Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0UHBXV
ADC Name	hD7-1 (VL-VH)-PE40
Synonyms	hD7 1 (VL VH) PE40 Click to Show/Hide
Drug Status	Investigative
Indication	In total 1 Indication(s) Prostate cancer [ICD11:2C82] Investigative
	3D MOL	2D MOL
Antibody Name	Anti-PSMA mAb hD7-1		Antibody Info
Antigen Name	Glutamate carboxypeptidase 2 (FOLH1)		Antigen Info
Payload Name	Pseudomonas exotoxin PE40		Payload Info
Therapeutic Target	Eukaryotic elongation factor 2 (EEF2)		Target Info
Linker Name	Undisclosed

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	37	pM	LNCaP C4-2 cells	Lymph node metastasis of prostate carcinoma
Half Maximal Inhibitory Concentration (IC50)	55	pM	LNCaP cells	Prostate carcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	37.00 pM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE40 was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Lymph node metastasis of prostate carcinoma	LNCaP C4-2 cells		CVCL_4782
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	55.00 pM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE40 was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Prostate carcinoma	LNCaP cells		CVCL_0395

References

Ref 1	In Vitro Evaluation of Humanized/De-immunized Anti-PSMA Immunotoxins for the Treatment of Prostate Cancer. Anticancer Res. 2018 Jan;38(1):61-69. doi: 10.21873/anticanres.12192.