Antibody Information

General Information of This Antibody
Antibody ID
ANI0AONAG
Antibody Name
Anti-CD138 mAb B-B4
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Murine IgG1
Antigen Name
Syndecan-1 (SDC1)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
B-B4-SPP-DM1 [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 77.45% (Day 20) Positive CD138 expression (CD138 +++/++)
Method Description
MOLP-8 cells (1.5x107 cells per mouse) suspended in a 50:50 mixture of serum free media and matrigel were injected subcutaneously in the area under the right shoulder in 100 ul. Nine groups (n=6) were treated with a single intravenous injection of ADCs, each at doses of 250 ug/kg.
In Vivo Model MOLP-8 CDX model
In Vitro Model Plasma cell myeloma MOLP-8 cells CVCL_2124
References
Ref 1 Immunoconjugates targeting cd138 and uses thereof; 2009-07-02.

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