Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0OUCXX
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| ADC Name |
Ab5-AM1 D265C.LALA.H435A
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| Synonyms |
Ab5-AM1 D265C.LALA.H435A
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| Organization |
Vor Biopharma Inec.
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| Drug Status |
Investigative
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| Antibody Name |
undisclosed
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| Antigen Name |
Receptor-type tyrosine-protein phosphatase C (PTPRC)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Undisclosed
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.0085 nM | Positive CD45,Ab5 expression (CD45,Ab5 +++/++) | ||
| Method Description |
In vitro cell line killing assay - IC50 values
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| In Vitro Model | Normal | PBMC cells | CVCL_0140 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.0085 nM | Positive CD45,Ab5 expression (CD45,Ab5 +++/++) | ||
| Method Description |
In vitro human and cyno PBMC cell killing assay with Ab5-AM1 - IC50 values
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| In Vitro Model | Normal | PBMC cells | CVCL_0140 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.0091 nM | Positive CD45,Ab5 expression (CD45,Ab5 +++/++) | ||
| Method Description |
In vitro human and cyno PBMC cell killing assay with Ab5-AM1 - IC50 values
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| In Vitro Model | Normal | PBMC cells | CVCL_0140 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.043 nM | Positive CD45,Ab5 expression (CD45,Ab5 +++/++) | ||
| Method Description |
In vitro Jurkat, REH, and SKNO-1 cell line killing assay - IC50 values
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| In Vitro Model | B lymphoblastic leukemia/lymphoma with t(12, B-lymphoblastic leukemia/lymphoma with t(12, Childhood B acute lymphoblastic leukemia | REH cells (CD45+) | CVCL_1650 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.043 nM | Negative CD45 expression (CD45-) | ||
| Method Description |
In vitro REH cell line killing assay - IC50 values
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| In Vitro Model | B lymphoblastic leukemia/lymphoma with t(12, B-lymphoblastic leukemia/lymphoma with t(12, Childhood B acute lymphoblastic leukemia | REH cells (CD45-) | CVCL_1650 | ||
| Experiment 6 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.091 nM | Positive CD45,Ab5 expression (CD45,Ab5 +++/++) | ||
| Method Description |
In vitro Jurkat, REH, and SKNO-1 cell line killing assay - IC50 values
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| In Vitro Model | Adult acute myeloid leukemia | SKNO-1 cells | CVCL_2196 | ||
| Experiment 7 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.49 nM | Positive CD45,Ab5 expression (CD45,Ab5 +++/++) | ||
| Method Description |
In vitro human and cyno PBMC cell killing assay with Ab5-AM1 - IC50 values
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| In Vitro Model | Normal | PBMC cells (CD34+CD90+) | CVCL_0140 | ||
| Experiment 8 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.58 nM | Positive CD45,Ab5 expression (CD45,Ab5 +++/++) | ||
| Method Description |
In vitro Jurkat, REH, and SKNO-1 cell line killing assay - IC50 values
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| In Vitro Model | T acute lymphoblastic leukemia | Jurkat cells | CVCL_0065 | ||