Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ID: DRG0YZHHC)
ADC Name
Ab3-AM1 (D265C.LALA.H435A)
Synonyms
Ab3-AM1 (D265C.LALA.H435A)
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Organization
Vor Biopharma Inec.
Drug Status
Investigative
Antibody Name
Undisclosed
Antigen Name
Receptor-type tyrosine-protein phosphatase C (PTPRC)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
Undisclosed
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (IC50) 
0.0071
nM
CVCL_0140
Normal
Half Maximal inhibitory Concentration (IC50) 
0.048
nM
CVCL_1650
B acute lymphoblastic leukemia
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (IC50) 0.0071 nM Positive CD45,Ab3 expression (CD45,Ab3 +++/++)
Method Description
In vitro cell line killing assay - IC51 values
In Vitro Model Normal PBMC cells CVCL_0140
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (IC50) 0.048 nM Positive CD45 expression (CD45+++/++)
Method Description
In vitro REH cell line killing assay - IC5S0O values
In Vitro Model B acute lymphoblastic leukemia Reh cells CVCL_1650
References
Ref 1 Anti-CD45 antibodies and conjugates thereof