Linker Information
General Information of This Linker
| Linker ID |
LIN0BYXTN
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| Linker Name |
Dibromomethyl pyridine-Val-Cit-PABC
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| Linker Type |
Flexible dual-reactive (thiol) linker; Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C31H44Br2N6O5
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| Isosmiles |
CC(C)C(NC(=O)CCCCCc1cc(CBr)nc(CBr)c1)C(=O)NC(CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1
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| InChI |
InChI=1S/C31H44Br2N6O5/c1-20(2)28(39-27(41)9-5-3-4-7-22-15-24(17-32)36-25(16-22)18-33)30(43)38-26(8-6-14-35-31(34)44)29(42)37-23-12-10-21(19-40)11-13-23/h10-13,15-16,20,26,28,40H,3-9,14,17-19H2,1-2H3,(H,37,42)(H,38,43)(H,39,41)(H3,34,35,44)
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| InChIKey |
XLGAWKFBGYYVIS-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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740.538
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Polar area
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175.54
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Complexity
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44
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xlogp Value
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4.1794
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Heavy Count
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44
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Rot Bonds
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19
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Hbond acc
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6
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
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