Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0NWIQB
ADC Name
CN114230664B 76E1: DBM- (C6)-MMAF
Synonyms
76E1: DBM- (C6)-MMAF
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Organization
Laboratories Pierre Fabre
Drug Status
Investigative
Drug-to-Antibody Ratio
4
Structure
Antibody Name
760
  Antibody Info 
Antigen Name
V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)
  Antigen Info 
Payload Name
Monomethyl auristatin F
  Payload Info 
Therapeutic Target
Microtubule (MT)
  Target Info 
Linker Name
DBM linker
  Linker Info 
Conjugate Type
site-specific bioconjugation via a dibromomaleimidelinker (DBM)
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Effective Concentration (EC50) 
0.06
nM
CVCL_0419
Breast adenocarcinoma
Half Maximal Effective Concentration (EC50) 
0.07
nM
CVCL_0553
Invasive breast carcinoma of no special type
Half Maximal Effective Concentration (EC50) 
0.78
nM
CVCL_0214
Normal
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Effective Concentration (EC50) 0.06 nM High Nectin-4 expression (Nectin-4 +++)
Method Description
NEC49-9-A was tested in MDA-MB-468,1×106/ml,1h
In Vitro Model Breast adenocarcinoma MDA-MB-468 cells CVCL_0419
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Effective Concentration (EC50) 0.07 nM High Nectin-4 expression (Nectin-4 +++)
Method Description
NEC49-9-A was tested in T47D,1×106/ml,1h
In Vitro Model Invasive breast carcinoma of no special type T47D cells CVCL_0553
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Effective Concentration (EC50) 0.78 nM High Nectin-4 expression (Nectin-4 +++)
Method Description
NEC49-9-A was tested in Nectin4-CHOK1,1×106/ml,1h
In Vitro Model Normal CHOK1 cells CVCL_0214
References
Ref 1 Pharmaceutical compositions comprising anti-Nectin-4 antibody-drug conjugates and uses thereof