Antibody Information

General Information of This Antibody

Antibody ID	ANI0GDTIL
Antibody Name	Anti-PSMA mAb hD7-1
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG
Antigen Name	Glutamate carboxypeptidase 2 (FOLH1)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

hD7-1 (VL-VH)-PE40 [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	37.00 pM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE40 was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Lymph node metastasis of prostate carcinoma	LNCaP C4-2 cells		CVCL_4782
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	55.00 pM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE40 was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Prostate carcinoma	LNCaP cells		CVCL_0395

hD7-1 (VL-VH)-PE24mut [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	39.00 pM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE24mut was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Lymph node metastasis of prostate carcinoma	LNCaP C4-2 cells		CVCL_4782
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.18 nM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE24mut was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Prostate carcinoma	LNCaP cells		CVCL_0395

hD7-1 (VL-VH)-PE24 [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.12 nM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE24 was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Prostate carcinoma	LNCaP cells		CVCL_0395
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	0.13 nM	Positive PSMA expression (PSMA+++/++)
Method Description	The immunotoxins hD7-1 (VL-VH)-PE24 was tested for specific cytotoxic activity against PSMA-positive LNCaP and C4-2 cells.
In Vitro Model	Lymph node metastasis of prostate carcinoma	LNCaP C4-2 cells		CVCL_4782

References

Ref 1	In Vitro Evaluation of Humanized/De-immunized Anti-PSMA Immunotoxins for the Treatment of Prostate Cancer. Anticancer Res. 2018 Jan;38(1):61-69. doi: 10.21873/anticanres.12192.