Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0JMFVP
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
C1.18 DBM- (C6)-MMAF
|
|||||
| Synonyms |
C1.18 DBM- (C6)-MMAF
Click to Show/Hide
|
|||||
| Organization |
Laboratories Pierre Fabre
|
|||||
| Drug Status |
Investigative
|
|||||
| Drug-to-Antibody Ratio |
4
|
|||||
| Structure |
|
|||||
| Antibody Name |
C1.18
|
Antibody Info | ||||
| Antigen Name |
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
|
Antigen Info | ||||
| Payload Name |
Monomethyl auristatin F
|
Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
|
Target Info | ||||
| Linker Name |
DBM linker
|
Linker Info | ||||
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 0.001 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
146C: DBM- (C6)-MMAF was tested in P31/FUJ,100-300nm,3days
|
||||
| In Vitro Model | Acute myeloid leukemia, Childhood acute myeloid leukemia | P31/FUJ cells | CVCL_1632 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 58.62 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
146C: DBM- (C6)-MMAF was tested in OCI/AML3,100-300nm,3days
|
||||
| In Vitro Model | Adult acute myelomonocytic leukemia, Acute myelomonocytic leukemia | OCI/AML3 cells | CVCL_1844 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
146C: DBM- (C6)-MMAF was tested in PL21,100-300nm,3days
|
||||
| In Vitro Model | Acute promyelocytic leukemia | PL21 cells | CVCL_2161 | ||