Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ID: DRG0UOMXH)
ADC Name
Ab2-AM2 (D265C LALA H435A)
Synonyms
Ab2-AM2 (D265C LALA H435A)
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Organization
Vor Biopharma Inec.
Drug Status
Investigative
Drug-to-Antibody Ratio
1.8
Antibody Name
Undisclosed
Antigen Name
Receptor-type tyrosine-protein phosphatase C (PTPRC)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
Undisclosed
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (IC50) 
0.0055
nM
CVCL_0140
Normal
Half Maximal inhibitory Concentration (IC50) 
0.0126
nM
CVCL_0140
Normal
Half Maximal inhibitory Concentration (IC50) 
0.266
nM
CVCL_0140
Normal
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (IC50) 0.0055 nM Positive CD45,Ab2 expression (CD45,Ab2 +++/++)
Method Description
In vitro cell line killing assay - IC50 values
In Vitro Model Normal PBMC cells CVCL_0140
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (IC50) 0.0126 nM Positive CD45,Ab2 expression (CD45,Ab2 +++/++)
Method Description
in vitro HSC PBMC killing assay (stimulated vs non-stimulated) IC50 values
In Vitro Model Normal PBMC cells CVCL_0140
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (IC50) 0.266 nM Positive CD45,Ab2 expression (CD45,Ab2 +++/++)
Method Description
in vitro HSC PBMC killing assay (stimulated vs non-stimulated) IC50 values
In Vitro Model Normal PBMC cells CVCL_0140
References
Ref 1 Anti-CD45 antibodies and conjugates thereof