Antigen ID	TAR0SERWS
Antigen Name	Syndecan-1 (SDC1)
Gene Name	SDC1
Gene ID	6382
Synonym	SDC; CD_antigen=CD138
Sequence	MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQ TPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGL.EQEAT PRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTED GGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGA SQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKP TKQEEFYA     Click to Show/Hide
Family	Sulfatase-modifying factor family
Function	Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.     Click to Show/Hide
Uniprot Entry	SDC1_HUMAN
HGNC ID	HGNC:10658
KEGG ID	hsa:6382

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	B-B4-SPP-DM1	Mertansine DM1	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)	[1]
ADC Info	B-B4-SMCC-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[1]
ADC Info	B-B4-SPDB-DM4	Mertansine DM4	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024181570A1 ADC1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[2]
ADC Info	WO2024181570A1 ADC3	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[2]
ADC Info	WO2024181570A1 ADC4	Monomethyl auristatin F	Microtubule (MT)	Mc-Val-Cit-PABC	[2]
ADC Info	WO2024181570A1 ADC5	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Mc-Gly-Gly-Phe-Gly	[2]
ADC Info	WO2024181570A1 ADC6	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Mc-Gly-Gly-Phe-Gly	[2]
ADC Info	WO2024181570A1 ADC7	PBD	Deoxyribonucleic acid (DNA)	Mc-Val-Ala	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024181570A1 ADC12	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024181570A1 ADC13	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024181570A1 ADC14	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024181570A1 ADC2	Mertansine DM4	Microtubule (MT)	SPDB	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024181570A1 ADC8	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024181570A1 ADC9	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024181570A1 ADC10	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024181570A1 ADC11	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	AB205-ADL1-D14	D14 payload	Undisclosed	Mc-Val-Cit-PABC	[3]
ADC Info	AB205-ADL5-D15	D15 payload	Undisclosed	Mc-Val-Cit-PAB (Qamine) linker	[3]
ADC Info	AB205-ADL5-D19	D19 payload	Undisclosed	Mc-Val-Cit-PAB (Qamine) linker	[3]
ADC Info	AB205-ADL1-D1	D1 payload	Undisclosed	Mc-Val-Cit-PABC	[3]
ADC Info	AB205-ADL1-D4	D4 payload	Undisclosed	Mc-Val-Cit-PABC	[3]
ADC Info	AB205-ADL5-D25	D25 payload	Undisclosed	Mc-Val-Cit-PABC	[3]
ADC Info	AB205-ADL10-D1	D1 payload	Undisclosed	6-Maleimidocaproic acid	[3]
ADC Info	AB205-ADL12-D1	D1 payload	Undisclosed	Mal- (CH2)6- linker	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	B-B4-DM1	Mertansine DM1	Microtubule (MT)	Undisclosed	[4]
ADC Info	HuC242-SPP-DC4	Phosphate prodrugs 40 (DC4)	Human Deoxyribonucleic acid (hDNA)	N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)	[5]
ADC Info	HuC242-SPDB-DC4	Phosphate prodrugs 40 (DC4)	Human Deoxyribonucleic acid (hDNA)	N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)	[5]
ADC Info	HuC242-SMCC-DC4	Phosphate prodrugs 40 (DC4)	Human Deoxyribonucleic acid (hDNA)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[5]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	BT062-SPDB-DM4	Mertansine DM4	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)	[6]
ADC Info	BT062-SPP-DM1	Mertansine DM1	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)	[6]
ADC Info	BT062-SMCC-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[6]
ADC Info	NBT062-SMCC-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[1]
ADC Info	NBT062-SPP-DM1	Mertansine DM1	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)	[1]
ADC Info	Wild type nBT062-DM4	Mertansine DM4	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)	[7]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Half nBT062-DM4	Mertansine DM4	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)	[7]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Stable nBT062-DM4	Mertansine DM4	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)	[7]

Ref 1	Immunoconjugates targeting cd138 and uses thereof; 2009-07-02.
Ref 2	Antibody-drug complexes containing anti-CD138 antibodies
Ref 3	Splicing modulator antibody-drug conjugates and methods of use
Ref 4	Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells. Blood. 2004 Dec 1;104(12):3688-96.
Ref 5	Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
Ref 6	The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res. 2009 Jun 15;15(12):4028-37.
Ref 7	Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate. PLoS One. 2018 Apr 19;13(4):e0195823. doi: 10.1371/journal.pone.0195823. eCollection 2018.