Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0UZHYM
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| ADC Name |
40187444 7DC4-DM1
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| Synonyms |
7DC4-DM1
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| Organization |
Fujian Normal University.; Fujian Medical University.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.7
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| Structure |
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| Antibody Name |
7DC4
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Antibody Info | ||||
| Antigen Name |
Leukocyte surface antigen CD47 (CD47)
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Antigen Info | ||||
| Payload Name |
Mertansine DM1
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
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Linker Info | ||||
| Conjugate Type |
Site-specific bioconjugation via AJICAP-M at K248.
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ADC-specific functional property(2027 Update)
Binding Affinity
| Dissocation Constant (Kd) | Binding Target | Description | Reference |
|---|---|---|---|
| 0.49 nM |
MC38-hCD47 cells (CD47)
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Constructed 7DC-DM1 ADCs was first determined for the binding affinities (EC50 values) at the molecule level.
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[1]
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References