General Information of This Antigen
Antigen ID
TAR0QPCSQ
Antigen Name
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Gene Name
TNFRSF8
Gene ID
943
Synonym
CD30L receptor;Ki-1 antigen;Lymphocyte activation antigen CD30;CD_antigen=CD30
Sequence
MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQ
RPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVN
SCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPT
PVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDC
RKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARC
VPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQA
SKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKL
HLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYL
ESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGL
AGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK

    Click to Show/Hide
Family
Tissue factor family
Function
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B.

    Click to Show/Hide
Uniprot Entry
TNR8_HUMAN
HGNC ID
HGNC:11923
KEGG ID
hsa:943
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CD30 alphaCD30-vcMMAE mAb
ADC Info ADC Name Payload Target Linker Ref
Alpha-CD30-Val-Cit-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[1]
Anti-CD30 DAR8-alphaCD30-mDPR-gluc-DMTub mAb
ADC Info ADC Name Payload Target Linker Ref
DAR8-alphaCD30-mDPR-Gluc-DMTub
DMTub
Microtubule (MT)
Quaternary ammonium linker Gluc
[2]
Anti-CD30 DAR8-alphaCD30-mDPR-gluc-MMAE mAb
ADC Info ADC Name Payload Target Linker Ref
DAR8-alphaCD30-mDPR-Gluc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Quaternary ammonium linker Gluc
[2]
Anti-CD30 DAR8-alphaCD30-mDPR-glucQ-AE mAb
ADC Info ADC Name Payload Target Linker Ref
DAR8-alphaCD30-mDPR-GlucQ-AE
Auristatin E
Microtubule (MT)
Quaternary ammonium linker GlucQ
[2]
Anti-CD30 DAR8-alphaCD30-mDPR-glucQ-Tub mAb
ADC Info ADC Name Payload Target Linker Ref
DAR8-alphaCD30-mDPR-GlucQ-Tub
Tubulysin analogue 3
Microtubule (MT)
Quaternary ammonium linker GlucQ
[2]
Anti-CD30 mAb
ADC Info ADC Name Payload Target Linker Ref
Alpha-CD30-7
Tubulysin 7
Microtubule (MT)
Glucuronide quaternary ammonium linker 7
[3]
Alpha-CD30-8
Tubulysin 8
Microtubule (MT)
Glucuronide quaternary ammonium linker 8
[3]
Alpha-CD30-9
Tubulysin 9
Microtubule (MT)
Glucuronide quaternary ammonium linker 9
[3]
Anti-CD30 mAb Ber-H2
ADC Info ADC Name Payload Target Linker Ref
Anti-CD30 monoclonal antibody-saporin conjugate
Saporin
Microtubule (MT)
Undisclosed
[4]
Anti-CD30 mAb cAC10Q
ADC Info ADC Name Payload Target Linker Ref
CD30-BTG-ADC
Monomethyl auristatin E
Microtubule (MT)
PEG3-benzotriazole-PEG-Val-Cit-PABC
[5]
Anti-CD30 mAb h00
ADC Info ADC Name Payload Target Linker Ref
H00-CPT-LC
Methylenedioxy CPT2 (CPT2)
DNA topoisomerase 1 (TOP1)
Mc-PEG8-Val-Lys-Gly
[6]
H00-CPT-LA
Methylenedioxy CPT1 (CPT1)
DNA topoisomerase 1 (TOP1)
Mc-PEG4-Val-Lys-Gly
[6]
H00-CPT-LB
Methylenedioxy CPT2 (CPT2)
DNA topoisomerase 1 (TOP1)
Mc-PEG4-Val-Lys-Gly
[6]
H00-GT
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
[7]
H00-DT
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[6]
Brentuximab
ADC Info ADC Name Payload Target Linker Ref
Brentuximab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[8]
F0002-ADC
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
[9]
Brentuximab-8
Monomethyl auristatin E
Microtubule (MT)
Alkyl phosphoramide-PEG24-Val-Cit-PAB
[10]
Brentuximab-7
Monomethyl auristatin E
Microtubule (MT)
Alkyl phosphoramide-PEG12-Val-Cit-PAB
[10]
CAC10-CPT-LB
Methylenedioxy CPT2 (CPT2)
DNA topoisomerase 1 (TOP1)
Mc-PEG4-Val-Lys-Gly
[6]
CAC10-CPT-LC
Methylenedioxy CPT2 (CPT2)
DNA topoisomerase 1 (TOP1)
Mc-PEG8-Val-Lys-Gly
[6]
CAC10-GT
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
[6]
CAC10-CPT-LA
Methylenedioxy CPT1 (CPT1)
DNA topoisomerase 1 (TOP1)
Mc-PEG4-Val-Lys-Gly
[6]
MF-BTX-MMAE
Monomethyl auristatin E
Microtubule (MT)
Dibromomethyl pyridine-Val-Cit-PABC
[11]
Brentuximab-PNUEDAGly5
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
LPETG-Gly5-EDA
[12]
Brentuximab-ADC-24-1
Brentuximab-ADC-24-1 payload
Undisclosed
Brentuximab-ADC-24-1 linker
[13]
Brentuximab-ADC-24-2
Brentuximab-ADC-24-2 payload
Undisclosed
Brentuximab-ADC-24-2 linker
[13]
Brentuximab-ADC-24-3
Brentuximab-ADC-24-3 payload
Undisclosed
Brentuximab-ADC-24-3 linker
[13]
Brentuximab-ADC-24-4
Brentuximab-ADC-24-4 payload
Undisclosed
Brentuximab-ADC-24-4 linker
[13]
Brentuximab-ADC-24-5
Brentuximab-ADC-24-5 payload
Undisclosed
Brentuximab-ADC-24-5 linker
[13]
Brentuximab-ADC-24-6
Brentuximab-ADC-24-6 payload
Undisclosed
Brentuximab-ADC-24-6 linker
[13]
Brentuximab-ADC-24-7
Brentuximab-ADC-24-7 payload
Undisclosed
Brentuximab-ADC-24-7 linker
[13]
Brentuximab-ADC-24-8
Brentuximab-ADC-24-8 payload
Undisclosed
Brentuximab-ADC-24-8 linker
[13]
Brentuximab-ADC-24-9
Brentuximab-ADC-24-9 payload
Undisclosed
Brentuximab-ADC-24-9 linker
[13]
Brentuximab-ADC-24-10
Brentuximab-ADC-24-10 payload
Undisclosed
Brentuximab-ADC-24-10 linker
[13]
Brentuximab-ADC-24-11
Brentuximab-ADC-24-11 payload
Undisclosed
Brentuximab-ADC-24-11 linker
[13]
Brentuximab-ADC-24-12
Brentuximab-ADC-24-12 payload
Undisclosed
Brentuximab-ADC-24-12 linker
[13]
Brentuximab-ADC-24-13
Brentuximab-ADC-24-13 payload
Undisclosed
Brentuximab-ADC-24-13 linker
[13]
EphA2-targeted mAb ADC B 12 (DAR8)
EphA2-targeted mAb ADC B 12 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 12 (DAR8) linker
[14]
EphA2-targeted mAb ADC B 12 (DAR4)
EphA2-targeted mAb ADC B 12 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 12 (DAR4) linker
[14]
EphA2-targeted mAb ADC B 17 (DAR8)
EphA2-targeted mAb ADC B 17 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 17 (DAR8) linker
[14]
EphA2-targeted mAb ADC B 17 (DAR4)
EphA2-targeted mAb ADC B 17 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 17 (DAR4) linker
[14]
EphA2-targeted mAb ADC B 21 (DAR8)
EphA2-targeted mAb ADC B 21 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 21 (DAR8) linker
[14]
EphA2-targeted mAb ADC B 21 (DAR4)
EphA2-targeted mAb ADC B 21 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 21 (DAR4) linker
[14]
EphA2-targeted mAb ADC B 22 (DAR6)
EphA2-targeted mAb ADC B 22 (DAR6) payload
Undisclosed
EphA2-targeted mAb ADC B 22 (DAR6) linker
[14]
EphA2-targeted mAb ADC B 22 (DAR2)
EphA2-targeted mAb ADC B 22 (DAR2) payload
Undisclosed
EphA2-targeted mAb ADC B 22 (DAR2) linker
[14]
EphA2-targeted mAb ADC B 19 (DAR8)
EphA2-targeted mAb ADC B 19 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 19 (DAR8) linker
[14]
EphA2-targeted mAb ADC B 19 (DAR4)
EphA2-targeted mAb ADC B 19 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 19 (DAR4) linker
[14]
EphA2-targeted mAb ADC B 20 (DAR8)
EphA2-targeted mAb ADC B 20 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 20 (DAR8) linker
[14]
EphA2-targeted mAb ADC B 20 (DAR4)
EphA2-targeted mAb ADC B 20 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 20 (DAR4) linker
[14]
EphA2-targeted mAb ADC B 24 (DAR8)
EphA2-targeted mAb ADC B 24 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 24 (DAR8) linker
[14]
EphA2-targeted mAb ADC B 24 (DAR4)
EphA2-targeted mAb ADC B 24 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 24 (DAR4) linker
[14]
EphA2-targeted mAb ADC B 23 (DAR8)
EphA2-targeted mAb ADC B 23 (DAR8) payload
Undisclosed
EphA2-targeted mAb ADC B 23 (DAR8) linker
[14]
EphA2-targeted mAb ADC B 23 (DAR4)
EphA2-targeted mAb ADC B 23 (DAR4) payload
Undisclosed
EphA2-targeted mAb ADC B 23 (DAR4) linker
[14]
CAC10-Gly5-PNU
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Gly5
[15]
CAC10-Gly5-MAY
Mertansine DM1
Microtubule (MT)
Gly5
[15]
CAC10-DT
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[6]
WO2007011968A2 cAC10-9a
Monomethyl auristatin E
Microtubule (MT)
WO2007011968A2_cAC10-9a linker
[16]
WO2007011968A2 cAC10-9b
Monomethyl auristatin F
Microtubule (MT)
WO2007011968A2_cAC10-9b linker
[16]
WO2007011968A2 cAC10-17
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
WO2007011968A2_cAC10-17 linker
[16]
WO2015095755A1 cAC10-1.3
Monomethyl auristatin E
Microtubule (MT)
WO2015095755A1_cAC10-1.3 linker
[17]
WO2015095755A1 cAC10-1006
WO2015095755A1_cAC10-1006 payload
Undisclosed
WO2015095755A1_cAC10-1006 linker
[17]
WO2015095755A1 cAC10-2.0
Monomethyl auristatin E
Microtubule (MT)
WO2015095755A1_cAC10-2.0 linker
[17]
WO2015095755A1 cAC10-5.6
WO2015095755A1_cAC10-5.6 payload
Undisclosed
WO2015095755A1_cAC10-5.6 linker
[17]
WO2015095755A1 cAC10-6.4
WO2015095755A1_cAC10-6.4 payload
Undisclosed
WO2015095755A1_cAC10-6.4 linker
[17]
WO2015095755A1 cAC10-7.7
WO2015095755A1_cAC10-7.7 payload
Undisclosed
WO2015095755A1_cAC10-7.7 linker
[17]
Crown Ether ADC 4a
Monomethyl auristatin E
Microtubule (MT)
6-Amino-alpha-cyclodextrin-Val-Cit-PABC
[18]
Crown Ether ADC 4b
Monomethyl auristatin E
Microtubule (MT)
6-Amino-beta-cyclodextrin-Val-Cit-PABC
[18]
Crown Ether ADC 4c
Monomethyl auristatin E
Microtubule (MT)
6-Amino-gama-cyclodextrin-Val-Cit-PABC
[18]
Crown Ether ADC 4d
Monomethyl auristatin E
Microtubule (MT)
3-Amino-alpha-cyclodextrin-Val-Cit-PABC
[18]
Crown Ether ADC 4e
Monomethyl auristatin E
Microtubule (MT)
3-Amino-beta-cyclodextrin-Val-Cit-PABC
[18]
Crown Ether ADC 4f
Monomethyl auristatin E
Microtubule (MT)
3-Amino-gama-cyclodextrin-Val-Cit-PABC
[18]
Crown Ether ADC 5a
Monomethyl auristatin E
Microtubule (MT)
1-Aza-24-crown-8-Val-Cit-PABC
[18]
Crown Ether ADC 5b
Monomethyl auristatin E
Microtubule (MT)
1-Aza-42-crown-14-Val-Cit-PABC
[18]
Crown Ether ADC 6a
Monomethyl auristatin E
Microtubule (MT)
PEG(8u)-Val-Cit-PABC
[18]
Crown Ether ADC 6b
Monomethyl auristatin E
Microtubule (MT)
PEG(24u)-Val-Cit-PABC
[18]
Brentuximab-Compound 9
Mertansine DM1
Microtubule (MT)
Brentuximab-Compound 9 linker
[19]
Brentuximab-Compound 17
Mertansine DM4
Microtubule (MT)
Brentuximab-Compound 17 linker
[19]
Brentuximab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 25 linker
[19]
Brentuximab-Compound 31
Auristatin 0101
Microtubule (MT)
Brentuximab-Compound 31 linker
[19]
Brentuximab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 36 linker
[19]
Brentuximab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Brentuximab-Compound 43 linker
[19]
Brentuximab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Brentuximab-Compound 49 linker
[19]
Brentuximab-Compound 55
Mertansine DM1
Microtubule (MT)
Brentuximab-Compound 55 linker
[19]
Brentuximab-Compound 59
Mertansine DM4
Microtubule (MT)
Brentuximab-Compound 59 linker
[19]
Brentuximab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 64 linker
[19]
Brentuximab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 69 linker
[19]
Brentuximab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Brentuximab-Compound 74 linker
[19]
Brentuximab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 75 linker
[19]
Brentuximab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Brentuximab-Compound 76 linker
[19]
Brentuximab-Compound 77
Mertansine DM1
Microtubule (MT)
Brentuximab-Compound 77 linker
[19]
Brentuximab-Compound 78
Auristatin 0101
Microtubule (MT)
Brentuximab-Compound 78 linker
[19]
Brentuximab-Compound 79
Auristatin 0101
Microtubule (MT)
Brentuximab-Compound 79 linker
[19]
Brentuximab-Compound 80
Mertansine DM4
Microtubule (MT)
Brentuximab-Compound 80 linker
[19]
ADC Info ADC Name Payload Target Linker Ref
Monoclonal antibody IRac-ricin A conjugate
Deglycosylated ricin A-chain (dgA)
Undisclosed
Undisclosed
[20]
Recombinant human CD30Fc fusion protein
ADC Info ADC Name Payload Target Linker Ref
Anti-CD30-LDM
Lidamycin
Human Deoxyribonucleic acid (hDNA)
Uncleavable linker
[21]
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
Recombinant chimeric anti-CD30 mAb-MCC-DM1
Undisclosed
Undisclosed
Undisclosed
[22]
TUB-010
Undisclosed
Undisclosed
Undisclosed
[23]
Anti-CD30 antibody drug conjugate (NBE-Therapeutics)
Undisclosed
Undisclosed
Undisclosed
[24]
AVP10
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[25]
Tissue/Disease specific Abundances of This Antigen
Tissue specific Abundances of This Antigen
ICD Disease Classification 01
Click to Show/Hide the 1 Disease of This Class
Bacterial infection [ICD-11: 1A00-1C4Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Bacterial infection of gingival
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.400086288; Fold-change: -0.011931585; Z-score: -0.053169615
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 02
Click to Show/Hide the 22 Disease of This Class
Brain cancer [ICD-11: 2A00]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Brainstem
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.704660292; Fold-change: 0.17937956; Z-score: 0.407717895
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue White matter
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 7.16E-07; Fold-change: -0.826434468; Z-score: -3.39709883
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Brainstem
The Specific Disease Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000922392; Fold-change: 0.692920239; Z-score: 1.887775648
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Nervous
The Specific Disease Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.12E-13; Fold-change: 0.087625355; Z-score: 0.346169452
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic myeloid leukemia [ICD-11: 2A20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Polycythemia vera
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.23E-14; Fold-change: -0.313272246; Z-score: -1.872527764
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Whole blood
The Specific Disease Myelofibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000219574; Fold-change: -0.326933553; Z-score: -1.888508989
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
MyeloDysplastic syndromes [ICD-11: 2A37]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myelodysplastic syndromes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.019294937; Fold-change: 0.086182001; Z-score: 0.629155767
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.250790442; Fold-change: -0.263361113; Z-score: -1.019802369
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lymphoma [ICD-11: 2A90- 2A85]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Tonsil
The Specific Disease Lymphoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.978093057; Fold-change: -0.05064933; Z-score: -0.22873554
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Gastric cancer [ICD-11: 2B72]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Gastric
The Specific Disease Gastric cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.967169379; Fold-change: -0.065119468; Z-score: -0.398948341
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.12701012; Fold-change: -0.103718457; Z-score: -0.359093798
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Colon cancer [ICD-11: 2B90]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Colon
The Specific Disease Colon cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.004669723; Fold-change: 0.076752432; Z-score: 0.320689643
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 9.52E-05; Fold-change: -0.140579025; Z-score: -0.541527589
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pancreatic cancer [ICD-11: 2C10]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Pancreas
The Specific Disease Pancreatic cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.012966549; Fold-change: -0.219416694; Z-score: -0.843049027
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.528660109; Fold-change: -0.019040539; Z-score: -0.060064828
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver cancer [ICD-11: 2C12]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.162652987; Fold-change: -0.05890579; Z-score: -0.252786231
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.441488482; Fold-change: -0.017139101; Z-score: -0.068876788
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.704883846; Fold-change: 0.048952918; Z-score: 0.194760877
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lung cancer [ICD-11: 2C25]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Lung cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.13E-12; Fold-change: -0.152861102; Z-score: -0.556958122
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 4.18E-08; Fold-change: -0.177942344; Z-score: -0.612413638
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Melanoma [ICD-11: 2C30]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Melanoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.303627253; Fold-change: -0.044207857; Z-score: -0.081203153
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sarcoma [ICD-11: 2C35]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Sarcoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 9.10E-27; Fold-change: -0.275794353; Z-score: -1.165908432
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.49100039; Fold-change: -0.051914848; Z-score: -0.316761624
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Breast cancer [ICD-11: 2C60]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Breast
The Specific Disease Breast cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.19E-33; Fold-change: -0.339449158; Z-score: -1.093399025
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.48E-05; Fold-change: -0.156597256; Z-score: -0.516495598
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ovarian cancer [ICD-11: 2C73]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Ovarian
The Specific Disease Ovarian cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.132466265; Fold-change: -0.203634435; Z-score: -0.475774805
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 5.90E-05; Fold-change: -0.867540294; Z-score: -1.512561858
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cervical cancer [ICD-11: 2C77]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Cervical
The Specific Disease Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.39978478; Fold-change: 0.106372011; Z-score: 0.427798316
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Uterine cancer [ICD-11: 2C78]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Uterine cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.002233541; Fold-change: -0.098172738; Z-score: -0.270463761
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.788833232; Fold-change: -0.024185905; Z-score: -0.131855384
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Prostate cancer [ICD-11: 2C82]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Prostate
The Specific Disease Prostate cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000400405; Fold-change: -0.382848452; Z-score: -0.851255482
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Bladder cancer [ICD-11: 2C94]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Bladder cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.015560926; Fold-change: 0.122160345; Z-score: 0.677235096
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Retina cancer [ICD-11: 2D02]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Uvea
The Specific Disease Retinoblastoma tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.615336538; Fold-change: 0.018973746; Z-score: 0.195913525
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thyroid cancer [ICD-11: 2D10]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Thyroid
The Specific Disease Thyroid cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.005520942; Fold-change: 0.098838792; Z-score: 0.332043186
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 8.41E-06; Fold-change: 0.170213352; Z-score: 0.926635333
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Adrenal cancer [ICD-11: 2D11]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Adrenal cortex
The Specific Disease Adrenocortical carcinoma
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.18139428; Fold-change: -0.042296716; Z-score: -0.265556275
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Head and neck cancer [ICD-11: 2D42]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Head and neck
The Specific Disease Head and neck cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.121407312; Fold-change: 0.022441605; Z-score: 0.084482892
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pituitary cancer [ICD-11: 2F37]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Pituitary
The Specific Disease Pituitary gonadotrope tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.443584254; Fold-change: -0.211644959; Z-score: -0.77726348
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Pituitary
The Specific Disease Pituitary cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.220323174; Fold-change: 0.106012552; Z-score: 0.365357614
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 03
Click to Show/Hide the 1 Disease of This Class
Thrombocytopenia [ICD-11: 3B64]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.912674692; Fold-change: -0.175211114; Z-score: -0.334878475
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 04
Click to Show/Hide the 2 Disease of This Class
Lupus erythematosus [ICD-11: 4A40]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Lupus erythematosus
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.085195348; Fold-change: 0.074296838; Z-score: 0.137401429
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autoimmune disease [ICD-11: 4A4Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral monocyte
The Specific Disease Autoimmune uveitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.780629696; Fold-change: -0.089012425; Z-score: -0.181888449
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 05
Click to Show/Hide the 1 Disease of This Class
Hyperlipoproteinaemia [ICD-11: 5C80]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Familial hypercholesterolemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.13E-06; Fold-change: 0.844411239; Z-score: 1.757345281
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 06
Click to Show/Hide the 1 Disease of This Class
Schizophrenia [ICD-11: 6A20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Superior temporal cortex
The Specific Disease Schizophrenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.471692133; Fold-change: 0.029134674; Z-score: 0.378217445
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 08
Click to Show/Hide the 3 Disease of This Class
Multiple sclerosis [ICD-11: 8A40]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Spinal cord
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.983884578; Fold-change: -0.081330408; Z-score: -0.45980084
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Plasmacytoid dendritic cells
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.218594209; Fold-change: 0.227595645; Z-score: 0.94686701
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Epilepsy [ICD-11: 8A60]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peritumoral cortex
The Specific Disease Epilepsy
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.192974403; Fold-change: 0.159719127; Z-score: 0.794436409
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cerebral ischaemic stroke [ICD-11: 8B11]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Cardioembolic Stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.022518307; Fold-change: 0.179308784; Z-score: 0.595488869
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Ischemic stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.226899906; Fold-change: -0.185925481; Z-score: -0.33859267
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 1
Click to Show/Hide the 6 Disease of This Class
HIV [ICD-11: 1C60-1C62]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue White matter
The Specific Disease HIV
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.257575551; Fold-change: -0.083326754; Z-score: -0.496173287
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Influenza [ICD-11: 1E30]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Influenza
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.027801383; Fold-change: -0.980221121; Z-score: -2.386507795
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic hepatitis C [ICD-11: 1E51.1]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Chronic hepatitis C
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.807492481; Fold-change: -0.005249554; Z-score: -0.023286916
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sepsis [ICD-11: 1G40-1G41]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Sepsis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.036072041; Fold-change: -0.023856457; Z-score: -0.061589399
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Septic shock [ICD-11: 1G41]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Septic shock
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.018456227; Fold-change: -0.028909514; Z-score: -0.083377161
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pediatric respiratory syncytial virus infection [ICD-11: CA40.11]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Pediatric respiratory syncytial virus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.266442735; Fold-change: 0.195975034; Z-score: 0.497652481
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 11
Click to Show/Hide the 6 Disease of This Class
Essential hypertension [ICD-11: BA00]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Essential hypertension
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.786409782; Fold-change: -0.003722087; Z-score: -0.099274703
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myocardial infarction [ICD-11: BA41]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Myocardial infarction
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000619174; Fold-change: 0.246030832; Z-score: 0.58360698
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Coronary artery disease [ICD-11: BA8Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Coronary artery disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.090151152; Fold-change: 0.12681423; Z-score: 0.588710083
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aortic stenosis [ICD-11: BB70]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Calcified aortic valve
The Specific Disease Aortic stenosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.992282057; Fold-change: 0.113953044; Z-score: 0.260929821
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arteriosclerosis [ICD-11: BD40]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arteriosclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.846330434; Fold-change: 0.010176159; Z-score: 0.041365215
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aneurysm [ICD-11: BD50]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Intracranial artery
The Specific Disease Aneurysm
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.883722522; Fold-change: 0.022561618; Z-score: 0.074853413
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 12
Click to Show/Hide the 8 Disease of This Class
Immunodeficiency [ICD-11: 4A00-4A20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Immunodeficiency
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.209509197; Fold-change: 0.008066105; Z-score: 0.110690503
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Apnea [ICD-11: 7A40]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Hyperplastic tonsil
The Specific Disease Apnea
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.395272603; Fold-change: 0.023985659; Z-score: 0.139036806
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Olive pollen allergy [ICD-11: CA08.00]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Olive pollen allergy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.004335033; Fold-change: 0.328222742; Z-score: 2.73985906
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic rhinosinusitis [ICD-11: CA0A]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Sinus mucosa
The Specific Disease Chronic rhinosinusitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.362133106; Fold-change: -0.088649284; Z-score: -0.523709994
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic obstructive pulmonary disease [ICD-11: CA22]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.326756823; Fold-change: -0.040868407; Z-score: -0.205495184
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Small airway epithelium
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.005085998; Fold-change: 0.128423353; Z-score: 0.593661107
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Asthma [ICD-11: CA23]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Nasal and bronchial airway
The Specific Disease Asthma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.007299711; Fold-change: -0.083493737; Z-score: -0.194924967
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Human rhinovirus infection [ICD-11: CA42]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Nasal Epithelium
The Specific Disease Human rhinovirus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.916496482; Fold-change: -0.000598005; Z-score: -0.004142339
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Idiopathic pulmonary fibrosis [ICD-11: CB03.4]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Idiopathic pulmonary fibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.340677325; Fold-change: -0.128438498; Z-score: -0.659753077
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 13
Click to Show/Hide the 5 Disease of This Class
Periodontal disease [ICD-11: DA0C]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Periodontal disease
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.941174087; Fold-change: -0.004250223; Z-score: -0.019435021
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Eosinophilic gastritis [ICD-11: DA42.2]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Gastric antrum
The Specific Disease Eosinophilic gastritis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.249227853; Fold-change: 0.104000873; Z-score: 0.612748998
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver failure [ICD-11: DB99.7-DB99.8]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver failure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.005511873; Fold-change: 0.370009384; Z-score: 2.373722547
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ulcerative colitis [ICD-11: DD71]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Colon mucosal
The Specific Disease Ulcerative colitis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.042616212; Fold-change: 0.107355526; Z-score: 0.490455303
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Irritable bowel syndrome [ICD-11: DD91.0]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Irritable bowel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.68679562; Fold-change: -0.008389096; Z-score: -0.030916271
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 14
Click to Show/Hide the 5 Disease of This Class
Atopic dermatitis [ICD-11: EA80]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Atopic dermatitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 9.64E-05; Fold-change: 0.092123742; Z-score: 0.873267631
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Psoriasis [ICD-11: EA90]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Psoriasis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.039305173; Fold-change: -0.078988502; Z-score: -0.265004882
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.613225781; Fold-change: -0.019963654; Z-score: -0.066927588
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Vitiligo [ICD-11: ED63.0]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Vitiligo
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.883162099; Fold-change: 0.006782493; Z-score: 0.045556713
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alopecia [ICD-11: ED70]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin from scalp
The Specific Disease Alopecia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.381208916; Fold-change: 0.060442261; Z-score: 0.189849858
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sensitive skin [ICD-11: EK0Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Sensitive skin
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.636996324; Fold-change: 0.166044243; Z-score: 0.562005631
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 15
Click to Show/Hide the 6 Disease of This Class
Osteoarthritis [ICD-11: FA00-FA0Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Osteoarthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.778782182; Fold-change: -0.040490231; Z-score: -0.321868282
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthropathy [ICD-11: FA00-FA5Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthropathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.892089363; Fold-change: 0.037811036; Z-score: 0.150491041
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthritis [ICD-11: FA20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000829838; Fold-change: -0.186395495; Z-score: -0.386784642
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rheumatoid arthritis [ICD-11: FA20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Rheumatoid arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.052847397; Fold-change: -0.238837613; Z-score: -0.755303112
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ankylosing spondylitis [ICD-11: FA92.0Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Pheripheral blood
The Specific Disease Ankylosing spondylitis
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Osteoporosis [ICD-11: FB83]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Osteoporosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.932424825; Fold-change: 0.021218124; Z-score: 0.133882358
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 16
Click to Show/Hide the 2 Disease of This Class
Endometriosis [ICD-11: GA10]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Endometriosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.022898234; Fold-change: 0.218821346; Z-score: 0.886676704
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Interstitial cystitis [ICD-11: GC00.3]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Interstitial cystitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.004498651; Fold-change: 0.253946882; Z-score: 2.71723071
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 19
Click to Show/Hide the 1 Disease of This Class
Preterm birth [ICD-11: KA21.4Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Myometrium
The Specific Disease Preterm birth
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.839524142; Fold-change: 0.081136261; Z-score: 0.235384511
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 2
Click to Show/Hide the 8 Disease of This Class
Acute myelocytic leukemia [ICD-11: 2A60]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Acute myelocytic leukemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.128109677; Fold-change: 0.006004097; Z-score: 0.023183487
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myeloma [ICD-11: 2A83]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.193605266; Fold-change: -0.079471712; Z-score: -0.231655976
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.87480477; Fold-change: -0.222162379; Z-score: -0.326976682
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Oral cancer [ICD-11: 2B6E]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Oral
The Specific Disease Oral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.047838929; Fold-change: -0.091024338; Z-score: -0.329744543
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 5.16E-09; Fold-change: 0.147290911; Z-score: 0.656823383
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Esophagal cancer [ICD-11: 2B70]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Esophagus
The Specific Disease Esophagal cancer
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.54341535; Fold-change: 0.212432919; Z-score: 0.678707348
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rectal cancer [ICD-11: 2B92]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Rectal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.401505969; Fold-change: -0.098796576; Z-score: -0.311608157
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.199490185; Fold-change: 0.127024326; Z-score: 0.665399644
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Skin cancer [ICD-11: 2C30-2C3Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Skin cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.020203978; Fold-change: -0.109194409; Z-score: -0.33029258
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.370937053; Fold-change: -0.046331664; Z-score: -0.144799041
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Renal cancer [ICD-11: 2C90-2C91]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Kidney
The Specific Disease Renal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.517306926; Fold-change: 0.099714494; Z-score: 0.362052252
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.015486846; Fold-change: 0.148541988; Z-score: 0.593334159
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ureter cancer [ICD-11: 2C92]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Urothelium
The Specific Disease Ureter cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.378295562; Fold-change: 0.004266959; Z-score: 0.016876422
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 20
Click to Show/Hide the 2 Disease of This Class
Simpson golabi behmel syndrome [ICD-11: LD2C]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Adipose
The Specific Disease Simpson golabi behmel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.65749431; Fold-change: -0.038719532; Z-score: -0.268058287
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Tuberous sclerosis complex [ICD-11: LD2D.2]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Perituberal
The Specific Disease Tuberous sclerosis complex
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.360186681; Fold-change: 0.102356584; Z-score: 0.644707326
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 3
Click to Show/Hide the 3 Disease of This Class
Anemia [ICD-11: 3A00-3A9Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Anemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.109704656; Fold-change: 0.272521296; Z-score: 1.425219173
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sickle cell disease [ICD-11: 3A51.0-3A51.3]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Sickle cell disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.488227597; Fold-change: 0.03816999; Z-score: 0.247442167
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thrombocythemia [ICD-11: 3B63]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocythemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 9.83E-12; Fold-change: -0.284009568; Z-score: -1.615236704
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 4
Click to Show/Hide the 4 Disease of This Class
Scleroderma [ICD-11: 4A42.Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Scleroderma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.013144696; Fold-change: 0.187453415; Z-score: 1.125424117
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sjogren syndrome [ICD-11: 4A43]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Salivary gland
The Specific Disease Sjogren syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.41886689; Fold-change: -0.036696632; Z-score: -0.133777534
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.565150435; Fold-change: -0.066686991; Z-score: -0.275237546
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Behcet disease [ICD-11: 4A62]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Behcet disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.088682767; Fold-change: 0.328882611; Z-score: 1.133004081
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autosomal dominant monocytopenia [ICD-11: 4B04]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autosomal dominant monocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.046440867; Fold-change: -0.368176819; Z-score: -0.553994845
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 5
Click to Show/Hide the 5 Disease of This Class
Type 2 diabetes [ICD-11: 5A11]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Type 2 diabetes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.573128814; Fold-change: -0.060399684; Z-score: -0.209283304
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Polycystic ovary syndrome [ICD-11: 5A80.1]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Vastus lateralis muscle
The Specific Disease Polycystic ovary syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.291197678; Fold-change: 0.068086079; Z-score: 0.276046231
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Obesity [ICD-11: 5B81]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Subcutaneous Adipose
The Specific Disease Obesity
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.2034344; Fold-change: 0.005306277; Z-score: 0.029266669
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pompe disease [ICD-11: 5C51.3]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Biceps muscle
The Specific Disease Pompe disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.372979213; Fold-change: -0.030995272; Z-score: -0.199055071
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Batten disease [ICD-11: 5C56.1]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Batten disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.297050366; Fold-change: -0.340645003; Z-score: -0.850792706
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 6
Click to Show/Hide the 2 Disease of This Class
Autism [ICD-11: 6A02]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autism
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.369714639; Fold-change: -0.003665534; Z-score: -0.014098975
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Anxiety disorder [ICD-11: 6B00-6B0Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Anxiety disorder
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.597467251; Fold-change: -0.019240482; Z-score: -0.050224782
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 8
Click to Show/Hide the 7 Disease of This Class
Parkinson disease [ICD-11: 8A00]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Substantia nigra
The Specific Disease Parkinson disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.742837748; Fold-change: 0.017887332; Z-score: 0.088761654
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Huntington disease [ICD-11: 8A01]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Huntington disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.6839406; Fold-change: 0.179025419; Z-score: 0.533774929
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alzheimer disease [ICD-11: 8A20]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Entorhinal cortex
The Specific Disease Alzheimer disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.005520943; Fold-change: -0.071109321; Z-score: -0.4136568
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Seizure [ICD-11: 8A60-8A6Z]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Seizure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.67014568; Fold-change: 0.017729083; Z-score: 0.044067523
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lateral sclerosis [ICD-11: 8B60.4]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.70667679; Fold-change: -0.000460051; Z-score: -0.003514891
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Cervical spinal cord
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.116387965; Fold-change: 0.300147544; Z-score: 1.09135371
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Muscular atrophy [ICD-11: 8C70]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Muscular atrophy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.94E-05; Fold-change: -0.272955904; Z-score: -1.803002735
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myopathy [ICD-11: 8C70.6]
Click to Show/Hide
Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Myopathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.341267963; Fold-change: -0.142279671; Z-score: -0.907706293
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
References
Ref 1 Recombinant anti-cd30 antibodies and uses thereof; 2006-02-02
Ref 2 Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates. Mol Cancer Ther. 2016 May;15(5):938-45. doi: 10.1158/1535-7163.MCT-16-0038. Epub 2016 Mar 4.
Ref 3 Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR(+) and Heterogeneous Tumor Models. Mol Cancer Ther. 2018 Aug;17(8):1752-1760. doi: 10.1158/1535-7163.MCT-18-0073. Epub 2018 Jun 4.
Ref 4 Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood. 1995 Apr 15;85(8):2139-46.
Ref 5 Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models. Mol Pharm. 2015 Jun 1;12(6):1863-71. doi: 10.1021/mp500666j. Epub 2015 Feb 9.
Ref 6 Development of Novel Antibody-Camptothecin Conjugates. Mol Cancer Ther. 2021 Feb;20(2):329-339.
Ref 7 Modified taxols .6. preparation of water-soluble prodrugs of taxol. J Nat Prod. 1991;54(6):1607-1611.
Ref 8 A phase I weekly dosing study of brentuximab vedotin in patients with relapsed/refractory CD30-positive hematologic malignancies. Clin Cancer Res. 2012 Jan 1;18(1):248-55.
Ref 9 Conjugation of DM1 to anti-CD30 antibody has potential antitumor activity in CD30-positive hematological malignancies with lower systemic toxicity. MAbs. 2019 Aug/Sep;11(6):1149-1161. doi: 10.1080/19420862.2019.1618674. Epub 2019 Jun 4.
Ref 10 Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile. Chem Sci. 2023 Jan 3;14(9):2259-2266. doi: 10.1039/d2sc05678j. eCollection 2023 Mar 1.
Ref 11 Innovative Bioconjugation Technology for Antibody-Drug Conjugates: Proof of Concept in a CD30-Positive Lymphoma Mouse Model. Bioconjug Chem. 2021 Mar 17;32(3):595-606. doi: 10.1021/acs.bioconjchem.1c00058. Epub 2021 Feb 25.
Ref 12 Binding protein drug conjugates comprising anthracycline derivatives; 2016-06-30.
Ref 13 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 14 Immunomodulatory antibody-drug conjugates; 2022-07-21.
Ref 15 Highly Potent, Anthracycline-based Antibody-Drug Conjugates Generated by Enzymatic, Site-specific Conjugation. Mol Cancer Ther. 2017 May;16(5):879-892.
Ref 16 Beta-glucuronide-linker drug conjugates; 2007-10-25.
Ref 17 Methylene carbamate linkers for use with targeted-drug conjugates; 2015-06-25.
Ref 18 Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance. Front Pharmacol. 2022 Jun 17;13:764540. doi: 10.3389/fphar.2022.764540. eCollection 2022.
Ref 19 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 20 Antitumor effects of ricin A chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's disease tumors in mice. Cancer Res. 1990 May 15;50(10):2929-35.
Ref 21 A novel enediyne-integrated antibody-drug conjugate shows promising antitumor efficacy against CD30(+) lymphomas. Mol Oncol. 2018 Mar;12(3):339-355. doi: 10.1002/1878-0261.12166. Epub 2018 Jan 26.
Ref 22 Indicative announcement on obtaining clinical trial approval for recombinant anti-CD30 human-mouse chimeric monoclonal Antibody-MCC-DM1 injection; 18 Jul 2018.
Ref 23 https://tubulis.com/
Ref 24 Research programme: CD30 targeting antibody drug conjugate therapeutics-NBE Therapeutics.
Ref 25 AVIPEP Therapeutics product pipeline

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.