Antigen Information

General Information of This Antigen (ID: TAR0AHWVD)
Antigen Name
Receptor-type tyrosine-protein phosphatase C (PTPRC)
Gene Name
PTPRC
Gene ID
5788
Synonym
CD45; Leukocyte common antigen;T200;CD45
Sequence
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPA
STFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSA
GTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAAL
PARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYL
YNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVP
PGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLE
PEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFH
NFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT
KSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFR
VKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYK
IYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSI
PRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPR
KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVV
VKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA
FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEA
QYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ
HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA
SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK
QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISM
IQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQV
VKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDAN
CVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS

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Family
Tyr protein familyn family
Function
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

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Uniprot Entry
PTPRC_HUMAN
HGNC ID
HGNC:9666
KEGG ID
hsa:5788
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
anti-mouse CD45.2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD45-ADC (37567393) [1]
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD45-targeted ETB [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
MGTA-C200 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
MGTA-C100 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD45 targeted antibody amanitin conjugate [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CDK11 antibody drug conjugate [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD45-ADC (37732224) [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab5-AM1 D265C.LALA.H435A [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab4-AM2 D265C.LALA.H435A [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab4-AM1 D265C.LALA.H436A [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab6-AMI1 (D265C.LALA.H435A) [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab2-AM2 (D265C LALA H435A) [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab3-AM2 (D265C LALA H435A) [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab2-AM1 (D265C.LALA.H435A) [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab6-AM1 (D265C.LALA.H435A) [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab3-AM1 (D265C.LALA.H435A) [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab7-AM1 (D265C.LALA.H435A) [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab5-PBD (D265C.LALA.H435A-SG3249) [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Isotype-AM1 D265C LALA H435A [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Isotype-AM2 D265C LALA H435A [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
AbA_D265C_LALA_IHH-PBD [7]
PBD
Undisclosed
Undisclosed
 ADC Info 
AbA_S239C_LALA_IHH-PBD [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Isotype-PBD [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
AbA_D265C_LALA_H435A-AM2 [7]
US12209180B2 AM2
Undisclosed
Undisclosed
 ADC Info 
AbA_D265C_LALA_H435A-AM1 [7]
US12209180B2 AM1
Undisclosed
Undisclosed
 ADC Info 
AbC_D265C_LALA_H435A-AM1 [7]
US12209180B2 AM1
Undisclosed
Undisclosed
 ADC Info 
Isotype-AM2 [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Isotype-AM1 [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Transplantation after CD45-ADC corrects Rag1 immunodeficiency in congenic and haploidentical settings
Ref 2 CD45 targeted engineered toxin bodies deplete hematopoietic and malignant cells. Cancer Res (2020) 80 (16_Supplement): 521.
Ref 3 Magenta therapeutics announcement; 2019
Ref 4 Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning. Blood 2018 Nov 29; 132(1): 4526.
Ref 5 Glythera licenses novel payload class from Cancer Research UK for the development of next-generation antibody drug conjugates; 2017
Ref 6 CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
Ref 7 Anti-CD45 antibodies and conjugates thereof