Antigen ID	TAR0QPCSQ
Antigen Name	Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Gene Name	TNFRSF8
Gene ID	943
Synonym	CD30L receptor;Ki-1 antigen;Lymphocyte activation antigen CD30;CD_antigen=CD30
Sequence	MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQ RPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVN SCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPT PVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDC RKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARC VPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQA SKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKL HLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYL ESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGL AGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK     Click to Show/Hide
Family	Tissue factor family
Function	Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B.     Click to Show/Hide
Uniprot Entry	TNR8_HUMAN
HGNC ID	HGNC:11923
KEGG ID	hsa:943

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	US12186310B2-6	Undisclosed	Undisclosed	Undisclosed	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	US12186310B2-7	Undisclosed	Undisclosed	Undisclosed	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Alpha-CD30-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	DAR8-alphaCD30-mDPR-Gluc-DMTub	DMTub	Microtubule (MT)	Quaternary ammonium linker Gluc	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	DAR8-alphaCD30-mDPR-Gluc-MMAE	Monomethyl auristatin E	Microtubule (MT)	Quaternary ammonium linker Gluc	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	DAR8-alphaCD30-mDPR-GlucQ-AE	Auristatin E	Microtubule (MT)	Quaternary ammonium linker GlucQ	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	DAR8-alphaCD30-mDPR-GlucQ-Tub	Tubulysin analogue 3	Microtubule (MT)	Quaternary ammonium linker GlucQ	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Alpha-CD30-7	Tubulysin 7	Microtubule (MT)	Glucuronide quaternary ammonium linker 7	[4]
ADC Info	Alpha-CD30-8	Tubulysin 8	Microtubule (MT)	Glucuronide quaternary ammonium linker 8	[4]
ADC Info	Alpha-CD30-9	Tubulysin 9	Microtubule (MT)	Glucuronide quaternary ammonium linker 9	[4]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Anti-CD30 monoclonal antibody-saporin conjugate	Saporin	Microtubule (MT)	Undisclosed	[5]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CD30-BTG-ADC	Monomethyl auristatin E	Microtubule (MT)	PEG3-benzotriazole-PEG-Val-Cit-PABC	[6]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	H00-CPT-LC	Methylenedioxy CPT2 (CPT2)	DNA topoisomerase 1 (TOP1)	Mc-PEG8-Val-Lys-Gly	[7]
ADC Info	H00-CPT-LA	Methylenedioxy CPT1 (CPT1)	DNA topoisomerase 1 (TOP1)	Mc-PEG4-Val-Lys-Gly	[7]
ADC Info	H00-CPT-LB	Methylenedioxy CPT2 (CPT2)	DNA topoisomerase 1 (TOP1)	Mc-PEG4-Val-Lys-Gly	[7]
ADC Info	H00-DT	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Mc-Gly-Gly-Phe-Gly	[7]
ADC Info	H00-GT	Active metabolite of irinotecan SN38	DNA topoisomerase 1 (TOP1)	CL2A	[8]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Brentuximab vedotin	MMAE	Microtubule (MT)	Mc-Val-Cit-PABC
ADC Info	F0002-ADC	DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
ADC Info	SGN-35T	MMAE	Microtubule (MT)	Mp-D-leucine-alanine-glutamate-PABC
ADC Info	CAC10-Gly5-PNU	PNU-159682	DNA topoisomerase 2-alpha (TOP2A)	Gly5	[9]
ADC Info	CAC10-Gly5-MAY	Mertansine DM1	Microtubule (MT)	Gly5	[9]
ADC Info	CAC10-CPT-LB	Methylenedioxy CPT2 (CPT2)	DNA topoisomerase 1 (TOP1)	Mc-PEG4-Val-Lys-Gly	[7]
ADC Info	CAC10-CPT-LC	Methylenedioxy CPT2 (CPT2)	DNA topoisomerase 1 (TOP1)	Mc-PEG8-Val-Lys-Gly	[7]
ADC Info	CAC10-DT	DX-8951 derivative (DXd)	DNA topoisomerase 1 (TOP1)	Mc-Gly-Gly-Phe-Gly	[7]
ADC Info	CAC10-GT	Active metabolite of irinotecan SN38	DNA topoisomerase 1 (TOP1)	CL2A	[7]
ADC Info	Brentuximab-8	Monomethyl auristatin E	Microtubule (MT)	Alkyl phosphoramide-PEG24-Val-Cit-PAB	[10]
ADC Info	Brentuximab-7	Monomethyl auristatin E	Microtubule (MT)	Alkyl phosphoramide-PEG12-Val-Cit-PAB	[10]
ADC Info	CAC10-CPT-LA	Methylenedioxy CPT1 (CPT1)	DNA topoisomerase 1 (TOP1)	Mc-PEG4-Val-Lys-Gly	[7]
ADC Info	MF-BTX-MMAE	Monomethyl auristatin E	Microtubule (MT)	Dibromomethyl pyridine-Val-Cit-PABC	[11]
ADC Info	Brentuximab-PNUEDAGly5	PNU-159682	DNA topoisomerase 2-alpha (TOP2A)	LPETG-Gly5-EDA	[12]
ADC Info	Brentuximab-ADC-24-1	Brentuximab-ADC-24-1 payload	Undisclosed	Brentuximab-ADC-24-1 linker	[13]
ADC Info	Brentuximab-ADC-24-2	Brentuximab-ADC-24-2 payload	Undisclosed	Brentuximab-ADC-24-2 linker	[13]
ADC Info	Brentuximab-ADC-24-3	Brentuximab-ADC-24-3 payload	Undisclosed	Brentuximab-ADC-24-3 linker	[13]
ADC Info	Brentuximab-ADC-24-4	Brentuximab-ADC-24-4 payload	Undisclosed	Brentuximab-ADC-24-4 linker	[13]
ADC Info	Brentuximab-ADC-24-5	Brentuximab-ADC-24-5 payload	Undisclosed	Brentuximab-ADC-24-5 linker	[13]
ADC Info	Brentuximab-ADC-24-6	Brentuximab-ADC-24-6 payload	Undisclosed	Brentuximab-ADC-24-6 linker	[13]
ADC Info	Brentuximab-ADC-24-7	Brentuximab-ADC-24-7 payload	Undisclosed	Brentuximab-ADC-24-7 linker	[13]
ADC Info	Brentuximab-ADC-24-8	Brentuximab-ADC-24-8 payload	Undisclosed	Brentuximab-ADC-24-8 linker	[13]
ADC Info	Brentuximab-ADC-24-9	Brentuximab-ADC-24-9 payload	Undisclosed	Brentuximab-ADC-24-9 linker	[13]
ADC Info	Brentuximab-ADC-24-10	Brentuximab-ADC-24-10 payload	Undisclosed	Brentuximab-ADC-24-10 linker	[13]
ADC Info	Brentuximab-ADC-24-11	Brentuximab-ADC-24-11 payload	Undisclosed	Brentuximab-ADC-24-11 linker	[13]
ADC Info	Brentuximab-ADC-24-12	Brentuximab-ADC-24-12 payload	Undisclosed	Brentuximab-ADC-24-12 linker	[13]
ADC Info	Brentuximab-ADC-24-13	Brentuximab-ADC-24-13 payload	Undisclosed	Brentuximab-ADC-24-13 linker	[13]
ADC Info	WO2007011968A2 cAC10-9a	Monomethyl auristatin E	Microtubule (MT)	WO2007011968A2_cAC10-9a linker	[14]
ADC Info	WO2007011968A2 cAC10-9b	Monomethyl auristatin F	Microtubule (MT)	WO2007011968A2_cAC10-9b linker	[14]
ADC Info	WO2007011968A2 cAC10-17	Doxorubicin	DNA topoisomerase 2-alpha (TOP2A)	WO2007011968A2_cAC10-17 linker	[14]
ADC Info	WO2015095755A1 cAC10-1.3	Monomethyl auristatin E	Microtubule (MT)	WO2015095755A1_cAC10-1.3 linker	[15]
ADC Info	WO2015095755A1 cAC10-1006	WO2015095755A1_cAC10-1006 payload	Undisclosed	WO2015095755A1_cAC10-1006 linker	[15]
ADC Info	WO2015095755A1 cAC10-2.0	Monomethyl auristatin E	Microtubule (MT)	WO2015095755A1_cAC10-2.0 linker	[15]
ADC Info	WO2015095755A1 cAC10-5.6	WO2015095755A1_cAC10-5.6 payload	Undisclosed	WO2015095755A1_cAC10-5.6 linker	[15]
ADC Info	WO2015095755A1 cAC10-6.4	WO2015095755A1_cAC10-6.4 payload	Undisclosed	WO2015095755A1_cAC10-6.4 linker	[15]
ADC Info	WO2015095755A1 cAC10-7.7	WO2015095755A1_cAC10-7.7 payload	Undisclosed	WO2015095755A1_cAC10-7.7 linker	[15]
ADC Info	EphA2-targeted mAb ADC B 12 (DAR8)	EphA2-targeted mAb ADC B 12 (DAR8) payload	Undisclosed	EphA2-targeted mAb ADC B 12 (DAR8) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 12 (DAR4)	EphA2-targeted mAb ADC B 12 (DAR4) payload	Undisclosed	EphA2-targeted mAb ADC B 12 (DAR4) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 17 (DAR8)	EphA2-targeted mAb ADC B 17 (DAR8) payload	Undisclosed	EphA2-targeted mAb ADC B 17 (DAR8) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 17 (DAR4)	EphA2-targeted mAb ADC B 17 (DAR4) payload	Undisclosed	EphA2-targeted mAb ADC B 17 (DAR4) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 21 (DAR8)	EphA2-targeted mAb ADC B 21 (DAR8) payload	Undisclosed	EphA2-targeted mAb ADC B 21 (DAR8) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 21 (DAR4)	EphA2-targeted mAb ADC B 21 (DAR4) payload	Undisclosed	EphA2-targeted mAb ADC B 21 (DAR4) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 22 (DAR6)	EphA2-targeted mAb ADC B 22 (DAR6) payload	Undisclosed	EphA2-targeted mAb ADC B 22 (DAR6) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 22 (DAR2)	EphA2-targeted mAb ADC B 22 (DAR2) payload	Undisclosed	EphA2-targeted mAb ADC B 22 (DAR2) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 19 (DAR8)	EphA2-targeted mAb ADC B 19 (DAR8) payload	Undisclosed	EphA2-targeted mAb ADC B 19 (DAR8) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 19 (DAR4)	EphA2-targeted mAb ADC B 19 (DAR4) payload	Undisclosed	EphA2-targeted mAb ADC B 19 (DAR4) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 20 (DAR8)	EphA2-targeted mAb ADC B 20 (DAR8) payload	Undisclosed	EphA2-targeted mAb ADC B 20 (DAR8) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 20 (DAR4)	EphA2-targeted mAb ADC B 20 (DAR4) payload	Undisclosed	EphA2-targeted mAb ADC B 20 (DAR4) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 24 (DAR8)	EphA2-targeted mAb ADC B 24 (DAR8) payload	Undisclosed	EphA2-targeted mAb ADC B 24 (DAR8) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 24 (DAR4)	EphA2-targeted mAb ADC B 24 (DAR4) payload	Undisclosed	EphA2-targeted mAb ADC B 24 (DAR4) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 23 (DAR8)	EphA2-targeted mAb ADC B 23 (DAR8) payload	Undisclosed	EphA2-targeted mAb ADC B 23 (DAR8) linker	[16]
ADC Info	EphA2-targeted mAb ADC B 23 (DAR4)	EphA2-targeted mAb ADC B 23 (DAR4) payload	Undisclosed	EphA2-targeted mAb ADC B 23 (DAR4) linker	[16]
ADC Info	Crown Ether ADC 4a	Monomethyl auristatin E	Microtubule (MT)	6-Amino-alpha-cyclodextrin-Val-Cit-PABC	[17]
ADC Info	Crown Ether ADC 4b	Monomethyl auristatin E	Microtubule (MT)	6-Amino-beta-cyclodextrin-Val-Cit-PABC	[17]
ADC Info	Crown Ether ADC 4c	Monomethyl auristatin E	Microtubule (MT)	6-Amino-gama-cyclodextrin-Val-Cit-PABC	[17]
ADC Info	Crown Ether ADC 4d	Monomethyl auristatin E	Microtubule (MT)	3-Amino-alpha-cyclodextrin-Val-Cit-PABC	[17]
ADC Info	Crown Ether ADC 4e	Monomethyl auristatin E	Microtubule (MT)	3-Amino-beta-cyclodextrin-Val-Cit-PABC	[17]
ADC Info	Crown Ether ADC 4f	Monomethyl auristatin E	Microtubule (MT)	3-Amino-gama-cyclodextrin-Val-Cit-PABC	[17]
ADC Info	Crown Ether ADC 5a	Monomethyl auristatin E	Microtubule (MT)	1-Aza-24-crown-8-Val-Cit-PABC	[17]
ADC Info	Crown Ether ADC 5b	Monomethyl auristatin E	Microtubule (MT)	1-Aza-42-crown-14-Val-Cit-PABC	[17]
ADC Info	Crown Ether ADC 6a	Monomethyl auristatin E	Microtubule (MT)	PEG(8u)-Val-Cit-PABC	[17]
ADC Info	Crown Ether ADC 6b	Monomethyl auristatin E	Microtubule (MT)	PEG(24u)-Val-Cit-PABC	[17]
ADC Info	Brentuximab-Compound 9	Mertansine DM1	Microtubule (MT)	Brentuximab-Compound 9 linker	[18]
ADC Info	Brentuximab-Compound 17	Mertansine DM4	Microtubule (MT)	Brentuximab-Compound 17 linker	[18]
ADC Info	Brentuximab-Compound 25	Monomethyl auristatin E	Microtubule (MT)	Brentuximab-Compound 25 linker	[18]
ADC Info	Brentuximab-Compound 31	Auristatin 0101	Microtubule (MT)	Brentuximab-Compound 31 linker	[18]
ADC Info	Brentuximab-Compound 36	Monomethyl auristatin E	Microtubule (MT)	Brentuximab-Compound 36 linker	[18]
ADC Info	Brentuximab-Compound 43	PBD dimer	Human Deoxyribonucleic acid (hDNA)	Brentuximab-Compound 43 linker	[18]
ADC Info	Brentuximab-Compound 49	PBD dimer	Human Deoxyribonucleic acid (hDNA)	Brentuximab-Compound 49 linker	[18]
ADC Info	Brentuximab-Compound 55	Mertansine DM1	Microtubule (MT)	Brentuximab-Compound 55 linker	[18]
ADC Info	Brentuximab-Compound 59	Mertansine DM4	Microtubule (MT)	Brentuximab-Compound 59 linker	[18]
ADC Info	Brentuximab-Compound 64	Monomethyl auristatin E	Microtubule (MT)	Brentuximab-Compound 64 linker	[18]
ADC Info	Brentuximab-Compound 69	Monomethyl auristatin E	Microtubule (MT)	Brentuximab-Compound 69 linker	[18]
ADC Info	Brentuximab-Compound 74	PBD dimer	Human Deoxyribonucleic acid (hDNA)	Brentuximab-Compound 74 linker	[18]
ADC Info	Brentuximab-Compound 75	Monomethyl auristatin E	Microtubule (MT)	Brentuximab-Compound 75 linker	[18]
ADC Info	Brentuximab-Compound 76	Monomethyl auristatin E	Microtubule (MT)	Brentuximab-Compound 76 linker	[18]
ADC Info	Brentuximab-Compound 77	Mertansine DM1	Microtubule (MT)	Brentuximab-Compound 77 linker	[18]
ADC Info	Brentuximab-Compound 78	Auristatin 0101	Microtubule (MT)	Brentuximab-Compound 78 linker	[18]
ADC Info	Brentuximab-Compound 79	Auristatin 0101	Microtubule (MT)	Brentuximab-Compound 79 linker	[18]
ADC Info	Brentuximab-Compound 80	Mertansine DM4	Microtubule (MT)	Brentuximab-Compound 80 linker	[18]
ADC Info	CN118401256A ADC 3	Monomethyl auristatin E	Microtubule (MT)	Allenamide-Amcap-Val-Cit-PABC	[19]
ADC Info	JP7623413B2 ExampleADC1	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC2	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC3	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC4	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC5	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC6	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC7	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC8	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC10	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC11	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC12	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC13	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC14	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC15	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC16	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC17	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC18	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC19	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC20	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC21	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC22	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC23	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC24	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC25	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC26	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC27	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC28	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC29	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC30	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC31	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC32	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC33	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC34	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC35	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC36	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC37	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC38	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC39	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC40	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC41	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC42	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC43	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	ExampleADC44	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC63	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	JP7623413B2 ExampleADC64	Undisclosed	Undisclosed	Undisclosed	[20]
ADC Info	Brentuximab-compound 1100	Undisclosed	Undisclosed	Undisclosed	[21]
ADC Info	Brentuximab-compound 1101	Undisclosed	Undisclosed	Undisclosed	[21]
ADC Info	Brentuximab-compound 1102	Undisclosed	Undisclosed	Undisclosed	[21]
ADC Info	Brentuximab-compound 1103	Undisclosed	Undisclosed	Undisclosed	[21]
ADC Info	Brentuximab-compound 1574	Undisclosed	Undisclosed	Undisclosed	[21]
ADC Info	Brentuximab-compound 1105	Undisclosed	Undisclosed	Undisclosed	[21]
ADC Info	Brentuximab-compound 1106	Undisclosed	Undisclosed	Undisclosed	[21]
ADC Info	Brentuximab-compound 1199	Undisclosed	Undisclosed	Undisclosed	[21]
ADC Info	JP2025004232A ADC1 7.55	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC2 8	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC3 7.31	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC4 8	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC5	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC6	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC7	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC8	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC10	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC11	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC12	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC13	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC14	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC15	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC16	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC17	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC18	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC19	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC20	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC21	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC22	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC23	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC24	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC25	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC26	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC27	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC28	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC29	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC33	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC34	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC35	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC36	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC37	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC38	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC39	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC40	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	JP2025004232A ADC41	undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	CN113453724B ADC-B	CN113453724B-ADCA-PAYLOAD	Undisclosed	CN113453724B-ADCA-LINKER	[23]
ADC Info	CN113453724B ADC-C	CN113453724B-ADCA-PAYLOAD	Undisclosed	CN113453724B-ADCA-LINKER	[23]
ADC Info	CN113453724B ADC-D	CN113453724B-ADCA-PAYLOAD	Undisclosed	CN113453724B-ADCA-LINKER	[23]
ADC Info	CN113453724B ADC-E	CN113453724B-ADCA-PAYLOAD	Undisclosed	CN113453724B-ADCA-LINKER	[23]
ADC Info	CN113453724B ADC-F	CN113453724B-ADCA-PAYLOAD	Undisclosed	CN113453724B-ADCA-LINKER	[23]
ADC Info	CN113453724B ADC-G	CN113453724B-ADCA-PAYLOAD	Undisclosed	CN113453724B-ADCA-LINKER	[23]
ADC Info	SGN-35C	AMDCPT	DNA topoisomerase 1 (TOP1)	A cleavable linker

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	cAC10ec-MC1ADC	BR112022020332A2 cAC10ec-MC1ADC Payload	Undisclosed	BR112022020332A2 cAC10ec-MC1ADC Linker	[24]
ADC Info	cAC10-MC2 (8)-MC4 (16)	BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1; BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload2	Undisclosed	BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Linker1; BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Linker2	[24]
ADC Info	cAC10-MC6 (8)-MC7 (16)	BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1; BR112022020332A2 cAC10-MC6 (8)-MC7 (17) Payload1	Undisclosed	BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker1; BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker2	[24]
ADC Info	cAC10-MC6 (8)-MC8 (16)	BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1; BR112022020332A2 cAC10-MC6 (8)-MC8 (16) Payload1	Undisclosed	BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker1; BR112022020332A2 cAC10-MC6 (8)-MC8 (16) Linker1	[24]
ADC Info	cAC10-MC6 (8)-MC9 (16)	BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1; BR112022020332A2 cAC10-MC6 (8)-MC9 (16) Payload1	Undisclosed	BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker1; BR112022020332A2 cAC10-MC6 (8)-MC9 (16) Linker1	[24]
ADC Info	cAC10-MC6 (8)-MC10 (16)	BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1;BR112022020332A2 cAC10-MC6 (8)-MC8 (16) Payload1	Undisclosed	BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker1; BR112022020332A2 cAC10-MC6 (8)-MC10 (16) Linker1	[24]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Monoclonal antibody IRac-ricin A conjugate	Deglycosylated ricin A-chain (dgA)	Undisclosed	Undisclosed	[25]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Anti-CD30-LDM	Lidamycin	Human Deoxyribonucleic acid (hDNA)	Uncleavable linker	[26]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TUB-010	Undisclosed	Undisclosed	Undisclosed	[27]
ADC Info	Anti-CD30 antibody drug conjugate (NBE-Therapeutics)	Undisclosed	Undisclosed	Undisclosed	[28]
ADC Info	AVP10	Monomethyl auristatin F	Microtubule (MT)	Undisclosed	[29]
ADC Info	Recombinant chimeric anti-CD30 mAb-MCC-DM1	Undisclosed	Undisclosed	Undisclosed	[30]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	US12186310B2-22	Undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	US12186310B2-31	Undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	US12186310B2-32	Undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	US12186310B2-33	Undisclosed	Undisclosed	Undisclosed	[1]
ADC Info	US12186310B2-47	Undisclosed	Undisclosed	Undisclosed	[1]

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Ref 2	Recombinant anti-cd30 antibodies and uses thereof; 2006-02-02
Ref 3	Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates. Mol Cancer Ther. 2016 May;15(5):938-45. doi: 10.1158/1535-7163.MCT-16-0038. Epub 2016 Mar 4.
Ref 4	Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR(+) and Heterogeneous Tumor Models. Mol Cancer Ther. 2018 Aug;17(8):1752-1760. doi: 10.1158/1535-7163.MCT-18-0073. Epub 2018 Jun 4.
Ref 5	Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood. 1995 Apr 15;85(8):2139-46.
Ref 6	Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models. Mol Pharm. 2015 Jun 1;12(6):1863-71. doi: 10.1021/mp500666j. Epub 2015 Feb 9.
Ref 7	Development of Novel Antibody-Camptothecin Conjugates. Mol Cancer Ther. 2021 Feb;20(2):329-339.
Ref 8	Modified taxols .6. preparation of water-soluble prodrugs of taxol. J Nat Prod. 1991;54(6):1607-1611.
Ref 9	Highly Potent, Anthracycline-based Antibody-Drug Conjugates Generated by Enzymatic, Site-specific Conjugation. Mol Cancer Ther. 2017 May;16(5):879-892.
Ref 10	Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile. Chem Sci. 2023 Jan 3;14(9):2259-2266. doi: 10.1039/d2sc05678j. eCollection 2023 Mar 1.
Ref 11	Innovative Bioconjugation Technology for Antibody-Drug Conjugates: Proof of Concept in a CD30-Positive Lymphoma Mouse Model. Bioconjug Chem. 2021 Mar 17;32(3):595-606. doi: 10.1021/acs.bioconjchem.1c00058. Epub 2021 Feb 25.
Ref 12	Binding protein drug conjugates comprising anthracycline derivatives; 2016-06-30.
Ref 13	Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 14	Beta-glucuronide-linker drug conjugates; 2007-10-25.
Ref 15	Methylene carbamate linkers for use with targeted-drug conjugates; 2015-06-25.
Ref 16	Immunomodulatory antibody-drug conjugates; 2022-07-21.
Ref 17	Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance. Front Pharmacol. 2022 Jun 17;13:764540. doi: 10.3389/fphar.2022.764540. eCollection 2022.
Ref 18	Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 19	Allenamide linkers for antibody-drug conjugates
Ref 20	Antibody-drug complexes containing hemiasterlin derivatives
Ref 21	Antibody-drug conjugates for delivering cytotoxic agents using MATE technology
Ref 22	Antibody-drug complexes containing hemiasterlin derivatives
Ref 23	Sulfonyl maleimide-based linkers and corresponding conjugates
Ref 24	Antibody-drug conjugate composition, method of treating cancer and an autoimmune disorder
Ref 25	Antitumor effects of ricin A chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's disease tumors in mice. Cancer Res. 1990 May 15;50(10):2929-35.
Ref 26	A novel enediyne-integrated antibody-drug conjugate shows promising antitumor efficacy against CD30(+) lymphomas. Mol Oncol. 2018 Mar;12(3):339-355. doi: 10.1002/1878-0261.12166. Epub 2018 Jan 26.
Ref 27	https://tubulis.com/
Ref 28	Research programme: CD30 targeting antibody drug conjugate therapeutics-NBE Therapeutics.
Ref 29	AVIPEP Therapeutics product pipeline
Ref 30	Indicative announcement on obtaining clinical trial approval for recombinant anti-CD30 human-mouse chimeric monoclonal Antibody-MCC-DM1 injection; 18 Jul 2018.