Antigen Information

General Information of This Antigen (ID: TAR0KQONX)
Antigen Name
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)
Gene Name
TNFRSF17
Gene ID
608
Synonym
BCM; BCMA; B-cell maturation protein;CD269
Sequence
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCL
GLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLE
YTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKS
ISAR

    Click to Show/Hide
Function
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

    Click to Show/Hide
Uniprot Entry
TNR17_HUMAN
HGNC ID
HGNC:11913
KEGG ID
hsa:608
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
008 (BCMA)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024222841A1 ADC62-4 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 ADC Info 
WO2024222841A1 ADC62 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 ADC Info 
WO2024222841A1 ADC64-4 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Undisclosed
 ADC Info 
WO2024222841A1 ADC64 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
NZ761939B 15B2GL-SG3249 [2]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-BCMA antibody 15B2GL
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-BCMA 15B2GL-SG3249 [3]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-BCMA 15B2GL-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-BCMA antibody 15B2WT
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-BCMA 15B2WT-SG3249 [3]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-BCMA 15B2WT-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-BCMA antibody I09
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-BCMA I09-SG3249 [3]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-BCMA I09-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-BCMA antibody J6M0
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-BCMA J6M0-SG3249 [3]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-BCMA J6M0-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-BCMA antibody L15
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-BCMA L15-SG3249 [3]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-BCMA L15-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-BCMA antibody M02
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-BCMA M02-SG3249 [3]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-BCMA M02-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-BCMA antibody N22
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-BCMA N22-SG3249 [3]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-BCMA N22-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-BCMA antibody P10
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-BCMA P10-SG3249 [3]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-BCMA P10-mcMMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-BCMA antibody R347
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-BCMA R347-SG3249 [3]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Anti-human BCMA IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AMG 224
DM1
Microtubule (MT)
4-[N-maleimidomethyl] cyclohexane-1-carboxylate (MCC)
 ADC Info 
BCMA-A Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BCMA-A Antibody-Compound (X) [4]
BCMA-A Antibody-Compound (X) payload
Undisclosed
BCMA-A Antibody-Compound (X) linker
 ADC Info 
BCMA-A Antibody-Compound (XI) [4]
BCMA-A Antibody-Compound (XI) payload
Undisclosed
BCMA-A Antibody-Compound (XI) linker
 ADC Info 
BCMA-A Antibody-Compound (XIV) [4]
BCMA-A Antibody-Compound (XIV) payload
Undisclosed
BCMA-A Antibody-Compound (XIV) linker
 ADC Info 
BCMA-A Antibody-Compound (XVIII) [4]
BCMA-A Antibody-Compound (XVIII) payload
Undisclosed
BCMA-A Antibody-Compound (XVIII) linker
 ADC Info 
BCMA-A Antibody-Compound (Ie) [4]
BCMA-A Antibody-Compound (Ie) payload
Undisclosed
BCMA-A Antibody-Compound (Ie) linker
 ADC Info 
BCMA-A Antibody-Compound (XIX) [4]
BCMA-A Antibody-Compound (XIX) payload
Undisclosed
BCMA-A Antibody-Compound (XIX) linker
 ADC Info 
BCMA-A Antibody-Compound (Ii) [4]
BCMA-A Antibody-Compound (Ii) payload
Undisclosed
BCMA-A Antibody-Compound (Ii) linker
 ADC Info 
BCMA-A Antibody-Compound (XLI) [4]
BCMA-A Antibody-Compound (XLI) payload
Undisclosed
BCMA-A Antibody-Compound (XLI) linker
 ADC Info 
BCMA-A Antibody-Compound (XVI) [4]
BCMA-A Antibody-Compound (XIX) payload
Undisclosed
BCMA-A Antibody-Compound (XIX) linker
 ADC Info 
BCMA-A Antibody-Compound (XL) [4]
BCMA-A Antibody-Compound (XL) payload
Undisclosed
BCMA-A Antibody-Compound (XL) linker
 ADC Info 
BCMA-A Antibody-Compound (XLIII) [4]
BCMA-A Antibody-Compound (XLIII) payload
Undisclosed
BCMA-A Antibody-Compound (XLIII) linker
 ADC Info 
BCMA-A Antibody-Compound (XLII) [4]
BCMA-A Antibody-Compound (XLII) payload
Undisclosed
BCMA-A Antibody-Compound (XLII) linker
 ADC Info 
BCMA-A Antibody-Compound (XV) [4]
BCMA-A Antibody-Compound (XV) payload
Undisclosed
BCMA-A Antibody-Compound (XV) linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
MEDI2228
SG3199 (SC-DR002)
Human deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
Belantamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
αBCMA-MC-I034
Amine-I034
IKZF1/3
MC
 ADC Info 
Belan-DVA-I030
I030
IKZF1/3
MC-DVA-PABC
 ADC Info 
Belan-VA-I034 (4)
I034
IKZF1/3
MC-VA
 ADC Info 
Belan-VA-I034 (8)
I034
IKZF1/3
MC-VA
 ADC Info 
Belantamab mafodotin [5]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Belantamab-Compound (Ia) [6]
NeoDegrader P1
Protein cereblon (CRBN)
Belantamab-Compound (Ia) linker
 ADC Info 
Belantamab-Compound (X) [4]
Belantamab-Compound (X) payload
Undisclosed
Belantamab-Compound (X) linker
 ADC Info 
Belantamab-Compound (XI) [4]
Belantamab-Compound (XI) payload
Undisclosed
Belantamab-Compound (XI) linker
 ADC Info 
Belantamab-Compound (XIV) [4]
Belantamab-Compound (XIV) payload
Undisclosed
Belantamab-Compound (XIV) linker
 ADC Info 
Belantamab-Compound (XVIII) [4]
Belantamab-Compound (XVIII) payload
Undisclosed
Belantamab-Compound (XVIII) linker
 ADC Info 
Belantamab-Compound (Ie) [4]
Belantamab-Compound (Ie) payload
Undisclosed
Belantamab-Compound (Ie) linker
 ADC Info 
Belantamab-Compound (XIX) [4]
Belantamab-Compound (XIX) payload
Undisclosed
Belantamab-Compound (XIX) linker
 ADC Info 
Belantamab-Compound (Ii) [4]
Belantamab-Compound (Ii) payload
Undisclosed
Belantamab-Compound (Ii) linker
 ADC Info 
Belantamab-Compound (XLI) [4]
Belantamab-Compound (XLI) payload
Undisclosed
Belantamab-Compound (XLI) linker
 ADC Info 
Belantamab-Compound (XVI) [4]
Belantamab-Compound (XIX) payload
Undisclosed
Belantamab-Compound (XIX) linker
 ADC Info 
Belantamab-Compound (XL) [4]
Belantamab-Compound (XL) payload
Undisclosed
Belantamab-Compound (XL) linker
 ADC Info 
Belantamab-Compound (XLIII) [4]
Belantamab-Compound (XLIII) payload
Undisclosed
Belantamab-Compound (XLIII) linker
 ADC Info 
Belantamab-Compound (XLII) [4]
Belantamab-Compound (XLII) payload
Undisclosed
Belantamab-Compound (XLII) linker
 ADC Info 
Belantamab-Compound (XV) [4]
Belantamab-Compound (XV) payload
Undisclosed
Belantamab-Compound (XV) linker
 ADC Info 
DB-1325 [7]
PDUP5
Undisclosed
Undisclosed
 ADC Info 
WO2024169913A1 ADC08-01-8 [8]
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
 ADC Info 
WO2024169913A1 ADC08-01-4 [8]
B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
GENA-111-AF [9]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
Humanized anti-BCMA mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DXC009
Undisclosed
Microtubule (MT)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
I09-SG3249 [2]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Ispectamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ispectamab debotansine
SC347
Microtubule (MT)
Cys-12 ADC linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
L15-SG3249 [2]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
ADC Name Payload Target Linker ADC Info
M02-SG3249 [2]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
ADC Name Payload Target Linker ADC Info
N22-SG3249 [2]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
ADC Name Payload Target Linker ADC Info
P10-SG3249 [2]
SG3199
Human Deoxyribonucleic acid (hDNA)
CL2A
 ADC Info 
Pamlectabart
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Pamlectabart tismanitin
HDP 30.2115
RNA polymerase II
Mal-Val-Ala-PAB
 ADC Info 
ADC Name Payload Target Linker ADC Info
SG1-Val-Cit-MMAF8 [10]
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
SG2-Val-Cit-MMAF8 [10]
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
SG3-Val-Cit-MMAF8 [10]
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
LN474-63 [11]
Monomethyl auristatin E
Microtubule (MT)
CN118079014A-linker-1
 ADC Info 
LN474-64 [11]
Monomethyl auristatin E
Microtubule (MT)
CN118079014A-linker-3
 ADC Info 
TNFRSF17 mAb1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN113549127A ADC-1 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-1-linker
 ADC Info 
CN113549127A ADC-2 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-2-linker
 ADC Info 
CN113549127A ADC-3 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-3-linker
 ADC Info 
CN113549127A ADC-4 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-4-linker
 ADC Info 
CN113549127A ADC-5 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-5-linker
 ADC Info 
CN113549127A ADC-6 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-6-linker
 ADC Info 
CN113549127A ADC-7 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-7-linker
 ADC Info 
CN113549127A ADC-8 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-8-linker
 ADC Info 
CN113549127A ADC-9 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-9-linker
 ADC Info 
CN113549127A ADC-10 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-10-linker
 ADC Info 
CN113549127A ADC-11 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-11-linker
 ADC Info 
CN113549127A ADC-12 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-12-linker
 ADC Info 
CN113549127A ADC-13 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-13-linker
 ADC Info 
CN113549127A ADC-14 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-14-linker
 ADC Info 
CN113549127A ADC-15 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-15-linker
 ADC Info 
CN113549127A ADC-16 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-16-linker
 ADC Info 
CN113549127A ADC-17 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-17-linker
 ADC Info 
CN113549127A ADC-18 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-18-linker
 ADC Info 
CN113549127A ADC-19 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-19-linker
 ADC Info 
CN113549127A ADC-20 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-20-linker
 ADC Info 
CN113549127A ADC-21 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-21-linker
 ADC Info 
CN113549127A ADC-22 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-22-linker
 ADC Info 
CN113549127A ADC-23 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-23-linker
 ADC Info 
CN113549127A ADC-24 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-24-linker
 ADC Info 
CN113549127A ADC-25 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-25-linker
 ADC Info 
CN113549127A ADC-26 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-26-linker
 ADC Info 
CN113549127A ADC-27 [12]
Undisclosed
Undisclosed
CN113549127A-ADC-27-linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JS115 [13]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HD-101 [14]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ispectamab tazide [15]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
LMB-75 [16]
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
LMB-70 [17]
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
BCMA-077 [18]
Duostatin 5.2
Microtubule (MT)
Proprietary Concortis linker
 ADC Info 
BCMA-024 [18]
Duostatin 5.2
Microtubule (MT)
Proprietary Concortis linker
 ADC Info 
References
Ref 1 Antibody-drug conjugate
Ref 2 BCMA monoclonal antibody-drug conjugate
Ref 3 Bcma monoclonal antibody-drug conjugate.
Ref 4 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 5 Belantamab Mafodotin: First Approval
Ref 6 Neodegrader conjugates; 2021-10-07.
Ref 7 DB-1325, a BCMA-targeting antibody-drug conjugate with a Duality Unique Payload, exhibits promising efficacy and safety in preclinical multiple myeloma treatment
Ref 8 Domide molecular glue derivative and use thereof
Ref 9 The antibody-drug conjugate GENA-111 conjugated to auristatin F shows therapeutic potency in BCAM positive epithelial cancer. 2022.
Ref 10 Antibody targeting of B-cell maturation antigen on malignant plasma cells. Mol Cancer Ther. 2007 Nov;6(11):3009-18. doi: 10.1158/1535-7163.MCT-07-0464.
Ref 11 Antibody-drug conjugate intermediate SET0562, and its preparation and uses
Ref 12 Vincristine and its antibody conjugates, preparation methods and medical uses
Ref 13 Junshi Biosciences biopharmaceutical company product pipeline
Ref 14 HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells. Mol Cancer Ther. 2021 Feb;20(2):367-378.
Ref 15 Introduction to basic information on ADC drug Ispectamab tazide.
Ref 16 Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4592-4598. doi: 10.1073/pnas.1821733116. Epub 2019 Feb 19.
Ref 17 Targeted Therapy With Immunoconjugates for Multiple Myeloma. Front Immunol. 2020 Jun 19;11:1155. doi: 10.3389/fimmu.2020.01155. eCollection 2020.
Ref 18 Preclinical Development of a Bcma Targeting Antibody-Drug Conjugate with Novel Payload for Multiple Myeloma Therapy. Blood. 2019 ;134():-. doi: 10.1182/blood-2019-132080.