Antigen Information

General Information of This Antigen
Antigen ID
TAR0KQONX
Antigen Name
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Gene Name
TNFRSF17
Synonym
BCM; BCMA; B-cell maturation protein;CD_antigen=CD269
Sequence
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCL
GLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLE
YTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKS
ISAR

    Click to Show/Hide
Function
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

    Click to Show/Hide
Uniprot Entry
TNR17_HUMAN
HGNC ID
HGNC:11913
KEGG ID
hsa:608
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
008 (BCMA)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
wO2024222841A1 ADC62-4
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 [1]
 ADC Info 
wO2024222841A1 ADC62
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 [1]
 ADC Info 
wO2024222841A1 ADC64-4
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Undisclosed
 [1]
 ADC Info 
wO2024222841A1 ADC64
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Undisclosed
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
NZ761939B 15B2GL-SG3249
SG3199
Undisclosed
CL2A
 [2]
Anti-BCMA antibody 15B2GL
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-BCMA 15B2GL-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 [3]
 ADC Info 
Anti-BCMA 15B2GL-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [3]
Anti-BCMA antibody 15B2WT
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-BCMA 15B2WT-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 [3]
 ADC Info 
Anti-BCMA 15B2WT-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [3]
Anti-BCMA antibody I09
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-BCMA I09-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 [3]
 ADC Info 
Anti-BCMA I09-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [3]
Anti-BCMA antibody J6M0
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-BCMA J6M0-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 [3]
 ADC Info 
Anti-BCMA J6M0-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [3]
Anti-BCMA antibody L15
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-BCMA L15-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 [3]
 ADC Info 
Anti-BCMA L15-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [3]
Anti-BCMA antibody M02
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-BCMA M02-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 [3]
 ADC Info 
Anti-BCMA M02-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [3]
Anti-BCMA antibody N22
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-BCMA N22-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 [3]
 ADC Info 
Anti-BCMA N22-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [3]
Anti-BCMA antibody P10
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-BCMA P10-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 [3]
 ADC Info 
Anti-BCMA P10-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [3]
Anti-BCMA antibody R347
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-BCMA R347-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 [3]
Anti-human BCMA IgG1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AMG 224
DM1
Microtubule (MT)
4-[N-maleimidomethyl] cyclohexane-1-carboxylate (MCC)
BCMA-A Anti-ody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BCMA-A Antibody-Compound (X)
BCMA-A Antibody-Compound (X) payload
Undisclosed
BCMA-A Antibody-Compound (X) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XI)
BCMA-A Antibody-Compound (XI) payload
Undisclosed
BCMA-A Antibody-Compound (XI) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XIV)
BCMA-A Antibody-Compound (XIV) payload
Undisclosed
BCMA-A Antibody-Compound (XIV) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XVIII)
BCMA-A Antibody-Compound (XVIII) payload
Undisclosed
BCMA-A Antibody-Compound (XVIII) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (Ie)
BCMA-A Antibody-Compound (Ie) payload
Undisclosed
BCMA-A Antibody-Compound (Ie) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XIX)
BCMA-A Antibody-Compound (XIX) payload
Undisclosed
BCMA-A Antibody-Compound (XIX) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (Ii)
BCMA-A Antibody-Compound (Ii) payload
Undisclosed
BCMA-A Antibody-Compound (Ii) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XLI)
BCMA-A Antibody-Compound (XLI) payload
Undisclosed
BCMA-A Antibody-Compound (XLI) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XVI)
BCMA-A Antibody-Compound (XIX) payload
Undisclosed
BCMA-A Antibody-Compound (XIX) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XL)
BCMA-A Antibody-Compound (XL) payload
Undisclosed
BCMA-A Antibody-Compound (XL) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XLIII)
BCMA-A Antibody-Compound (XLIII) payload
Undisclosed
BCMA-A Antibody-Compound (XLIII) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XLII)
BCMA-A Antibody-Compound (XLII) payload
Undisclosed
BCMA-A Antibody-Compound (XLII) linker
 [4]
 ADC Info 
BCMA-A Antibody-Compound (XV)
BCMA-A Antibody-Compound (XV) payload
Undisclosed
BCMA-A Antibody-Compound (XV) linker
 [4]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MEDI2228
SG3199 (SC-DR002)
Human deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
Belantamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
αBCMA-MC-I034
Amine-I034
IKZF1/3
MC
 ADC Info 
Belan-DVA-I030
I030
IKZF1/3
MC-DVA-PABC
 ADC Info 
Belan-VA-I034 (4)
I034
IKZF1/3
MC-VA
 ADC Info 
Belan-VA-I034 (8)
I034
IKZF1/3
MC-VA
 ADC Info 
Belantamab mafodotin
MMAF
Microtubule (MT)
Maleimido-caproyl
 [5]
 ADC Info 
Belantamab-Compound (Ia)
NeoDegrader P1
Protein cereblon (CRBN)
Belantamab-Compound (Ia) linker
 [6]
 ADC Info 
Belantamab-Compound (X)
Belantamab-Compound (X) payload
Undisclosed
Belantamab-Compound (X) linker
 [4]
 ADC Info 
Belantamab-Compound (XI)
Belantamab-Compound (XI) payload
Undisclosed
Belantamab-Compound (XI) linker
 [4]
 ADC Info 
Belantamab-Compound (XIV)
Belantamab-Compound (XIV) payload
Undisclosed
Belantamab-Compound (XIV) linker
 [4]
 ADC Info 
Belantamab-Compound (XVIII)
Belantamab-Compound (XVIII) payload
Undisclosed
Belantamab-Compound (XVIII) linker
 [4]
 ADC Info 
Belantamab-Compound (Ie)
Belantamab-Compound (Ie) payload
Undisclosed
Belantamab-Compound (Ie) linker
 [4]
 ADC Info 
Belantamab-Compound (XIX)
Belantamab-Compound (XIX) payload
Undisclosed
Belantamab-Compound (XIX) linker
 [4]
 ADC Info 
Belantamab-Compound (Ii)
Belantamab-Compound (Ii) payload
Undisclosed
Belantamab-Compound (Ii) linker
 [4]
 ADC Info 
Belantamab-Compound (XLI)
Belantamab-Compound (XLI) payload
Undisclosed
Belantamab-Compound (XLI) linker
 [4]
 ADC Info 
Belantamab-Compound (XVI)
Belantamab-Compound (XIX) payload
Undisclosed
Belantamab-Compound (XIX) linker
 [4]
 ADC Info 
Belantamab-Compound (XL)
Belantamab-Compound (XL) payload
Undisclosed
Belantamab-Compound (XL) linker
 [4]
 ADC Info 
Belantamab-Compound (XLIII)
Belantamab-Compound (XLIII) payload
Undisclosed
Belantamab-Compound (XLIII) linker
 [4]
 ADC Info 
Belantamab-Compound (XLII)
Belantamab-Compound (XLII) payload
Undisclosed
Belantamab-Compound (XLII) linker
 [4]
 ADC Info 
Belantamab-Compound (XV)
Belantamab-Compound (XV) payload
Undisclosed
Belantamab-Compound (XV) linker
 [4]
 ADC Info 
DB-1325
PDUP5
Undisclosed
Undisclosed
 [7]
 ADC Info 
wO2024169913A1 ADC08-01-8
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
 [8]
 ADC Info 
wO2024169913A1 ADC08-01-4
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
GENA-111-AF
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 [9]
Humanized anti-BCMA mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DXC009
Undisclosed
Microtubule (MT)
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
I09-SG3249
SG3199
Undisclosed
CL2A
 [2]
Ispectamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ispectamab debotansine
SC347
Microtubule (MT)
Cys-12 ADC linker
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
L15-SG3249
SG3199
Undisclosed
CL2A
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
M02-SG3249
SG3199
Undisclosed
CL2A
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
N22-SG3249
SG3199
Undisclosed
CL2A
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
P10-SG3249
SG3199
Undisclosed
CL2A
 [2]
Pamlectabart
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Pamlectabart tismanitin
HDP 30.2115
RNA polymerase II
Mal-Val-Ala-PAB
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SG1-Val-Cit-MMAF8
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 [10]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SG2-Val-Cit-MMAF8
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 [10]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SG3-Val-Cit-MMAF8
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 [10]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
LN474-63
Monomethyl auristatin E
Microtubule (MT)
CN118079014A-linker-1
 [11]
 ADC Info 
LN474-64
Monomethyl auristatin E
Microtubule (MT)
CN118079014A-linker-3
 [11]
TNFRSF17 mAb1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
cN113549127A ADC-1
Undisclosed
Undisclosed
CN113549127A-ADC-1-linker
 [12]
 ADC Info 
cN113549127A ADC-2
Undisclosed
Undisclosed
CN113549127A-ADC-2-linker
 [12]
 ADC Info 
cN113549127A ADC-3
Undisclosed
Undisclosed
CN113549127A-ADC-3-linker
 [12]
 ADC Info 
cN113549127A ADC-4
Undisclosed
Undisclosed
CN113549127A-ADC-4-linker
 [12]
 ADC Info 
cN113549127A ADC-5
Undisclosed
Undisclosed
CN113549127A-ADC-5-linker
 [12]
 ADC Info 
cN113549127A ADC-6
Undisclosed
Undisclosed
CN113549127A-ADC-6-linker
 [12]
 ADC Info 
cN113549127A ADC-7
Undisclosed
Undisclosed
CN113549127A-ADC-7-linker
 [12]
 ADC Info 
cN113549127A ADC-8
Undisclosed
Undisclosed
CN113549127A-ADC-8-linker
 [12]
 ADC Info 
cN113549127A ADC-9
Undisclosed
Undisclosed
CN113549127A-ADC-9-linker
 [12]
 ADC Info 
cN113549127A ADC-10
Undisclosed
Undisclosed
CN113549127A-ADC-10-linker
 [12]
 ADC Info 
cN113549127A ADC-11
Undisclosed
Undisclosed
CN113549127A-ADC-11-linker
 [12]
 ADC Info 
cN113549127A ADC-12
Undisclosed
Undisclosed
CN113549127A-ADC-12-linker
 [12]
 ADC Info 
cN113549127A ADC-13
Undisclosed
Undisclosed
CN113549127A-ADC-13-linker
 [12]
 ADC Info 
cN113549127A ADC-14
Undisclosed
Undisclosed
CN113549127A-ADC-14-linker
 [12]
 ADC Info 
cN113549127A ADC-15
Undisclosed
Undisclosed
CN113549127A-ADC-15-linker
 [12]
 ADC Info 
cN113549127A ADC-16
Undisclosed
Undisclosed
CN113549127A-ADC-16-linker
 [12]
 ADC Info 
cN113549127A ADC-17
Undisclosed
Undisclosed
CN113549127A-ADC-17-linker
 [12]
 ADC Info 
cN113549127A ADC-18
Undisclosed
Undisclosed
CN113549127A-ADC-18-linker
 [12]
 ADC Info 
cN113549127A ADC-19
Undisclosed
Undisclosed
CN113549127A-ADC-19-linker
 [12]
 ADC Info 
cN113549127A ADC-20
Undisclosed
Undisclosed
CN113549127A-ADC-20-linker
 [12]
 ADC Info 
cN113549127A ADC-21
Undisclosed
Undisclosed
CN113549127A-ADC-21-linker
 [12]
 ADC Info 
cN113549127A ADC-22
Undisclosed
Undisclosed
CN113549127A-ADC-22-linker
 [12]
 ADC Info 
cN113549127A ADC-23
Undisclosed
Undisclosed
CN113549127A-ADC-23-linker
 [12]
 ADC Info 
cN113549127A ADC-24
Undisclosed
Undisclosed
CN113549127A-ADC-24-linker
 [12]
 ADC Info 
cN113549127A ADC-25
Undisclosed
Undisclosed
CN113549127A-ADC-25-linker
 [12]
 ADC Info 
cN113549127A ADC-26
Undisclosed
Undisclosed
CN113549127A-ADC-26-linker
 [12]
 ADC Info 
cN113549127A ADC-27
Undisclosed
Undisclosed
CN113549127A-ADC-27-linker
 [12]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
JS115
Undisclosed
Undisclosed
Undisclosed
 [13]
 ADC Info 
HD-101
Undisclosed
Undisclosed
Undisclosed
 [14]
 ADC Info 
Ispectamab tazide
Undisclosed
Undisclosed
Undisclosed
 [15]
 ADC Info 
LMB-75
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 [16]
 ADC Info 
LMB-70
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 [17]
 ADC Info 
BCMA-077
Duostatin 5.2
Microtubule (MT)
Proprietary Concortis linker
 [18]
 ADC Info 
BCMA-024
Duostatin 5.2
Microtubule (MT)
Proprietary Concortis linker
 [18]
References
Ref 1 Antibody-drug conjugate
Ref 2 BCMA monoclonal antibody-drug conjugate
Ref 3 Bcma monoclonal antibody-drug conjugate.
Ref 4 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 5 Belantamab Mafodotin: First Approval
Ref 6 Neodegrader conjugates; 2021-10-07.
Ref 7 DB-1325, a BCMA-targeting antibody-drug conjugate with a Duality Unique Payload, exhibits promising efficacy and safety in preclinical multiple myeloma treatment
Ref 8 Domide molecular glue derivative and use thereof
Ref 9 The antibody-drug conjugate GENA-111 conjugated to auristatin F shows therapeutic potency in BCAM positive epithelial cancer. 2022.
Ref 10 Antibody targeting of B-cell maturation antigen on malignant plasma cells. Mol Cancer Ther. 2007 Nov;6(11):3009-18. doi: 10.1158/1535-7163.MCT-07-0464.
Ref 11 Antibody-drug conjugate intermediate SET0562, and its preparation and uses
Ref 12 Vincristine and its antibody conjugates, preparation methods and medical uses
Ref 13 Junshi Biosciences biopharmaceutical company product pipeline
Ref 14 HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells. Mol Cancer Ther. 2021 Feb;20(2):367-378.
Ref 15 Introduction to basic information on ADC drug Ispectamab tazide.
Ref 16 Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4592-4598. doi: 10.1073/pnas.1821733116. Epub 2019 Feb 19.
Ref 17 Targeted Therapy With Immunoconjugates for Multiple Myeloma. Front Immunol. 2020 Jun 19;11:1155. doi: 10.3389/fimmu.2020.01155. eCollection 2020.
Ref 18 Preclinical Development of a Bcma Targeting Antibody-Drug Conjugate with Novel Payload for Multiple Myeloma Therapy. Blood. 2019 ;134():-. doi: 10.1182/blood-2019-132080.