Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ZGWEK
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| ADC Name |
XB010
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| Synonyms |
XB010
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| Organization |
Exelixis (Originator);Catalent (Top20 MNC);Invenra
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| Drug Status |
Phase 1
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| Drug-to-Antibody Ratio |
1.8
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| Structure |
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| Antibody Name |
Anti-5T4 antibody
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Antibody Info | ||||
| Antigen Name |
Trophoblast glycoprotein (TPBG)
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Antigen Info | ||||
| Payload Name |
MMAE
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
RED-601 linker
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Linker Info | ||||
| Conjugate Type |
Enzymatic Catalysis
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The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
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| Breast cancer |
1 Trials
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| Head and neck cancer |
1 Trials
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| Lung cancer |
1 Trials
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| Oesophageal cancer |
1 Trials
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| Unspecific solid tumor |
1 Trials
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Patients Enrolled |
Key inclusion criteria: age ≥18; ECOG 0-1; adequate organ function; histologically confirmed advanced/metastatic solid tumors (NSCLC, HR+ BC, HNSCC, ESCC, TNBC); protocol compliance capability with signed informed consent.
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| Administration Dosage |
IV administration of XB010
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| Related Clinical Trial | |||||
| NCT Number | NCT06545331 | Clinical Status | PHASE1 | ||
| Clinical Description | A Dose-Escalation and Expansion Study of XB010 as a Single Agent and Combination Therapy in Subjects With Locally Advanced or Metastatic Solid Tumors | ||||
| Primary Endpoint |
Primary endpoints include MTD/RDE determination (18 months), safety profile (AE/SAE incidence), tolerability (exposure duration/dose intensity), and preliminary antitumor activity (ORR per RECIST 1.1) for XB010 monotherapy and combination therapy.
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| Other Endpoint |
Secondary endpoints comprise PK parameters (Cmax, Tmax, clearance, AUC, Cmin) and immunogenicity (ADA analysis) for both dose-escalation (18 months) and cohort-expansion stages (24 months), along with continued tolerability assessments.
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