Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0TEICG
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| ADC Name |
M603-SN38 DAR8
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| Synonyms |
M603 SN38 DAR8
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| Drug Status |
Investigative
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| Indication |
In total 2 Indication(s)
Hepatocellular carcinoma [ICD11:2C12]
Investigative
Pancreatic cancer [ICD11:2C10]
Investigative
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| Drug-to-Antibody Ratio |
8
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| Structure |
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| Antibody Name |
Anti-5T4 mAb m603
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Antibody Info | ||||
| Antigen Name |
Trophoblast glycoprotein (TPBG)
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Antigen Info | ||||
| Payload Name |
Active metabolite of irinotecan SN38
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
CL2A
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Linker Info | ||||
| Combination Type |
Govitecan
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