Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0RSKAC
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| ADC Name |
Ab5-PBD (D265C.LALA.H435A-SG3249)
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| Synonyms |
Ab5-PBD (D265C.LALA.H435A-SG3249)
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| Organization |
Vor Biopharma Inec.
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| Drug Status |
Investigative
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| Antibody Name |
undisclosed
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| Antigen Name |
Receptor-type tyrosine-protein phosphatase C (PTPRC)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
Undisclosed
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.0023 nM | Positive CD45,Ab5 expression (CD45,Ab5 +++/++) | ||
| Method Description |
In vitro REH cell line killing assay - IC5S0O values
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| In Vitro Model | Normal | PBMC cells | CVCL_0140 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (IC50) | 0.13 nM | Positive CD45,Ab5 expression (CD45,Ab5 +++/++) | ||
| Method Description |
In vitro cell line killing assay - IC50 values
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| In Vitro Model | B acute lymphoblastic leukemia | Reh cells | CVCL_1650 | ||