Antigen Information

General Information of This Antigen
Antigen ID
TAR0LTTSS
Antigen Name
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Gene Name
ROR1
Gene ID
6095
Synonym
NTRKR1; Neurotrophic tyrosine kinase, receptor-related 1
Sequence
MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTL
DEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRN
LDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACAR
FIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS
VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIG
IPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHS
YCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAL
LFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELG
ECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLG
AVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIA
AGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMP
PEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPR
MYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSN
LSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTG
PPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGIT
VFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL

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Family
Protein kinase family
Function
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells.

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Uniprot Entry
ROR1_HUMAN
HGNC ID
HGNC:10256
KEGG ID
hsa:4919
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
19F6_Hu35v1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2022253035A1 ADC-27
WO2022253035A1 ADC-27 payload
Undisclosed
WO2022253035A1 ADC-27 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-28
WO2022253035A1 ADC-28 payload
Undisclosed
WO2022253035A1 ADC-28 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-29
WO2022253035A1 ADC-29 payload
Undisclosed
WO2022253035A1 ADC-29 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-30
WO2022253035A1 ADC-30 payload
Undisclosed
WO2022253035A1 ADC-30 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-31
WO2022253035A1 ADC-31 payload
Undisclosed
WO2022253035A1 ADC-31 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-32
WO2022253035A1 ADC-32 payload
Undisclosed
WO2022253035A1 ADC-32 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-33
WO2022253035A1 ADC-33 payload
Undisclosed
WO2022253035A1 ADC-33 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-34
WO2022253035A1 ADC-34 payload
Undisclosed
WO2022253035A1 ADC-34 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-35
WO2022253035A1 ADC-35 payload
Undisclosed
WO2022253035A1 ADC-35 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-36
WO2022253035A1 ADC-36 payload
Undisclosed
WO2022253035A1 ADC-36 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-37
WO2022253035A1 ADC-37 payload
Undisclosed
WO2022253035A1 ADC-37 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-38
WO2022253035A1 ADC-38 payload
Undisclosed
WO2022253035A1 ADC-38 linker
 [1]
 ADC Info 
WO2022253035A1 ADC-39
WO2022253035A1 ADC-39 payload
Undisclosed
WO2022253035A1 ADC-39 linker
 [1]
2188-D04-F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A 2188-D04-F404-LP8
Undisclosed
Undisclosed
Undisclosed
 [2]
2188-D04-Y180
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A 2188-D04-Y180-LP9
PBD dimer
Human Deoxyribonucleic acid (hDNA)
DBCO-PEG4-VA
 [2]
2188-D04-Y180/F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A 2188-D04-Y180/F404-LP1
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [2]
 ADC Info 
ZA202500202A 2188-D04-Y180/F404-LP10
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 [2]
2188-D04-Y180/F404/K42
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A 2188-D04-Y180/F404/K42-LP1
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [2]
2188-D04-Y180/F404/K42/E161
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A 2188-D04-Y180/F404/K42/E161-LP1
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-L-cysteic acid-PEG4-VKG
 [2]
 ADC Info 
ZA202500202A 2188-D04-Y180/F404/K42/E161-LP10
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN119371541A 99961.1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [3]
 ADC Info 
CO20240013452A2 99961-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [4]
 ADC Info 
KR1020250008730A 99961.1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [5]
A05xB04-F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A A05xB04-F404-LP8 biparatopic
Undisclosed
Undisclosed
Undisclosed
 [2]
A05xC06-F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A A05xC06-F404-LP8 bioaratopic
Undisclosed
Undisclosed
Undisclosed
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2025019787A1 ADC-4
ADC-4 Payload
Undisclosed
ADC-4 Linker
 [6]
 ADC Info 
WO2025019787A1 ADC-8
ADC-4 Payload
Undisclosed
ADC-4 Linker
 [6]
AGFP-Y180/F241/F404/K42
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A AGFP-Y180/F241/F404/K42-LP3
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 [2]
 ADC Info 
ZA202500202A AGFP-Y180/F241/F404/K42-LP4
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [2]
Anti-ROR1 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
TQB2101
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HDM2005
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
Anti-ROR1 Fc-silenced mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SYS6005
MMAE
Microtubule (MT)
A cleavable linker
Anti-ROR1 IgG1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ABL202
PBD dimer
Human deoxyribonucleic acid (hDNA)
β-glucuronide trigger linker
Anti-ROR1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BR111
Eribulin
Microtubule (MT)
Undisclosed
 [7]
 ADC Info 
ZPC-21
HC74
DNA topoisomerase 1 (TOP1)
A cleavable linker
Anti-ROR1 mAb 2A2
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC9
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC9 linker
 [8]
 ADC Info 
WO2021044208A1 ADC10
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC10 linker
 [8]
 ADC Info 
WO2021044208A1 ADC 2A2-4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC 2A2-4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC 2A2-5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC 2A2-5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC 2A2-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC 2A2-6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC 2A2-7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC 2A2-7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC AB4-1
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC AB4-1 linker
 [8]
Anti-ROR1 mAb A2F2
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC A2F2-2
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC A2F2-2 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2-3
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2-3 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2-4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2-4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2-5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2-5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2-6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2-7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2-7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F3-1
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F3-1 linker
 [8]
Anti-ROR1 mAb A2F2 M1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC A2F2 M1-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2 M1-6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2 M1-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2 M1-7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2 M1-2
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC A2F2 M1-2 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2 M1-3
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2 M1-3 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2 M1-4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2 M1-4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2 M1-5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2 M1-5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2 M1-7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2 M1-7 linker
 [8]
Anti-ROR1 mAb A2F3
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC A2F3-2
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC A2F3-2 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F3-3
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F3-3 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F3-4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F3-4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F3-5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F3-5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F3-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F3-6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F3-7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F3-7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC BA6-1
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC BA6-1 linker
 [8]
Anti-ROR1 mAb AB4
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC AB4-2
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC AB4-2 linker
 [8]
 ADC Info 
WO2021044208A1 ADC AB4-3
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC AB4-3 linker
 [8]
 ADC Info 
WO2021044208A1 ADC AB4-4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC AB4-4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC AB4-5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC AB4-5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC AB4-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC AB4-6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC AB4-7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC AB4-7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2-1
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2-1 linker
 [8]
Anti-ROR1 mAb BA6
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC BA6-2
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC BA6-2 linker
 [8]
 ADC Info 
WO2021044208A1 ADC BA6-3
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC BA6-3 linker
 [8]
 ADC Info 
WO2021044208A1 ADC BA6-4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC BA6-4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC BA6-5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC BA6-5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC BA6-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC BA6-6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC BA6-7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC BA6-7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC CC9-1
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC CC9-1 linker
 [8]
Anti-ROR1 mAb C2E3
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC2
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC2 linker
 [8]
 ADC Info 
WO2021044208A1 ADC3
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC3 linker
 [8]
 ADC Info 
WO2021044208A1 ADC4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC8
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC8 linker
 [8]
Anti-ROR1 mAb CC9
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC CC9-2
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC CC9-2 linker
 [8]
 ADC Info 
WO2021044208A1 ADC CC9-3
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC CC9-3 linker
 [8]
 ADC Info 
WO2021044208A1 ADC CC9-4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC CC9-4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC CC9-5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC CC9-5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC CC9-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC CC9-6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC CC9-7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC CC9-7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC DG6-1
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC DG6-1 linker
 [8]
Anti-ROR1 mAb D2B12
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC D2B12-2
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC D2B12-2 linker
 [8]
 ADC Info 
WO2021044208A1 ADC D2B12-3
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC D2B12-3 linker
 [8]
 ADC Info 
WO2021044208A1 ADC D2B12-4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC D2B12-4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC D2B12-5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC D2B12-5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC D2B12-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC D2B12-6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC D2B12-7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC D2B12-7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC A2F2 M1-1
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2 M1-1 linker
 [8]
Anti-ROR1 mAb DG6
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2021044208A1 ADC DG6-2
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC DG6-2 linker
 [8]
 ADC Info 
WO2021044208A1 ADC DG6-3
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC DG6-3 linker
 [8]
 ADC Info 
WO2021044208A1 ADC DG6-4
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC DG6-4 linker
 [8]
 ADC Info 
WO2021044208A1 ADC DG6-5
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC DG6-5 linker
 [8]
 ADC Info 
WO2021044208A1 ADC DG6-6
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC DG6-6 linker
 [8]
 ADC Info 
WO2021044208A1 ADC DG6-7
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC DG6-7 linker
 [8]
 ADC Info 
WO2021044208A1 ADC D2B12-1
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC D2B12-1 linker
 [8]
Anti-ROR1 mAb huXBR1-402
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuXBR1-402-G5-PNU
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Gly5-FITC
 [9]
B2E5-48 antibody H2-L2
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
B2E5-ADC
Undisclosed
Undisclosed
Undisclosed
 [10]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN119371541A B31-H3L3-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [3]
 ADC Info 
CO20240013452A2 ADC1 (2)
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [4]
 ADC Info 
KR1020250008730A ADC2
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [5]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
B62-H3L3-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [3]
 ADC Info 
CO20240013452A2 ADC1
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [4]
 ADC Info 
KR1020250008730A ADC1
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [5]
Cirmtuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Cirmtuzumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Lysine-linker
[11]
 ADC Info 
Cirmtuzumab-ADC-7
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [12]
COMP mAb1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2023173132A1 ADC-1
P9
Undisclosed
IBAC-suC-PEG4
 [13]
 ADC Info 
WO2023173132A1 ADC-3
P9
Undisclosed
DIBAC-suC-PEG8
 [13]
 ADC Info 
WO2023173132A1 ADC-5
P9
Undisclosed
DIBAC-suC-PEG12
 [13]
 ADC Info 
WO2023173132A1 ADC-7
P9
Undisclosed
Undisclosed
 [13]
 ADC Info 
WO2023173132A1 ADC-16
P9
Undisclosed
Undisclosed
 [13]
control mAb5
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2023173132A1 ADC-19
P9
Undisclosed
Undisclosed
 [13]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04-F404-LP8 1.87
Undisclosed
Undisclosed
Undisclosed
 [2]
 ADC Info 
ZA202500202A D04-F404-LP32
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4-Gly
 [2]
 ADC Info 
ZA202500202A D04-F404-LP30
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-PEG4-Gly (NH2)
 [2]
 ADC Info 
ZA202500202A D04-F404-LP31
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4 (OH)
 [2]
 ADC Info 
ZA202500202A D04-F404-LP14
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-PEG-VKG
 [2]
 ADC Info 
ZA202500202A D04-F404-LP33
PNU EDA
Undisclosed
DBCO-PEG4-AAN
 [2]
 ADC Info 
ZA202500202A D04-F404-LP24
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-PEG4
 [2]
 ADC Info 
ZA202500202A D04-F404-LP25
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-PEG4-Gly
 [2]
 ADC Info 
ZA202500202A D04-F404-LP26
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-PEG4-EDA
 [2]
 ADC Info 
ZA202500202A D04-F404-LP27
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-sidechain PEG12-EDA
 [2]
 ADC Info 
ZA202500202A D04-F404-LP28
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-sidechain PEG12
 [2]
 ADC Info 
ZA202500202A D04-F404-LP8 1.99
Undisclosed
Undisclosed
Undisclosed
 [2]
D04-Y180/F241/F404/K42
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04-Y180/F241/F404/K42-LP3
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 [2]
 ADC Info 
ZA202500202A D04-Y180/F241/F404/K42-LP4
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [2]
D04-Y180/F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04-Y180/F404-LP11
Monomethyl auristatin E
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404-LP1
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404-LP32
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4-Gly
 [2]
D04-Y180/F404/K42/E161
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP2
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-L-cysteic acid-PEG4-VKG
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP3 8
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP4 (8)
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP7
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nAA-PEG13-VKG
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP5
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAN
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP6
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAA
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP12
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValLys-pAB
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP13
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValGlu-pAB
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP1 7.99
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP34
Undisclosed
Undisclosed
Undisclosed
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP1 7.95
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP4 (7.52)
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP3 7.46
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 [2]
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP4
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [2]
D04-Y180F404/K42/E161
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP14
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-PEG-VKG
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP15
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,6 nnAA-PEG-VKG
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP16
Undisclosed
Undisclosed
Undisclosed
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP17
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-bridged nnAA-PEG-VKG
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP18
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,6 nnAA-B-Glucuronide-PEG12
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP19
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-B-Glucuronide-PEG12
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP20
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,4 nnAA-B-Glucuronide-PEG12
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP23
SC209
Microtubule (MT)
DBCO-6,4 nnAA-B-Glucuronide-PEG12
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP22
SC209
Microtubule (MT)
DBCO-nnAA-PEG13-AAN
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP21
SC209
Microtubule (MT)
DBCO-nnAA-PEG13-VKG
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP1
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [2]
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP4
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [2]
D04xA05-F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04xA05-F404-LP8 biparatopic
Undisclosed
Undisclosed
Undisclosed
 [2]
D04xB04-F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04xB04-F404-LP8 biparatopic
Undisclosed
Undisclosed
Undisclosed
 [2]
D04xB09-F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04xB09-F404-LP8 biparatopic
Undisclosed
Undisclosed
Undisclosed
 [2]
D04xC01-F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04xC01-F404-LP8 biraratopic
Undisclosed
Undisclosed
Undisclosed
 [2]
D04xD04-F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZA202500202A D04xZA202500202A D04-F404-LP8
Undisclosed
Undisclosed
Undisclosed
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Hu001-2-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [14]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Hu001-3-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [14]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Hu005-44-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [14]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Hu005-46-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [14]
HuXBR1-402
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
NBE-002
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
LPETG-Gly5-EDA
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
mAb001c-vc-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [14]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
JP2025500952A ADC-2
WO2023173026A 8-6
Undisclosed
Undisclosed
 [15]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ab-AL2-LP32
Pro-DHT
Undisclosed
COT-PEG4-EvcPAB
 [10]
 ADC Info 
Ab-AL2-LP41
DHT
Undisclosed
Mc-PEG4-VK-PABC
 [10]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ab-AL3-LP4
Pro-DHT
Undisclosed
Tz-PEG4-EvcPAB
 [10]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Ab-AL4-LP4
Pro-DHT
Undisclosed
Tz-PEG4-EvcPAB
 [10]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2020252015A1 ADCLP-1
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [16]
 ADC Info 
WO2020252015A1 ADCLP-2
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-SO3-PEG4-Val-Cit-PABC
 [16]
 ADC Info 
WO2020252015A1 ADCLP-3
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-B-Glucuronide-PEG12
 [16]
 ADC Info 
WO2020252015A1 ADCLP-4
Gly-Exatecan
Undisclosed
DBCO-nAA-PEG13-VKG
 [16]
 ADC Info 
WO2020252015A1 ADCLP-5
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAN
 [16]
 ADC Info 
WO2020252015A1 ADCLP-6
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAA
 [16]
 ADC Info 
WO2020252015A1 ADCLP-7
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nAA-PEG13-VKG
 [16]
 ADC Info 
WO2016102679A1 ADCLP-8
PNU EDA
Undisclosed
DBCO-GGG
 [17]
 ADC Info 
WO2016102679A1 ADCLP-9
PBD
Undisclosed
DBCO-PEG4-VA
 [17]
 ADC Info 
WO2015115091A1 ADCLP-10
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 [18]
 ADC Info 
WO2020252015A1 ADCLP-11
Monomethyl auristatin E
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [16]
 ADC Info 
WO2020252015A1 ADCLP-12
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValLys-pAB
 [16]
 ADC Info 
WO2020252015A1 ADCLP-13
SC209
Microtubule (MT)
DBCO SIDECHAIN PEG12-PAB
 [16]
 ADC Info 
WO2020252015A1 ADCLP-14
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4nnAA-PEG-VKG
 [16]
 ADC Info 
WO2020252015A1 ADCLP-15
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,6nnAA-PEG-VKG
 [16]
 ADC Info 
WO2020252015A1 ADCLP-16
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,4nnAA-PEG-VKG
 [16]
 ADC Info 
WO2016102679A1 ADCLP-17
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-BridgednnAA-PEG-VKG
 [17]
 ADC Info 
WO2020252015A1 ADCLP-18
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6.6nnAA-B-Glucuronide-PEG1
 [16]
 ADC Info 
WO2020252015A1 ADCLP-19
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6.4nnAA-B-Glucuronide-PEG12
 [16]
 ADC Info 
WO2020252015A1 ADCLP-20
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4.4 nAA-B-Glucuronide-PEG12
 [16]
 ADC Info 
WO2020252015A1 ADCLP-21
SC209
Microtubule (MT)
DBCO-nAA-PEG13-VKG
 [16]
 ADC Info 
WO2020252015A1 ADCLP-22
SC209
Microtubule (MT)
DBCO-AA-PEG13-AAN
 [16]
 ADC Info 
WO2020252015A1 ADCLP-23
SC209
Microtubule (MT)
DBCO-6.4nnAA-B-Glucuronide-PEG12
 [16]
 ADC Info 
WO2020252015A1 ADCLP-24
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nAA-PEG4
 [16]
 ADC Info 
WO2020252015A1 ADCLP-25
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-PEG4-Gly
 [16]
 ADC Info 
WO2020252015A1 ADCLP-26
PNU EDA
Undisclosed
DBCO-nAA-PEG4
 [16]
 ADC Info 
WO2020252015A1 ADCLP-27
PNU EDA
Undisclosed
DBCO-nAA-sidechain PEG12
 [16]
 ADC Info 
WO2020252015A1 ADCLP-28
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nAA-sidechain PEG12
 [16]
 ADC Info 
WO2020252015A1 ADCLP-29
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-PEG4
 [16]
 ADC Info 
WO2020252015A1 ADCLP-30
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-PEG4-Gly (OH)
 [16]
 ADC Info 
WO2020252015A1 ADCLP-31
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4 (OH)
 [16]
 ADC Info 
WO2020252015A1 ADCLP-32
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4-Gly
 [16]
 ADC Info 
WO2020252015A1 ADCLP-33
PNU EDA
Undisclosed
DBCO-PEG4-AAN
 [16]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
P015004-vc-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [19]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
P015042-vc-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [19]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
P015043-vc-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [19]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
P015044-vc-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [19]
ROR1 mAb (K149C)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ROR1 DAC (K149C)
MZ1
Undisclosed
Maleimide-PEG4-DBCO
 [20]
ROR1 mAb (KLY)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ROR1 DAC (KLY)
MZ1
Undisclosed
Maleimide-PEG4-DBCO
 [20]
ROR1 mAb (KV)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ROR1 DAC (KV)
MZ1
Undisclosed
Maleimide-PEG4-DBCO
 [20]
ROR1 mAb (LY)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ROR1 DAC (LY)
MZ1
Undisclosed
Maleimide-PEG4-DBCO
 [20]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
STRO-003
Exatecan
DNA topoisomerase 1 (TOP1)
SC3417
 [21]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
UC961-vc-PAB-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [19]
 ADC Info 
UC961-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [14]
Zilovertamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Zilovertamab vedotin
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Site-sepcific ADC 1
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 2
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 3
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 4
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 5
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 6
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 7
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 8
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 9
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 10
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 11
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
 ADC Info 
Site-sepcific ADC 12
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 [22]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HDM-2005
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-ROR1 antibody scFv conjugate (Oncternal)
Undisclosed
Undisclosed
Undisclosed
 [23]
 ADC Info 
ELN-11
Undisclosed
Undisclosed
Undisclosed
 [24]
 ADC Info 
ABL-202
Undisclosed
Undisclosed
Undisclosed
 [25]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AMB303
Undisclosed
Undisclosed
Undisclosed
 [26]
 ADC Info 
IN202417103159A 2188-D04-Yl80/F404-LP1
SC209
Microtubule (MT)
DBCO-Val-Cit-PABC
 [27]
 ADC Info 
IN202417103159A 2188-D04-Yl80/F404/K42-LP1
SC209
Microtubule (MT)
DBCO-Val-Cit-PABC
 [27]
 ADC Info 
IN202417103159A 2188-D04-Yl80/F404/K42/E161-LP1
SC209
Microtubule (MT)
DBCO-Val-Cit-PABC
 [27]
 ADC Info 
IN202417103159A 2188-D04-F404-LP8
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A 2188-D04-Yl80-LP9
PBD
Deoxyribonucleic acid (DNA)
Undisclosed
 [27]
 ADC Info 
IN202417103159A 2188-IN202417103159A D04-Yl80/F404-LP10
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 [27]
 ADC Info 
IN202417103159A 2188-IN202417103159A D04-Yl80/F404/K42/E161 LP10
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP2
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-L-cysteic acid-PEG4-VKG
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP3
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP4
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP7
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nAA-PEG13-VKG
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP5
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAN
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP6
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAA
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP12
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValLys-pAB
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP13
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValGlu-pAB
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP1
SC209
Microtubule (MT)
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP34
Undisclosed
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-Yl80/F404/K42/E161-LP1
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [27]
 ADC Info 
IN202417103159A D04-Yl80/F404/K42/E161-LP4 7.52
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [27]
 ADC Info 
IN202417103159A D04-Yl80/F404-LP11
Monomethyl auristatin E
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [27]
 ADC Info 
IN202417103159A D04-Yl80/F404-LP1
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [27]
 ADC Info 
IN202417103159A D04-Yl80/F404-LP32
PNU EDA
Undisclosed
DBCO-L-Cysteic acid-PEG4-Gly
 [27]
 ADC Info 
IN202417103159A D04-F404-LP8
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-F404-LP32
PNU EDA
Undisclosed
DBCO-L-Cysteic acid-PEG4-Gly
 [27]
 ADC Info 
IN202417103159A D04-F404-LP30
PNU EDA
Undisclosed
DBCO-PEG4-Gly (OH)
 [27]
 ADC Info 
IN202417103159A D04-F404-LP31
PNU EDA
Undisclosed
DBCO-L-Cysteic acid-PEG4 (OH)
 [27]
 ADC Info 
IN202417103159A D04-F404-LP14
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-PEG-VKG
 [27]
 ADC Info 
IN202417103159A D04 x IN202417103159A D04-F404-LP8
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04 x C01-F404-LP8 biparatopic
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04 x B09-F404- LP8 biparatopic
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04 x A05-F404- LP8 biparatopic
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04 x B04-F404- LP8 biparatopic
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A A05 x B04-F404- LP8 biparatopic
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A A05 x C06-F404- LP8 biparatopic
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP14
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-PEG-VKG
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161- LP15
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,6 nnAA-PEG-VKG
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP16
Undisclosed
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP17
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-bridged nnAA-PEG-VKG
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP18
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP19
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP20
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-F404-LP33
Undisclosed
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP23
SC209
Microtubule (MT)
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP22
SC209
Microtubule (MT)
DBCO-nnAA-PEG13-AAN
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP21
PNU EDA
Undisclosed
DBCO-nnAA-PEG13-VKG
 [27]
 ADC Info 
IN202417103159A D04-F404-LP24
PNU EDA
Undisclosed
DBCO-nnAA-PEG4
 [27]
 ADC Info 
IN202417103159A D04-F404-LP25
PNU EDA
Undisclosed
DBCO-nnAA-PEG4-Gly
 [27]
 ADC Info 
IN202417103159A D04-F404-LP26
PNU EDA
Undisclosed
DBCO-nnAA-PEG4-EDA
 [27]
 ADC Info 
IN202417103159A D04-F404-LP27
PNU EDA
Undisclosed
DBCO-nnAA-sidechain PEG12-EDA
 [27]
 ADC Info 
IN202417103159A D04-F404-LP28
PNU EDA
Undisclosed
DBCO-nnAA-sidechain PEG12
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP1
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 [27]
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP4
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-F404- LP8
PNU EDA
Undisclosed
Undisclosed
 [27]
 ADC Info 
IN202417103159A D04-Yl80/F241/F404/K42-LP3
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 [27]
 ADC Info 
IN202417103159A D04-Yl80/F404/K42/E161-LP3
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 [27]
 ADC Info 
IN202417103159A D04-Yl80/F241/F404/K42-LP4
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [27]
 ADC Info 
IN202417103159A D04-Yl80/F404/K42/E161-LP4 8
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [27]
 ADC Info 
IN202417103159A aGFP-Y180/F241/F404/K42-LP3
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 [27]
 ADC Info 
IN202417103159A aGFP-Y180/F241/F404/K42-LP4
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 [27]
 ADC Info 
Anti-pTalpha-DM1-ADC
Undisclosed
Undisclosed
Undisclosed
 [10]
 ADC Info 
Anti-pTalpha-MMAE-ADC
Undisclosed
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-030-LT
L078-030 payload
Undisclosed
WO2023173026A1-ADC-L078-030-LT-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-045
L078-043 payload
Undisclosed
Mal-PEG4-Val-Cit-PABC
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-044
L078-042 payload
Undisclosed
Mal-PEG4-Val-Cit-PABC
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-055
L078-047 payload
Undisclosed
WO2023173026A1-ADC-L078-055-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-056
L078-048 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-058
L078-046 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-081-LT
L078-081 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-059
L078-049 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-057
L078-051 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-063
L078-042 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-064
L078-043 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-062
L078-030 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-065-LT
L078-065 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-066-LT
L078-066 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-084
L078-048 payload
Undisclosed
WO2023173026A1-ADC-L078-084-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-079
L078-030 payload
Undisclosed
WO2023173026A1-ADC-L078-079-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-078
L078-048 payload
Undisclosed
WO2023173026A1-ADC-L078-079-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-090
L078-088 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-091
L078-089 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-092
L078-049 payload
Undisclosed
WO2023173026A1-ADC-L078-092-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-093
L078-048 payload
Undisclosed
WO2023173026A1-ADC-L078-093-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L079-018
L078-029 payload
Undisclosed
WO2023173026A1-ADC-L079-018-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L079-019
WO2023173026A 47
Undisclosed
WO2023173026A1-ADC-L079-019-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-171
WO2023173026A 5
Undisclosed
WO2023173026A1-ADC-L078-171-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-173
WO2023173026A 5
Undisclosed
WO2023173026A1-ADC-L078-173-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L079-027
WO2023173026A 47
Undisclosed
WO2023173026A1-ADC-L079-027-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L079-035
WO2023173026A 67
Undisclosed
WO2023173026A1-ADC-L079-035-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L079-034
WO2023173026A 63
Undisclosed
Mal-PEG4-Val-Cit-PABC
 [10]
 ADC Info 
WO2023173026A1 ADC-L079-040
WO2023173026A 61
Undisclosed
WO2023173026A1-ADC-L079-040-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-121
L078-030 payload
Undisclosed
WO2023173026A1-ADC-L078-121-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-118
L078-088 payload
Undisclosed
WO2023173026A1-ADC-L078-118-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-119
L078-042 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-120
L078-048 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-177
L078-088 payload
Undisclosed
WO2023173026A1-ADC-L078-117-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-130
L078-042 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-123
L078-047 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-139
L078-042 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-163
L078-149 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-164
L078-150 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-170
L078-089 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-162
WO2023173026A 5
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-178
L078-030 payload
Undisclosed
WO2023173026A1-ADC-L078-117-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-182
L078-088 payload
Undisclosed
WO2023173026A1-ADC-L078-117-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L078-184
WO2023173026A 130
Undisclosed
Undisclosed
 [10]
 ADC Info 
WO2023173026A1 ADC-L081-034
WO2023173026A 130
Undisclosed
WO2023173026A1-ADC-L081-034-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L081-036
WO2023173026A 130
Undisclosed
WO2023173026A1-ADC-L081-036-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L081-038
WO2023173026A 94
Undisclosed
WO2023173026A1-ADC-L081-038-Linker
 [10]
 ADC Info 
WO2023173026A1 ADC-L081-045
WO2023173026A 94
Undisclosed
WO2023173026A1-ADC-L081-034-Linker
 [10]
 ADC Info 
JP2025500952A ADC-1
WO2023173026A 8-6
Undisclosed
JP2025500952A-ADC-1-Linker
 [15]
 ADC Info 
WO2023173132A1 ADC-8
P9
Undisclosed
Undisclosed
 [13]
 ADC Info 
WO2023173132A1 ADC-9
P9
Undisclosed
Undisclosed
 [13]
 ADC Info 
WO2023173132A1ADC-10
P9
Undisclosed
Undisclosed
 [13]
 ADC Info 
WO2023173132A1 ADC-11
P9
Undisclosed
Undisclosed
 [13]
 ADC Info 
WO2023173132A1 ADC-17
P9
Undisclosed
Undisclosed
 [13]
 ADC Info 
WO2023173132A1 ADC-18
P9
Undisclosed
Undisclosed
 [13]
 ADC Info 
WO2023173132A1 ADC-20
P8 Payload
Undisclosed
BCN-PEG4-triazole
 [13]
 ADC Info 
WO2023173132A1 ADC-21
P8 Payload
Undisclosed
NH2-PEG8-triazole
 [13]
References
Ref 1 Antibody drug conjugate, and preparation method therefor and use thereof; 2022-12-08.
Ref 2 Anti-ROR1 antibodies and antibody conjugates, compositions comprising Anti-ROR1 antibodies or antibody conjugates, and methods of making and using Anti-ROR1 antibodies and antibody conjugates
Ref 3 Binding molecules targeting ROR1 and uses thereof
Ref 4 Binding molecule directed to ror1 and its use
Ref 5 Ror1-targeted binding molecules and their Applications
Ref 6 Tyrosine-protein kinase membrane receptor 1 (ROR1) antibody-drug conjugates and uses thereof
Ref 7 Translational medicine studies of BR111, a biparatopic anti-ROR1 antibody drug conjugate for hematological and solid tumor treatment
Ref 8 Antibody-drug conjugate comprising antibody against human ror1, and use for the same; 2021-04-01.
Ref 9 The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia. Blood Adv. 2021 Aug 24;5(16):3152-3162.
Ref 10 Antibody-drug conjugates and uses thereof
Ref 11 Cirmtuzumab Vedotin (UC-961ADC3), An Anti-ROR1-Monomethyl Auristatin E Antibody-Drug Conjugate, Is a Potential Treatment For ROR1-Positive Leukemia and Solid Tumors. Blood (2013) 122 (21): 1637.
Ref 12 Development of Cirmtuzumab Antibody-Drug Conjugates (ADCs) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1). Blood. 2018 ;132():-. doi: 10.1182/blood-2018-99-119447.
Ref 13 Anti-GLP1R antibody-drug conjugates comprising GLP-1 peptidomimetics and uses thereof
Ref 14 Antibodies specifically binding ROR1, their drug conjugates, preparation methods and uses
Ref 15 Anti-DLL3 antibodies, antibody-drug complexes and medical uses thereof
Ref 16 Immunomodulator antibody drug conjugates and uses thereof
Ref 17 Binding protein drug conjugates comprising anthracycline derivatives; 2016-06-30.
Ref 18 Anti-HER2 antibody-drug conjugate
Ref 19 Anti-ror1 antibodies and their uses
Ref 20 A novel ROR1-targeting antibody-PROTAC conjugate promotes BRD4 degradation for solid tumor treatment
Ref 21 STRO-003 is a novel ROR1-targeted ADC for breast and lung cancer. Journal for ImmunoTherapy of Cancer 2022;10:doi: 10.1136/jitc-2022-SITC2022.1191.
Ref 22 Direct Preparation of Site-Specific Antibody-Drug Conjugates with Unpurified Antibodies in Culture Medium
Ref 23 ROR1: an orphan becomes apparent. Blood. 2022 Oct 6;140(14):1583-1591. doi: 10.1182/blood.2021014760.
Ref 24 Introduction to basic information on ADC drug ELN 11- Almac Discovery/Elasmogen.
Ref 25 Introduction to basic information on ADC drug ABL-202
Ref 26 AMB303: A novel topo I payload ADC showing efficacy in NSCLC and TNBC, with potential for immune checkpoint combination therapy
Ref 27 Anti-ROR1 antibodies and antibody conjugates, compositions comprising Anti-ROR1 antibodies or antibody conjugates, and methods of making and using Anti-ROR1 antibodies and antibody conjugates