Antibody Information

General Information of This Antibody

Antibody ID	ANI0YUFWB
Antibody Name	Anti-ROR1 mAb huXBR1-402
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG
Antigen Name	Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

HuXBR1-402-G5-PNU [Clinical candidate]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	1.27 ng/mL	Positive ROR1 expression (ROR1+++/++)
Method Description	Cell lines obtained from ATCC were serum starved for 16 hours and reintroduced to full serum media supplemented huXBR1-402-G5-PNU for 72 hours. Viability was measured by using MTS assays, and relative light unit (RLU) values for each dose were generated after 72 hours of treatment in 2 independent experiments.
In Vitro Model	Childhood B acute lymphoblastic leukemia	Kasumi-2 cells		CVCL_0590
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	75.68 ng/mL	Positive ROR1 expression (ROR1+++/++)
Method Description	Cell lines obtained from ATCC were serum starved for 16 hours and reintroduced to full serum media supplemented huXBR1-402-G5-PNU for 72 hours. Viability was measured by using MTS assays, and relative light unit (RLU) values for each dose were generated after 72 hours of treatment in 2 independent experiments.
In Vitro Model	Childhood B acute lymphoblastic leukemia	697 cells		CVCL_0079

References

Ref 1	The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia. Blood Adv. 2021 Aug 24;5(16):3152-3162.

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