Antigen Information

General Information of This Antigen
Antigen ID
TAR0AHWVD
Antigen Name
Receptor-type tyrosine-protein phosphatase C (PTPRC)
Gene Name
PTPRC
Synonym
CD45; Leukocyte common antigen;T200;CD_antigen=CD45
Sequence
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPA
STFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSA
GTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAAL
PARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYL
YNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVP
PGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLE
PEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFH
NFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT
KSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFR
VKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYK
IYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSI
PRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPR
KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVV
VKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA
FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEA
QYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ
HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA
SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK
QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISM
IQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQV
VKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDAN
CVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS

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Family
Tyr protein familyn family
Function
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

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Uniprot Entry
PTPRC_HUMAN
HGNC ID
HGNC:9666
KEGG ID
hsa:5788
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
anti-mouse CD45.2
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
cD45-ADC (37567393)
SG3199
Undisclosed
Mal-PEG8-Val-Ala-PABC
 [1]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD45-targeted ETB
Undisclosed
Undisclosed
Undisclosed
 [2]
 ADC Info 
MGTA-C200
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
MGTA-C100
Undisclosed
Undisclosed
Undisclosed
 [3]
 ADC Info 
CD45 targeted antibody amanitin conjugate
Undisclosed
Undisclosed
Undisclosed
 [4]
 ADC Info 
Anti-CDK11 antibody drug conjugate
Undisclosed
Undisclosed
Undisclosed
 [5]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD45-ADC (37732224)
Undisclosed
Undisclosed
Undisclosed
 [6]
 ADC Info 
Ab5-AM1 D265C.LALA.H435A
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab4-AM2 D265C.LALA.H435A
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab4-AM1 D265C.LALA.H436A
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab6-AMI1 (D265C.LALA.H435A)
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab2-AM2 (D265C LALA H435A)
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab3-AM2 (D265C LALA H435A)
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab2-AM1 (D265C.LALA.H435A)
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab6-AM1 (D265C.LALA.H435A)
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab3-AM1 (D265C.LALA.H435A)
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab7-AM1 (D265C.LALA.H435A)
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Ab5-PBD (D265C.LALA.H435A-SG3249)
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Isotype-AM1 D265C LALA H435A
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Isotype-AM2 D265C LALA H435A
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
AbA_D265C_LALA_IHH-PBD
PBD
Undisclosed
Undisclosed
 [7]
 ADC Info 
AbA_S239C_LALA_IHH-PBD
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Isotype-PBD
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
AbA_D265C_LALA_H435A-AM2
US12209180B2 AM2
Undisclosed
Undisclosed
 [7]
 ADC Info 
AbA_D265C_LALA_H435A-AM1
US12209180B2 AM1
Undisclosed
Undisclosed
 [7]
 ADC Info 
AbC_D265C_LALA_H435A-AM1
US12209180B2 AM1
Undisclosed
Undisclosed
 [7]
 ADC Info 
Isotype-AM2
Undisclosed
Undisclosed
Undisclosed
 [7]
 ADC Info 
Isotype-AM1
Undisclosed
Undisclosed
Undisclosed
 [7]
References
Ref 1 Transplantation after CD45-ADC corrects Rag1 immunodeficiency in congenic and haploidentical settings
Ref 2 CD45 targeted engineered toxin bodies deplete hematopoietic and malignant cells. Cancer Res (2020) 80 (16_Supplement): 521.
Ref 3 Magenta therapeutics announcement; 2019
Ref 4 Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning. Blood 2018 Nov 29; 132(1): 4526.
Ref 5 Glythera licenses novel payload class from Cancer Research UK for the development of next-generation antibody drug conjugates; 2017
Ref 6 CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
Ref 7 Anti-CD45 antibodies and conjugates thereof