Antigen Information

General Information of This Antigen (ID: TAR0QPCSQ)
Antigen Name
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Gene Name
TNFRSF8
Gene ID
943
Synonym
CD30L receptor;Ki-1 antigen;Lymphocyte activation antigen CD30;CD30
Sequence
MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQ
RPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVN
SCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPT
PVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDC
RKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARC
VPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQA
SKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKL
HLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYL
ESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGL
AGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK

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Family
Tissue factor family
Function
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B.

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Uniprot Entry
TNR8_HUMAN
HGNC ID
HGNC:11923
KEGG ID
hsa:943
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CD30
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US12186310B2-6 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD30 (US12186310B2)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US12186310B2-7 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD30 alphaCD30-vcMMAE mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Alpha-CD30-Val-Cit-MMAE [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD30 DAR8-alphaCD30-mDPR-gluc-DMTub mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DAR8-alphaCD30-mDPR-Gluc-DMTub [3]
DMTub
Microtubule (MT)
Quaternary ammonium linker Gluc
 ADC Info 
Anti-CD30 DAR8-alphaCD30-mDPR-gluc-MMAE mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DAR8-alphaCD30-mDPR-Gluc-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Quaternary ammonium linker Gluc
 ADC Info 
Anti-CD30 DAR8-alphaCD30-mDPR-glucQ-AE mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DAR8-alphaCD30-mDPR-GlucQ-AE [3]
Auristatin E
Microtubule (MT)
Quaternary ammonium linker GlucQ
 ADC Info 
Anti-CD30 DAR8-alphaCD30-mDPR-glucQ-Tub mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DAR8-alphaCD30-mDPR-GlucQ-Tub [3]
Tubulysin analogue 3
Microtubule (MT)
Quaternary ammonium linker GlucQ
 ADC Info 
Anti-CD30 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Alpha-CD30-7 [4]
Tubulysin 7
Microtubule (MT)
Glucuronide quaternary ammonium linker 7
 ADC Info 
Alpha-CD30-8 [4]
Tubulysin 8
Microtubule (MT)
Glucuronide quaternary ammonium linker 8
 ADC Info 
Alpha-CD30-9 [4]
Tubulysin 9
Microtubule (MT)
Glucuronide quaternary ammonium linker 9
 ADC Info 
Anti-CD30 mAb Ber-H2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD30 monoclonal antibody-saporin conjugate [5]
Saporin
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-CD30 mAb cAC10Q
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD30-BTG-ADC [6]
Monomethyl auristatin E
Microtubule (MT)
PEG3-benzotriazole-PEG-Val-Cit-PABC
 ADC Info 
Anti-CD30 mAb h00
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H00-CPT-LC [7]
Methylenedioxy CPT2 (CPT2)
DNA topoisomerase 1 (TOP1)
Mc-PEG8-Val-Lys-Gly
 ADC Info 
H00-CPT-LA [7]
Methylenedioxy CPT1 (CPT1)
DNA topoisomerase 1 (TOP1)
Mc-PEG4-Val-Lys-Gly
 ADC Info 
H00-CPT-LB [7]
Methylenedioxy CPT2 (CPT2)
DNA topoisomerase 1 (TOP1)
Mc-PEG4-Val-Lys-Gly
 ADC Info 
H00-DT [7]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
H00-GT [8]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Brentuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Brentuximab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
F0002-ADC
DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
SGN-35T
Monomethyl auristatin E
Microtubule (MT)
Mp-D-leucine-alanine-glutamate-PABC
 ADC Info 
CAC10-Gly5-PNU [9]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Gly5
 ADC Info 
CAC10-Gly5-MAY [9]
Mertansine DM1
Microtubule (MT)
Gly5
 ADC Info 
CAC10-CPT-LB [7]
Methylenedioxy CPT2 (CPT2)
DNA topoisomerase 1 (TOP1)
Mc-PEG4-Val-Lys-Gly
 ADC Info 
CAC10-CPT-LC [7]
Methylenedioxy CPT2 (CPT2)
DNA topoisomerase 1 (TOP1)
Mc-PEG8-Val-Lys-Gly
 ADC Info 
CAC10-DT [7]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
CAC10-GT [7]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Brentuximab-8 [10]
Monomethyl auristatin E
Microtubule (MT)
Alkyl phosphoramide-PEG24-Val-Cit-PAB
 ADC Info 
Brentuximab-7 [10]
Monomethyl auristatin E
Microtubule (MT)
Alkyl phosphoramide-PEG12-Val-Cit-PAB
 ADC Info 
CAC10-CPT-LA [7]
Methylenedioxy CPT1 (CPT1)
DNA topoisomerase 1 (TOP1)
Mc-PEG4-Val-Lys-Gly
 ADC Info 
MF-BTX-MMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Dibromomethyl pyridine-Val-Cit-PABC
 ADC Info 
Brentuximab-PNUEDAGly5 [12]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
LPETG-Gly5-EDA
 ADC Info 
Brentuximab-ADC-24-1 [13]
Brentuximab-ADC-24-1 payload
Undisclosed
Brentuximab-ADC-24-1 linker
 ADC Info 
Brentuximab-ADC-24-2 [13]
Brentuximab-ADC-24-2 payload
Undisclosed
Brentuximab-ADC-24-2 linker
 ADC Info 
Brentuximab-ADC-24-3 [13]
Brentuximab-ADC-24-3 payload
Undisclosed
Brentuximab-ADC-24-3 linker
 ADC Info 
Brentuximab-ADC-24-4 [13]
Brentuximab-ADC-24-4 payload
Undisclosed
Brentuximab-ADC-24-4 linker
 ADC Info 
Brentuximab-ADC-24-5 [13]
Brentuximab-ADC-24-5 payload
Undisclosed
Brentuximab-ADC-24-5 linker
 ADC Info 
Brentuximab-ADC-24-6 [13]
Brentuximab-ADC-24-6 payload
Undisclosed
Brentuximab-ADC-24-6 linker
 ADC Info 
Brentuximab-ADC-24-7 [13]
Brentuximab-ADC-24-7 payload
Undisclosed
Brentuximab-ADC-24-7 linker
 ADC Info 
Brentuximab-ADC-24-8 [13]
Brentuximab-ADC-24-8 payload
Undisclosed
Brentuximab-ADC-24-8 linker
 ADC Info 
Brentuximab-ADC-24-9 [13]
Brentuximab-ADC-24-9 payload
Undisclosed
Brentuximab-ADC-24-9 linker
 ADC Info 
Brentuximab-ADC-24-10 [13]
Brentuximab-ADC-24-10 payload
Undisclosed
Brentuximab-ADC-24-10 linker
 ADC Info 
Brentuximab-ADC-24-11 [13]
Brentuximab-ADC-24-11 payload
Undisclosed
Brentuximab-ADC-24-11 linker
 ADC Info 
Brentuximab-ADC-24-12 [13]
Brentuximab-ADC-24-12 payload
Undisclosed
Brentuximab-ADC-24-12 linker
 ADC Info 
Brentuximab-ADC-24-13 [13]
Brentuximab-ADC-24-13 payload
Undisclosed
Brentuximab-ADC-24-13 linker
 ADC Info 
WO2007011968A2 cAC10-9a [14]
Monomethyl auristatin E
Microtubule (MT)
WO2007011968A2_cAC10-9a linker
 ADC Info 
WO2007011968A2 cAC10-9b [14]
Monomethyl auristatin F
Microtubule (MT)
WO2007011968A2_cAC10-9b linker
 ADC Info 
WO2007011968A2 cAC10-17 [14]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
WO2007011968A2_cAC10-17 linker
 ADC Info 
WO2015095755A1 cAC10-1.3 [15]
Monomethyl auristatin E
Microtubule (MT)
WO2015095755A1_cAC10-1.3 linker
 ADC Info 
WO2015095755A1 cAC10-1006 [15]
WO2015095755A1_cAC10-1006 payload
Undisclosed
WO2015095755A1_cAC10-1006 linker
 ADC Info 
WO2015095755A1 cAC10-2.0 [15]
Monomethyl auristatin E
Microtubule (MT)
WO2015095755A1_cAC10-2.0 linker
 ADC Info 
WO2015095755A1 cAC10-5.6 [15]
WO2015095755A1_cAC10-5.6 payload
Undisclosed
WO2015095755A1_cAC10-5.6 linker
 ADC Info 
WO2015095755A1 cAC10-6.4 [15]
WO2015095755A1_cAC10-6.4 payload
Undisclosed
WO2015095755A1_cAC10-6.4 linker
 ADC Info 
WO2015095755A1 cAC10-7.7 [15]
WO2015095755A1_cAC10-7.7 payload
Undisclosed
WO2015095755A1_cAC10-7.7 linker
 ADC Info 
EphA2-targeted mAb ADC B 12 (DAR8) [16]
EphA2-targeted mAb ADC B 12 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 12 (DAR8) linker
 ADC Info 
EphA2-targeted mAb ADC B 12 (DAR4) [16]
EphA2-targeted mAb ADC B 12 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 12 (DAR4) linker
 ADC Info 
EphA2-targeted mAb ADC B 17 (DAR8) [16]
EphA2-targeted mAb ADC B 17 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 17 (DAR8) linker
 ADC Info 
EphA2-targeted mAb ADC B 17 (DAR4) [16]
EphA2-targeted mAb ADC B 17 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 17 (DAR4) linker
 ADC Info 
EphA2-targeted mAb ADC B 21 (DAR8) [16]
EphA2-targeted mAb ADC B 21 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 21 (DAR8) linker
 ADC Info 
EphA2-targeted mAb ADC B 21 (DAR4) [16]
EphA2-targeted mAb ADC B 21 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 21 (DAR4) linker
 ADC Info 
EphA2-targeted mAb ADC B 22 (DAR6) [16]
EphA2-targeted mAb ADC B 22 (DAR6) payload
Undisclosed
EphA2-targeted mAb ADC B 22 (DAR6) linker
 ADC Info 
EphA2-targeted mAb ADC B 22 (DAR2) [16]
EphA2-targeted mAb ADC B 22 (DAR2) payload
Undisclosed
EphA2-targeted mAb ADC B 22 (DAR2) linker
 ADC Info 
EphA2-targeted mAb ADC B 19 (DAR8) [16]
EphA2-targeted mAb ADC B 19 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 19 (DAR8) linker
 ADC Info 
EphA2-targeted mAb ADC B 19 (DAR4) [16]
EphA2-targeted mAb ADC B 19 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 19 (DAR4) linker
 ADC Info 
EphA2-targeted mAb ADC B 20 (DAR8) [16]
EphA2-targeted mAb ADC B 20 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 20 (DAR8) linker
 ADC Info 
EphA2-targeted mAb ADC B 20 (DAR4) [16]
EphA2-targeted mAb ADC B 20 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 20 (DAR4) linker
 ADC Info 
EphA2-targeted mAb ADC B 24 (DAR8) [16]
EphA2-targeted mAb ADC B 24 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 24 (DAR8) linker
 ADC Info 
EphA2-targeted mAb ADC B 24 (DAR4) [16]
EphA2-targeted mAb ADC B 24 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 24 (DAR4) linker
 ADC Info 
EphA2-targeted mAb ADC B 23 (DAR8) [16]
EphA2-targeted mAb ADC B 23 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 23 (DAR8) linker
 ADC Info 
EphA2-targeted mAb ADC B 23 (DAR4) [16]
EphA2-targeted mAb ADC B 23 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 23 (DAR4) linker
 ADC Info 
Crown Ether ADC 4a [17]
Monomethyl auristatin E
Microtubule (MT)
6-Amino-alpha-cyclodextrin-Val-Cit-PABC
 ADC Info 
Crown Ether ADC 4b [17]
Monomethyl auristatin E
Microtubule (MT)
6-Amino-beta-cyclodextrin-Val-Cit-PABC
 ADC Info 
Crown Ether ADC 4c [17]
Monomethyl auristatin E
Microtubule (MT)
6-Amino-gama-cyclodextrin-Val-Cit-PABC
 ADC Info 
Crown Ether ADC 4d [17]
Monomethyl auristatin E
Microtubule (MT)
3-Amino-alpha-cyclodextrin-Val-Cit-PABC
 ADC Info 
Crown Ether ADC 4e [17]
Monomethyl auristatin E
Microtubule (MT)
3-Amino-beta-cyclodextrin-Val-Cit-PABC
 ADC Info 
Crown Ether ADC 4f [17]
Monomethyl auristatin E
Microtubule (MT)
3-Amino-gama-cyclodextrin-Val-Cit-PABC
 ADC Info 
Crown Ether ADC 5a [17]
Monomethyl auristatin E
Microtubule (MT)
1-Aza-24-crown-8-Val-Cit-PABC
 ADC Info 
Crown Ether ADC 5b [17]
Monomethyl auristatin E
Microtubule (MT)
1-Aza-42-crown-14-Val-Cit-PABC
 ADC Info 
Crown Ether ADC 6a [17]
Monomethyl auristatin E
Microtubule (MT)
PEG(8u)-Val-Cit-PABC
 ADC Info 
Crown Ether ADC 6b [17]
Monomethyl auristatin E
Microtubule (MT)
PEG(24u)-Val-Cit-PABC
 ADC Info 
Brentuximab-Compound 9 [18]
Mertansine DM1
Microtubule (MT)
Brentuximab-Compound 9 linker
 ADC Info 
Brentuximab-Compound 17 [18]
Mertansine DM4
Microtubule (MT)
Brentuximab-Compound 17 linker
 ADC Info 
Brentuximab-Compound 25 [18]
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 25 linker
 ADC Info 
Brentuximab-Compound 31 [18]
Auristatin 0101
Microtubule (MT)
Brentuximab-Compound 31 linker
 ADC Info 
Brentuximab-Compound 36 [18]
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 36 linker
 ADC Info 
Brentuximab-Compound 43 [18]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Brentuximab-Compound 43 linker
 ADC Info 
Brentuximab-Compound 49 [18]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Brentuximab-Compound 49 linker
 ADC Info 
Brentuximab-Compound 55 [18]
Mertansine DM1
Microtubule (MT)
Brentuximab-Compound 55 linker
 ADC Info 
Brentuximab-Compound 59 [18]
Mertansine DM4
Microtubule (MT)
Brentuximab-Compound 59 linker
 ADC Info 
Brentuximab-Compound 64 [18]
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 64 linker
 ADC Info 
Brentuximab-Compound 69 [18]
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 69 linker
 ADC Info 
Brentuximab-Compound 74 [18]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Brentuximab-Compound 74 linker
 ADC Info 
Brentuximab-Compound 75 [18]
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 75 linker
 ADC Info 
Brentuximab-Compound 76 [18]
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 76 linker
 ADC Info 
Brentuximab-Compound 77 [18]
Mertansine DM1
Microtubule (MT)
Brentuximab-Compound 77 linker
 ADC Info 
Brentuximab-Compound 78 [18]
Auristatin 0101
Microtubule (MT)
Brentuximab-Compound 78 linker
 ADC Info 
Brentuximab-Compound 79 [18]
Auristatin 0101
Microtubule (MT)
Brentuximab-Compound 79 linker
 ADC Info 
Brentuximab-Compound 80 [18]
Mertansine DM4
Microtubule (MT)
Brentuximab-Compound 80 linker
 ADC Info 
CN118401256A ADC 3 [19]
Monomethyl auristatin E
Microtubule (MT)
Allenamide-Amcap-Val-Cit-PABC
 ADC Info 
JP7623413B2 ExampleADC1 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC2 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC3 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC4 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC5 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC6 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC7 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC8 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC10 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC11 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC12 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC13 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC14 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC15 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC16 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC17 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC18 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC19 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC20 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC21 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC22 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC23 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC24 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC25 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC26 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC27 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC28 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC29 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC30 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC31 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC32 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC33 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC34 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC35 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC36 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC37 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC38 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC39 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC40 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC41 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ExampleADC42 [20]
Undisclosed
Undisclosed
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 ADC Info 
ExampleADC43 [20]
Undisclosed
Undisclosed
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 ADC Info 
ExampleADC44 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC63 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC64 [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Brentuximab-compound 1100 [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Brentuximab-compound 1101 [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Brentuximab-compound 1102 [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Brentuximab-compound 1103 [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Brentuximab-compound 1574 [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Brentuximab-compound 1105 [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Brentuximab-compound 1106 [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Brentuximab-compound 1199 [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC1 7.55 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC2 8 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC3 7.31 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC4 8 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC5 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC6 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC7 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC8 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC10 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC11 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC12 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC13 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC14 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC15 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC16 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC17 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC18 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC19 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC20 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC21 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC22 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC23 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC24 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC25 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC26 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC27 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC28 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC29 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC33 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC34 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC35 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC36 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC37 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC38 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC39 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC40 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2025004232A ADC41 [22]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN113453724B ADC-B [23]
CN113453724B-ADCA-PAYLOAD
Undisclosed
CN113453724B-ADCA-LINKER
 ADC Info 
CN113453724B ADC-C [23]
CN113453724B-ADCA-PAYLOAD
Undisclosed
CN113453724B-ADCA-LINKER
 ADC Info 
CN113453724B ADC-D [23]
CN113453724B-ADCA-PAYLOAD
Undisclosed
CN113453724B-ADCA-LINKER
 ADC Info 
CN113453724B ADC-E [23]
CN113453724B-ADCA-PAYLOAD
Undisclosed
CN113453724B-ADCA-LINKER
 ADC Info 
CN113453724B ADC-F [23]
CN113453724B-ADCA-PAYLOAD
Undisclosed
CN113453724B-ADCA-LINKER
 ADC Info 
CN113453724B ADC-G [23]
CN113453724B-ADCA-PAYLOAD
Undisclosed
CN113453724B-ADCA-LINKER
 ADC Info 
SGN-35C
AMDCPT
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
cAC10ec-MC1ADC [24]
BR112022020332A2 cAC10ec-MC1ADC Payload
Undisclosed
BR112022020332A2 cAC10ec-MC1ADC Linker
 ADC Info 
cAC10-MC2 (8)-MC4 (16) [24]
BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1; BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload2
Undisclosed
BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Linker1; BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Linker2
 ADC Info 
cAC10-MC6 (8)-MC7 (16) [24]
BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1; BR112022020332A2 cAC10-MC6 (8)-MC7 (17) Payload1
Undisclosed
BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker1; BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker2
 ADC Info 
cAC10-MC6 (8)-MC8 (16) [24]
BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1; BR112022020332A2 cAC10-MC6 (8)-MC8 (16) Payload1
Undisclosed
BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker1; BR112022020332A2 cAC10-MC6 (8)-MC8 (16) Linker1
 ADC Info 
cAC10-MC6 (8)-MC9 (16) [24]
BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1; BR112022020332A2 cAC10-MC6 (8)-MC9 (16) Payload1
Undisclosed
BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker1; BR112022020332A2 cAC10-MC6 (8)-MC9 (16) Linker1
 ADC Info 
cAC10-MC6 (8)-MC10 (16) [24]
BR112022020332A2 cAC10-MC2 (8)-MC4 (16) Payload1;BR112022020332A2 cAC10-MC6 (8)-MC8 (16) Payload1
Undisclosed
BR112022020332A2 cAC10-MC6 (8)-MC7 (16) Linker1; BR112022020332A2 cAC10-MC6 (8)-MC10 (16) Linker1
 ADC Info 
ADC Name Payload Target Linker ADC Info
Monoclonal antibody IRac-ricin A conjugate [25]
Deglycosylated ricin A-chain (dgA)
Undisclosed
Undisclosed
 ADC Info 
Recombinant human CD30Fc fusion protein
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD30-LDM [26]
Lidamycin
Human Deoxyribonucleic acid (hDNA)
Uncleavable linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TUB-010 [27]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD30 antibody drug conjugate (NBE-Therapeutics) [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
AVP10 [29]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
Recombinant chimeric anti-CD30 mAb-MCC-DM1 [30]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-22 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-31 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-32 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-33 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-47 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Antibody-drug conjugate
Ref 2 Recombinant anti-cd30 antibodies and uses thereof; 2006-02-02
Ref 3 Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates. Mol Cancer Ther. 2016 May;15(5):938-45. doi: 10.1158/1535-7163.MCT-16-0038. Epub 2016 Mar 4.
Ref 4 Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR(+) and Heterogeneous Tumor Models. Mol Cancer Ther. 2018 Aug;17(8):1752-1760. doi: 10.1158/1535-7163.MCT-18-0073. Epub 2018 Jun 4.
Ref 5 Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood. 1995 Apr 15;85(8):2139-46.
Ref 6 Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models. Mol Pharm. 2015 Jun 1;12(6):1863-71. doi: 10.1021/mp500666j. Epub 2015 Feb 9.
Ref 7 Development of Novel Antibody-Camptothecin Conjugates. Mol Cancer Ther. 2021 Feb;20(2):329-339.
Ref 8 Modified taxols .6. preparation of water-soluble prodrugs of taxol. J Nat Prod. 1991;54(6):1607-1611.
Ref 9 Highly Potent, Anthracycline-based Antibody-Drug Conjugates Generated by Enzymatic, Site-specific Conjugation. Mol Cancer Ther. 2017 May;16(5):879-892.
Ref 10 Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile. Chem Sci. 2023 Jan 3;14(9):2259-2266. doi: 10.1039/d2sc05678j. eCollection 2023 Mar 1.
Ref 11 Innovative Bioconjugation Technology for Antibody-Drug Conjugates: Proof of Concept in a CD30-Positive Lymphoma Mouse Model. Bioconjug Chem. 2021 Mar 17;32(3):595-606. doi: 10.1021/acs.bioconjchem.1c00058. Epub 2021 Feb 25.
Ref 12 Binding protein drug conjugates comprising anthracycline derivatives; 2016-06-30.
Ref 13 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 14 Beta-glucuronide-linker drug conjugates; 2007-10-25.
Ref 15 Methylene carbamate linkers for use with targeted-drug conjugates; 2015-06-25.
Ref 16 Immunomodulatory antibody-drug conjugates; 2022-07-21.
Ref 17 Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance. Front Pharmacol. 2022 Jun 17;13:764540. doi: 10.3389/fphar.2022.764540. eCollection 2022.
Ref 18 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 19 Allenamide linkers for antibody-drug conjugates
Ref 20 Antibody-drug complexes containing hemiasterlin derivatives
Ref 21 Antibody-drug conjugates for delivering cytotoxic agents using MATE technology
Ref 22 Antibody-drug complexes containing hemiasterlin derivatives
Ref 23 Sulfonyl maleimide-based linkers and corresponding conjugates
Ref 24 Antibody-drug conjugate composition, method of treating cancer and an autoimmune disorder
Ref 25 Antitumor effects of ricin A chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's disease tumors in mice. Cancer Res. 1990 May 15;50(10):2929-35.
Ref 26 A novel enediyne-integrated antibody-drug conjugate shows promising antitumor efficacy against CD30(+) lymphomas. Mol Oncol. 2018 Mar;12(3):339-355. doi: 10.1002/1878-0261.12166. Epub 2018 Jan 26.
Ref 27 https://tubulis.com/
Ref 28 Research programme: CD30 targeting antibody drug conjugate therapeutics-NBE Therapeutics.
Ref 29 AVIPEP Therapeutics product pipeline
Ref 30 Indicative announcement on obtaining clinical trial approval for recombinant anti-CD30 human-mouse chimeric monoclonal Antibody-MCC-DM1 injection; 18 Jul 2018.