Antigen Information

General Information of This Antigen (ID: TAR0XFYLU)
Antigen Name
Trophoblast glycoprotein (TPBG)
Gene Name
TPBG
Gene ID
7162
Synonym
5T4; 5T4 oncofetal antigen;5T4 oncofetal trophoblast glycoprotein;M6P1;Wnt-activated inhibitory factor 1
Sequence
MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD
QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL
AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL
NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD
LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC
HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG
IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

    Click to Show/Hide
Function
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.

    Click to Show/Hide
Uniprot Entry
TPBG_HUMAN
HGNC ID
HGNC:12004
KEGG ID
hsa:7162
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
WO2024193682A1 32G1-ADC [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
MEDI-0641 [2]
5T4-PBD
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024193682A1 8D9-ADC [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024193682A1 8H10-ADC [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
US11147852B2 5T4-L443C 2.1 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-K392C 1.74 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-E380C 1.8 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-L398C 1.76 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-V422C 1.76 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-L443C 2 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-V422C 1.8 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-K392C 2 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-E380C-L398C [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-L398C-L443C 1 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-E380C-L443C [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-E380C-V422C [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-L398C-L443C 2 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-L398C-V422C [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-K392C-L443C [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
IL316790A-1 [4]
WO2023225359A1 payload
Undisclosed
IL316790A-1linker
 ADC Info 
IL317340A-2 2 [4]
WO2023225359A1 payload
Undisclosed
IL316790A-2linker
 ADC Info 
Anti-5T4 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TUB-030
Exatecan
DNA topoisomerase 1 (TOP1)
P5 (PEG24)-Val-Cit-PABC
 ADC Info 
JK06
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
XB010
Monomethyl auristatin E
Microtubule (MT)
RED-601 linker
 ADC Info 
Anti-5T4 humanized mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ACR246 [5]
D-2102
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-5T4 mAb H8 P41C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-H8-HC41 [6]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-5T4 mAb H8 S40C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-H8-HC40 [6]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-H8-HC40-vcMMAE [6]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2015177360A1 ADC-H8-HC40-mcMMAF [6]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-5T4 mAb H8 wt
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-H8-wt [6]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-H8-wt-mcMMAF [6]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-5T4 mAb m603
 Antibody Info 
ADC Name Payload Target Linker ADC Info
M603-SN38 DAR6 [7]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
M603-SN38 DAR8 [7]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
M603-SN38 DAR4 [7]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Anti-5T4 n501 (nanobody)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
N501-SN38 [7]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Anti-5T4 scFv-Fc mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ASN004
AF-HPA
Microtubule (MT)
Fleximer polymer
 ADC Info 
ADC Name Payload Target Linker ADC Info
n501-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
n501-alphaHSA
 Antibody Info 
ADC Name Payload Target Linker ADC Info
n501-alphaHSA-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
PF-06281192
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PF-06263507
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
ADC Name Payload Target Linker ADC Info
SYD1875
Seco-DUBA
Human deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
ADC Name Payload Target Linker ADC Info
ZV-0501 [9]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
ZV-0508 [9]
Duostatin 5
Human Deoxyribonucleic acid (hDNA)
C-Lock-ANN tri-peptide
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Antibody-drug conjugate (Zova Biotherapeutics) [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-TPBG antibody-drug conjugate (XDCExplorer) [11]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CME-548 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
5T4-FC-Mc-Lys-MMETA [13]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
A1-121-PHC-D-2 [14]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ISO-ADC [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
WO2024193682A1 32G1-2F11-ADC [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
WO2024193682A1 32G1-8H10-ADC [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
WO2024193682A1 32G1-8D9-ADC [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
Telisotuzumab-ADC [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
PF06263507-ADC [1]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
WO2024193682A1 32G1-8D9-CPT2 [1]
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
WO2024193682A1 32G1-8H10-CPT2 [1]
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
WO2024193682A1 32G1-2F11-CPT2 [1]
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
PF06263507-CPT2 [1]
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
SYD-1875-CPT2 [1]
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
Telisotuzumab-CPT2 [1]
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
WO2024193682A1 32G1-CPT2 [1]
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
WO2024193682A1 2F11-CPT2 [1]
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
US11147852B2 5T4-E380C 1.78 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-L398C 1.82 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US11147852B2 5T4-V422C 1.37 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Anti-TPBG/MET antibodies and uses thereof
Ref 2 Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4. Mol Cancer Ther. 2017 Aug;16(8):1576-1587. doi: 10.1158/1535-7163.MCT-16-0825. Epub 2017 May 18.
Ref 3 Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
Ref 4 Antibody-drug conjugates of antineoplastic compounds and methods of use thereof
Ref 5 A dose escalation and cohort expansion phase I/IIa study of ACR246, an innovative 5T4- antibody drug conjugate (ADC), in patients (pts) with advanced solid tumors
Ref 6 Site-specific conjugation of linker drugs to antibodies and resulting adcs.
Ref 7 A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors. Mol Ther. 2022 Aug 3;30(8):2785-2799.
Ref 8 Half-life extension of single-domain antibody-drug conjugates by albumin binding moiety enhances antitumor efficacy
Ref 9 Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C-Lock linker. Cancer Med. 2019 Apr;8(4):1793-1805. doi: 10.1002/cam4.2066. Epub 2019 Mar 7.
Ref 10 Introduction to basic information on ADC drug Antibody-drug conjugate(Zova Biotherapeutics)
Ref 11 Introduction to basic information on ADC drug anti-TPBG antibody-drug conjugate(XDCExplorer).
Ref 12 Research programme: 5T4 monoclonal antibody conjugates (CME-548)-Oxford BioMedica/Pfizer; 4 Nov 2017.
Ref 13 Introduction to basic information on 5T4-FC-mc-Lys-MMETA (Astrazeneca).
Ref 14 Antibody-drug conjugates; 2012-10-27