Antigen Information

General Information of This Antigen (ID: TAR0SERWS)
Antigen Name
Syndecan-1 (SDC1)
Gene Name
SDC1
Gene ID
6382
Synonym
SDC; CD138
Sequence
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQ
TPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGL.EQEAT
PRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTED
GGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGA
SQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKP
TKQEEFYA

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Family
Sulfatase-modifying factor family
Function
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.

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Uniprot Entry
SDC1_HUMAN
HGNC ID
HGNC:10658
KEGG ID
hsa:6382
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CD138 mAb B-B4
 Antibody Info 
ADC Name Payload Target Linker ADC Info
B-B4-SPP-DM1 [1]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
B-B4-SMCC-DM1 [1]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
B-B4-SPDB-DM4 [1]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Antibody 1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024181570A1 ADC1 [2]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
WO2024181570A1 ADC3 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2024181570A1 ADC4 [2]
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2024181570A1 ADC5 [2]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024181570A1 ADC6 [2]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024181570A1 ADC7 [2]
PBD
Deoxyribonucleic acid (DNA)
Mc-Val-Ala
 ADC Info 
Antibody 10
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024181570A1 ADC12 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Antibody 11
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024181570A1 ADC13 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Antibody 12
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024181570A1 ADC14 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Antibody 2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024181570A1 ADC2 [2]
Mertansine DM4
Microtubule (MT)
SPDB
 ADC Info 
Antibody 3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024181570A1 ADC8 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Antibody 4
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024181570A1 ADC9 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Antibody 5
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024181570A1 ADC10 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Antibody 6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024181570A1 ADC11 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
AB205-ADL1-D14 [3]
D14 payload
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
AB205-ADL5-D15 [3]
D15 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
 ADC Info 
AB205-ADL5-D19 [3]
D19 payload
Undisclosed
Mc-Val-Cit-PAB (Qamine) linker
 ADC Info 
AB205-ADL1-D1 [3]
D1 payload
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
AB205-ADL1-D4 [3]
D4 payload
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
AB205-ADL5-D25 [3]
D25 payload
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
AB205-ADL10-D1 [3]
D1 payload
Undisclosed
6-Maleimidocaproic acid
 ADC Info 
AB205-ADL12-D1 [3]
D1 payload
Undisclosed
Mal- (CH2)6- linker
 ADC Info 
Cantuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
B-B4-DM1 [4]
Mertansine DM1
Microtubule (MT)
Undisclosed
 ADC Info 
HuC242-SPP-DC4 [5]
Phosphate prodrugs 40 (DC4)
Human Deoxyribonucleic acid (hDNA)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
HuC242-SPDB-DC4 [5]
Phosphate prodrugs 40 (DC4)
Human Deoxyribonucleic acid (hDNA)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
HuC242-SMCC-DC4 [5]
Phosphate prodrugs 40 (DC4)
Human Deoxyribonucleic acid (hDNA)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Indatuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Indatuximab ravtansine [1]
DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
BT062-SPDB-DM4 [6]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
BT062-SPP-DM1 [6]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
BT062-SMCC-DM1 [6]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
NBT062-SMCC-DM1 [1]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
NBT062-SPP-DM1 [1]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
Wild type nBT062-DM4 [7]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Indatuximab (C226S + C229S)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Half nBT062-DM4 [7]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Indatuximab (S228P + R409K)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Stable nBT062-DM4 [7]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
References
Ref 1 Immunoconjugates targeting cd138 and uses thereof; 2009-07-02.
Ref 2 Antibody-drug complexes containing anti-CD138 antibodies
Ref 3 Splicing modulator antibody-drug conjugates and methods of use
Ref 4 Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells. Blood. 2004 Dec 1;104(12):3688-96.
Ref 5 Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
Ref 6 The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res. 2009 Jun 15;15(12):4028-37.
Ref 7 Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate. PLoS One. 2018 Apr 19;13(4):e0195823. doi: 10.1371/journal.pone.0195823. eCollection 2018.