Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0AVUQH |
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| Antibody Name | 146C: |
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| Organization | Laboratories Pierre Fabre |
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| Synonyms |
146C:
Click to Show/Hide
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized lgG1 |
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| Antigen Name | V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Varible Domain |
MGWSCIIFFLVATATGVHSQVQLQQSGAELVRPGVSVKISCKGSGYTFTDYGMHWVKQSH
AKSLEWIGLIDTYYGDATYNHKFKGKATMTVDKSSRTAYMELARLTSEDSAIYYCARRAG NAMDYWGOGTSVTASS Click to Show/Hide
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| Light Chain Varible Domain |
MKSQTQVFVFLLLCVSGTHGNIAMTQTPKFLLVSAGDRVTITCKASQSVSNDIAWYQQKP
GQSPRLLIYYASNRYTGVPDRFTGSGYGTDFTFTISTVQAEDLAVYFCQQDYSSPRTFGG GTKLEIK Click to Show/Hide
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
CN114230664B 146C: DBM- (C6)-MMAF [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 0.001 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
164A: DBM- (C6)-MMAF was tested in P31/FUJ,100-300nm,3days
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| In Vitro Model | Acute myeloid leukemia, Childhood acute myeloid leukemia | P31/FUJ cells | CVCL_1632 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.3 nM
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High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
164A: DBM- (C6)-MMAF was tested in OCI/AML3,100-300nm,3days
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| In Vitro Model | Adult acute myelomonocytic leukemia, Acute myelomonocytic leukemia | OCI/AML3 cells | CVCL_1844 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
62.86 nM
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High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
164A: DBM- (C6)-MMAF was tested in PL21,100-300nm,3days
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| In Vitro Model | Acute promyelocytic leukemia | PL21 cells | CVCL_2161 | ||