Antigen Information

General Information of This Antigen (ID: TAR0LTTSS)
Antigen Name
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Gene Name
ROR1
Gene ID
6095
Synonym
NTRKR1; Neurotrophic tyrosine kinase, receptor-related 1
Sequence
MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTL
DEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRN
LDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACAR
FIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS
VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIG
IPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHS
YCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAL
LFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELG
ECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLG
AVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIA
AGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMP
PEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPR
MYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSN
LSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTG
PPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGIT
VFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL

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Family
Protein kinase family
Function
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells.

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Uniprot Entry
ROR1_HUMAN
HGNC ID
HGNC:10256
KEGG ID
hsa:4919
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
19F6_Hu35v1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2022253035A1 ADC-27 [1]
WO2022253035A1 ADC-27 payload
Undisclosed
WO2022253035A1 ADC-27 linker
 ADC Info 
WO2022253035A1 ADC-28 [1]
WO2022253035A1 ADC-28 payload
Undisclosed
WO2022253035A1 ADC-28 linker
 ADC Info 
WO2022253035A1 ADC-29 [1]
WO2022253035A1 ADC-29 payload
Undisclosed
WO2022253035A1 ADC-29 linker
 ADC Info 
WO2022253035A1 ADC-30 [1]
WO2022253035A1 ADC-30 payload
Undisclosed
WO2022253035A1 ADC-30 linker
 ADC Info 
WO2022253035A1 ADC-31 [1]
WO2022253035A1 ADC-31 payload
Undisclosed
WO2022253035A1 ADC-31 linker
 ADC Info 
WO2022253035A1 ADC-32 [1]
WO2022253035A1 ADC-32 payload
Undisclosed
WO2022253035A1 ADC-32 linker
 ADC Info 
WO2022253035A1 ADC-33 [1]
WO2022253035A1 ADC-33 payload
Undisclosed
WO2022253035A1 ADC-33 linker
 ADC Info 
WO2022253035A1 ADC-34 [1]
WO2022253035A1 ADC-34 payload
Undisclosed
WO2022253035A1 ADC-34 linker
 ADC Info 
WO2022253035A1 ADC-35 [1]
WO2022253035A1 ADC-35 payload
Undisclosed
WO2022253035A1 ADC-35 linker
 ADC Info 
WO2022253035A1 ADC-36 [1]
WO2022253035A1 ADC-36 payload
Undisclosed
WO2022253035A1 ADC-36 linker
 ADC Info 
WO2022253035A1 ADC-37 [1]
WO2022253035A1 ADC-37 payload
Undisclosed
WO2022253035A1 ADC-37 linker
 ADC Info 
WO2022253035A1 ADC-38 [1]
WO2022253035A1 ADC-38 payload
Undisclosed
WO2022253035A1 ADC-38 linker
 ADC Info 
WO2022253035A1 ADC-39 [1]
WO2022253035A1 ADC-39 payload
Undisclosed
WO2022253035A1 ADC-39 linker
 ADC Info 
2188-D04-F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A 2188-D04-F404-LP8 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
2188-D04-Y180
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A 2188-D04-Y180-LP9 [2]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
DBCO-PEG4-VA
 ADC Info 
2188-D04-Y180/F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A 2188-D04-Y180/F404-LP1 [2]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
ZA202500202A 2188-D04-Y180/F404-LP10 [2]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 ADC Info 
2188-D04-Y180/F404/K42
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A 2188-D04-Y180/F404/K42-LP1 [2]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
2188-D04-Y180/F404/K42/E161
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A 2188-D04-Y180/F404/K42/E161-LP1 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-L-cysteic acid-PEG4-VKG
 ADC Info 
ZA202500202A 2188-D04-Y180/F404/K42/E161-LP10 [2]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN119371541A 99961.1-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CO20240013452A2 99961-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
KR1020250008730A 99961.1-MMAE [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
A05xB04-F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A A05xB04-F404-LP8 biparatopic [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
A05xC06-F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A A05xC06-F404-LP8 bioaratopic [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2025019787A1 ADC-4 [6]
ADC-4 Payload
Undisclosed
ADC-4 Linker
 ADC Info 
WO2025019787A1 ADC-8 [6]
ADC-4 Payload
Undisclosed
ADC-4 Linker
 ADC Info 
AGFP-Y180/F241/F404/K42
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A AGFP-Y180/F241/F404/K42-LP3 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 ADC Info 
ZA202500202A AGFP-Y180/F241/F404/K42-LP4 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
Anti-ROR1 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TQB2101
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HDM2005
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-ROR1 Fc-silenced mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYS6005
Monomethyl auristatin E
Microtubule (MT)
A cleavable linker
 ADC Info 
Anti-ROR1 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ABL202
PBD dimer
Human deoxyribonucleic acid (hDNA)
β-glucuronide trigger linker
 ADC Info 
Anti-ROR1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BR111 [7]
Eribulin
Microtubule (MT)
Undisclosed
 ADC Info 
ZPC-21
HC74
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-ROR1 mAb 2A2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC9 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC9 linker
 ADC Info 
WO2021044208A1 ADC10 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC10 linker
 ADC Info 
WO2021044208A1 ADC 2A2-4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC 2A2-4 linker
 ADC Info 
WO2021044208A1 ADC 2A2-5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC 2A2-5 linker
 ADC Info 
WO2021044208A1 ADC 2A2-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC 2A2-6 linker
 ADC Info 
WO2021044208A1 ADC 2A2-7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC 2A2-7 linker
 ADC Info 
WO2021044208A1 ADC AB4-1 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC AB4-1 linker
 ADC Info 
Anti-ROR1 mAb A2F2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC A2F2-2 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC A2F2-2 linker
 ADC Info 
WO2021044208A1 ADC A2F2-3 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2-3 linker
 ADC Info 
WO2021044208A1 ADC A2F2-4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2-4 linker
 ADC Info 
WO2021044208A1 ADC A2F2-5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2-5 linker
 ADC Info 
WO2021044208A1 ADC A2F2-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2-6 linker
 ADC Info 
WO2021044208A1 ADC A2F2-7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2-7 linker
 ADC Info 
WO2021044208A1 ADC A2F3-1 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F3-1 linker
 ADC Info 
Anti-ROR1 mAb A2F2 M1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC A2F2 M1-2 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC A2F2 M1-2 linker
 ADC Info 
WO2021044208A1 ADC A2F2 M1-3 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2 M1-3 linker
 ADC Info 
WO2021044208A1 ADC A2F2 M1-4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2 M1-4 linker
 ADC Info 
WO2021044208A1 ADC A2F2 M1-5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F2 M1-5 linker
 ADC Info 
WO2021044208A1 ADC A2F2 M1-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2 M1-6 linker
 ADC Info 
WO2021044208A1 ADC A2F2 M1-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2 M1-7 linker
 ADC Info 
WO2021044208A1 ADC A2F2 M1-7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2 M1-7 linker
 ADC Info 
Anti-ROR1 mAb A2F3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC A2F3-2 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC A2F3-2 linker
 ADC Info 
WO2021044208A1 ADC A2F3-3 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F3-3 linker
 ADC Info 
WO2021044208A1 ADC A2F3-4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F3-4 linker
 ADC Info 
WO2021044208A1 ADC A2F3-5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC A2F3-5 linker
 ADC Info 
WO2021044208A1 ADC A2F3-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F3-6 linker
 ADC Info 
WO2021044208A1 ADC A2F3-7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F3-7 linker
 ADC Info 
WO2021044208A1 ADC BA6-1 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC BA6-1 linker
 ADC Info 
Anti-ROR1 mAb AB4
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC AB4-2 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC AB4-2 linker
 ADC Info 
WO2021044208A1 ADC AB4-3 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC AB4-3 linker
 ADC Info 
WO2021044208A1 ADC AB4-4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC AB4-4 linker
 ADC Info 
WO2021044208A1 ADC AB4-5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC AB4-5 linker
 ADC Info 
WO2021044208A1 ADC AB4-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC AB4-6 linker
 ADC Info 
WO2021044208A1 ADC AB4-7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC AB4-7 linker
 ADC Info 
WO2021044208A1 ADC A2F2-1 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2-1 linker
 ADC Info 
Anti-ROR1 mAb BA6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC BA6-2 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC BA6-2 linker
 ADC Info 
WO2021044208A1 ADC BA6-3 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC BA6-3 linker
 ADC Info 
WO2021044208A1 ADC BA6-4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC BA6-4 linker
 ADC Info 
WO2021044208A1 ADC BA6-5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC BA6-5 linker
 ADC Info 
WO2021044208A1 ADC BA6-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC BA6-6 linker
 ADC Info 
WO2021044208A1 ADC BA6-7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC BA6-7 linker
 ADC Info 
WO2021044208A1 ADC CC9-1 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC CC9-1 linker
 ADC Info 
Anti-ROR1 mAb C2E3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC2 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC2 linker
 ADC Info 
WO2021044208A1 ADC3 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC3 linker
 ADC Info 
WO2021044208A1 ADC4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC4 linker
 ADC Info 
WO2021044208A1 ADC5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC5 linker
 ADC Info 
WO2021044208A1 ADC6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC6 linker
 ADC Info 
WO2021044208A1 ADC7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC7 linker
 ADC Info 
WO2021044208A1 ADC8 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC8 linker
 ADC Info 
Anti-ROR1 mAb CC9
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC CC9-2 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC CC9-2 linker
 ADC Info 
WO2021044208A1 ADC CC9-3 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC CC9-3 linker
 ADC Info 
WO2021044208A1 ADC CC9-4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC CC9-4 linker
 ADC Info 
WO2021044208A1 ADC CC9-5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC CC9-5 linker
 ADC Info 
WO2021044208A1 ADC CC9-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC CC9-6 linker
 ADC Info 
WO2021044208A1 ADC CC9-7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC CC9-7 linker
 ADC Info 
WO2021044208A1 ADC DG6-1 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC DG6-1 linker
 ADC Info 
Anti-ROR1 mAb D2B12
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC D2B12-2 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC D2B12-2 linker
 ADC Info 
WO2021044208A1 ADC D2B12-3 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC D2B12-3 linker
 ADC Info 
WO2021044208A1 ADC D2B12-4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC D2B12-4 linker
 ADC Info 
WO2021044208A1 ADC D2B12-5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC D2B12-5 linker
 ADC Info 
WO2021044208A1 ADC D2B12-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC D2B12-6 linker
 ADC Info 
WO2021044208A1 ADC D2B12-7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC D2B12-7 linker
 ADC Info 
WO2021044208A1 ADC A2F2 M1-1 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC A2F2 M1-1 linker
 ADC Info 
Anti-ROR1 mAb DG6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2021044208A1 ADC DG6-2 [8]
Monomethyl auristatin F
Microtubule (MT)
WO2021044208A1_ADC DG6-2 linker
 ADC Info 
WO2021044208A1 ADC DG6-3 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC DG6-3 linker
 ADC Info 
WO2021044208A1 ADC DG6-4 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC DG6-4 linker
 ADC Info 
WO2021044208A1 ADC DG6-5 [8]
Monomethyl auristatin E
Microtubule (MT)
WO2021044208A1_ADC DG6-5 linker
 ADC Info 
WO2021044208A1 ADC DG6-6 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC DG6-6 linker
 ADC Info 
WO2021044208A1 ADC DG6-7 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC DG6-7 linker
 ADC Info 
WO2021044208A1 ADC D2B12-1 [8]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2021044208A1_ADC D2B12-1 linker
 ADC Info 
Anti-ROR1 mAb huXBR1-402
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuXBR1-402-G5-PNU [9]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Gly5-FITC
 ADC Info 
B2E5-48 antibody H2-L2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
B2E5-ADC [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN119371541A B31-H3L3-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CO20240013452A2 ADC1 (2) [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
KR1020250008730A ADC2 [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
B62-H3L3-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CO20240013452A2 ADC1 [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
KR1020250008730A ADC1 [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Cirmtuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cirmtuzumab vedotin [11]
Monomethyl auristatin E
Microtubule (MT)
Lysine-linker
 ADC Info 
Cirmtuzumab-ADC-7 [12]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
COMP mAb1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2023173132A1 ADC-1 [13]
P9
Undisclosed
IBAC-suC-PEG4
 ADC Info 
WO2023173132A1 ADC-3 [13]
P9
Undisclosed
DIBAC-suC-PEG8
 ADC Info 
WO2023173132A1 ADC-5 [13]
P9
Undisclosed
DIBAC-suC-PEG12
 ADC Info 
WO2023173132A1 ADC-7 [13]
P9
Undisclosed
Undisclosed
 ADC Info 
WO2023173132A1 ADC-16 [13]
P9
Undisclosed
Undisclosed
 ADC Info 
control mAb5
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2023173132A1 ADC-19 [13]
P9
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04-F404-LP33 [2]
PNU EDA
Undisclosed
DBCO-PEG4-AAN
 ADC Info 
ZA202500202A D04-F404-LP32 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4-Gly
 ADC Info 
ZA202500202A D04-F404-LP31 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4 (OH)
 ADC Info 
ZA202500202A D04-F404-LP30 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-PEG4-Gly (NH2)
 ADC Info 
ZA202500202A D04-F404-LP28 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-sidechain PEG12
 ADC Info 
ZA202500202A D04-F404-LP27 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-sidechain PEG12-EDA
 ADC Info 
ZA202500202A D04-F404-LP26 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-PEG4-EDA
 ADC Info 
ZA202500202A D04-F404-LP25 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-PEG4-Gly
 ADC Info 
ZA202500202A D04-F404-LP24 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-PEG4
 ADC Info 
ZA202500202A D04-F404-LP8 1.87 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ZA202500202A D04-F404-LP14 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-PEG-VKG
 ADC Info 
ZA202500202A D04-F404-LP8 1.99 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
D04-Y180/F241/F404/K42
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04-Y180/F241/F404/K42-LP3 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 ADC Info 
ZA202500202A D04-Y180/F241/F404/K42-LP4 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
D04-Y180/F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04-Y180/F404-LP32 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4-Gly
 ADC Info 
ZA202500202A D04-Y180/F404-LP11 [2]
Monomethyl auristatin E
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
ZA202500202A D04-Y180/F404-LP1 [2]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
D04-Y180/F404/K42/E161
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04-Y180/F404/K42/E161-LP34 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP2 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-L-cysteic acid-PEG4-VKG
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP3 8 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP4 (8) [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP7 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nAA-PEG13-VKG
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP5 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAN
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP6 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAA
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP12 [2]
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValLys-pAB
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP13 [2]
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValGlu-pAB
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP1 7.99 [2]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP1 7.95 [2]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP4 (7.52) [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP3 7.46 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 ADC Info 
ZA202500202A D04-Y180/F404/K42/E161-LP4 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
D04-Y180F404/K42/E161
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04-Y180F404/K42/E161-LP23 [2]
SC209
Microtubule (MT)
DBCO-6,4 nnAA-B-Glucuronide-PEG12
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP22 [2]
SC209
Microtubule (MT)
DBCO-nnAA-PEG13-AAN
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP21 [2]
SC209
Microtubule (MT)
DBCO-nnAA-PEG13-VKG
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP20 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,4 nnAA-B-Glucuronide-PEG12
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP14 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-PEG-VKG
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP15 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,6 nnAA-PEG-VKG
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP16 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP17 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-bridged nnAA-PEG-VKG
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP18 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,6 nnAA-B-Glucuronide-PEG12
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP19 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-B-Glucuronide-PEG12
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP1 [2]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
ZA202500202A D04-Y180F404/K42/E161-LP4 [2]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
D04xA05-F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04xA05-F404-LP8 biparatopic [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
D04xB04-F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04xB04-F404-LP8 biparatopic [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
D04xB09-F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04xB09-F404-LP8 biparatopic [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
D04xC01-F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04xC01-F404-LP8 biraratopic [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
D04xD04-F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZA202500202A D04xZA202500202A D04-F404-LP8 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
Hu001-2-MMAE [14]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Hu001-3-MMAE [14]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Hu005-44-MMAE [14]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Hu005-46-MMAE [14]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
HuXBR1-402
 Antibody Info 
ADC Name Payload Target Linker ADC Info
NBE-002
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
LPETG-Gly5-EDA
 ADC Info 
ADC Name Payload Target Linker ADC Info
mAb001c-vc-MMAE [14]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2025500952A ADC-2 [15]
WO2023173026A 8-6
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
Ab-AL2-LP32 [10]
Pro-DHT
Undisclosed
COT-PEG4-EvcPAB
 ADC Info 
Ab-AL2-LP41 [10]
DHT
Undisclosed
Mc-PEG4-VK-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Ab-AL3-LP4 [10]
Pro-DHT
Undisclosed
Tz-PEG4-EvcPAB
 ADC Info 
ADC Name Payload Target Linker ADC Info
Ab-AL4-LP4 [10]
Pro-DHT
Undisclosed
Tz-PEG4-EvcPAB
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2020252015A1 ADCLP-1 [16]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
WO2020252015A1 ADCLP-2 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
WO2020252015A1 ADCLP-3 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-B-Glucuronide-PEG12
 ADC Info 
WO2020252015A1 ADCLP-4 [16]
Gly-Exatecan
Undisclosed
DBCO-nAA-PEG13-VKG
 ADC Info 
WO2020252015A1 ADCLP-5 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAN
 ADC Info 
WO2020252015A1 ADCLP-6 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAA
 ADC Info 
WO2020252015A1 ADCLP-7 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nAA-PEG13-VKG
 ADC Info 
WO2016102679A1 ADCLP-8 [17]
PNU EDA
Undisclosed
DBCO-GGG
 ADC Info 
WO2016102679A1 ADCLP-9 [17]
PBD
Undisclosed
DBCO-PEG4-VA
 ADC Info 
WO2015115091A1 ADCLP-10 [18]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 ADC Info 
WO2020252015A1 ADCLP-11 [16]
Monomethyl auristatin E
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
WO2020252015A1 ADCLP-12 [16]
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValLys-pAB
 ADC Info 
WO2020252015A1 ADCLP-13 [16]
SC209
Microtubule (MT)
DBCO SIDECHAIN PEG12-PAB
 ADC Info 
WO2020252015A1 ADCLP-14 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4nnAA-PEG-VKG
 ADC Info 
WO2020252015A1 ADCLP-15 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,6nnAA-PEG-VKG
 ADC Info 
WO2020252015A1 ADCLP-16 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,4nnAA-PEG-VKG
 ADC Info 
WO2016102679A1 ADCLP-17 [17]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-BridgednnAA-PEG-VKG
 ADC Info 
WO2020252015A1 ADCLP-18 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6.6nnAA-B-Glucuronide-PEG1
 ADC Info 
WO2020252015A1 ADCLP-19 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6.4nnAA-B-Glucuronide-PEG12
 ADC Info 
WO2020252015A1 ADCLP-20 [16]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4.4 nAA-B-Glucuronide-PEG12
 ADC Info 
WO2020252015A1 ADCLP-21 [16]
SC209
Microtubule (MT)
DBCO-nAA-PEG13-VKG
 ADC Info 
WO2020252015A1 ADCLP-22 [16]
SC209
Microtubule (MT)
DBCO-AA-PEG13-AAN
 ADC Info 
WO2020252015A1 ADCLP-23 [16]
SC209
Microtubule (MT)
DBCO-6.4nnAA-B-Glucuronide-PEG12
 ADC Info 
WO2020252015A1 ADCLP-24 [16]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nAA-PEG4
 ADC Info 
WO2020252015A1 ADCLP-25 [16]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nnAA-PEG4-Gly
 ADC Info 
WO2020252015A1 ADCLP-26 [16]
PNU EDA
Undisclosed
DBCO-nAA-PEG4
 ADC Info 
WO2020252015A1 ADCLP-27 [16]
PNU EDA
Undisclosed
DBCO-nAA-sidechain PEG12
 ADC Info 
WO2020252015A1 ADCLP-28 [16]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-nAA-sidechain PEG12
 ADC Info 
WO2020252015A1 ADCLP-29 [16]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-PEG4
 ADC Info 
WO2020252015A1 ADCLP-30 [16]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-PEG4-Gly (OH)
 ADC Info 
WO2020252015A1 ADCLP-31 [16]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4 (OH)
 ADC Info 
WO2020252015A1 ADCLP-32 [16]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
DBCO-L-Cysteic acid-PEG4-Gly
 ADC Info 
WO2020252015A1 ADCLP-33 [16]
PNU EDA
Undisclosed
DBCO-PEG4-AAN
 ADC Info 
ADC Name Payload Target Linker ADC Info
P015004-vc-PAB-MMAE [19]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
P015042-vc-PAB-MMAE [19]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
P015043-vc-PAB-MMAE [19]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
P015044-vc-PAB-MMAE [19]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ROR1 mAb (K149C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ROR1 DAC (K149C) [20]
MZ1
Undisclosed
Maleimide-PEG4-DBCO
 ADC Info 
ROR1 mAb (KLY)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ROR1 DAC (KLY) [20]
MZ1
Undisclosed
Maleimide-PEG4-DBCO
 ADC Info 
ROR1 mAb (KV)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ROR1 DAC (KV) [20]
MZ1
Undisclosed
Maleimide-PEG4-DBCO
 ADC Info 
ROR1 mAb (LY)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ROR1 DAC (LY) [20]
MZ1
Undisclosed
Maleimide-PEG4-DBCO
 ADC Info 
ADC Name Payload Target Linker ADC Info
STRO-003 [21]
Exatecan
DNA topoisomerase 1 (TOP1)
SC3417
 ADC Info 
ADC Name Payload Target Linker ADC Info
UC961-vc-PAB-MMAE [19]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
UC961-MMAE [14]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Zilovertamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Zilovertamab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Site-sepcific ADC 1 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 2 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 3 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 4 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 5 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 6 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 7 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 8 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 9 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 10 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 11 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Site-sepcific ADC 12 [22]
Monomethyl auristatin E
Microtubule (MT)
TE-VC-PAB
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HDM-2005
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-ROR1 antibody scFv conjugate (Oncternal) [23]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ELN-11 [24]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ABL-202 [25]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
AMB303 [26]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A 2188-D04-Yl80/F404-LP1 [27]
SC209
Microtubule (MT)
DBCO-Val-Cit-PABC
 ADC Info 
IN202417103159A 2188-D04-Yl80/F404/K42-LP1 [27]
SC209
Microtubule (MT)
DBCO-Val-Cit-PABC
 ADC Info 
IN202417103159A 2188-D04-Yl80/F404/K42/E161-LP1 [27]
SC209
Microtubule (MT)
DBCO-Val-Cit-PABC
 ADC Info 
IN202417103159A 2188-D04-F404-LP8 [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A 2188-D04-Yl80-LP9 [27]
PBD
Deoxyribonucleic acid (DNA)
Undisclosed
 ADC Info 
IN202417103159A 2188-IN202417103159A D04-Yl80/F404-LP10 [27]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 ADC Info 
IN202417103159A 2188-IN202417103159A D04-Yl80/F404/K42/E161 LP10 [27]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP2 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-L-cysteic acid-PEG4-VKG
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP3 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP4 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP7 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nAA-PEG13-VKG
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP5 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAN
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP6 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-AAA
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP12 [27]
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValLys-pAB
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP13 [27]
SC209
Microtubule (MT)
DBCO sidechain PEG12 ValGlu-pAB
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP1 [27]
SC209
Microtubule (MT)
Undisclosed
 ADC Info 
IN202417103159A D04-Y180/F404/K42/E161-LP34 [27]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04-Yl80/F404/K42/E161-LP1 [27]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
IN202417103159A D04-Yl80/F404/K42/E161-LP4 7.52 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
IN202417103159A D04-Yl80/F404-LP11 [27]
Monomethyl auristatin E
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
IN202417103159A D04-Yl80/F404-LP1 [27]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
IN202417103159A D04-Yl80/F404-LP32 [27]
PNU EDA
Undisclosed
DBCO-L-Cysteic acid-PEG4-Gly
 ADC Info 
IN202417103159A D04-F404-LP8 [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04-F404-LP32 [27]
PNU EDA
Undisclosed
DBCO-L-Cysteic acid-PEG4-Gly
 ADC Info 
IN202417103159A D04-F404-LP30 [27]
PNU EDA
Undisclosed
DBCO-PEG4-Gly (OH)
 ADC Info 
IN202417103159A D04-F404-LP31 [27]
PNU EDA
Undisclosed
DBCO-L-Cysteic acid-PEG4 (OH)
 ADC Info 
IN202417103159A D04-F404-LP14 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-PEG-VKG
 ADC Info 
IN202417103159A D04 x IN202417103159A D04-F404-LP8 [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04 x C01-F404-LP8 biparatopic [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04 x B09-F404- LP8 biparatopic [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04 x A05-F404- LP8 biparatopic [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04 x B04-F404- LP8 biparatopic [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A A05 x B04-F404- LP8 biparatopic [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A A05 x C06-F404- LP8 biparatopic [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP14 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-6,4 nnAA-PEG-VKG
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161- LP15 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-4,6 nnAA-PEG-VKG
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP16 [27]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP17 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-bridged nnAA-PEG-VKG
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP18 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP19 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP20 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
IN202417103159A D04-F404-LP33 [27]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP23 [27]
SC209
Microtubule (MT)
Undisclosed
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP22 [27]
SC209
Microtubule (MT)
DBCO-nnAA-PEG13-AAN
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP21 [27]
PNU EDA
Undisclosed
DBCO-nnAA-PEG13-VKG
 ADC Info 
IN202417103159A D04-F404-LP24 [27]
PNU EDA
Undisclosed
DBCO-nnAA-PEG4
 ADC Info 
IN202417103159A D04-F404-LP25 [27]
PNU EDA
Undisclosed
DBCO-nnAA-PEG4-Gly
 ADC Info 
IN202417103159A D04-F404-LP26 [27]
PNU EDA
Undisclosed
DBCO-nnAA-PEG4-EDA
 ADC Info 
IN202417103159A D04-F404-LP27 [27]
PNU EDA
Undisclosed
DBCO-nnAA-sidechain PEG12-EDA
 ADC Info 
IN202417103159A D04-F404-LP28 [27]
PNU EDA
Undisclosed
DBCO-nnAA-sidechain PEG12
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP1 [27]
SC209
Microtubule (MT)
DBCO-SO3-PEG4-Val-Cit-PABC
 ADC Info 
IN202417103159A D04-Yl80F404/K42/E161-LP4 [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04-F404- LP8 [27]
PNU EDA
Undisclosed
Undisclosed
 ADC Info 
IN202417103159A D04-Yl80/F241/F404/K42-LP3 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 ADC Info 
IN202417103159A D04-Yl80/F404/K42/E161-LP3 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 ADC Info 
IN202417103159A D04-Yl80/F241/F404/K42-LP4 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
IN202417103159A D04-Yl80/F404/K42/E161-LP4 8 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
IN202417103159A aGFP-Y180/F241/F404/K42-LP3 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-beta-Glucuronide-PEG12
 ADC Info 
IN202417103159A aGFP-Y180/F241/F404/K42-LP4 [27]
Exatecan
DNA topoisomerase 1 (TOP1)
DBCO-nnAA-PEG13-VKG
 ADC Info 
Anti-pTalpha-DM1-ADC [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-pTalpha-MMAE-ADC [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-030-LT [10]
L078-030 payload
Undisclosed
WO2023173026A1-ADC-L078-030-LT-Linker
 ADC Info 
WO2023173026A1 ADC-L078-045 [10]
L078-043 payload
Undisclosed
Mal-PEG4-Val-Cit-PABC
 ADC Info 
WO2023173026A1 ADC-L078-044 [10]
L078-042 payload
Undisclosed
Mal-PEG4-Val-Cit-PABC
 ADC Info 
WO2023173026A1 ADC-L078-055 [10]
L078-047 payload
Undisclosed
WO2023173026A1-ADC-L078-055-Linker
 ADC Info 
WO2023173026A1 ADC-L078-056 [10]
L078-048 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-058 [10]
L078-046 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-081-LT [10]
L078-081 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-059 [10]
L078-049 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-057 [10]
L078-051 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-063 [10]
L078-042 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-064 [10]
L078-043 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-062 [10]
L078-030 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-065-LT [10]
L078-065 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-066-LT [10]
L078-066 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-084 [10]
L078-048 payload
Undisclosed
WO2023173026A1-ADC-L078-084-Linker
 ADC Info 
WO2023173026A1 ADC-L078-079 [10]
L078-030 payload
Undisclosed
WO2023173026A1-ADC-L078-079-Linker
 ADC Info 
WO2023173026A1 ADC-L078-078 [10]
L078-048 payload
Undisclosed
WO2023173026A1-ADC-L078-079-Linker
 ADC Info 
WO2023173026A1 ADC-L078-090 [10]
L078-088 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-091 [10]
L078-089 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-092 [10]
L078-049 payload
Undisclosed
WO2023173026A1-ADC-L078-092-Linker
 ADC Info 
WO2023173026A1 ADC-L078-093 [10]
L078-048 payload
Undisclosed
WO2023173026A1-ADC-L078-093-Linker
 ADC Info 
WO2023173026A1 ADC-L079-018 [10]
L078-029 payload
Undisclosed
WO2023173026A1-ADC-L079-018-Linker
 ADC Info 
WO2023173026A1 ADC-L079-019 [10]
WO2023173026A 47
Undisclosed
WO2023173026A1-ADC-L079-019-Linker
 ADC Info 
WO2023173026A1 ADC-L078-171 [10]
WO2023173026A 5
Undisclosed
WO2023173026A1-ADC-L078-171-Linker
 ADC Info 
WO2023173026A1 ADC-L078-173 [10]
WO2023173026A 5
Undisclosed
WO2023173026A1-ADC-L078-173-Linker
 ADC Info 
WO2023173026A1 ADC-L079-027 [10]
WO2023173026A 47
Undisclosed
WO2023173026A1-ADC-L079-027-Linker
 ADC Info 
WO2023173026A1 ADC-L079-035 [10]
WO2023173026A 67
Undisclosed
WO2023173026A1-ADC-L079-035-Linker
 ADC Info 
WO2023173026A1 ADC-L079-034 [10]
WO2023173026A 63
Undisclosed
Mal-PEG4-Val-Cit-PABC
 ADC Info 
WO2023173026A1 ADC-L079-040 [10]
WO2023173026A 61
Undisclosed
WO2023173026A1-ADC-L079-040-Linker
 ADC Info 
WO2023173026A1 ADC-L078-121 [10]
L078-030 payload
Undisclosed
WO2023173026A1-ADC-L078-121-Linker
 ADC Info 
WO2023173026A1 ADC-L078-118 [10]
L078-088 payload
Undisclosed
WO2023173026A1-ADC-L078-118-Linker
 ADC Info 
WO2023173026A1 ADC-L078-119 [10]
L078-042 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 ADC Info 
WO2023173026A1 ADC-L078-120 [10]
L078-048 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 ADC Info 
WO2023173026A1 ADC-L078-177 [10]
L078-088 payload
Undisclosed
WO2023173026A1-ADC-L078-117-Linker
 ADC Info 
WO2023173026A1 ADC-L078-130 [10]
L078-042 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 ADC Info 
WO2023173026A1 ADC-L078-123 [10]
L078-047 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 ADC Info 
WO2023173026A1 ADC-L078-139 [10]
L078-042 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 ADC Info 
WO2023173026A1 ADC-L078-163 [10]
L078-149 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 ADC Info 
WO2023173026A1 ADC-L078-164 [10]
L078-150 payload
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 ADC Info 
WO2023173026A1 ADC-L078-170 [10]
L078-089 payload
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L078-162 [10]
WO2023173026A 5
Undisclosed
WO2023173026A1-ADC-L078-119-Linker
 ADC Info 
WO2023173026A1 ADC-L078-178 [10]
L078-030 payload
Undisclosed
WO2023173026A1-ADC-L078-117-Linker
 ADC Info 
WO2023173026A1 ADC-L078-182 [10]
L078-088 payload
Undisclosed
WO2023173026A1-ADC-L078-117-Linker
 ADC Info 
WO2023173026A1 ADC-L078-184 [10]
WO2023173026A 130
Undisclosed
Undisclosed
 ADC Info 
WO2023173026A1 ADC-L081-034 [10]
WO2023173026A 130
Undisclosed
WO2023173026A1-ADC-L081-034-Linker
 ADC Info 
WO2023173026A1 ADC-L081-036 [10]
WO2023173026A 130
Undisclosed
WO2023173026A1-ADC-L081-036-Linker
 ADC Info 
WO2023173026A1 ADC-L081-038 [10]
WO2023173026A 94
Undisclosed
WO2023173026A1-ADC-L081-038-Linker
 ADC Info 
WO2023173026A1 ADC-L081-045 [10]
WO2023173026A 94
Undisclosed
WO2023173026A1-ADC-L081-034-Linker
 ADC Info 
JP2025500952A ADC-1 [15]
WO2023173026A 8-6
Undisclosed
JP2025500952A-ADC-1-Linker
 ADC Info 
WO2023173132A1 ADC-8 [13]
P9
Undisclosed
Undisclosed
 ADC Info 
WO2023173132A1 ADC-9 [13]
P9
Undisclosed
Undisclosed
 ADC Info 
WO2023173132A1ADC-10 [13]
P9
Undisclosed
Undisclosed
 ADC Info 
WO2023173132A1 ADC-11 [13]
P9
Undisclosed
Undisclosed
 ADC Info 
WO2023173132A1 ADC-17 [13]
P9
Undisclosed
Undisclosed
 ADC Info 
WO2023173132A1 ADC-18 [13]
P9
Undisclosed
Undisclosed
 ADC Info 
WO2023173132A1 ADC-20 [13]
P8 Payload
Undisclosed
BCN-PEG4-triazole
 ADC Info 
WO2023173132A1 ADC-21 [13]
P8 Payload
Undisclosed
NH2-PEG8-triazole
 ADC Info 
References
Ref 1 Antibody drug conjugate, and preparation method therefor and use thereof; 2022-12-08.
Ref 2 Anti-ROR1 antibodies and antibody conjugates, compositions comprising Anti-ROR1 antibodies or antibody conjugates, and methods of making and using Anti-ROR1 antibodies and antibody conjugates
Ref 3 Binding molecules targeting ROR1 and uses thereof
Ref 4 Binding molecule directed to ror1 and its use
Ref 5 Ror1-targeted binding molecules and their Applications
Ref 6 Tyrosine-protein kinase membrane receptor 1 (ROR1) antibody-drug conjugates and uses thereof
Ref 7 Translational medicine studies of BR111, a biparatopic anti-ROR1 antibody drug conjugate for hematological and solid tumor treatment
Ref 8 Antibody-drug conjugate comprising antibody against human ror1, and use for the same; 2021-04-01.
Ref 9 The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia. Blood Adv. 2021 Aug 24;5(16):3152-3162.
Ref 10 Antibody-drug conjugates and uses thereof
Ref 11 Cirmtuzumab Vedotin (UC-961ADC3), An Anti-ROR1-Monomethyl Auristatin E Antibody-Drug Conjugate, Is a Potential Treatment For ROR1-Positive Leukemia and Solid Tumors. Blood (2013) 122 (21): 1637.
Ref 12 Development of Cirmtuzumab Antibody-Drug Conjugates (ADCs) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1). Blood. 2018 ;132():-. doi: 10.1182/blood-2018-99-119447.
Ref 13 Anti-GLP1R antibody-drug conjugates comprising GLP-1 peptidomimetics and uses thereof
Ref 14 Antibodies specifically binding ROR1, their drug conjugates, preparation methods and uses
Ref 15 Anti-DLL3 antibodies, antibody-drug complexes and medical uses thereof
Ref 16 Immunomodulator antibody drug conjugates and uses thereof
Ref 17 Binding protein drug conjugates comprising anthracycline derivatives; 2016-06-30.
Ref 18 Anti-HER2 antibody-drug conjugate
Ref 19 Anti-ror1 antibodies and their uses
Ref 20 A novel ROR1-targeting antibody-PROTAC conjugate promotes BRD4 degradation for solid tumor treatment
Ref 21 STRO-003 is a novel ROR1-targeted ADC for breast and lung cancer. Journal for ImmunoTherapy of Cancer 2022;10:doi: 10.1136/jitc-2022-SITC2022.1191.
Ref 22 Direct Preparation of Site-Specific Antibody-Drug Conjugates with Unpurified Antibodies in Culture Medium
Ref 23 ROR1: an orphan becomes apparent. Blood. 2022 Oct 6;140(14):1583-1591. doi: 10.1182/blood.2021014760.
Ref 24 Introduction to basic information on ADC drug ELN 11- Almac Discovery/Elasmogen.
Ref 25 Introduction to basic information on ADC drug ABL-202
Ref 26 AMB303: A novel topo I payload ADC showing efficacy in NSCLC and TNBC, with potential for immune checkpoint combination therapy
Ref 27 Anti-ROR1 antibodies and antibody conjugates, compositions comprising Anti-ROR1 antibodies or antibody conjugates, and methods of making and using Anti-ROR1 antibodies and antibody conjugates