Antigen Information

General Information of This Antigen
Antigen ID
TAR0XFYLU
Antigen Name
Trophoblast glycoprotein (TPBG)
Gene Name
TPBG
Gene ID
7162
Synonym
5T4; 5T4 oncofetal antigen;5T4 oncofetal trophoblast glycoprotein;M6P1;Wnt-activated inhibitory factor 1
Sequence
MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD
QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL
AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL
NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD
LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC
HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG
IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

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Function
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.

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Uniprot Entry
TPBG_HUMAN
HGNC ID
HGNC:12004
KEGG ID
hsa:7162
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024193682A1 32G1-ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MEDI-0641
5T4-PBD
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024193682A1 8D9-ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024193682A1 8H10-ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
US11147852B2 5T4-L443C 2.1
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-K392C 1.74
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-E380C 1.8
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-L398C 1.76
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-V422C 1.76
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-L443C 2
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-V422C 1.8
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-K392C 2
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-E380C-L398C
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-L398C-L443C 1
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-E380C-L443C
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-E380C-V422C
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-L398C-L443C 2
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-L398C-V422C
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-K392C-L443C
Undisclosed
Undisclosed
Undisclosed
 [3]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
IL316790A-1
WO2023225359A1 payload
Undisclosed
IL316790A-1linker
 [4]
 ADC Info 
IL317340A-2 2
WO2023225359A1 payload
Undisclosed
IL316790A-2linker
 [4]
Anti-5T4 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
TUB-030
Exatecan
DNA topoisomerase 1 (TOP1)
P5 (PEG24)-Val-Cit-PABC
 ADC Info 
JK06
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
XB010
MMAE
Microtubule (MT)
RED-601 linker
Anti-5T4 humanized mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ACR246
D-2102
DNA topoisomerase 1 (TOP1)
A cleavable linker
 [5]
Anti-5T4 mAb H8 P41C
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2015177360A1 ADC-H8-HC41
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 [6]
Anti-5T4 mAb H8 S40C
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2015177360A1 ADC-H8-HC40
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 [6]
 ADC Info 
WO2015177360A1 ADC-H8-HC40-vcMMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [6]
 ADC Info 
WO2015177360A1 ADC-H8-HC40-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [6]
Anti-5T4 mAb H8 wt
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2015177360A1 ADC-H8-wt
seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 [6]
 ADC Info 
WO2015177360A1 ADC-H8-wt-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [6]
Anti-5T4 mAb m603
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
M603-SN38 DAR6
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 [7]
 ADC Info 
M603-SN38 DAR8
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 [7]
 ADC Info 
M603-SN38 DAR4
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 [7]
Anti-5T4 n501 (nanobody)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
N501-SN38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 [7]
Anti-5T4 scFv-Fc mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ASN004
AF-HPA
Microtubule (MT)
Fleximer polymer
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
n501-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [8]
n501-alphaHSA
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
n501-alphaHSA-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [8]
PF-06281192
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PF-06263507
MMAF
Microtubule (MT)
Maleimido-caproyl
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SYD1875
Seco-DUBA
Human deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZV-0501
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [9]
 ADC Info 
ZV-0508
Duostatin 5
Human Deoxyribonucleic acid (hDNA)
C-Lock-ANN tri-peptide
 [9]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Antibody-drug conjugate (Zova Biotherapeutics)
Undisclosed
Undisclosed
Undisclosed
 [10]
 ADC Info 
Anti-TPBG antibody-drug conjugate (XDCExplorer)
Undisclosed
Undisclosed
Undisclosed
 [11]
 ADC Info 
CME-548
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
5T4-FC-Mc-Lys-MMETA
Undisclosed
Undisclosed
Undisclosed
 [13]
 ADC Info 
A1-121-PHC-D-2
Undisclosed
Undisclosed
Undisclosed
 [14]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ISO-ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
 ADC Info 
WO2024193682A1 32G1-2F11-ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
 ADC Info 
WO2024193682A1 32G1-8H10-ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
 ADC Info 
WO2024193682A1 32G1-8D9-ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
 ADC Info 
Telisotuzumab-ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
 ADC Info 
PF06263507-ADC
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [1]
 ADC Info 
WO2024193682A1 32G1-8D9-CPT2
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 [1]
 ADC Info 
WO2024193682A1 32G1-8H10-CPT2
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 [1]
 ADC Info 
WO2024193682A1 32G1-2F11-CPT2
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 [1]
 ADC Info 
PF06263507-CPT2
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 [1]
 ADC Info 
SYD-1875-CPT2
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 [1]
 ADC Info 
Telisotuzumab-CPT2
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 [1]
 ADC Info 
WO2024193682A1 32G1-CPT2
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 [1]
 ADC Info 
WO2024193682A1 2F11-CPT2
CPT2
DNA topoisomerase I (TOP1)
Undisclosed
 [1]
 ADC Info 
US11147852B2 5T4-E380C 1.78
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-L398C 1.82
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
US11147852B2 5T4-V422C 1.37
Undisclosed
Undisclosed
Undisclosed
 [3]
References
Ref 1 Anti-TPBG/MET antibodies and uses thereof
Ref 2 Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4. Mol Cancer Ther. 2017 Aug;16(8):1576-1587. doi: 10.1158/1535-7163.MCT-16-0825. Epub 2017 May 18.
Ref 3 Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
Ref 4 Antibody-drug conjugates of antineoplastic compounds and methods of use thereof
Ref 5 A dose escalation and cohort expansion phase I/IIa study of ACR246, an innovative 5T4- antibody drug conjugate (ADC), in patients (pts) with advanced solid tumors
Ref 6 Site-specific conjugation of linker drugs to antibodies and resulting adcs.
Ref 7 A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors. Mol Ther. 2022 Aug 3;30(8):2785-2799.
Ref 8 Half-life extension of single-domain antibody-drug conjugates by albumin binding moiety enhances antitumor efficacy
Ref 9 Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C-Lock linker. Cancer Med. 2019 Apr;8(4):1793-1805. doi: 10.1002/cam4.2066. Epub 2019 Mar 7.
Ref 10 Introduction to basic information on ADC drug Antibody-drug conjugate(Zova Biotherapeutics)
Ref 11 Introduction to basic information on ADC drug anti-TPBG antibody-drug conjugate(XDCExplorer).
Ref 12 Research programme: 5T4 monoclonal antibody conjugates (CME-548)-Oxford BioMedica/Pfizer; 4 Nov 2017.
Ref 13 Introduction to basic information on 5T4-FC-mc-Lys-MMETA (Astrazeneca).
Ref 14 Antibody-drug conjugates; 2012-10-27