Antigen ID	TAR0LCGUX
Antigen Name	V-set domain-containing T-cell activation inhibitor 1 (VTCN1)
Gene Name	VTCN1
Gene ID	79679
Synonym	B7 homolog 4;B7h.5;Immune costimulatory protein B7-H4;Protein B7S1;T-cell costimulatory molecule B7x
Sequence	MASLGQILFWSIISIIIILAGAIALIIGFGISGRHSITVTTVASAGNIGEDGILSCTFEP DIKLSDIVIQWLKEGVLGLVHEFKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNV QLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVV WASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKV TESEIKRRSHLQLLNSKASLCVSSFFAISWALLPLSPYLMLK     Click to Show/Hide
Family	HIV-1 env protein family
Function	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.     Click to Show/Hide
Uniprot Entry	VTCN1_HUMAN
HGNC ID	HGNC:28873
KEGG ID	hsa:79679

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	LNCB74	MMAE	Microtubule (MT)	β-glucuronide linker

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	BG-C9074	TOP1 inhibitor	DNA topoisomerase 1 (TOP1)	A cleavable linker
ADC Info	MHB009C	MH30010008	DNA topoisomerase 1 (TOP1)	Undisclosed	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	JP2024501894A5-11	Undisclosed	Undisclosed	Undisclosed	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	JP2024501894A5-5	Undisclosed	Undisclosed	Undisclosed	[2]
ADC Info	JP2024501894A5-6	Undisclosed	Undisclosed	Undisclosed	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	JP2024501894A5-7	Undisclosed	Undisclosed	Undisclosed	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	JP2024501894A5-20	Undisclosed	Undisclosed	Undisclosed	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Emiltatug ledadotin	AF-HPA	Microtubule (MT)	A cleavable ester linker

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Felmetatug vedotin	MMAE	Microtubule (MT)	Mc-Val-Cit-PABC

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Mocertatug rezetecan	SHR9265	DNA topoisomerase 1 (TOP1)	Mc-Gly-Gly-Phe-Gly

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CN112341521B+ADC-1	Undisclosed	Undisclosed	Undisclosed	[3]
ADC Info	CN112341521B+ADC-2	Undisclosed	Undisclosed	Undisclosed	[3]
ADC Info	CN112341521B+ADC-3	Camptothecin	DNA topoisomerase 1 (TOP1)	CN112341521B+Linker3	[3]
ADC Info	CN112341521B+ADC-4	Camptothecin	DNA topoisomerase 1 (TOP1)	Undisclosed	[3]
ADC Info	CN112341521B+ADC-5	Topo1 inhibitor D	DNA topoisomerase I (TOP1)	CN112341521B+Linker3	[3]
ADC Info	CN112341521B+ADC-6	Topo1 inhibitor D	DNA topoisomerase I (TOP1)	Undisclosed	[3]
ADC Info	CN112341521B+ADC-7	Topo1 inhibitor D	DNA topoisomerase I (TOP1)	Undisclosed	[3]
ADC Info	CN112341521B+ADC-8	Undisclosed	Undisclosed	Undisclosed	[3]
ADC Info	CN112341521B+ADC-9	Undisclosed	Undisclosed	Undisclosed	[3]
ADC Info	CN112341521B+ADC-10	Undisclosed	Undisclosed	CN112341521B+Linker10	[3]
ADC Info	CN112341521B+ADC-11	CN112341521B+Payload11	DNA topoisomerase I (TOP1)	CN112341521B+Linker11	[3]
ADC Info	CN112341521B+ADC-12	CN112341521B+Payload11	DNA topoisomerase I (TOP1)	CN112341521B+Linker12	[3]
ADC Info	CN112341521B+ADC-13	Undisclosed	Undisclosed	CN112341521B+Linker12	[3]
ADC Info	CN112341521B+ADC-14	Undisclosed	Undisclosed	CN112341521B+Linker12	[3]
ADC Info	CN112341521B+ADC-15	Undisclosed	Undisclosed	CN112341521B+Linker11	[3]
ADC Info	CN112341521B+ADC-16	Undisclosed	Undisclosed	CN112341521B+Linker11	[3]
ADC Info	CN112341521B+ADC-17	Undisclosed	Undisclosed	CN112341521B+Linker10	[3]
ADC Info	CN112341521B+ADC-18	Undisclosed	Undisclosed	CN112341521B+Linker11	[3]
ADC Info	CN112341521B+ADC-19	Undisclosed	Undisclosed	Undisclosed	[3]
ADC Info	CN112341521B+ADC-20	Undisclosed	Undisclosed	CN112341521B+Linker20	[3]
ADC Info	CN112341521B+ADC-21	Undisclosed	Undisclosed	CN112341521B+Linker20	[3]
ADC Info	CN112341521B+ADC-22	Undisclosed	Undisclosed	CN112341521B+Linker22	[3]
ADC Info	CN112341521B+ADC-23	Undisclosed	Undisclosed	CN112341521B+Linker22	[3]
ADC Info	CN112341521B+ADC-24	Undisclosed	Undisclosed	CN112341521B+Linker24	[3]
ADC Info	CN112341521B+ADC-25	Undisclosed	Undisclosed	Undisclosed	[3]
ADC Info	CN112341521B+ADC-26	Undisclosed	Undisclosed	CN112341521B+Linker26	[3]
ADC Info	CN112341521B+ADC-27	Undisclosed	Undisclosed	CN112341521B+Linker22	[3]
ADC Info	CN112341521B+ADC-28	Undisclosed	Undisclosed	CN112341521B+Linker24	[3]
ADC Info	CN112341521B+ADC-29	Undisclosed	Undisclosed	CN112341521B+Linker26	[3]
ADC Info	CN112341521B+ADC-30	CN112341521B+Payload30	Undisclosed	CN112341521B+Linker26	[3]
ADC Info	CN112341521B+ADC-31	CN112341521B+Payload30	Undisclosed	CN112341521B+Linker31	[3]
ADC Info	CN112341521B+ADC-32	Undisclosed	Undisclosed	CN112341521B+Linker31	[3]
ADC Info	CN112341521B+ADC-33	Undisclosed	Undisclosed	Undisclosed	[3]
ADC Info	CN112341521B+ADC-34	Undisclosed	Undisclosed	CN112341521B+Linker10	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Puxitatug samrotecan	AZ14170132 (AZ0132)	DNA topoisomerase 1 (TOP1)	Mal-PEG8-Val-Ala

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CN118436801A PAC 2	undisclosed	Undisclosed	Mc-Val-Cit-PABC	[4]
ADC Info	CN118436801A PAC 4	undisclosed	Undisclosed	Mc-Val-Cit-PABC	[4]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	JP2024501894A5-3	Undisclosed	Undisclosed	Undisclosed	[2]
ADC Info	JP2024501894A5-4	Undisclosed	Undisclosed	Undisclosed	[2]
ADC Info	JP2024501894A5-13	Undisclosed	Undisclosed	Undisclosed	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	JP2024501894A5-2	Undisclosed	Undisclosed	Undisclosed	[2]
ADC Info	JP2024501894A5-12	Undisclosed	Undisclosed	Undisclosed	[2]
ADC Info	JP2024501894A5-15	Undisclosed	Undisclosed	Undisclosed	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	BA-3151	Undisclosed	Undisclosed	Undisclosed	[5]

Ref 1	Preclinical development of MHB009C: A novel anti-B7-H4 ADC with a potent topoisomerase I inhibitor
Ref 2	B7h4 targeting antibody-drug conjugate and its use
Ref 3	Small-molecule active compounds and their antibody conjugates, preparation methods and medical uses
Ref 4	PROTAC antibody conjugates and methods of use
Ref 5	Bioatla biotechnology company announcement; 2021