Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0CMBTM
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| ADC Name |
CN114230664B 53A: DBM- (C6)-MMAF
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| Synonyms |
53A: DBM- (C6)-MMAF
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| Organization |
Laboratories Pierre Fabre
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
4
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| Structure |
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| Antibody Name |
53A
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Antibody Info | ||||
| Antigen Name |
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin F
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
DBM linker
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Linker Info | ||||
| Conjugate Type |
site-specific bioconjugation via a dibromomaleimidelinker (DBM)
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 0.001 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
5B: DBM- (C6)-MMAF was tested in P31/FUJ,100-300nm,3days
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| In Vitro Model | Acute myeloid leukemia, Childhood acute myeloid leukemia | P31/FUJ cells | CVCL_1632 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 1.01 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
5B: DBM- (C6)-MMAF was tested in OCI/AML3,100-300nm,3days
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| In Vitro Model | Adult acute myelomonocytic leukemia, Acute myelomonocytic leukemia | OCI/AML3 cells | CVCL_1844 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
5B: DBM- (C6)-MMAF was tested in PL21,100-300nm,3days
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| In Vitro Model | Acute promyelocytic leukemia | PL21 cells | CVCL_2161 | ||