General Information of This Antigen
Antigen ID
TAR0KQONX
Antigen Name
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Gene Name
TNFRSF17
Gene ID
608
Synonym
BCM; BCMA; B-cell maturation protein;CD_antigen=CD269
Sequence
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCL
GLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLE
YTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKS
ISAR

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Function
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

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Uniprot Entry
TNR17_HUMAN
HGNC ID
HGNC:11913
KEGG ID
hsa:608
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-BCMA antibody 15B2GL
ADC Info ADC Name Payload Target Linker Ref
Anti-BCMA 15B2GL-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
[1]
Anti-BCMA 15B2GL-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[1]
Anti-BCMA antibody 15B2WT
ADC Info ADC Name Payload Target Linker Ref
Anti-BCMA 15B2WT-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
[1]
Anti-BCMA 15B2WT-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[1]
Anti-BCMA antibody I09
ADC Info ADC Name Payload Target Linker Ref
Anti-BCMA I09-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
[1]
Anti-BCMA I09-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[1]
Anti-BCMA antibody J6M0
ADC Info ADC Name Payload Target Linker Ref
Anti-BCMA J6M0-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
[1]
Anti-BCMA J6M0-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[1]
Anti-BCMA antibody L15
ADC Info ADC Name Payload Target Linker Ref
Anti-BCMA L15-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
[1]
Anti-BCMA L15-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[1]
Anti-BCMA antibody M02
ADC Info ADC Name Payload Target Linker Ref
Anti-BCMA M02-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
[1]
Anti-BCMA M02-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[1]
Anti-BCMA antibody N22
ADC Info ADC Name Payload Target Linker Ref
Anti-BCMA N22-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
[1]
Anti-BCMA N22-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[1]
Anti-BCMA antibody P10
ADC Info ADC Name Payload Target Linker Ref
Anti-BCMA P10-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
[1]
Anti-BCMA P10-mcMMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[1]
Anti-BCMA antibody R347
ADC Info ADC Name Payload Target Linker Ref
Anti-BCMA R347-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
[1]
Anti-human BCMA IgG1 Anti-ody
ADC Info ADC Name Payload Target Linker Ref
AMG-224
Mertansine DM1
Microtubule (MT)
Noncleavable linker
[2]
BCMA-A Anti-ody
ADC Info ADC Name Payload Target Linker Ref
BCMA-A Antibody-Compound (X)
BCMA-A Antibody-Compound (X) payload
Undisclosed
BCMA-A Antibody-Compound (X) linker
[3]
BCMA-A Antibody-Compound (XI)
BCMA-A Antibody-Compound (XI) payload
Undisclosed
BCMA-A Antibody-Compound (XI) linker
[3]
BCMA-A Antibody-Compound (XIV)
BCMA-A Antibody-Compound (XIV) payload
Undisclosed
BCMA-A Antibody-Compound (XIV) linker
[3]
BCMA-A Antibody-Compound (XVIII)
BCMA-A Antibody-Compound (XVIII) payload
Undisclosed
BCMA-A Antibody-Compound (XVIII) linker
[3]
BCMA-A Antibody-Compound (Ie)
BCMA-A Antibody-Compound (Ie) payload
Undisclosed
BCMA-A Antibody-Compound (Ie) linker
[3]
BCMA-A Antibody-Compound (XIX)
BCMA-A Antibody-Compound (XIX) payload
Undisclosed
BCMA-A Antibody-Compound (XIX) linker
[3]
BCMA-A Antibody-Compound (Ii)
BCMA-A Antibody-Compound (Ii) payload
Undisclosed
BCMA-A Antibody-Compound (Ii) linker
[3]
BCMA-A Antibody-Compound (XLI)
BCMA-A Antibody-Compound (XLI) payload
Undisclosed
BCMA-A Antibody-Compound (XLI) linker
[3]
BCMA-A Antibody-Compound (XVI)
BCMA-A Antibody-Compound (XIX) payload
Undisclosed
BCMA-A Antibody-Compound (XIX) linker
[3]
BCMA-A Antibody-Compound (XL)
BCMA-A Antibody-Compound (XL) payload
Undisclosed
BCMA-A Antibody-Compound (XL) linker
[3]
BCMA-A Antibody-Compound (XLII)
BCMA-A Antibody-Compound (XLII) payload
Undisclosed
BCMA-A Antibody-Compound (XLII) linker
[3]
BCMA-A Antibody-Compound (XV)
BCMA-A Antibody-Compound (XV) payload
Undisclosed
BCMA-A Antibody-Compound (XV) linker
[3]
BCMA-A Antibody-Compound (XLIII)
BCMA-A Antibody-Compound (XLIII) payload
Undisclosed
BCMA-A Antibody-Compound (XLIII) linker
[3]
ADC Info ADC Name Payload Target Linker Ref
MEDI-2228
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
[4]
Belantamab
ADC Info ADC Name Payload Target Linker Ref
Belantamab mafodotin
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[5]
Belantamab-Compound (Ia)
NeoDegrader P1
Protein cereblon (CRBN)
Belantamab-Compound (Ia) linker
[6]
Belantamab-Compound (X)
Belantamab-Compound (X) payload
Undisclosed
Belantamab-Compound (X) linker
[3]
Belantamab-Compound (XI)
Belantamab-Compound (XI) payload
Undisclosed
Belantamab-Compound (XI) linker
[3]
Belantamab-Compound (XIV)
Belantamab-Compound (XIV) payload
Undisclosed
Belantamab-Compound (XIV) linker
[3]
Belantamab-Compound (XVIII)
Belantamab-Compound (XVIII) payload
Undisclosed
Belantamab-Compound (XVIII) linker
[3]
Belantamab-Compound (Ie)
Belantamab-Compound (Ie) payload
Undisclosed
Belantamab-Compound (Ie) linker
[3]
Belantamab-Compound (XIX)
Belantamab-Compound (XIX) payload
Undisclosed
Belantamab-Compound (XIX) linker
[3]
Belantamab-Compound (Ii)
Belantamab-Compound (Ii) payload
Undisclosed
Belantamab-Compound (Ii) linker
[3]
Belantamab-Compound (XLI)
Belantamab-Compound (XLI) payload
Undisclosed
Belantamab-Compound (XLI) linker
[3]
Belantamab-Compound (XVI)
Belantamab-Compound (XIX) payload
Undisclosed
Belantamab-Compound (XIX) linker
[3]
Belantamab-Compound (XL)
Belantamab-Compound (XL) payload
Undisclosed
Belantamab-Compound (XL) linker
[3]
Belantamab-Compound (XLII)
Belantamab-Compound (XLII) payload
Undisclosed
Belantamab-Compound (XLII) linker
[3]
Belantamab-Compound (XV)
Belantamab-Compound (XV) payload
Undisclosed
Belantamab-Compound (XV) linker
[3]
Belantamab-Compound (XLIII)
Belantamab-Compound (XLIII) payload
Undisclosed
Belantamab-Compound (XLIII) linker
[3]
ADC Info ADC Name Payload Target Linker Ref
GENA-111-AF
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[7]
Ispectamab
ADC Info ADC Name Payload Target Linker Ref
Ispectamab debotansine
Undisclosed
Undisclosed
Undisclosed
[8]
J22.9-ISY
ADC Info ADC Name Payload Target Linker Ref
HDP-101
HDP 30.2115
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mal-Val-Ala-PAB
[9]
ADC Info ADC Name Payload Target Linker Ref
SG1-Val-Cit-MMAF8
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
[10]
ADC Info ADC Name Payload Target Linker Ref
SG2-Val-Cit-MMAF8
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
[10]
ADC Info ADC Name Payload Target Linker Ref
SG3-Val-Cit-MMAF8
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
[10]
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
LMB-75
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 (EEF2)
Undisclosed
[11]
LMB-70
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 (EEF2)
Undisclosed
[12]
JS115
Undisclosed
Undisclosed
Undisclosed
[13]
HD-101
Undisclosed
Undisclosed
Undisclosed
[9]
BCMA-077
Duostatin 5.2
Microtubule (MT)
Proprietary Concortis linker
[14]
BCMA-024
Duostatin 5.2
Microtubule (MT)
Proprietary Concortis linker
[14]
Ispectamab tazide
Undisclosed
Undisclosed
Undisclosed
[15]
Tissue/Disease specific Abundances of This Antigen
Tissue specific Abundances of This Antigen
ICD Disease Classification 01
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Bacterial infection [ICD-11: 1A00-1C4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Bacterial infection of gingival
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 8.52E-18; Fold-change: 3.122347755; Z-score: 1.994226681
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 02
Click to Show/Hide the 22 Disease of This Class
Brain cancer [ICD-11: 2A00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Brainstem
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.331881317; Fold-change: -0.010849904; Z-score: -0.284950846
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue White matter
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.66778461; Fold-change: -0.113561904; Z-score: -0.292199765
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Brainstem
The Specific Disease Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.986211929; Fold-change: -0.073840353; Z-score: -0.220288714
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Nervous
The Specific Disease Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 3.00E-08; Fold-change: 0.082541462; Z-score: 0.371827938
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic myeloid leukemia [ICD-11: 2A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Polycythemia vera
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001505918; Fold-change: -0.484175194; Z-score: -0.59155559
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Whole blood
The Specific Disease Myelofibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.00066657; Fold-change: -0.953146094; Z-score: -1.213878203
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
MyeloDysplastic syndromes [ICD-11: 2A37]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myelodysplastic syndromes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.05E-08; Fold-change: 0.122374208; Z-score: 0.520641354
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.297346353; Fold-change: -1.447986786; Z-score: -0.855843791
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lymphoma [ICD-11: 2A90- 2A85]
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Differential expression pattern of antigen in diseases
The Studied Tissue Tonsil
The Specific Disease Lymphoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.602881605; Fold-change: -0.25461628; Z-score: -0.554510831
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Gastric cancer [ICD-11: 2B72]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gastric
The Specific Disease Gastric cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.469257303; Fold-change: -1.441058242; Z-score: -0.569339339
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 5.58E-06; Fold-change: -3.03439155; Z-score: -1.881174726
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Colon cancer [ICD-11: 2B90]
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Differential expression pattern of antigen in diseases
The Studied Tissue Colon
The Specific Disease Colon cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.16E-90; Fold-change: -3.644835204; Z-score: -3.574469107
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.95E-24; Fold-change: -3.384712234; Z-score: -1.632028843
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pancreatic cancer [ICD-11: 2C10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pancreas
The Specific Disease Pancreatic cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.320491645; Fold-change: 0.715020891; Z-score: 0.477242758
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.351116344; Fold-change: 0.427818262; Z-score: 0.205393941
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver cancer [ICD-11: 2C12]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.077813056; Fold-change: -0.34277196; Z-score: -0.605229713
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 5.23E-19; Fold-change: -0.916138396; Z-score: -0.98851839
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.360741231; Fold-change: -0.654375938; Z-score: -1.448375561
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lung cancer [ICD-11: 2C25]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Lung cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 8.53E-14; Fold-change: 1.094372667; Z-score: 0.78263291
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 2.08E-20; Fold-change: 1.400408395; Z-score: 1.256330216
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Melanoma [ICD-11: 2C30]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Melanoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000691944; Fold-change: 0.697305369; Z-score: 0.711230787
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sarcoma [ICD-11: 2C35]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Sarcoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 4.42E-07; Fold-change: -0.005788607; Z-score: -0.029638646
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.053924158; Fold-change: -0.006136129; Z-score: -0.043753387
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Breast cancer [ICD-11: 2C60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Breast
The Specific Disease Breast cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 9.02E-09; Fold-change: -0.861758859; Z-score: -0.609745709
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 7.47E-05; Fold-change: -1.773956431; Z-score: -1.007424618
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ovarian cancer [ICD-11: 2C73]
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Differential expression pattern of antigen in diseases
The Studied Tissue Ovarian
The Specific Disease Ovarian cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.002597083; Fold-change: 0.094195267; Z-score: 0.262564046
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.002906071; Fold-change: 0.026919535; Z-score: 0.060702909
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cervical cancer [ICD-11: 2C77]
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Differential expression pattern of antigen in diseases
The Studied Tissue Cervical
The Specific Disease Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.004426047; Fold-change: 0.702512474; Z-score: 0.771339411
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Uterine cancer [ICD-11: 2C78]
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Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Uterine cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.20E-26; Fold-change: 0.772715444; Z-score: 1.191506134
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.001982672; Fold-change: 0.431916354; Z-score: 1.373884752
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Prostate cancer [ICD-11: 2C82]
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Differential expression pattern of antigen in diseases
The Studied Tissue Prostate
The Specific Disease Prostate cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.481147797; Fold-change: 0.900597982; Z-score: 0.470364291
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Bladder cancer [ICD-11: 2C94]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Bladder cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.143352931; Fold-change: -2.08586932; Z-score: -1.22977056
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Retina cancer [ICD-11: 2D02]
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Differential expression pattern of antigen in diseases
The Studied Tissue Uvea
The Specific Disease Retinoblastoma tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.082204747; Fold-change: -0.086243846; Z-score: -0.923802851
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thyroid cancer [ICD-11: 2D10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Thyroid
The Specific Disease Thyroid cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.223159191; Fold-change: 0.087496957; Z-score: 0.039809326
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.716038437; Fold-change: -0.023761149; Z-score: -0.013399718
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Adrenal cancer [ICD-11: 2D11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Adrenal cortex
The Specific Disease Adrenocortical carcinoma
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.32139533; Fold-change: -0.06312443; Z-score: -0.648095634
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Head and neck cancer [ICD-11: 2D42]
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Differential expression pattern of antigen in diseases
The Studied Tissue Head and neck
The Specific Disease Head and neck cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.10E-09; Fold-change: 2.306981513; Z-score: 1.282688704
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pituitary cancer [ICD-11: 2F37]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pituitary
The Specific Disease Pituitary gonadotrope tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.769823349; Fold-change: -0.058985747; Z-score: -0.338538097
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Pituitary
The Specific Disease Pituitary cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.867231208; Fold-change: -0.104764579; Z-score: -0.545691903
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 03
Click to Show/Hide the 1 Disease of This Class
Thrombocytopenia [ICD-11: 3B64]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.709519071; Fold-change: -0.500279897; Z-score: -0.273951143
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 04
Click to Show/Hide the 2 Disease of This Class
Lupus erythematosus [ICD-11: 4A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Lupus erythematosus
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 4.59E-05; Fold-change: 1.078783947; Z-score: 0.567806736
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autoimmune disease [ICD-11: 4A4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral monocyte
The Specific Disease Autoimmune uveitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.829579722; Fold-change: -0.021963433; Z-score: -0.185800787
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 05
Click to Show/Hide the 1 Disease of This Class
Hyperlipoproteinaemia [ICD-11: 5C80]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Familial hypercholesterolemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.457568661; Fold-change: 0.281140409; Z-score: 0.391603567
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 06
Click to Show/Hide the 1 Disease of This Class
Schizophrenia [ICD-11: 6A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Superior temporal cortex
The Specific Disease Schizophrenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.367687603; Fold-change: 0.011552709; Z-score: 0.083540365
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 08
Click to Show/Hide the 3 Disease of This Class
Multiple sclerosis [ICD-11: 8A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Spinal cord
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.934463264; Fold-change: -0.021904152; Z-score: -0.030076374
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Plasmacytoid dendritic cells
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.113545751; Fold-change: -0.632726737; Z-score: -0.92087781
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Epilepsy [ICD-11: 8A60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peritumoral cortex
The Specific Disease Epilepsy
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.643124069; Fold-change: 0.079884903; Z-score: 0.145718378
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cerebral ischaemic stroke [ICD-11: 8B11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Cardioembolic Stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.083164636; Fold-change: 0.087614168; Z-score: 0.124859396
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Ischemic stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.004937732; Fold-change: -0.749534003; Z-score: -0.647970162
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 1
Click to Show/Hide the 6 Disease of This Class
HIV [ICD-11: 1C60-1C62]
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Differential expression pattern of antigen in diseases
The Studied Tissue White matter
The Specific Disease HIV
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.90186037; Fold-change: 0.032865358; Z-score: 0.136043953
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Influenza [ICD-11: 1E30]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Influenza
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.038092191; Fold-change: 0.849460691; Z-score: 2.528155663
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic hepatitis C [ICD-11: 1E51.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Chronic hepatitis C
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.722258147; Fold-change: 0.008218961; Z-score: 0.007575839
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sepsis [ICD-11: 1G40-1G41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Sepsis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 3.17E-05; Fold-change: -1.601560055; Z-score: -1.034796918
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Septic shock [ICD-11: 1G41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Septic shock
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 5.68E-11; Fold-change: -0.937005656; Z-score: -0.650945592
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pediatric respiratory syncytial virus infection [ICD-11: CA40.11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Pediatric respiratory syncytial virus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.438194681; Fold-change: -0.317308295; Z-score: -0.450287966
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 11
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Essential hypertension [ICD-11: BA00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Essential hypertension
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.871009692; Fold-change: -0.013623589; Z-score: -0.087124486
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myocardial infarction [ICD-11: BA41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Myocardial infarction
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.008000262; Fold-change: -1.775927781; Z-score: -0.896140866
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Coronary artery disease [ICD-11: BA8Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Coronary artery disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.180597375; Fold-change: -0.556538134; Z-score: -1.387628222
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aortic stenosis [ICD-11: BB70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Calcified aortic valve
The Specific Disease Aortic stenosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.474610846; Fold-change: 0.191206333; Z-score: 0.389274079
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arteriosclerosis [ICD-11: BD40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arteriosclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.464785744; Fold-change: 0.4398841; Z-score: 0.512139465
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aneurysm [ICD-11: BD50]
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Differential expression pattern of antigen in diseases
The Studied Tissue Intracranial artery
The Specific Disease Aneurysm
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.035542589; Fold-change: 0.214848291; Z-score: 0.911369993
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 12
Click to Show/Hide the 8 Disease of This Class
Immunodeficiency [ICD-11: 4A00-4A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Immunodeficiency
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.189349808; Fold-change: 0.10708905; Z-score: 1.217479485
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Apnea [ICD-11: 7A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Hyperplastic tonsil
The Specific Disease Apnea
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.080586549; Fold-change: 2.12079696; Z-score: 2.311352155
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Olive pollen allergy [ICD-11: CA08.00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Olive pollen allergy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.839252145; Fold-change: -0.017869431; Z-score: -0.063221691
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic rhinosinusitis [ICD-11: CA0A]
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Differential expression pattern of antigen in diseases
The Studied Tissue Sinus mucosa
The Specific Disease Chronic rhinosinusitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.229492491; Fold-change: 0.261278843; Z-score: 0.934160744
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic obstructive pulmonary disease [ICD-11: CA22]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.891678293; Fold-change: -0.039350044; Z-score: -0.031961155
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Small airway epithelium
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.267414984; Fold-change: 0.018771853; Z-score: 0.105007829
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Asthma [ICD-11: CA23]
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Differential expression pattern of antigen in diseases
The Studied Tissue Nasal and bronchial airway
The Specific Disease Asthma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.400063306; Fold-change: -0.060649909; Z-score: -0.121765438
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Human rhinovirus infection [ICD-11: CA42]
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Differential expression pattern of antigen in diseases
The Studied Tissue Nasal Epithelium
The Specific Disease Human rhinovirus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.988336386; Fold-change: -0.00942386; Z-score: -0.074518331
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Idiopathic pulmonary fibrosis [ICD-11: CB03.4]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Idiopathic pulmonary fibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.010165763; Fold-change: 0.868092582; Z-score: 1.489605978
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 13
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Periodontal disease [ICD-11: DA0C]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Periodontal disease
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.45E-14; Fold-change: 2.83963031; Z-score: 1.840723446
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Eosinophilic gastritis [ICD-11: DA42.2]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gastric antrum
The Specific Disease Eosinophilic gastritis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.51778432; Fold-change: 2.755146669; Z-score: 1.069692685
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver failure [ICD-11: DB99.7-DB99.8]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver failure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.47E-07; Fold-change: 4.078429654; Z-score: 5.777773844
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ulcerative colitis [ICD-11: DD71]
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Differential expression pattern of antigen in diseases
The Studied Tissue Colon mucosal
The Specific Disease Ulcerative colitis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.29926457; Fold-change: 1.812488533; Z-score: 0.694481436
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Irritable bowel syndrome [ICD-11: DD91.0]
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Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Irritable bowel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.520181336; Fold-change: -0.007762066; Z-score: -0.010543021
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 14
Click to Show/Hide the 5 Disease of This Class
Atopic dermatitis [ICD-11: EA80]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Atopic dermatitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.382701944; Fold-change: -0.106123212; Z-score: -0.889604265
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Psoriasis [ICD-11: EA90]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Psoriasis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001252733; Fold-change: 0.166662346; Z-score: 0.365654166
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.00529483; Fold-change: -0.181326453; Z-score: -0.267723181
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Vitiligo [ICD-11: ED63.0]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Vitiligo
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.86843161; Fold-change: -0.512572481; Z-score: -0.736890451
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alopecia [ICD-11: ED70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin from scalp
The Specific Disease Alopecia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.115470043; Fold-change: 0.201020383; Z-score: 0.294601826
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sensitive skin [ICD-11: EK0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Sensitive skin
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.298603057; Fold-change: -0.741406085; Z-score: -1.208530981
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 15
Click to Show/Hide the 6 Disease of This Class
Osteoarthritis [ICD-11: FA00-FA0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Osteoarthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.484871728; Fold-change: 0.003238464; Z-score: 0.017916721
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthropathy [ICD-11: FA00-FA5Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthropathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.602097403; Fold-change: -0.211635796; Z-score: -0.25312834
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthritis [ICD-11: FA20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.008311748; Fold-change: -0.449930451; Z-score: -0.408613931
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rheumatoid arthritis [ICD-11: FA20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Rheumatoid arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.63E-06; Fold-change: 0.144790081; Z-score: 0.471805681
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ankylosing spondylitis [ICD-11: FA92.0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pheripheral blood
The Specific Disease Ankylosing spondylitis
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Osteoporosis [ICD-11: FB83]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Osteoporosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.949028373; Fold-change: 0.018983694; Z-score: 0.167964264
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 16
Click to Show/Hide the 2 Disease of This Class
Endometriosis [ICD-11: GA10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Endometriosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.441880235; Fold-change: 0.058673002; Z-score: 0.276974793
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Interstitial cystitis [ICD-11: GC00.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Interstitial cystitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.012553607; Fold-change: 2.830998312; Z-score: 1.321690948
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 19
Click to Show/Hide the 1 Disease of This Class
Preterm birth [ICD-11: KA21.4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Myometrium
The Specific Disease Preterm birth
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.228749378; Fold-change: -0.173097614; Z-score: -0.244213349
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 2
Click to Show/Hide the 8 Disease of This Class
Acute myelocytic leukemia [ICD-11: 2A60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Acute myelocytic leukemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 4.35E-12; Fold-change: -0.735187612; Z-score: -0.556394377
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myeloma [ICD-11: 2A83]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.32E-05; Fold-change: 1.013408162; Z-score: 3.369312108
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.45088209; Fold-change: 0.050809789; Z-score: 0.070104221
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Oral cancer [ICD-11: 2B6E]
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Differential expression pattern of antigen in diseases
The Studied Tissue Oral
The Specific Disease Oral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.173774683; Fold-change: 0.64794547; Z-score: 0.415954085
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.102548296; Fold-change: -0.419699023; Z-score: -0.261027717
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Esophagal cancer [ICD-11: 2B70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Esophagus
The Specific Disease Esophagal cancer
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.61953701; Fold-change: -1.321979217; Z-score: -0.770168497
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rectal cancer [ICD-11: 2B92]
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Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Rectal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.05E-08; Fold-change: -4.164218927; Z-score: -7.930142665
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 4.84E-07; Fold-change: -3.994749261; Z-score: -6.449341803
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Skin cancer [ICD-11: 2C30-2C3Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Skin cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.86E-22; Fold-change: 0.39656187; Z-score: 0.637529941
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 2.73E-16; Fold-change: 0.235560466; Z-score: 0.393709702
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Renal cancer [ICD-11: 2C90-2C91]
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Differential expression pattern of antigen in diseases
The Studied Tissue Kidney
The Specific Disease Renal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.47E-07; Fold-change: 0.155922165; Z-score: 0.810036741
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.45E-08; Fold-change: 0.202915133; Z-score: 0.459464123
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ureter cancer [ICD-11: 2C92]
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Differential expression pattern of antigen in diseases
The Studied Tissue Urothelium
The Specific Disease Ureter cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.858759505; Fold-change: 0.017656704; Z-score: 0.105668858
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 20
Click to Show/Hide the 2 Disease of This Class
Simpson golabi behmel syndrome [ICD-11: LD2C]
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Differential expression pattern of antigen in diseases
The Studied Tissue Adipose
The Specific Disease Simpson golabi behmel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.634474519; Fold-change: -0.02097205; Z-score: -0.195095581
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Tuberous sclerosis complex [ICD-11: LD2D.2]
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Differential expression pattern of antigen in diseases
The Studied Tissue Perituberal
The Specific Disease Tuberous sclerosis complex
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.127087943; Fold-change: 0.117312348; Z-score: 1.197261551
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 3
Click to Show/Hide the 3 Disease of This Class
Anemia [ICD-11: 3A00-3A9Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Anemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.8771069; Fold-change: -0.022134295; Z-score: -0.019540198
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sickle cell disease [ICD-11: 3A51.0-3A51.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Sickle cell disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.052883545; Fold-change: -0.25925456; Z-score: -0.662454418
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thrombocythemia [ICD-11: 3B63]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocythemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.946830968; Fold-change: 0.244673525; Z-score: 0.309246589
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 4
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Scleroderma [ICD-11: 4A42.Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Scleroderma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.048465514; Fold-change: -0.981047836; Z-score: -0.964562137
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sjogren syndrome [ICD-11: 4A43]
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Differential expression pattern of antigen in diseases
The Studied Tissue Salivary gland
The Specific Disease Sjogren syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.576230753; Fold-change: -0.384590939; Z-score: -0.589062898
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.446986039; Fold-change: 0.325119576; Z-score: 0.609109489
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Behcet disease [ICD-11: 4A62]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Behcet disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.982098699; Fold-change: 0.056990255; Z-score: 0.094030724
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autosomal dominant monocytopenia [ICD-11: 4B04]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autosomal dominant monocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.205221306; Fold-change: -0.028696527; Z-score: -0.14702984
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 5
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Type 2 diabetes [ICD-11: 5A11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Type 2 diabetes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.131930703; Fold-change: 0.142362865; Z-score: 0.718803486
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Polycystic ovary syndrome [ICD-11: 5A80.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Vastus lateralis muscle
The Specific Disease Polycystic ovary syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.403139285; Fold-change: 0.048691558; Z-score: 0.414820926
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Obesity [ICD-11: 5B81]
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Differential expression pattern of antigen in diseases
The Studied Tissue Subcutaneous Adipose
The Specific Disease Obesity
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.124799433; Fold-change: 0.027732304; Z-score: 0.136374259
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pompe disease [ICD-11: 5C51.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Biceps muscle
The Specific Disease Pompe disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.943630696; Fold-change: -0.016826339; Z-score: -0.095039255
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Batten disease [ICD-11: 5C56.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Batten disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.180693553; Fold-change: -0.510682679; Z-score: -0.459759146
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 6
Click to Show/Hide the 2 Disease of This Class
Autism [ICD-11: 6A02]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autism
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.62126815; Fold-change: -0.322105267; Z-score: -0.288818296
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Anxiety disorder [ICD-11: 6B00-6B0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Anxiety disorder
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.048795047; Fold-change: -0.146210439; Z-score: -0.205636477
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 8
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Parkinson disease [ICD-11: 8A00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Substantia nigra
The Specific Disease Parkinson disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.983324164; Fold-change: 0.041501377; Z-score: 0.463914273
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Huntington disease [ICD-11: 8A01]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Huntington disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.070766614; Fold-change: -0.842991405; Z-score: -0.954804545
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alzheimer disease [ICD-11: 8A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Entorhinal cortex
The Specific Disease Alzheimer disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.492811429; Fold-change: -0.015439834; Z-score: -0.119547347
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Seizure [ICD-11: 8A60-8A6Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Seizure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.103724032; Fold-change: 1.147566597; Z-score: 0.81121349
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lateral sclerosis [ICD-11: 8B60.4]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.748333447; Fold-change: -0.07410185; Z-score: -0.602136061
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Cervical spinal cord
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.489721215; Fold-change: 0.112985335; Z-score: 0.483443731
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Muscular atrophy [ICD-11: 8C70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Muscular atrophy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.315601706; Fold-change: -0.108966403; Z-score: -0.523970888
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myopathy [ICD-11: 8C70.6]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Myopathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001208142; Fold-change: 0.32133498; Z-score: 2.035871441
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
References
Ref 1 Bcma monoclonal antibody-drug conjugate.
Ref 2 Phase 1 study of the anti-BCMA antibody-drug conjugate AMG 224 in patients with relapsed/refractory multiple myeloma. Leukemia. 2021 Jan;35(1):255-258.
Ref 3 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 4 BCMA-Specific ADC MEDI2228 and Daratumumab Induce Synergistic Myeloma Cytotoxicity via IFN-Driven Immune Responses and Enhanced CD38 Expression. Clin Cancer Res. 2021 Oct 1;27(19):5376-5388.
Ref 5 Belantamab Mafodotin-blmf: A Novel Antibody-Drug Conjugate for Treatment of Patients With Relapsed/Refractory Multiple Myeloma. J Adv Pract Oncol. 2022 Jan;13(1):77-85. doi: 10.6004/jadpro.2022.13.1.7. Epub 2022 Feb 1.
Ref 6 Neodegrader conjugates; 2021-10-07.
Ref 7 The antibody-drug conjugate GENA-111 conjugated to auristatin F shows therapeutic potency in BCAM positive epithelial cancer. 2022.
Ref 8 A Study of CC-99712, a BCMA Antibody-Drug Conjugate, in Participants With Relapsed and Refractory Multiple Myeloma.
Ref 9 HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells. Mol Cancer Ther. 2021 Feb;20(2):367-378.
Ref 10 Antibody targeting of B-cell maturation antigen on malignant plasma cells. Mol Cancer Ther. 2007 Nov;6(11):3009-18. doi: 10.1158/1535-7163.MCT-07-0464.
Ref 11 Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4592-4598. doi: 10.1073/pnas.1821733116. Epub 2019 Feb 19.
Ref 12 Targeted Therapy With Immunoconjugates for Multiple Myeloma. Front Immunol. 2020 Jun 19;11:1155. doi: 10.3389/fimmu.2020.01155. eCollection 2020.
Ref 13 Junshi Biosciences biopharmaceutical company product pipeline
Ref 14 Preclinical Development of a Bcma Targeting Antibody-Drug Conjugate with Novel Payload for Multiple Myeloma Therapy. Blood. 2019 ;134():-. doi: 10.1182/blood-2019-132080.
Ref 15 Introduction to basic information on ADC drug Ispectamab tazide.

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