Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ID: DRG0CUQHI)

ADC Name	Isotype-AM1 D265C LALA H435A
Synonyms	Isotype-AM1 D265C LALA H435A Click to Show/Hide
Organization	Vor Biopharma Inec.
Drug Status	Investigative
Antibody Name	Undisclosed
Antigen Name	Receptor-type tyrosine-protein phosphatase C (PTPRC)	Antigen Info
Payload Name	Undisclosed
Linker Name	Undisclosed

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal inhibitory Concentration (IC50)	100	nM	CVCL_0140	Normal

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal inhibitory Concentration (IC50)	100 nM	Positive CD45 expression (CD45+++/++)
Method Description	In vitro human and cyno PBMC cell killing assay with Ab5-AM1 - IC50 values
In Vitro Model	Normal	PBMC cells		CVCL_0140

References

Ref 1	Anti-CD45 antibodies and conjugates thereof