Antibody Information

General Information of This Antibody

Antibody ID	ANI0BMZTB
Antibody Name	5T4_0108
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG
Antigen Name	Trophoblast glycoprotein (TPBG)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

MEDI-0641 [Clinical candidate]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 91.30% (Day 49)	Positive 5T4 expression (5T4+++/++)
Method Description	A single dose of 5T4-PBD was administrated at 0.1 and 0.3 mg/kg intravenously into nude mice.
In Vivo Model	MDA-MB-361 CDX model
In Vitro Model	Breast adenocarcinoma	MDA-MB-361 cells		CVCL_0620

References

Ref 1	Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition. Mol Cancer Ther. 2019 Jan;18(1):89-99. doi: 10.1158/1535-7163.MCT-18-0314. Epub 2018 Oct 23.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.