Antigen Information

General Information of This Antigen
Antigen ID
TAR0XXXDU
Antigen Name
Lupus La protein (SSB)
Gene Name
SSB
Synonym
La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen
Sequence
MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNR
LTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPT
DATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDL
LILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDL
DDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKE
VTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGK
KTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

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Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES- mediated translation.

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Uniprot Entry
LA_HUMAN
HGNC ID
HGNC:11316
KEGG ID
hsa:6741
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Chimeric DAB4 (chDAB4)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ChDAB4-SG3249
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DAB4-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [1]
 ADC Info 
DAB4-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [1]
 ADC Info 
DAB4-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
 ADC Info 
DAB4-MMAF
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
 ADC Info 
DAB4-DuoDM
DEAEA duocarmycin
Human Deoxyribonucleic acid (hDNA)
Mal-PEG4-Val-Cit-PABC
 [1]
References
Ref 1 APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo. Mol Cancer Ther. 2019 Feb;18(2):335-345. doi: 10.1158/1535-7163.MCT-18-0842. Epub 2018 Nov 9.