Antigen Information

General Information of This Antigen (ID: TAR0ZIMMG)
Antigen Name
Tissue factor (F3)
Gene Name
F3
Gene ID
2152
Synonym
Coagulation factor III; Thromboplastin; TF; CD142
Sequence
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS

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Family
Thiolase-like family
Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

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Uniprot Entry
TF_HUMAN
HGNC ID
HGNC:3541
KEGG ID
hsa:2152
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
EP4495597A2 1F-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4495597A2 25A-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4495597A2 25A3-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4495597A2 25G1-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4495597A2 29E-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4495597A2 39A-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4495597A2 43B1-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4495597A2 43D7-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4495597A2 43Ea-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4495597A2 54E-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
AMT-754 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
T1000
 ADC Info 
Anit-TF mAb 1F
 Antibody Info 
ADC Name Payload Target Linker ADC Info
1F-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anit-TF mAb 25A
 Antibody Info 
ADC Name Payload Target Linker ADC Info
25A-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anit-TF mAb 25A3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
25A3-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anit-TF mAb 25G1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
25G1-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anit-TF mAb 29E
 Antibody Info 
ADC Name Payload Target Linker ADC Info
29E-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anit-TF mAb 39A
 Antibody Info 
ADC Name Payload Target Linker ADC Info
39A-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anit-TF mAb 43B1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
43B1-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anit-TF mAb 43D7
 Antibody Info 
ADC Name Payload Target Linker ADC Info
43D7-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anit-TF mAb 43Ea
 Antibody Info 
ADC Name Payload Target Linker ADC Info
43Ea-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anit-TF mAb 54E
 Antibody Info 
ADC Name Payload Target Linker ADC Info
54E-Val-Cit-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-TF mAb 1849
 Antibody Info 
ADC Name Payload Target Linker ADC Info
111In-1849 [4]
Indium-111
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
Anti-tissue factor antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
XB371 [5]
Belotecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
SHR-4375
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
XNW28012
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
 ADC Info 
YLSH003
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-tissue factor mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
STRO-004 [6]
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
HJAA-F11 ADC [7]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
ADC Name Payload Target Linker ADC Info
MRG004A
Monomethyl auristatin E
Microtubule (MT)
BCN-Val-Cit linker
 ADC Info 
Samatatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Samatatug zovodotin
ZD02044
Microtubule (MT)
Mc-PEG3-Val-Cit
 ADC Info 
TF-mAb-H29
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H29-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H29-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H30
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H30-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H30-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H31
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H31-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H31-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H32
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H32-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H32-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H33
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H33-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H33-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H34
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H34-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H34-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H35
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H35-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H35-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H36
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H36-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H36-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H37
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H37-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H37-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H38
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H38-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H38-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H39
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H39-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H39-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H40
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H40-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H40-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H41
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H41-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H41-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H42
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H42-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H42-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H43
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H43-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H43-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H44
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H44-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H44-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H45
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H45-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H45-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H46
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H46-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H46-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H47
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H47-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H47-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-H48
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-H48-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-H48-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
TF-mAb-SC1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TF-mAb-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
TF-mAb-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Tisotumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Tisotumab vedotin [9]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MRG-004A
Monomethyl auristatin E
Microtubule (MT)
Valine-Citrulline (BCN-valyl-citrulline; Protease-cleavable linker)
 ADC Info 
EDO-B278 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
SYS6051 [11]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
T320-ADC
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
Ref 2 ADCE-T02: A first-in-class topoisomerase-1 inhibitor based antibody drug conjugate against tissue factor demonstrates excellent preclinical efficacy and tolerability
Ref 3 Treating Tissue Factor-Positive Cancers with Antibody-Drug Conjugates That Do Not Affect Blood Clotting. Mol Cancer Ther. 2018 Nov;17(11):2412-2426.
Ref 4 Anti?tissue factor antibody?mediated immuno?SPECT imaging of tissue factor expression in mouse models of pancreatic cancer. Oncol Rep. 2019 Apr;41(4):2371-2378. doi: 10.3892/or.2019.7017. Epub 2019 Feb 14.
Ref 5 Exelixis biotechnology company product pipeline
Ref 6 Sutro biopharmaceutical company product pipeline
Ref 7 Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and InVitro Efficacy Analysis. Neoplasia. 2017 Sep;19(9):716-733. doi: 10.1016/j.neo.2017.07.001. Epub 2017 Aug 19.
Ref 8 Tissue factor-targeted antibody-drug conjugate; 2018-03-01.
Ref 9 Tisotumab Vedotin: First Approval
Ref 10 Challenges in Optimising the Successful Construction of Antibody Drug Conjugates in Cancer Therapy. Antibodies (Basel). 2018 Feb 13;7(1):11. doi: 10.3390/antib7010011.
Ref 11 SYS6051, a next-generation tissue factor-targeted antibody-drug conjugates for the treatment of TF-expressing malignancies