Antigen Information

General Information of This Antigen (ID: TAR0XXXDU)
Antigen Name
Lupus La protein (SSB)
Gene Name
SSB
Gene ID
6741
Synonym
La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen
Sequence
MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNR
LTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPT
DATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDL
LILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDL
DDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKE
VTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGK
KTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

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Function
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES- mediated translation.

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Uniprot Entry
LA_HUMAN
HGNC ID
HGNC:11316
KEGG ID
hsa:6741
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Chimeric DAB4 (chDAB4)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ChDAB4-SG3249 [1]
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
DAB4-DM1 [1]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
DAB4-DM4 [1]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
DAB4-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
DAB4-MMAF [1]
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
DAB4-DuoDM [1]
DEAEA duocarmycin
Human Deoxyribonucleic acid (hDNA)
Mal-PEG4-Val-Cit-PABC
 ADC Info 
References
Ref 1 APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo. Mol Cancer Ther. 2019 Feb;18(2):335-345. doi: 10.1158/1535-7163.MCT-18-0842. Epub 2018 Nov 9.