Antigen Information

General Information of This Antigen (ID: TAR0LCGUX)
Antigen Name
V-set domain-containing T-cell activation inhibitor 1 (VTCN1)
Gene Name
VTCN1
Gene ID
79679
Synonym
B7 homolog 4;B7h.5;Immune costimulatory protein B7-H4;Protein B7S1;T-cell costimulatory molecule B7x
Sequence
MASLGQILFWSIISIIIILAGAIALIIGFGISGRHSITVTTVASAGNIGEDGILSCTFEP
DIKLSDIVIQWLKEGVLGLVHEFKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNV
QLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVV
WASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKV
TESEIKRRSHLQLLNSKASLCVSSFFAISWALLPLSPYLMLK

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Family
HIV-1 env protein family
Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

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Uniprot Entry
VTCN1_HUMAN
HGNC ID
HGNC:28873
KEGG ID
hsa:79679
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-B7-H4 IgG1k mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LNCB74
Monomethyl auristatin E
Microtubule (MT)
β-glucuronide linker
 ADC Info 
Anti-B7H4 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BG-C9074
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
MHB009C [1]
MH30010008
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
B7-H4 2F9
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP2024501894A5-11 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
B7-H4 2F9V11 (K+)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP2024501894A5-5 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2024501894A5-6 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
B7-H4 2F9V17 (K+)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP2024501894A5-7 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
B7-H4 2F9V18
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP2024501894A5-20 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Emiltatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Emiltatug ledadotin
AF-HPA
Microtubule (MT)
A cleavable ester linker
 ADC Info 
Felmetatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Felmetatug vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Mocertatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Mocertatug rezetecan
SHR9265
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Nimotuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN112341521B+ADC-1 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN112341521B+ADC-2 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN112341521B+ADC-3 [3]
Camptothecin
DNA topoisomerase 1 (TOP1)
CN112341521B+Linker3
 ADC Info 
CN112341521B+ADC-4 [3]
Camptothecin
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
CN112341521B+ADC-5 [3]
Topo1 inhibitor D
DNA topoisomerase I (TOP1)
CN112341521B+Linker3
 ADC Info 
CN112341521B+ADC-6 [3]
Topo1 inhibitor D
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
CN112341521B+ADC-7 [3]
Topo1 inhibitor D
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
CN112341521B+ADC-8 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN112341521B+ADC-9 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN112341521B+ADC-10 [3]
Undisclosed
Undisclosed
CN112341521B+Linker10
 ADC Info 
CN112341521B+ADC-11 [3]
CN112341521B+Payload11
DNA topoisomerase I (TOP1)
CN112341521B+Linker11
 ADC Info 
CN112341521B+ADC-12 [3]
CN112341521B+Payload11
DNA topoisomerase I (TOP1)
CN112341521B+Linker12
 ADC Info 
CN112341521B+ADC-13 [3]
Undisclosed
Undisclosed
CN112341521B+Linker12
 ADC Info 
CN112341521B+ADC-14 [3]
Undisclosed
Undisclosed
CN112341521B+Linker12
 ADC Info 
CN112341521B+ADC-15 [3]
Undisclosed
Undisclosed
CN112341521B+Linker11
 ADC Info 
CN112341521B+ADC-16 [3]
Undisclosed
Undisclosed
CN112341521B+Linker11
 ADC Info 
CN112341521B+ADC-17 [3]
Undisclosed
Undisclosed
CN112341521B+Linker10
 ADC Info 
CN112341521B+ADC-18 [3]
Undisclosed
Undisclosed
CN112341521B+Linker11
 ADC Info 
CN112341521B+ADC-19 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN112341521B+ADC-20 [3]
Undisclosed
Undisclosed
CN112341521B+Linker20
 ADC Info 
CN112341521B+ADC-21 [3]
Undisclosed
Undisclosed
CN112341521B+Linker20
 ADC Info 
CN112341521B+ADC-22 [3]
Undisclosed
Undisclosed
CN112341521B+Linker22
 ADC Info 
CN112341521B+ADC-23 [3]
Undisclosed
Undisclosed
CN112341521B+Linker22
 ADC Info 
CN112341521B+ADC-24 [3]
Undisclosed
Undisclosed
CN112341521B+Linker24
 ADC Info 
CN112341521B+ADC-25 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN112341521B+ADC-26 [3]
Undisclosed
Undisclosed
CN112341521B+Linker26
 ADC Info 
CN112341521B+ADC-27 [3]
Undisclosed
Undisclosed
CN112341521B+Linker22
 ADC Info 
CN112341521B+ADC-28 [3]
Undisclosed
Undisclosed
CN112341521B+Linker24
 ADC Info 
CN112341521B+ADC-29 [3]
Undisclosed
Undisclosed
CN112341521B+Linker26
 ADC Info 
CN112341521B+ADC-30 [3]
CN112341521B+Payload30
Undisclosed
CN112341521B+Linker26
 ADC Info 
CN112341521B+ADC-31 [3]
CN112341521B+Payload30
Undisclosed
CN112341521B+Linker31
 ADC Info 
CN112341521B+ADC-32 [3]
Undisclosed
Undisclosed
CN112341521B+Linker31
 ADC Info 
CN112341521B+ADC-33 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN112341521B+ADC-34 [3]
Undisclosed
Undisclosed
CN112341521B+Linker10
 ADC Info 
Puxitatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Puxitatug samrotecan
AZ14170132 (AZ0132)
DNA topoisomerase 1 (TOP1)
Mal-PEG8-Val-Ala
 ADC Info 
Thio Hu Anti-B7-H4 1D11v1.9_VarD LC K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN118436801A PAC 2 [4]
undisclosed
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
CN118436801A PAC 4 [4]
undisclosed
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
XMT-1603 (B7-H4 2F9V7)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP2024501894A5-3 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2024501894A5-4 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2024501894A5-13 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
XMT-1604 (B7-H4 2F9V18)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP2024501894A5-2 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2024501894A5-12 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP2024501894A5-15 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BA-3151 [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Preclinical development of MHB009C: A novel anti-B7-H4 ADC with a potent topoisomerase I inhibitor
Ref 2 B7h4 targeting antibody-drug conjugate and its use
Ref 3 Small-molecule active compounds and their antibody conjugates, preparation methods and medical uses
Ref 4 PROTAC antibody conjugates and methods of use
Ref 5 Bioatla biotechnology company announcement; 2021