Antigen Information

General Information of This Antigen
Antigen ID
TAR0SOZLV
Antigen Name
Cadherin-6 (CDH6)
Gene Name
CDH6
Synonym
Kidney cadherin
Sequence
MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQF
FLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREE
KPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQ
VTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKD
MGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGEN
AEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLY
LGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYS
VDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLD
VNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQ
DNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSC
HAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYN
DEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTP.DNTDVRDFINQRLKE
NDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYG
GVDSDKDS

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Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

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Uniprot Entry
CADH6_HUMAN
HGNC ID
HGNC:1765
KEGG ID
hsa:1004
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CDH6 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
hS-20124
SHR9265
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
sIM0505
CPT116
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
qLS5133
QLS6916
DNA topoisomerase 1 (TOP1)
A cleavable linker
Anti-CDH6 HKT-288 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HKT288
DM4
Microtubule (MT)
Sulfo-SPDB
Anti-CDH6 IgG1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AMT-707
Exatecan
DNA topoisomerase 1 (TOP1)
T1000
Anti-CDH6 mAb H01L02
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
H01L02-DXd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [1]
 ADC Info 
H01L02-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [1]
 ADC Info 
H01L02-ADC
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [2]
Anti-CDH6 mAb H02L02
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
H02L02-DXd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [1]
 ADC Info 
H02L02-ADC
undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [2]
Anti-CDH6 mAb H02L03
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
H02L03-DXd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [1]
 ADC Info 
H02L03-ADC
undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [2]
Anti-CDH6 mAb H04L02
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
H04L02-DXd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [1]
 ADC Info 
H04L02-ADC
undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [2]
Anti-CDH6 mAb NOV0712
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
NOV0712-DXd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [1]
 ADC Info 
NOV0712-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [1]
CDH6 Ab1a
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
US20250000991A1 Ab1a ADC
undisclosed
Undisclosed
US20250000991A1 Ab1 ADC Linker
 [3]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
US20240245795A1 Antibody Conjugate 10
Exatecan
Undisclosed
Undisclosed
 [4]
Human Anti-CDH6 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CDH6-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [5]
NEC49 (Anti-nectin-4 mAb)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
NEC49-9-A
WO2023221971A1 NEC49-4 Payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [6]
Raludotatug
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Raludotatug deruxtecan
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [7]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BSI-709
Undisclosed
Undisclosed
Undisclosed
 [8]
 ADC Info 
bR122024023391 antibody-drug conjugate (3)
undisclosed
Undisclosed
Undisclosed
 [11]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
KR1020250012631A+ADC
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [9]
 ADC Info 
H1L2-Dxd
undisclosed
Undisclosed
CN119255825A H1L2-Dxd Linker
 [10]
 ADC Info 
production of the antibody-drug conjugate (6)
undisclosed
Undisclosed
Undisclosed
 [12]
References
Ref 1 Anti-cdh6 antibody and anti-cdh6 antibody-drug conjugate.
Ref 2 Anti-CDH6 antibodies and anti-CDH6 antibody-drug conjugates
Ref 3 Nectin-4 antibodies and antibody-drug conjugates
Ref 4 Preparation method and application of antibody drug conjugate
Ref 5 Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov. 2017 Sep;7(9):1030-1045.
Ref 6 Pharmaceutical compositions comprising anti-Nectin-4 antibody-drug conjugates and uses thereof
Ref 7 Daiichi-Sankyo showcases latest research towards creating new standards of care for patients with cancer with data at ASCO and EHA; 25 May 2023.
Ref 8 Biosion biotechnology company product pipeline
Ref 9 Anti-cdh6 antibody - Dosing drug zygote
Ref 10 Dosing regimens of anti-CDH6 antibody-drug conjugates
Ref 11 Use of an antibody-drug conjugate, pharmaceutical composition and pharmaceutical combination
Ref 12 Combination of antibody-drug conjugate with anti-SIRPα antibody