Antigen Information

General Information of This Antigen (ID: TAR0SOZLV)
Antigen Name
Cadherin-6 (CDH6)
Gene Name
CDH6
Gene ID
1004
Synonym
Kidney cadherin
Sequence
MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQF
FLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREE
KPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQ
VTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKD
MGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGEN
AEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLY
LGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYS
VDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLD
VNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQ
DNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSC
HAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYN
DEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTP.DNTDVRDFINQRLKE
NDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYG
GVDSDKDS

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Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

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Uniprot Entry
CADH6_HUMAN
HGNC ID
HGNC:1765
KEGG ID
hsa:1004
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
A humanized anti-CDH6 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AMT-707
Exatecan
DNA topoisomerase 1 (TOP1)
T1000
 ADC Info 
Anti-CDH6 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HS-20124
SHR9265
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
SIM0505
CPT116
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
QLS5133
QLS6916
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-CDH6 HKT-288 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HKT288
DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
Anti-CDH6 mAb H01L02
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H01L02-DXd [1]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
H01L02-DM4 [1]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
H01L02-ADC [2]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Anti-CDH6 mAb H02L02
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H02L02-DXd [1]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
H02L02-ADC [2]
undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Anti-CDH6 mAb H02L03
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H02L03-DXd [1]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
H02L03-ADC [2]
undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Anti-CDH6 mAb H04L02
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H04L02-DXd [1]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
H04L02-ADC [2]
undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Anti-CDH6 mAb NOV0712
 Antibody Info 
ADC Name Payload Target Linker ADC Info
NOV0712-DM4 [1]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
NOV0712-DXd [1]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
CDH6 Ab1a
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US20250000991A1 Ab1a ADC [3]
undisclosed
Undisclosed
US20250000991A1 Ab1 ADC Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
US20240245795A1 Antibody Conjugate 10 [4]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
Human Anti-CDH6 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CDH6-SPDB-DM4 [5]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
NEC49 (Anti-nectin-4 mAb)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
NEC49-9-A [6]
WO2023221971A1 NEC49-4 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Raludotatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Raludotatug deruxtecan [7]
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BSI-709 [8]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
KR1020250012631A+ADC [9]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
H1L2-Dxd [10]
undisclosed
Undisclosed
CN119255825A H1L2-Dxd Linker
 ADC Info 
BR122024023391 antibody-drug conjugate (3) [11]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
Production of the antibody-drug conjugate (6) [12]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Anti-cdh6 antibody and anti-cdh6 antibody-drug conjugate.
Ref 2 Anti-CDH6 antibodies and anti-CDH6 antibody-drug conjugates
Ref 3 Nectin-4 antibodies and antibody-drug conjugates
Ref 4 Preparation method and application of antibody drug conjugate
Ref 5 Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov. 2017 Sep;7(9):1030-1045.
Ref 6 Pharmaceutical compositions comprising anti-Nectin-4 antibody-drug conjugates and uses thereof
Ref 7 Daiichi-Sankyo showcases latest research towards creating new standards of care for patients with cancer with data at ASCO and EHA; 25 May 2023.
Ref 8 Biosion biotechnology company product pipeline
Ref 9 Anti-cdh6 antibody - Dosing drug zygote
Ref 10 Dosing regimens of anti-CDH6 antibody-drug conjugates
Ref 11 Use of an antibody-drug conjugate, pharmaceutical composition and pharmaceutical combination
Ref 12 Combination of antibody-drug conjugate with anti-SIRPα antibody