Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0FPQOM
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| ADC Name |
Emiltatug ledadotin
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| Synonyms |
emiltatug ledadotin; XMT-1660; Emi-Le
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| Organization |
Mersana Therapeutics (Originator)
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| Drug Status |
Phase 1
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| Drug-to-Antibody Ratio |
6
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| Structure |
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| Antibody Name |
Emiltatug
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Antibody Info | ||||
| Antigen Name |
V-set domain-containing T-cell activation inhibitor 1 (VTCN1)
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Antigen Info | ||||
| Payload Name |
AF-HPA
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
A cleavable ester linker
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Linker Info | ||||
| Conjugate Type |
Enzymatic Catalysis
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| Combination Type |
ledadotin
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The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
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| Breast cancer |
1 Trials
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| Endometrial cancer |
1 Trials
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| Fallopian tube cancer |
1 Trials
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| Ovarian cancer |
1 Trials
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| Peritoneal cancer |
1 Trials
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| Unspecific solid tumor |
1 Trials
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Patients Enrolled |
Eligible patients (ECOG 0-1) have recurrent/advanced solid tumors (measurable per RECIST 1.1) and available tumor tissue. Key exclusions: prior auristatin-ADC treatment, untreated CNS metastases, active liver disease (cirrhosis/varices), uncontrolled systemic illness, or recent anticancer therapy/surgery (within specified washout periods). Brain MRI is required for TNBC or symptomatic/metastatic CNS history.
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| Administration Dosage |
XMT-1660 will be administered through a vein in your arm or port catheter (intravenously)
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| Related Clinical Trial | |||||
| NCT Number | NCT05377996 | Clinical Status | PHASE1 | ||
| Clinical Description | A Phase 1, First-in-human, Dose Escalation and Expansion, Multicenter Study of XMT-1660 in Participants With Solid Tumors | ||||
| Primary Endpoint |
The Phase 1 study evaluates DLTs within the first treatment cycle (17 months) to establish MTD/RP2D for XMT-1660, with safety/tolerability assessed via AEs over 3 years. Phase 2 expansion measures ORR per RECIST 1.1 (investigator-assessed CR/PR rates).
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| Other Endpoint |
Secondary endpoints include ORR (dose escalation), DOR (time to progression/death), and comprehensive PK analysis (Tmax, Cmax, AUC, clearance, half-life, volume of distribution, Ctrough) over 3 years. Immunogenicity (ADA/nAb development) is monitored throughout both phases.
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