Antibody Information
General Information of This Antibody (ID: ANI0UQONW)
| Antibody Name | Chimeric DAB4 (chDAB4) |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Chimeric mAb IgG1 |
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| Antigen Name | Lupus La protein (SSB) |
Antigen Info | ||||
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
ChDAB4-SG3249 [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 96.50% | Positive La/SSB expression (La/SSB +++/++) | ||
| Method Description |
ChDAB4-SG3249 (3 mg/kg, the day after chemotherapy (Day 3)) induces efficient tumor cell killing in cell line-derived models of Lewis lung carcinoma cell with HER3 expression with high expression.
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| In Vivo Model | LL2 CDX model | ||||
| In Vitro Model | Normal | LL2 cells | CVCL_C4MM | ||
References