Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ZBRFQ
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| ADC Name |
H04L02-DXd
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| Synonyms |
H04L02 DXd
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| Organization |
Daiichi Sankyo Co., Ltd.;
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| Drug Status |
Investigative
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| Indication |
In total 2 Indication(s)
Ovarian cancer [ICD11:2C73]
Investigative
Renal cell carcinoma [ICD11:2C90]
Investigative
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| Drug-to-Antibody Ratio |
7.6
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| Antibody Name |
Anti-CDH6 mAb H04L02
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Antibody Info | ||||
| Antigen Name |
Cadherin-6 (CDH6)
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Antigen Info | ||||
| Payload Name |
DX-8951 derivative (DXd)
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
Mc-Gly-Gly-Phe-Gly
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Deruxtecan
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General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Tumor Growth Inhibition value (TGI) |
≈ 88.53
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%
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CVCL_1051
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Renal cell carcinoma
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Revealed Based on the Cell Line Data
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Half Maximal Inhibitory Concentration (IC50) |
0.10-1.00
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nM
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CVCL_0479
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Ovarian mixed germ cell tumor
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Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 88.53% (Day 24) | Positive CDH6 expression (CDH6+++/++) | ||
| Method Description |
The CDH6-positive human renal cell tumor cell line 786-O was subcutaneously inoculated at a dose of 5,000,000 cells to the right flank regionof each male SCID mouse (Day 0). On the day 18 of grouping, H04L02-DXd was intravenously administered at a dose of 3 mg/kg to the tail of each mouse.
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| In Vivo Model | 786-O CDX model | ||||
| In Vitro Model | Renal cell carcinoma | 786-O cells | CVCL_1051 | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 0.10-1.00 nM | Positive CDH6 expression (CDH6+++/++) | ||
| Method Description |
CDH6-positive human ovarian tumor cell line PA-1 was seeded over a 96-well plate at 2,000 cells/100 L/well in MEM medium supplemented with 10% FBS, and the cells were then cultured overnight. On the next day, each of the 4 humanized hG019-drug conjugates or NOV0712-DM4 was added to the cells.
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| In Vitro Model | Ovarian mixed germ cell tumor | PA-1 cells | CVCL_0479 | ||
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