Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0NOMFE |
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| Antibody Name | 7DC4 |
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| Organization | Fujian Normal University.; Fujian Medical University. |
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| Synonyms |
7DC4
Click to Show/Hide
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antigen Name | Leukocyte surface antigen CD47 (CD47) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Sequence |
QVQLKQSGAELVQPGASVKLSCKASGYTFTNYYMYVLRQRPGQGLEWIGEINPSKGGTDF
NEKFKSKATLTVDKSSSTAFMQLSSLTSDDSAVYYCARGGFTMDYIGQGTTVTVSSASTK GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSVNSGALTSGVHTFPAVLQSSGLYS LSSVVNVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVF LFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNIYVDGVEVHNAKTKPREEQYNSTYR VVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKN QVSLTCLVKGFYPSDIAVEVESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRVQQGN VFSCSVLHEALHSHYTQKSLSLSPGK Click to Show/Hide
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| Light Chain Sequence |
DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSMGNTYLHWYLQKPGQSPKLLIYKVSNRF
SGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPLTFGAGTKLELKRTVAAPSV F1FPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC Click to Show/Hide
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The Activity Data of This Antibody
| Antibody Activity Information 1 | [1] | |||||
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Half Maximal Effective Concentration (EC50)
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0.49
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nM
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MC38-hCD47 cells | CVCL_B288 | ||
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| Antigen Expression | Positive CD47 expression (CD47+++/++) | |||||
| Antibody Function | 7DC4 bound to MC38-hCD47 cells | |||||
| Antibody Antigen Binding Assay | Constructed 7DC-DM1 ADCs was first determined for the binding affinities (EC50 values) at the molecule level. | |||||
Each Antibody-drug Conjugate Related to This Antibody
References