Antibody Information

General Information of This Antibody

Antibody ID	ANI0UQONW
Antibody Name	Chimeric DAB4 (chDAB4)
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Chimeric mAb IgG1
Antigen Name	Lupus-associated/Sjogren Syndrome-B (La/SSB)antigen	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

chDAB4-SG3249 [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 96.50% (Day 14)	Positive La/SSB expression (La/SSB +++/++)
Method Description	ChDAB4-SG3249 (3 mg/kg, the day after chemotherapy (Day 3)) induces efficient tumor cell killing in cell line-derived models of Lewis lung carcinoma cell with HER3 expression with high expression.
In Vivo Model	LL2 CDX model
In Vitro Model	Normal	LL2 cells		CVCL_C4MM

References

Ref 1	Tumour-associated macrophages process drug and radio-conjugates of the dead tumour cell-targeting APOMAB antibody. J Control Release. 2020 Nov 10;327:779-787. doi: 10.1016/j.jconrel.2020.09.027.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.