Antigen Information

General Information of This Antigen

Antigen ID	TAR0ZIMMG
Antigen Name	Tissue factor (F3)
Gene Name	F3
Gene ID	2152
Synonym	Coagulation factor III; Thromboplastin; TF; CD142
Sequence	METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS Click to Show/Hide
Family	Thiolase-like family
Function	Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Click to Show/Hide
Uniprot Entry	TF_HUMAN
HGNC ID	HGNC:3541
KEGG ID	hsa:2152

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 1F-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

25A

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 25A-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

25A3

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 25A3-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

25G1

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 25G1-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

29E

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 29E-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

39A

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 39A-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

43B1

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 43B1-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

43D7

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 43D7-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

43Ea

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 43Ea-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

54E

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	EP4495597A2 54E-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[1]

Ab-754

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	AMT-754	Exatecan	DNA topoisomerase 1 (TOP1)	T1000	[2]

Anit-TF mAb 1F

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	1F-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anit-TF mAb 25A

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	25A-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anit-TF mAb 25A3

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	25A3-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anit-TF mAb 25G1

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	25G1-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anit-TF mAb 29E

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	29E-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anit-TF mAb 39A

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	39A-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anit-TF mAb 43B1

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	43B1-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anit-TF mAb 43D7

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	43D7-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anit-TF mAb 43Ea

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	43Ea-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anit-TF mAb 54E

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	54E-Val-Cit-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[3]

Anti-TF mAb 1849

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	¹¹¹In-1849	Indium-111	Human Deoxyribonucleic acid (hDNA)	Undisclosed	[4]

Anti-tissue factor antibody

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	XB371	Belotecan	DNA topoisomerase 1 (TOP1)	A cleavable linker	[5]
ADC Info	SHR-4375	Undisclosed	Undisclosed	Undisclosed
ADC Info	XNW28012	YL0010014	DNA topoisomerase 1 (TOP1)	VK*G-NHCH2-O linker
ADC Info	YLSH003	TOP1 inhibitor	DNA topoisomerase 1 (TOP1)	A cleavable linker

Anti-tissue factor mAb

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	STRO-004	Exatecan	DNA topoisomerase 1 (TOP1)	A cleavable linker	[6]

JAA-F11

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	HJAA-F11 ADC	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[7]

MAB804

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	MRG004A	MMAE	Microtubule (MT)	BCN-Val-Cit linker

Samatatug

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Samatatug zovodotin	ZD02044	Microtubule (MT)	Mc-PEG3-Val-Cit

TF-mAb-H29

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H29-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H29-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H30

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H30-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H30-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H31

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H31-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H31-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H32

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H32-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H32-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H33

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H33-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H33-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H34

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H34-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H34-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H35

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H35-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H35-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H36

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H36-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H36-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H37

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H37-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H37-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H38

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H38-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H38-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H39

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H39-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H39-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H40

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H40-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H40-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H41

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H41-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H41-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H42

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H42-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H42-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H43

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H43-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H43-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H44

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H44-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H44-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H45

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H45-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H45-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H46

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H46-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H46-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H47

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H47-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H47-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-H48

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-H48-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-H48-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

TF-mAb-SC1

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TF-mAb-DM1	Mertansine DM1	Microtubule (MT)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[8]
ADC Info	TF-mAb-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[8]

Tisotumab

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Tisotumab vedotin	MMAE	Microtubule (MT)	Mc-Val-Cit-PABC	[9]

Undisclosed

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	MRG-004A	Monomethyl auristatin E	Microtubule (MT)	Valine-Citrulline (BCN-valyl-citrulline; Protease-cleavable linker)
ADC Info	EDO-B278	Undisclosed	Undisclosed	Undisclosed	[10]

undisclosed

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	SYS6051	Exatecan	DNA topoisomerase 1 (TOP1)	Undisclosed	[11]
ADC Info	T320-ADC	Undisclosed	Undisclosed	Undisclosed

References

Ref 1	Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
Ref 2	ADCE-T02: A first-in-class topoisomerase-1 inhibitor based antibody drug conjugate against tissue factor demonstrates excellent preclinical efficacy and tolerability
Ref 3	Treating Tissue Factor-Positive Cancers with Antibody-Drug Conjugates That Do Not Affect Blood Clotting. Mol Cancer Ther. 2018 Nov;17(11):2412-2426.
Ref 4	Anti?tissue factor antibody?mediated immuno?SPECT imaging of tissue factor expression in mouse models of pancreatic cancer. Oncol Rep. 2019 Apr;41(4):2371-2378. doi: 10.3892/or.2019.7017. Epub 2019 Feb 14.
Ref 5	Exelixis biotechnology company product pipeline
Ref 6	Sutro biopharmaceutical company product pipeline
Ref 7	Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and InVitro Efficacy Analysis. Neoplasia. 2017 Sep;19(9):716-733. doi: 10.1016/j.neo.2017.07.001. Epub 2017 Aug 19.
Ref 8	Tissue factor-targeted antibody-drug conjugate; 2018-03-01.
Ref 9	Tisotumab Vedotin: First Approval
Ref 10	Challenges in Optimising the Successful Construction of Antibody Drug Conjugates in Cancer Therapy. Antibodies (Basel). 2018 Feb 13;7(1):11. doi: 10.3390/antib7010011.
Ref 11	SYS6051, a next-generation tissue factor-targeted antibody-drug conjugates for the treatment of TF-expressing malignancies

Antigen Information

Citation

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xiaowu DONG (dongxw@zju.edu.cn)

Prof. Luo FANG (fangluo@zjcc.org.cn)