14 [13]
Monomethyl auristatin F
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
EP4461318A2 anti-PSMA ADC15 [13]
Monomethyl auristatin E
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
ADC Name Payload Target Linker ADC Info
SDV2102 [14]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
Fully human anti-PSMA IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA ADC
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
TD001 [15]
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Humanized Anti-PSMA Antibody Variant 1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EP4461318A2 anti-PSMA ADC1 [13]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC2 [13]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC3 [13]
Monomethyl auristatin F
Microtubule (MT)
CLeavable (Val-Citruline-PEG1) linker
 ADC Info 
EP4461318A2 anti-PSMA ADC4 [13]
Monomethyl auristatin F
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
EP4461318A2 anti-PSMA ADC5 [13]
Monomethyl auristatin E
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
Humanized Anti-PSMA Antibody Variant 2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EP4461318A2 anti-PSMA ADC6 [13]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC7 [13]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC8 [13]
Monomethyl auristatin F
Microtubule (MT)
CLeavable (Val-Citruline-PEG1) linker
 ADC Info 
EP4461318A2 anti-PSMA ADC9 [13]
Monomethyl auristatin F
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
EP4461318A2 anti-PSMA ADC10 [13]
Monomethyl auristatin E
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
Humanized anti-PSMA IgG1k mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ARX-517
Amberstatin-269
Undisclosed
Oxime-PEG3
 ADC Info 
ADC Name Payload Target Linker ADC Info
MEDI3726
SG3199 (SC-DR002)
Human deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
YC1613 [16]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Ab-MC-VC-PAB-DMEDA-PEG (N3)-SN38 Linker
 ADC Info 
YC1628 [16]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Ab-MP2-VC-PAB-DMEDA-PEG (N3)-SN38 Linker
 ADC Info 
YC1605 [16]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
YC1667 [16]
MK4827
Undisclosed
Ab-MC-MMAF-VC-PAB-MK4827 Linker
 ADC Info 
YC1663 [16]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Ab-MC-MMAF-VC-PAB-DMEDA-PEG (N3)-SN38 Linker
 ADC Info 
J591 THIOMAB
 Antibody Info 
ADC Name Payload Target Linker ADC Info
J591 DAC [17]
GNE-987 (R)
Bromodomain-containing protein 4 (BRD4)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
J591-SC239C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-D Antibody-Compound (X) [18]
PSMA-D Antibody-Compound (X) payload
Undisclosed
PSMA-D Antibody-Compound (X) linker
 ADC Info 
PSMA-D Antibody-Compound (XI) [18]
PSMA-D Antibody-Compound (XI) payload
Undisclosed
PSMA-D Antibody-Compound (XI) linker
 ADC Info 
PSMA-D Antibody-Compound (XIV) [18]
PSMA-D Antibody-Compound (XIV) payload
Undisclosed
PSMA-D Antibody-Compound (XIV) linker
 ADC Info 
PSMA-D Antibody-Compound (XVIII) [18]
PSMA-D Antibody-Compound (XVIII) payload
Undisclosed
PSMA-D Antibody-Compound (XVIII) linker
 ADC Info 
PSMA-D Antibody-Compound (Ie) [18]
PSMA-D Antibody-Compound (Ie) payload
Undisclosed
PSMA-D Antibody-Compound (Ie) linker
 ADC Info 
PSMA-D Antibody-Compound (XIX) [18]
PSMA-D Antibody-Compound (XIX) payload
Undisclosed
PSMA-D Antibody-Compound (XIX) linker
 ADC Info 
PSMA-D Antibody-Compound (Ii) [18]
PSMA-D Antibody-Compound (Ii) payload
Undisclosed
PSMA-D Antibody-Compound (Ii) linker
 ADC Info 
PSMA-D Antibody-Compound (XLI) [18]
PSMA-D Antibody-Compound (XLI) payload
Undisclosed
PSMA-D Antibody-Compound (XLI) linker
 ADC Info 
PSMA-D Antibody-Compound (XVI) [18]
PSMA-D Antibody-Compound (XIX) payload
Undisclosed
PSMA-D Antibody-Compound (XIX) linker
 ADC Info 
PSMA-D Antibody-Compound (XL) [18]
PSMA-D Antibody-Compound (XL) payload
Undisclosed
PSMA-D Antibody-Compound (XL) linker
 ADC Info 
PSMA-D Antibody-Compound (XLIII) [18]
PSMA-D Antibody-Compound (XLIII) payload
Undisclosed
PSMA-D Antibody-Compound (XLIII) linker
 ADC Info 
PSMA-D Antibody-Compound (XLII) [18]
PSMA-D Antibody-Compound (XLII) payload
Undisclosed
PSMA-D Antibody-Compound (XLII) linker
 ADC Info 
J591-SC239C-Compound (XV) [18]
J591-SC239C-Compound (XV) payload
Undisclosed
J591-SC239C-Compound (XV) linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
MLN2704
DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
PSMA-A Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-A Antibody-Compound (X) [18]
PSMA-A Antibody-Compound (X) payload
Undisclosed
PSMA-A Antibody-Compound (X) linker
 ADC Info 
PSMA-A Antibody-Compound (XI) [18]
PSMA-A Antibody-Compound (XI) payload
Undisclosed
PSMA-A Antibody-Compound (XI) linker
 ADC Info 
PSMA-A Antibody-Compound (XIV) [18]
PSMA-A Antibody-Compound (XIV) payload
Undisclosed
PSMA-A Antibody-Compound (XIV) linker
 ADC Info 
PSMA-A Antibody-Compound (XVIII) [18]
PSMA-A Antibody-Compound (XVIII) payload
Undisclosed
PSMA-A Antibody-Compound (XVIII) linker
 ADC Info 
PSMA-A Antibody-Compound (Ie) [18]
PSMA-A Antibody-Compound (Ie) payload
Undisclosed
PSMA-A Antibody-Compound (Ie) linker
 ADC Info 
PSMA-A Antibody-Compound (XIX) [18]
PSMA-A Antibody-Compound (XIX) payload
Undisclosed
PSMA-A Antibody-Compound (XIX) linker
 ADC Info 
PSMA-A Antibody-Compound (Ii) [18]
PSMA-A Antibody-Compound (Ii) payload
Undisclosed
PSMA-A Antibody-Compound (Ii) linker
 ADC Info 
PSMA-A Antibody-Compound (XLI) [18]
PSMA-A Antibody-Compound (XLI) payload
Undisclosed
PSMA-A Antibody-Compound (XLI) linker
 ADC Info 
PSMA-A Antibody-Compound (XVI) [18]
PSMA-A Antibody-Compound (XIX) payload
Undisclosed
PSMA-A Antibody-Compound (XIX) linker
 ADC Info 
PSMA-A Antibody-Compound (XL) [18]
PSMA-A Antibody-Compound (XL) payload
Undisclosed
PSMA-A Antibody-Compound (XL) linker
 ADC Info 
PSMA-A Antibody-Compound (XLIII) [18]
PSMA-A Antibody-Compound (XLIII) payload
Undisclosed
PSMA-A Antibody-Compound (XLIII) linker
 ADC Info 
PSMA-A Antibody-Compound (XLII) [18]
PSMA-A Antibody-Compound (XLII) payload
Undisclosed
PSMA-A Antibody-Compound (XLII) linker
 ADC Info 
PSMA-A Antibody-Compound (XV) [18]
PSMA-A Antibody-Compound (XV) payload
Undisclosed
PSMA-A Antibody-Compound (XV) linker
 ADC Info 
PSMA-B Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-B Antibody-Compound (X) [18]
PSMA-B Antibody-Compound (X) payload
Undisclosed
PSMA-B Antibody-Compound (X) linker
 ADC Info 
PSMA-B Antibody-Compound (XI) [18]
PSMA-B Antibody-Compound (XI) payload
Undisclosed
PSMA-B Antibody-Compound (XI) linker
 ADC Info 
PSMA-B Antibody-Compound (XIV) [18]
PSMA-B Antibody-Compound (XIV) payload
Undisclosed
PSMA-B Antibody-Compound (XIV) linker
 ADC Info 
PSMA-B Antibody-Compound (XVIII) [18]
PSMA-B Antibody-Compound (XVIII) payload
Undisclosed
PSMA-B Antibody-Compound (XVIII) linker
 ADC Info 
PSMA-B Antibody-Compound (Ie) [18]
PSMA-B Antibody-Compound (Ie) payload
Undisclosed
PSMA-B Antibody-Compound (Ie) linker
 ADC Info 
PSMA-B Antibody-Compound (XIX) [18]
PSMA-B Antibody-Compound (XIX) payload
Undisclosed
PSMA-B Antibody-Compound (XIX) linker
 ADC Info 
PSMA-B Antibody-Compound (Ii) [18]
PSMA-B Antibody-Compound (Ii) payload
Undisclosed
PSMA-B Antibody-Compound (Ii) linker
 ADC Info 
PSMA-B Antibody-Compound (XLI) [18]
PSMA-B Antibody-Compound (XLI) payload
Undisclosed
PSMA-B Antibody-Compound (XLI) linker
 ADC Info 
PSMA-B Antibody-Compound (XVI) [18]
PSMA-B Antibody-Compound (XIX) payload
Undisclosed
PSMA-B Antibody-Compound (XIX) linker
 ADC Info 
PSMA-B Antibody-Compound (XL) [18]
PSMA-B Antibody-Compound (XL) payload
Undisclosed
PSMA-B Antibody-Compound (XL) linker
 ADC Info 
PSMA-B Antibody-Compound (XLIII) [18]
PSMA-B Antibody-Compound (XLIII) payload
Undisclosed
PSMA-B Antibody-Compound (XLIII) linker
 ADC Info 
PSMA-B Antibody-Compound (XLII) [18]
PSMA-B Antibody-Compound (XLII) payload
Undisclosed
PSMA-B Antibody-Compound (XLII) linker
 ADC Info 
PSMA-B Antibody-Compound (XV) [18]
PSMA-B Antibody-Compound (XV) payload
Undisclosed
PSMA-B Antibody-Compound (XV) linker
 ADC Info 
PSMA-C Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-C Antibody-Compound (X) [18]
PSMA-C Antibody-Compound (X) payload
Undisclosed
PSMA-C Antibody-Compound (X) linker
 ADC Info 
PSMA-C Antibody-Compound (XI) [18]
PSMA-C Antibody-Compound (XI) payload
Undisclosed
PSMA-C Antibody-Compound (XI) linker
 ADC Info 
PSMA-C Antibody-Compound (XIV) [18]
PSMA-C Antibody-Compound (XIV) payload
Undisclosed
PSMA-C Antibody-Compound (XIV) linker
 ADC Info 
PSMA-C Antibody-Compound (XVIII) [18]
PSMA-C Antibody-Compound (XVIII) payload
Undisclosed
PSMA-C Antibody-Compound (XVIII) linker
 ADC Info 
PSMA-C Antibody-Compound (Ie) [18]
PSMA-C Antibody-Compound (Ie) payload
Undisclosed
PSMA-C Antibody-Compound (Ie) linker
 ADC Info 
PSMA-C Antibody-Compound (XIX) [18]
PSMA-C Antibody-Compound (XIX) payload
Undisclosed
PSMA-C Antibody-Compound (XIX) linker
 ADC Info 
PSMA-C Antibody-Compound (Ii) [18]
PSMA-C Antibody-Compound (Ii) payload
Undisclosed
PSMA-C Antibody-Compound (Ii) linker
 ADC Info 
PSMA-C Antibody-Compound (XLI) [18]
PSMA-C Antibody-Compound (XLI) payload
Undisclosed
PSMA-C Antibody-Compound (XLI) linker
 ADC Info 
PSMA-C Antibody-Compound (XVI) [18]
PSMA-C Antibody-Compound (XIX) payload
Undisclosed
PSMA-C Antibody-Compound (XIX) linker
 ADC Info 
PSMA-C Antibody-Compound (XL) [18]
PSMA-C Antibody-Compound (XL) payload
Undisclosed
PSMA-C Antibody-Compound (XL) linker
 ADC Info 
PSMA-C Antibody-Compound (XLIII) [18]
PSMA-C Antibody-Compound (XLIII) payload
Undisclosed
PSMA-C Antibody-Compound (XLIII) linker
 ADC Info 
PSMA-C Antibody-Compound (XLII) [18]
PSMA-C Antibody-Compound (XLII) payload
Undisclosed
PSMA-C Antibody-Compound (XLII) linker
 ADC Info 
PSMA-C Antibody-Compound (XV) [18]
PSMA-C Antibody-Compound (XV) payload
Undisclosed
PSMA-C Antibody-Compound (XV) linker
 ADC Info 
Rosopatamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Rosopatamab tetraxetan [19]
Y90 (Radioactive isotope)
Undisclosed
Tetraxetan
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-PSMA antibody-drug conjugate (Protanbio) [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA ADC (Jiangsu hengrui) [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA antibody-deBouganin fusion protein (Crescendo/Sesen Bio) [22]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HDP-103 [23]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Undisclosed
 ADC Info 
DAN-405 [24]
Cabazitaxel
Microtubule (MT)
Undisclosed
 ADC Info 
MMAE.VC.SA.617 [25]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-PSMA antibody-drug conjugate [26]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CB-108 [27]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot41 [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot42 [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot55 [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot75 [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Development and therapeutic evaluation of 5D3(CC-MLN8237)(3.2) antibody-theranostic conjugates for PSMA-positive prostate cancer therapy
Ref 2 Monoclonal antibody 7E11 C5-selenocystamine conjugate; 29 Apr 2002.
Ref 3 Non-linear self-immolative linkers and conjugates thereof
Ref 4 Preclinical development of MHB048C: A novel anti-PSMA ADC with a potent topoisomerase I inhibitor
Ref 5 Characterization of Site-Specifically Conjugated Monomethyl Auristatin E- and Duocarmycin-Based Anti-PSMA Antibody-Drug Conjugates for Treatment of PSMA-Expressing Tumors. J Nucl Med. 2018 Mar;59(3):494-501. doi: 10.2967/jnumed.117.196279. Epub 2017 Nov 16.
Ref 6 Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.
Ref 7 Evaluation of 111In-DOTA-5D3, a Surrogate SPECT Imaging Agent for Radioimmunotherapy of Prostate-Specific Membrane Antigen. J Nucl Med. 2019 Mar;60(3):400-406. doi: 10.2967/jnumed.118.214403. Epub 2018 Sep 20.
Ref 8 Duocarmycin-based antibody-drug conjugates as an emerging biotherapeutic entity for targeted cancer therapy: Pharmaceutical strategy and clinical progress. Drug Discov Today. 2021 Aug;26(8):1857-1874. doi: 10.1016/j.drudis.2021.06.012. Epub 2021 Jul 3.
Ref 9 Amatoxin antibody-drug conjugates and uses thereof; 2020-10-29.
Ref 10 In Vitro Evaluation of Humanized/De-immunized Anti-PSMA Immunotoxins for the Treatment of Prostate Cancer. Anticancer Res. 2018 Jan;38(1):61-69. doi: 10.21873/anticanres.12192.
Ref 11 Site-specific conjugation of linker drugs to antibodies and resulting adcs.
Ref 12 Anti-PSMA (124)I-scFvD2B as a new immuno-PET tool for prostate cancer: preclinical proof of principle. J Exp Clin Cancer Res. 2019 Jul 23;38(1):326. doi: 10.1186/s13046-019-1325-6.
Ref 13 Novel anti-prostate-specific membrane antigen (PSMA) antibody drug conjugates
Ref 14 Preclinical evaluation of SDV2102, a novel PSMA-targeting DAR1 ADC for mCRPC treatment
Ref 15 Improved tumor penetration and cytotoxic payload release with TD001, a novel PSMA-targeting ADC with optimized linker-payload composition, in PSMA-expressing CRPC CDX castrated mouse models
Ref 16 Anti-PSMA antibody-drug conjugates and their preparation methods and applications
Ref 17 In Silico-Driven THIOMAB Approach for Stable PROTAC Conjugates by Docking Payloads in Antibody Cavities
Ref 18 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 19 ADC review ROSOPATAMAB TETRAXETAN
Ref 20 Introduction to basic information on anti PRLR anti-PSMA antibody-drug conjugate(Protanbio).
Ref 21 Introduction to basic information on ADC drug PSMA ADC (Jiangsu hengrui)
Ref 22 Engineering and characterization of anti-PSMA humabody-deBouganin fusion proteins. Cancer Res (2018) 78 (13_Supplement): 5770.
Ref 23 Heidelberg pharma product pipeline
Ref 24 Dantari biotechnology company product pipeline
Ref 25 Old Drug, New Delivery Strategy: MMAE Repackaged. Int J Mol Sci. 2023 May 10;24(10):8543. doi: 10.3390/ijms24108543.
Ref 26 Introduction to basic information on ADC drug Anti-PSMA antibody-drug conjugates(Medarex)
Ref 27 Multifunctional biologics for targeted T-cell therapy based on in vivo matured fully human VH domains. Cancer Res (2018) 78 (13_Supplement): 5766.
Ref 28 TLR7 agonists and antibody-drug conjugates thereof