Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0CLSRD
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| ADC Name |
AbA_D265C_LALA_IHH-PBD
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| Synonyms |
AbA_D265C_LALA_IHH-PBD
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| Organization |
Vor Biopharma Inec.
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| Drug Status |
Investigative
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| Antibody Name |
undisclosed
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| Antigen Name |
Receptor-type tyrosine-protein phosphatase C (PTPRC)
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Antigen Info | ||||
| Payload Name |
PBD
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Payload Info | ||||
| Therapeutic Target |
Deoxyribonucleic acid (DNA)
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Target Info | ||||
| Linker Name |
Undisclosed
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.0294 nM | Positive CD34+,CD90+ expression (CD34+,CD90+ +++/++) | ||
| Method Description |
In vitro BM HSC killing assay: ADCs conjugated to AM1 or PBD
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| In Vitro Model | Bone marrow hematopoietic stem cells | BM HSC cells (CD34+CD90+) | Homo sapiens | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.042 nM | Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro cell line killing assays
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| In Vitro Model | B acute lymphoblastic leukemia | Reh cells | CVCL_1650 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.36 nM | Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro cell line killing assays
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| In Vitro Model | T acute lymphoblastic leukemia | Jurkat cells | CVCL_0065 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.8185 nM | Positive CD45,AbA expression (CD45,AbA +++/++) | ||
| Method Description |
In vitro cell line killing assays
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| In Vitro Model | Adult acute myeloid leukemia | SKNO-1 cells | CVCL_2196 | ||