Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0TMBNQ |
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| Antibody Name | 353A |
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| Synonyms |
353A
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| Antigen Name | V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR) |
Antigen Info | ||||
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
CN114230664B 353A: DBM- (C6)-MMAF [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.16 nM
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High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
53A: DBM- (C6)-MMAF was tested in P31/FUJ,100-300nm,3days
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| In Vitro Model | Acute myeloid leukemia, Childhood acute myeloid leukemia | P31/FUJ cells | CVCL_1632 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.34 nM
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High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
53A: DBM- (C6)-MMAF was tested in OCI/AML3,100-300nm,3days
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| In Vitro Model | Adult acute myelomonocytic leukemia, Acute myelomonocytic leukemia | OCI/AML3 cells | CVCL_1844 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
4.97 nM
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High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
53A: DBM- (C6)-MMAF was tested in PL21,100-300nm,3days
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| In Vitro Model | Acute promyelocytic leukemia | PL21 cells | CVCL_2161 | ||