Antigen Information

General Information of This Antigen (ID: TAR0WTBIA)
Antigen Name
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
Gene Name
VSIR
Gene ID
64115
Synonym
C10orf54; SISP1; VISTA
Sequence
MGVPTALEAGSWRWGSLLFALFLAASLGPVAAFKVATPYSLYVCPEGQNVTLTCRLLGPV
DKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLTFQDLHLHHGGHQAANTSHDLAQRHGLE
SASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEHRVHGAMELQVQTGKDAPSNCVV
YPSSSQDSENITAAALATGACIVGILCLPLILLLVYKQRQAASNRRAQELVRMDSNIQGI
ENPGFEASPPAQGIPEAKVRHPLSYVAQRQPSESGRHLLSEPSTPLSPPGPGDVFFPSLD
PVPDSPNFEVI

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Function
FUNCTION: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}.

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Uniprot Entry
VISTA_HUMAN
HGNC ID
HGNC:30085 ,
KEGG ID
hsa:64115
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
CN114230664B 146C: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 164A: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 175A: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 208A: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 215A: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 230A: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 259A: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 305A: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 353A: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 53A: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 5B: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114230664B 76E1: DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
767-IgG1.3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN116096413A 767-IgG1.3A [2]
INX-A-2 payload
Undisclosed
INX-A-3 linker
 ADC Info 
Anti-VISTA antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LFD-200
Undisclosed
Glucocorticoid receptor (NR3C1)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
C1.18 DBM- (C6)-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
DBM linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
INX-200A 7.8 [2]
INX-A-2 payload
Undisclosed
INX-A-3 linker
 ADC Info 
INX-200A 8 [2]
INX-A-2 payload
Undisclosed
INX-A-3 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
INX-201A [2]
INX-A-2 payload
Undisclosed
INX-A-3 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
INX-210A [2]
INX-A-2 payload
Undisclosed
INX-A-3 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
INX201J [3]
Cpd 2
Glucocorticoid receptor (GR)
Cys linker
 ADC Info 
INX201N [3]
INX-SM-1 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX201O [3]
INX-SM-4 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX201P [3]
INX-SM-3 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX201V [3]
INX-SM-3 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
INX231P [3]
INX-SM-3 payload
Undisclosed
Cys linker
 ADC Info 
INX231V [3]
INX-SM-3 payload
Undisclosed
Cys linker
 ADC Info 
INX231J [3]
Cpd 2
Glucocorticoid receptor (GR)
Cys linker
 ADC Info 
INX231R [3]
INX-SM-3 payload
Undisclosed
JP2024502360A5 INX231R Linker
 ADC Info 
INX231S [3]
INX-SM-24 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX231W [3]
INX-SM-3 payload
Undisclosed
JP2024502360A5 INX231W Linker
 ADC Info 
INX231A7 [3]
INX-SM-3 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX231A23 [3]
INX-SM-25 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX231A12 [3]
INX-SM-25 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
INX233P [3]
INX-SM-3 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
INX234A11 [3]
INX-SM-3 payload
Undisclosed
Cys linker
 ADC Info 
INX234V [3]
INX-SM-3 payload
Undisclosed
Cys linker
 ADC Info 
INX234J [3]
Cpd 2
Glucocorticoid receptor (GR)
JP2024502360A5 INX201N Linker
 ADC Info 
INX234P [3]
INX-SM-3 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX234A4 [3]
INX-SM-43 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX234A13 [3]
INX-SM-34 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX234A1 [3]
INX-SM-35 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
INX234A9 [3]
INX-SM-46 payload
Undisclosed
JP2024502360A5 INX201N Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
INX240J [3]
Cpd 2
Glucocorticoid receptor (GR)
JP2024502360A5 INX201N Linker
 ADC Info 
References
Ref 1 Anti-C10orf54 antibodies and uses thereof
Ref 2 Anti-human VISTA antibodies and uses thereof
Ref 3 New stelloid payloads, stelloid linkers, adcs, and their use