Antigen Information
General Information of This Antigen (ID: TAR0FPXYP)
| Antigen Name | Undisclosed |
|||||
|---|---|---|---|---|---|---|
| Gene Name | Undisclosed |
|||||
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
14B6
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-04
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
14C4
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-05
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-14
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
17C2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-06
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
1D11
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
JP2024501894A5-8
[2]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP2024501894A5-16
[2]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP2024501894A5-18
[2]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP2024501894A5-19
[2]
|
Undisclosed |
Undisclosed |
Undisclosed |
23C2 Her2-2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
EP4183421A1 23C2 Her2-2-DXD
[3]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
EP4183421A1+Trastuzumab-DXD+Linker |
|
|
EP4183421A1 23C2 Her2-2-DDDXD
[3]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
EP4183421A1+Trastuzumab-DDDXD+Linker |
|
|
CN114569739A 23C2 Her2-2-DXD
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN114569739A ADC-1 (23C2 Her2-2)
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN114569739A ADC-2 (23C2 Her2-2)
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN114569739A ADC-3 (23C2 Her2-2)
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN114569739A ADC-4 (23C2 Her2-2)
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN114569739A ADC-5 (23C2 Her2-2)
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN114569739A ADC-6 (23C2 Her2-2)
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN114569739A ADC-7 (23C2 Her2-2)
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN114569739A ADC-8 (23C2 Her2-2)
[4]
|
Undisclosed |
Undisclosed |
Undisclosed |
345A12-14AAS
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
CN119630431A ADC-9
[5]
|
CN119630431A-ADC-1-PAYLOAD |
Undisclosed |
Undisclosed |
|
|
CN119630431A ADC-10
[5]
|
CN119630431A-ADC-1-PAYLOAD |
Undisclosed |
CN119630431A-ADC-3-LINKER |
|
|
CN119630431A ADC-11
[5]
|
CN119630431A-ADC-1-PAYLOAD |
Undisclosed |
CN119630431A-ADC-5-LINKER |
45-2D9
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Monoclonal antibody 45-2D9-haematoporphyrin conjugate
[6]
|
Hematoporphyrin |
Undisclosed |
Undisclosed |
5A8
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-01
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
7B12
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-02
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-12
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
7D12-fGly
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
39138197 7D12-fGly MNB-Pyra
[7]
|
MNB-Pyra |
Undisclosed |
Undisclosed |
9D10
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-03
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-13
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-20
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-22
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-24
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
a therapeutic human IgG4 mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
40037092 ADC-1
[8]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
40037092 ADC-2
[8]
|
Undisclosed |
Undisclosed |
Undisclosed |
Ab-2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
39757732 ADC1
[9]
|
Monomethyl auristatin E |
Microtubule (MT) |
D1 Linker |
|
|
39757732 ADC2
[9]
|
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
D2 Linker |
|
|
39757732 ADC3
[9]
|
Monomethyl auristatin E |
Microtubule (MT) |
D3 Linker |
|
|
39757732 ADC4
[9]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
D4 Linker |
ABT-700
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-10
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-18 (ABBV-399
analogue)
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
AHK
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AHK-PABC-Exa
[10]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mc-Val-Cit-PABC |
Anti-B-cell mAb SN7
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Monoclonal antibody SN7-ricin chain A conjugate
[11]
|
Deglycosylated ricin A-chain (dgA) |
Undisclosed |
Undisclosed |
Anti-mAb303
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
TW202444426A ADC-301
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-043-A
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-043-B
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-302
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-045-A
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-046-B
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-303
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
Anti-mAb304
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
TW202444426A ADC-031
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-310-A
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-311-B
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-032
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-312-A
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-313-B
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-033
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-034
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
Anti-mAb305
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
TW202444426A ADC-027
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-028
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-304
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-305-A
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-306-B
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-307
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-308-A
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202444426A ADC-309-B
[12]
|
Undisclosed |
Undisclosed |
Undisclosed |
anti-mPD-L1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AU2020291014A1 IC-46
[13]
|
AU2020291014A1-Payload-35 |
Undisclosed |
Undisclosed |
Anti-TPP-5442
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
US12144865B2 31t-4
[14]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12144865B2 34t-4
[14]
|
Undisclosed |
Undisclosed |
Undisclosed |
Anti-TPP-7511
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
US12144865B2 34te-4
[14]
|
Undisclosed |
Undisclosed |
Undisclosed |
ARKRA
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
ARKRA-PABC-MMAE
[10]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Azido Modified XMT-1604
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
JP2024501894A5-1
[2]
|
Undisclosed |
Undisclosed |
Undisclosed |
B12
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-11
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-19
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20230285580A1 B12-B1
[15]
|
B4 Payload |
Deoxyribonucleic acid (DNA) |
US20230285580A1 B12-B2 linker |
|
|
US20230285580A1 B12-B2
[15]
|
US20230285580A1 B12-B3 payload |
Undisclosed |
US20230285580A1 B12-B2 linker |
|
|
US20230285580A1 B12-B3
[15]
|
US20230285580A1 B12-B3 payload |
Undisclosed |
US20230285580A1 B12-B6 linker |
|
|
US20230285580A1 B12-B4
[15]
|
US20230285580A1 B12-B4 payload |
Undisclosed |
US20230285580A1 B12-B6 linker |
|
|
US20230285580A1 B12-B6
[15]
|
B4 Payload |
Deoxyribonucleic acid (DNA) |
US20230285580A1 B12-B6 linker |
CA1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
CA1-vedotin
[16]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
CANO01
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
CANO01-MC-MMAF
[17]
|
Monomethyl auristatin F |
Microtubule (MT) |
Maleimidocaproyl (me) linker |
CEA.5GlfhL2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AU2020291014A1 IC-51
[13]
|
AU2020291014A1-Payload-49 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-57
[13]
|
AU2020291014A1-Payload-35 |
Undisclosed |
Undisclosed |
CEA.9-G1fhL2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AU2020291014A1 IC-81
[13]
|
AU2020291014A1-Payload-77 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-82
[13]
|
AU2020291014A1-Payload-72 |
Undisclosed |
Aminobenzazepine-linker Formula II-72 |
|
|
AU2020291014A1 IC-83
[13]
|
AU2020291014A1-Payload-74 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-84
[13]
|
AU2020291014A1-Payload-80 |
Undisclosed |
Aminobenzazepine-linker Formula II-80 |
CEA.9-GlfhL2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AU2020291014A1 IC-67
[13]
|
AU2020291014A1-Payload-41 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-68
[13]
|
AU2020291014A1-Payload-35 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-69
[13]
|
AU2020291014A1-Payload-69 |
Undisclosed |
Aminobenzazepine-linker Formula II-69 |
control mouse IgG
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Nonbinding control-ADC
[18]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Control mouse IgG
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Non-binding IgG -ADC
[19]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Goat anti-mouse IgG
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
IgG-p (HEMA-co-MPS)
[20]
|
p (HEMA-co-MPS) |
Undisclosed |
HEMA linker |
H1H21234N
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
H1H21234N-compound 25
[21]
|
Undisclosed |
Undisclosed |
Undisclosed |
H1H6958N2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
H1H6958N2-N297Q-Ex23 4
[22]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
H1H6958N2-N297Q-Ex22 4
[22]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
H1H6958N2-N297Q-Ex19
[22]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
H1H6958N2-N297Q-Ex20
[22]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
H1H6958N2-N297Q-Ex23 3.9
[22]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
H1H6958N2-N297Q-Ex22 3.9
[22]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
H1H6958N2-N297Q-Ex24
[22]
|
Undisclosed |
Undisclosed |
Undisclosed |
hIgG1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
hIgG1-MMAE (gylcan conjugation)
[23]
|
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
|
|
hIgG1-MMAE (Lysine conjugation)
[23]
|
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
|
|
CN116916962A-ADC-B14
[24]
|
Compound I-5c |
Undisclosed |
CN116916962A-C-18-linker |
|
|
CN116916962A-ADC-B15
[24]
|
Compound I-5c |
Undisclosed |
CN116916962A-C-30-linker |
|
|
CN116916962A-ADC-B16
[24]
|
Compound I-5c |
Undisclosed |
CN116916962A-C-41-linker |
|
|
CN116916962A-ADC-B17
[24]
|
Compound No.14 |
Undisclosed |
CN116916962A-C-38-linker |
|
|
CN116916962A-ADC-B18
[24]
|
Compound I-5c |
Undisclosed |
CN116916962A-C-18-linker |
|
|
CN116916962A-ADC-B19
[24]
|
Compound I-5c |
Undisclosed |
CN116916962A-C-39-linker |
|
|
CN116916962A-ADC-B20
[24]
|
Compound No.14 |
Undisclosed |
CN116916962A-C-38-linker |
HK
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
HK-PABC-Exa
[10]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mc-Val-Cit-PABC |
HKA
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
HKA-PABC-Exa
[10]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mc-Val-Cit-PABC |
HS627
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024140449A1 ADC1
[25]
|
WO2024140449A1+ADC1+payload |
Undisclosed |
Mc-Val-Cit |
|
|
WO2024140449A1 ADC3
[25]
|
WO2024140449A1+ADC1+payload |
Undisclosed |
WO2024140449A1+ADC3+Linker |
|
|
WO2024140449A1 ADC5
[25]
|
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC5+Linker |
|
|
WO2024140449A1 ADC7
[25]
|
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC7+Linker |
|
|
WO2024140449A1 ADC9
[25]
|
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC9+Linker |
|
|
WO2024140449A1 ADC11
[25]
|
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC9+Linker |
|
|
WO2024140449A1 ADC13
[25]
|
WO2024140449A1+ADC13+payload |
Undisclosed |
WO2024140449A1+ADC13+Linker |
|
|
WO2024140449A1 ADC15
[25]
|
WO2024140449A1+ADC13+payload |
Undisclosed |
WO2024140449A1+ADC13+Linker |
|
|
WO2024140449A1 ADC17
[25]
|
WO2024140449A1+ADC17+payload |
Undisclosed |
WO2024140449A1+ADC17+Linker |
|
|
WO2024140449A1 ADC19
[25]
|
WO2024140449A1+ADC19+payload |
Undisclosed |
WO2024140449A1+ADC19+Linker |
|
|
WO2024140449A1 ADC21
[25]
|
WO2024140449A1+ADC5+payload |
DNA topoisomerase I (TOP1) |
WO2024140449A1+ADC5+Linker |
|
|
CN117159739A ADC3
[26]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
CN117159739A ADC4
[26]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
CN117159739A ADC6
[26]
|
undisclosed |
Undisclosed |
Undisclosed |
Hu1084
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
hu1084-MMAE-DAR3
[27]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
hu1084-MMAE-DAR8
[27]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
hu1084-DXd-DAR3
[27]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
hu1084-DXd-DAR8
[27]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
hu2H11_R35-74
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
US11998611B2 ADC1
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11998611B2 ADC3
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11998611B2 Ex.3
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11998611B2 Ex.6
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11998611B2 Ex.16
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11998611B2 Ex.19
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11998611B2 Ex.23
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11998611B2 Ex.26
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11998611B2 Ex.29
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11998611B2 Ex.32
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
hu2H11_R35-75
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
US11998611B2 ADC2
[28]
|
Undisclosed |
Undisclosed |
Undisclosed |
huCDCP1 (F30-T667 Q525)-8xHis_T3
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AU2023308528A1 ADC4
[29]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mal-amido-PEG8-acid |
|
|
AU2023308528A1 mAb-vcMMAE (DAR of 4)
[29]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AU2023308528A1 ADC3 (DAR of 8)
[29]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mal-amido-PEG8-acid |
HuSS1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
EP4161582A4 Compound 3
[30]
|
EP4161582A4+Compound 3+payload |
Undisclosed |
EP4161582A4+Compound 3+Linker |
|
|
DBCO-vc-MMAE
[30]
|
Monomethyl auristatin E |
Microtubule (MT) |
EP4161582A4+DBCO-vc-MMAE+Linker |
|
|
DBCO-S-DM1
[30]
|
Mertansine DM1 |
Microtubule (MT) |
DBCO-PEG3-amine |
|
|
DBCO-vc-seco DUBA
[30]
|
Seco-DUBA |
Human Deoxyribonucleic acid (hDNA) |
EP4161582A4+DBCO-vc-seco DUBA+Linker |
|
|
DBCO-DTPA
[30]
|
Seco-DUBA |
Human Deoxyribonucleic acid (hDNA) |
EP4161582A4+DBCO-DTPA+Linker |
|
|
DBCO-PEG3-vc-Exatecan
[30]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
DBCO-PEG3 linker |
|
|
DBCO-PEG3-GGFG-Exatecan
[30]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
EP4161582A4+DBCO-PEG3-GGFG-Exatecan+Linker |
|
|
DBCO-PEG12-GGFG-Exatecan
[30]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
EP4161582A4+DBCO-PEG12-GGFG-Exatecan+Linker |
|
|
DBCO-PEG3-GGFG-DXd2
[30]
|
Dxd |
Undisclosed |
DBCO-PEG3 linker |
|
|
DBCO-PEG12-GGFG-DXd2
[30]
|
Dxd |
Undisclosed |
EP4161582A4+DBCO-PEG12-GGFG-DXd2+Linker |
|
|
BCN-PEG3-VC-PAB-MMAE
[30]
|
Monomethyl auristatin E |
Microtubule (MT) |
EP4161582A4+BCN-PEG3-VC-PAB-MMAE+Linker |
|
|
BCN-PEG12-GGFG-Exatecan
[30]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
EP4161582A4+BCN-PEG12-GGFG-Exatecan +Linker |
|
|
BCN-PEG12-GGFG-DXd2
[30]
|
Dxd |
Undisclosed |
EP4161582A4+BCN-PEG12-GGFG-DXd2 +Linker |
|
|
DBCO-PEG3-2 (PEG3-VC-PAB-MMAE)
[30]
|
Monomethyl auristatin E |
Microtubule (MT) |
EP4161582A4+DBCO-PEG3-2 (PEG3-VC-PAB-MMAE)+Linker |
|
|
DCBPR2002-4 (DBCO-vc-MMAE)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-S-DM1)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-vc-seco DUBA)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-PEG4-vc-PAB-MMAF)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-DTPA)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-PEG3-vc-Exatecan )
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-PEG3-GGFG-Exatecan)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-PEG12-GGFG-Exatecan)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-PEG3-GGFG-DXd2)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-PEG12-GGFG-DXd2)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (BCN-PEG3-VC-PAB-MMAE)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (BCN-PEG12-GGFG-Exatecan)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (BCN-PEG3-GGFG-Exatecan)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (BCN-PEG12-GGFG-DXd2)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-4 (DBCO-PEG3-2 (PEG3-VC-PAB-MMAE))
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-2 (DBCO-vc-MMAE)-2 (DBCO-vc-seco DUBA)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-2 (DBCO-vc-MMAE)-2 (DBCO-S-DM1)
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DCBPR2002-2 (DBCO-vc-seco DUBA)-2 (DBCO-S-DM1)
|
Undisclosed |
Undisclosed |
Undisclosed |
IGF-1R
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
US11661457B2 Ab-E-11
[31]
|
US11661457B2+Ab-E-11+payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
US11661457B2 Ab-E-12
[31]
|
US11661457B2+Ab-E-12+payload |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
US11661457B2 Ab-G-12
[31]
|
US11661457B2+Ab-E-12+payload |
Microtubule (MT) |
6-Maleimidocaproic acid |
|
|
US11661457B2 Ab-E-13
[31]
|
US11661457B2+Ab-E-13+payload |
Undisclosed |
US11661457B2+Ab-E-13+Linker |
|
|
US11661457B2 Ab-F-13
[31]
|
US11661457B2+Ab-F-13+payload |
Undisclosed |
US11661457B2+Ab-F-13+Linker |
|
|
US11661457B2 Ab-G-13
[31]
|
US11661457B2+Ab-G-13+payload |
Undisclosed |
6-Maleimidocaproic acid |
|
|
US11661457B2 Ab-E-15
[31]
|
US11661457B2+Ab-E-15+payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
US11661457B2 Ab-G-15
[31]
|
US11661457B2+Ab-G-15+payload |
Undisclosed |
6-Maleimidocaproic acid |
|
|
US11661457B2 Ab-F-61
[31]
|
US11661457B2+Ab-F-61+payload |
Undisclosed |
US11661457B2+Ab-F-13+Linker |
|
|
US11661457B2 Ab-F-62
[31]
|
US11661457B2+Ab-F-62+payload |
Undisclosed |
US11661457B2+Ab-F-13+Linker |
|
|
US11661457B2 Ab-F-63
[31]
|
US11661457B2+Ab-F-63+payload |
Undisclosed |
US11661457B2+Ab-F-13+Linker |
IL13Ra2-AB08-v1.0
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
US11365263B2 ADC#1
[32]
|
US11365263B2 ADC#6 payload |
Undisclosed |
US11365263B2 ADC#6 linker |
IN202417078684A+Ab1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
IN202417078684A+ADC1
[33]
|
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
IN202417078684A+Ab2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
IN202417078684A+ADC2
[33]
|
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
IN202417078684A+Ab3
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
IN202417078684A+ADC3
[33]
|
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
IN202417078684A+Ab4
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
IN202417078684A+ADC4
[33]
|
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
|
|
IN202417078684A+ADC5
[33]
|
Mertansine DM4 |
Microtubule (MT) |
SPDB |
|
|
IN202417078684A+ADC6
[33]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
IN202417078684A+ADC7
[33]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
IN202417078684A+ADC8
[33]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
IN202417078684A+ADC9
[33]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
IN202417078684A+ADC10
[33]
|
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
J591
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
MC-VC-PAB-MMAE
[34]
|
Undisclosed |
Undisclosed |
CN116196428A+MC-VC-PAB-MMAE+Linker |
KAR
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
KAR-PABC-MMAE
[10]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
KM8047
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
KM8047-SG3249
[35]
|
SG3199 |
Human Deoxyribonucleic acid (hDNA) |
Undisclosed |
KS1/4
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
LY203725
|
4-desacetylvinblastine (DAVLB) |
Microtubule (MT) |
A cleavable linker |
|
|
LY256787
|
4-desacetylvinblastine (DAVLB) |
Microtubule (MT) |
A cleavable linker |
LR004
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
LR004-VC-MMAE
[36]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
lsotype control mAb3
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2023173132A1 ADC-2
[37]
|
P9 |
Undisclosed |
IBAC-suC-PEG4 |
|
|
WO2023173132A1 ADC-4
[37]
|
P9 |
Undisclosed |
DIBAC-suC-PEG8 |
|
|
WO2023173132A1 ADC-6
[37]
|
P9 |
Undisclosed |
DIBAC-suC-PEG12 |
|
|
WO2023173132A1 ADC-15
[37]
|
P9 |
Undisclosed |
Undisclosed |
|
|
WO2023173132A1 ADC-29
[37]
|
P8 Payload |
Undisclosed |
NH2-PEG8-triazole |
M30-H1-L-4P
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
US12186310B2-1
[38]
|
Undisclosed |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
US12186310B2-2
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-3
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-4
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-5
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-12
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-13
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-14
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-15
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-16
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-17
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-18
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-19
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-20
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-21
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-23
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-24
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-25
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-26
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-27
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-28
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-29
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-30
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-38
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-39
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-40
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-41
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-42
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-43
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-44
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-45
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-46
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-50
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-51
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-52
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-53
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-54
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-55
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US12186310B2-56
[38]
|
Undisclosed |
Undisclosed |
Undisclosed |
mAb-B
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024140927A1-ADC-B (DAR4)
[39]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
mAb1DesignA
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
mAb1DesignA-SLAE
[40]
|
SLAuristatin E derivate |
Undisclosed |
DBCO-C4-PEG3-VC-PABC |
|
|
mAb1DesignA-LLAE
[40]
|
LLAuristatin E derivate |
Undisclosed |
DBCO-C6-PEG8-VC-PABC-AE |
mAb1DesignB
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
mAb1DesignB-SLAE
[40]
|
SLAuristatin E derivate |
Undisclosed |
DBCO-C4-PEG3-VC-PABC |
|
|
mAb1DesignB-LLAE
[40]
|
LLAuristatin E derivate |
Undisclosed |
DBCO-C6-PEG8-VC-PABC-AE |
mAb1DesignC
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
mAb1DesignC-SLAE
[40]
|
SLAuristatin E derivate |
Undisclosed |
DBCO-C4-PEG3-VC-PABC |
|
|
mAb1DesignC-LLAE
[40]
|
LLAuristatin E derivate |
Undisclosed |
DBCO-C6-PEG8-VC-PABC-AE |
mAb2DesignA
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
mAb2DesignA-SLAE
[40]
|
SLAuristatin E derivate |
Undisclosed |
DBCO-C4-PEG3-VC-PABC |
|
|
mAb2DesignA-LLAE
[40]
|
LLAuristatin E derivate |
Undisclosed |
DBCO-C6-PEG8-VC-PABC-AE |
mAb2DesignB
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
mAb2DesignB-SLAE
[40]
|
SLAuristatin E derivate |
Undisclosed |
DBCO-C4-PEG3-VC-PABC |
|
|
mAb2DesignB-LLAE
[40]
|
LLAuristatin E derivate |
Undisclosed |
DBCO-C6-PEG8-VC-PABC-AE |
mAb2DesignC
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
mAb2DesignC-SLAE
[40]
|
SLAuristatin E derivate |
Undisclosed |
DBCO-C4-PEG3-VC-PABC |
|
|
mAb2DesignC-LLAE
[40]
|
LLAuristatin E derivate |
Undisclosed |
DBCO-C6-PEG8-VC-PABC-AE |
Masked chicken-derived anti-IgM (aIgM) antibody
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
algM ADC
[41]
|
Monomethyl auristatin E |
Microtubule (MT) |
DBCO-PEG4-Val-Cit-PABC |
mil40
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
CN112638426B ADC1
[42]
|
Tubulin inhibitor B |
Microtubule (MT) |
CN112638426B +ADC1+Linker |
|
|
CN112638426B ADC2
[42]
|
Tubulin inhibitor B |
Microtubule (MT) |
CN112638426B +ADC2+Linker |
mMAB1129
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Control surrogate and mouse SG
[43]
|
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
CL2A |
Mouse IgG2a
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Mouse IgG2a-Val-Cit-Pab-MMAE
[23]
|
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
|
|
Mouse IgG2a-PEG8-MMAE
[23]
|
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
mRS7
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Murinized SG
[43]
|
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
CL2A |
Neg-8-8-H16-K222R- hGl
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Neg-8-8-H16-K222R- hGl-LP19
[44]
|
Undisclosed |
Undisclosed |
Undisclosed |
Neg-8-8-H16-K222R-hG1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Neg-8-8-H16-K222R- hG1 -LP1
[44]
|
Undisclosed |
Undisclosed |
Undisclosed |
Neg-8-8-H16-K222R-hGl
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Neg-8-8-H16-K222R- hGl -LP13
[44]
|
Undisclosed |
Undisclosed |
Undisclosed |
NGS111
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-09
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-17
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
NGS75
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-07
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-15
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-21
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-23
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-25
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
NGS91
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024131835A1 ADC-08
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024131835A1 ADC-16
[1]
|
Undisclosed |
Undisclosed |
Undisclosed |
Nontargeting antibody control 1- 25
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Nontargeting antibody control 1- 25
[21]
|
Undisclosed |
Undisclosed |
Undisclosed |
Nontargeting antibody control 1- 36
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Nontargeting antibody control 1- 36
[21]
|
Undisclosed |
Undisclosed |
Undisclosed |
Nontargeting antibody control 1- rifalog
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Nontargeting antibody control 1- rifalog
[21]
|
Undisclosed |
Undisclosed |
Undisclosed |
Nontargeting antibody control 1- rifampicin N
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Nontargeting antibody control 1- rifampicin N
[21]
|
Undisclosed |
Undisclosed |
Undisclosed |
PDL1.24-G1f
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AU2020291014A1 IC-36
[13]
|
AU2020291014A1-Payload-40 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-37
[13]
|
AU2020291014A1-Payload-39 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-72
[13]
|
AU2020291014A1-Payload-35 |
Undisclosed |
Undisclosed |
PDL1.85-G1f
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AU2020291014A1 IC-48
[13]
|
AU2020291014A1-Payload-49 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-49
[13]
|
AU2020291014A1-Payload-49 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-73
[13]
|
AU2020291014A1-Payload-35 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-85
[13]
|
AU2020291014A1-Payload-69 |
Undisclosed |
Aminobenzazepine-linker Formula II-69 |
|
|
AU2020291014A1 IC-88
[13]
|
AU2020291014A1-Payload-77 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-89
[13]
|
AU2020291014A1-Payload-74 |
Undisclosed |
Undisclosed |
PR300159
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
PR300159-B81
[45]
|
NZ818359A+PR300159-B81+payload |
Undisclosed |
NZ818359A+PR300159-B81+Linker |
|
|
PR300159-B71
[45]
|
NZ818359A+PR300159-B81+payload |
Undisclosed |
NZ818359A+PR300159-B71+Linker |
PR300159-8
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
PR300159-8-B81
[45]
|
NZ818359A+PR300159-B81+payload |
Undisclosed |
NZ818359A+PR300159-B81+Linker |
PR300186
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
PR300186-B81
[45]
|
NZ818359A+PR300159-B81+payload |
Undisclosed |
NZ818359A+PR300159-B81+Linker |
|
|
PR300186-B71
[45]
|
NZ818359A+PR300159-B81+payload |
Undisclosed |
NZ818359A+PR300159-B71+Linker |
PR300186-10
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
PR300186-10-B81
[45]
|
NZ818359A+PR300159-B81+payload |
Undisclosed |
NZ818359A+PR300159-B81+Linker |
Protease-activated chicken-derived anti-IgM (aIgM) antibody
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Masked Protease-activated CH2-aIgM ADC
[41]
|
Monomethyl auristatin E |
Microtubule (MT) |
DBCO-PEG4-Val-Cit-PABC |
Rab64
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Surrogate SG
[43]
|
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
CL2A |
Rabbit derived VL single-domain Anti-ody
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
VL-DAB31-SN38
[46]
|
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Mal-Cyc-PEG3-DAB |
|
|
ROS-responsive SN38 ADC
[46]
|
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
Mal-Cyc-PEG3-DAB |
rat IgG2b
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AU2020291014A1 IC-47
[13]
|
AU2020291014A1-Payload-35 |
Undisclosed |
Undisclosed |
RKAA
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
RKAA-PABC-MMAE
[10]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
RKAAR
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
RKAAR-PABC-MMAE
[10]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
RKAAR-PABC-Exa
[10]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mc-Val-Cit-PABC |
|
|
RKAAR-EDA-CS
[10]
|
cortisol |
Undisclosed |
Undisclosed |
ROSPATAMAB
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
IGAC-92
[47]
|
IG-L-18 Payload |
Undisclosed |
IG-L-25 linker |
RRK
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
RRK-PABC-MMAE
[10]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
RRK-PABC-Exa
[10]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Mc-Val-Cit-PABC |
RRKAY
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
RRKAY-PABC-MMAE
[10]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
S-49-8
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
CN119019562A ADC1 S-49-8
[48]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
CN119019562A ADC2 S-49-8
[48]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
CN119019562A ADC3 S-49-8
[48]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
CN119019562A ADC4 S-49-8
[48]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
S-60-6
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
CN119019562A ADC1 S-60-6
[48]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
CN119019562A ADC2 S-60-6
[48]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
CN119019562A ADC3 S-60-6
[48]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
CN119019562A ADC4 S-60-6
[48]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
S423
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
KR1020250011922A ADC-S423
[49]
|
Undisclosed |
Undisclosed |
Undisclosed |
S426
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
KR1020250011922A ADC-S426
[49]
|
Undisclosed |
Undisclosed |
Undisclosed |
TPP-5657
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2024105206A1 16i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 17i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 18i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 19i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 20i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 21i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 22i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 23i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 24i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 25i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 26i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 27i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 28i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 33i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 35i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 41i-5657 1
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 16i-5657 2
[50]
|
Mdo-cpt |
DNA topoisomerase I (TOP1) |
16i-5657 Linker |
|
|
WO2024105206A1 17i-5657 2
[50]
|
41i-5657 Payload |
Undisclosed |
17i-5657 Linker |
|
|
WO2024105206A1 18i-5657 2
[50]
|
41i-5657 Payload |
Undisclosed |
18i-5657 Linker |
|
|
WO2024105206A1 19i-5657 2
[50]
|
Mdo-cpt |
DNA topoisomerase I (TOP1) |
6i-5657 Linker |
|
|
WO2024105206A1 20i-5657 2
[50]
|
41i-5657 Payload |
Undisclosed |
17i-5657 Linker |
|
|
WO2024105206A1 21i-5657 2
[50]
|
41i-5657 Payload |
Undisclosed |
21i-5657 Linker |
|
|
WO2024105206A1 22i-5657 2
[50]
|
22i-5657 Payload |
Undisclosed |
22i-5657 Linker |
|
|
WO2024105206A1 23i-5657 2
[50]
|
Mdo-cpt |
DNA topoisomerase I (TOP1) |
23i-5657 Linker |
|
|
WO2024105206A1 24i-5657 2
[50]
|
41i-5657 Payload |
Undisclosed |
24i-5657 Linker |
|
|
WO2024105206A1 25i-5657 2
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 26i-5657 2
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 27i-5657 2
[50]
|
Mdo-cpt |
DNA topoisomerase I (TOP1) |
22i-5657 Linker |
|
|
WO2024105206A1 28i-5657 2
[50]
|
Mdo-cpt |
DNA topoisomerase I (TOP1) |
6i-5657 Linker |
|
|
WO2024105206A1 33i-5657 2
[50]
|
Monomethyl auristatin E |
Microtubule (MT) |
22i-5657 Linker |
|
|
WO2024105206A1 35i-5657 2
[50]
|
41i-5657 Payload |
Undisclosed |
22i-5657 Linker |
|
|
WO2024105206A1 41i-5657 2
[50]
|
41i-5657 Payload |
Undisclosed |
41i-5657 Linker |
|
|
WO2024105206A1 1i-5657
[50]
|
CHH0170, 1i-5657, Payload |
Undisclosed |
32p-Avelu Linker |
|
|
WO2024105206A1 2i-5657
[50]
|
Camptothecin |
DNA topoisomerase 1 (TOP1) |
2i-5657 Linker |
|
|
WO2024105206A1 3i-5657
[50]
|
Ac-Exatecan |
DNA topoisomerase I (TOP1) |
32p-Avelu Linker |
|
|
WO2024105206A1 4i-5657
[50]
|
CHH0177, 4i-5657, Payload |
Undisclosed |
CHH0177, 4i-5657, Linker |
|
|
WO2024105206A1 5i-5657
[50]
|
CHH0177, 4i-5657, Payload |
Undisclosed |
3i-5657 Linker |
|
|
WO2024105206A1 6i-5657
[50]
|
6i-5657 Payload |
DNA topoisomerase I (TOP1) |
3i-5657 Linker |
|
|
WO2024105206A1 7i-5657
[50]
|
CHH0183, 7i-5657, Payload |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 8i-5657
[50]
|
Mdo-cpt |
DNA topoisomerase I (TOP1) |
Undisclosed |
|
|
WO2024105206A1 9i-5657
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 10i-5657
[50]
|
Ac-Exatecan |
DNA topoisomerase I (TOP1) |
CHH0187, 10i-5657, Linker |
|
|
WO2024105206A1 11i-5657
[50]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024105206A1 12i-5657
[50]
|
CHH0189, 12i-5657, Payload |
Undisclosed |
CHH0189, 12i-5657, Linker |
|
|
WO2024105206A1 13i-5657
[50]
|
CHH0191, 13i-5657, Payload |
Undisclosed |
CHH0191, 13i-5657, Linker |
|
|
WO2024105206A1 14i-5657
[50]
|
CHH0192, 14i-5657, Payload 1; CHH0192, 14i-5657, Payload 2 |
Undisclosed |
CHH0192, 14i-5657, Linker1; CHH0192, 14i-5657, Linker2 |
|
|
WO2024105206A1 15i-5657
[50]
|
CHH0193, 15i-5657, Payload 1; CHH0193, 15i-5657, Payload 2 |
Undisclosed |
Undisclosed |
Tras-Glf-N297A
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
AU2020291014A1 IC-58
[13]
|
AU2020291014A1-Payload-35 |
Undisclosed |
Undisclosed |
|
|
AU2020291014A1 IC-64
[13]
|
AU2020291014A1-Payload-69 |
Undisclosed |
Aminobenzazepine-linker Formula II-69 |
Tz
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Tz-IR700
[51]
|
IRDye 700DX |
Undisclosed |
NHS ester linker |
YTH24.5
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
YTH24.5-SG3249
[52]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
YTH24.5-SG3376
[52]
|
Undisclosed |
Undisclosed |
Undisclosed |
Undisclosed
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
DS3610
|
Undisclosed |
Stimulator of interferon genes protein (STING1) |
Undisclosed |
|
|
DB-1202
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CPO-204
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG-1901
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG-2001
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG-2002A
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PHN-010
|
TOP1 inhibitor |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
|
|
SC-007
|
PBD dimer |
Human deoxyribonucleic acid (hDNA) |
Undisclosed |
|
|
SC-005
[53]
|
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Undisclosed |
|
|
RC-168
[54]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
RC-178
[54]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
RC-188
[54]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
XNW-28012
[55]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Bi-specific antibody drug conjugate
[56]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ZV03-ADC
[57]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AR081
[58]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BC5084
[59]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WTX-116
[60]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WTX-231
[60]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WTX-222
[60]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
VIS-705
[61]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Second ADC (Virtuoso Therapeutics)
[62]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LEAD ADC (Virtuoso Therapeutics)
[63]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Additional antibody drug conjugate (Virtuoso Therapeutics)
[64]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
VLS-301
[65]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
VLS-201
[66]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Vas-202
[67]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Vas-201
[68]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Anticancer antibody-drug conjugate (Vaccinex/Catalent Pharma Solutions)
[69]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TUB-060
[70]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TUB-050
[70]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TAE-020
[71]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TT-01
[72]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TGM-005
[73]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TGM-004
[74]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TGM-003
[75]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TGM-002
[76]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody boron conjugate radiopharmaceuticals (TAE Life Sciences)
[77]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SIM-005A
[78]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SIM-002A
[79]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SIB-004A
[80]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BL-B029A1
[81]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BL-M002A2
[82]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate 4 (Synthon)
[83]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate 3 (Synthon)
[84]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SAB-Y17
[85]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SAB-Y1
[85]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SDV-1001
[86]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate (SynAffix)
[87]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC project 7 (Suzhou Medilink Therapeutics Ltd.)
[88]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC project 6 (Suzhou Medilink Therapeutics Ltd.)
[88]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC project 5 (Suzhou Medilink Therapeutics Ltd.)
[88]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC project 4 (Suzhou Medilink Therapeutics Ltd.)
[88]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BsAb-ADC (Medilink Therapeutics)
[89]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SOT106
[90]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SMD-5033
[91]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SMD-3117
[92]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
HY-0001
[93]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BL-M005
[94]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BL-M22D1
[95]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
P-BsAb-ADC
[96]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JY210
[97]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JY208
[97]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SY-1558
[98]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MRG-006
[99]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MRX-23
[100]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG2106E
[101]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG2018
[101]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG2011C
[101]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG2002B
[101]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate (Sanofi/Seagen)
[102]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SGN-25
[103]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
APEC-3
[104]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
APEC-2
[105]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
RAD-501
[106]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PLBC-003
[107]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PLBC-002
[107]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PLBC-001
[107]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PLBA-005
[107]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PLBA-004
[107]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PLBA-003
[107]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PLBA-002
[107]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PLBA-001
[107]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PSM-101
[108]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DN-028
[109]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DN-027
[110]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PHN-020
[111]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate containing OXS-2175 (Oxis Biotech/MultiCell ImmunoTherapeutics)
[112]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
OX-004
[113]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate (Oxford BioTherapeutics/Boehringer Ingelheim)
[114]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
OBT542
[115]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
OBT207
[115]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
OBT029
[115]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Next generation antibody-drug conjugate (Oxford BioTherapeutics)
[116]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NBT-598
[117]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NBT-588
[118]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NBT-588
[118]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NBT-578
[119]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NBT-568
[120]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NBT-528
[121]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NW-12-005
[122]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NTX-1107
[123]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SO-N107
[124]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NBE-003
[125]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NBE-001
[126]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MBC-301
[127]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
G-100 (Magenta Therapeutics)
[128]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MBK-101
[129]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-69
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-91
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-09A
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-42A
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-20A
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-19A
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-18A
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB14-15nm
[131]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-12A
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-06A
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-04A
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-02A
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-88
[132]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB-85
[130]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LP-A18
[133]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LM-007
[134]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LM-006
[134]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LM-005
[134]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LM-004
[134]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LM-001
[134]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LM-317
[135]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LM-008
[134]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
KGX201
[136]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IOG-101
[137]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DBAF-301
[138]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IN30718
[139]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
131I-ImmuRAIT-HCG
[140]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IMB-213I
[141]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IMB-212
[141]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IKS-02
[142]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IKS-04
[142]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Glaucoma therapy
[143]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
HDP-104
[144]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-020
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-019
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-018
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-017
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-016
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-015
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-013
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-012
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-011
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DXC-010
[145]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Monoclonal Antibody-Drug Conjugate (Kind Pharmaceuticals)
[146]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GBM-12401
[147]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GMA-305
[148]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GMA-205
[149]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SeeloMab-GEX
[150]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
P-1000
[151]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GL-231
[152]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GF-2014
[153]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GR1018
[154]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GR-1016
[154]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GR-1015
[154]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GR-1014
[154]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
GQ-1009
[154]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
M-131
[155]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
EVOLVE-104 ADC
[156]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
EP-400
[157]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PCG-N003
[158]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PCG-C006
[158]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PCG-C004
[158]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PCG-C002
[158]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DOM-1314
[159]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AccuADC-001
[160]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CM-09
[161]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CS-5002
[162]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CBP-1609
[163]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antiviral Fc-conjugate (Cidara Therapeutics)
[164]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CRB-2107
[165]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Monoclonal Antibody-Drug conjugate (Celltrion Chemical Research Institute/Immunogen/Celltrion)
[166]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CT-P26
[167]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CAT-03-106
[168]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BMT-125961
[169]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BRKB-28
[170]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIO104
[171]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIO103
[171]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LD016
[172]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BSC-4201
[173]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BSC-4101
[174]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BSI-023
[175]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIOO-4
[176]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIOO-3
[177]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIOO-2
[178]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIOO-1
[179]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIO-201
[180]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIO-108
[180]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIO-107
[180]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIO-110
[180]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIO-109
[180]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Advanced antibody drug conjugate (Belrose Pharma)
[181]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NX-08
[182]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JY-023
[183]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AT-01
[184]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AT-00
[185]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AT-04
[184]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AVP20
[186]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody drug conjugate containing duocarmycin analogue
[187]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody drug conjugate (Halozyme)
[188]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
APB-CS
[189]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Monoclonal Antibody-Drug Conjugate (Antengene)
[190]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ANG-101
[191]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Anti-cancer therapeutic (Amgen)
[192]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AK 30 NGF
[193]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AMB-015
[194]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADRX-863
[195]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AbGn-108
[196]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIO-112
[180]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
STING based antibody-drug conjugate (Exelixis)
[197]
|
STING agonist |
Stimulator of interferon genes protein (STING1) |
Undisclosed |
|
|
BL-M005A2
[198]
|
Dual-warhead |
Undisclosed |
Undisclosed |
|
|
SMP-190
[199]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Unique hydrophilic Linker |
|
|
CBX-13
[200]
|
Mertansine DM4 |
Microtubule (MT) |
Undisclosed |
|
|
PTM-001-ADC
[201]
|
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
|
|
APH-0912
[202]
|
Docetaxel |
Microtubule (MT) |
Hydrophilic linker containing sugar molecules |
|
|
Dual-payload ADC (Mersana Therapeutics)
[203]
|
AF-HPA+DNA monoalkylator I-BiP |
Ribosome (RB); Human Deoxyribonucleic acid (hDNA) |
Undisclosed |
|
|
TAK-ATACs
[204]
|
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Undisclosed |
|
|
Antibody targeted amanitin conjugate
[205]
|
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Undisclosed |
|
|
Alpha-amanitin antibody-drug conjugate (Agensys)
[206]
|
Alpha-amanitin |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G) |
Undisclosed |
|
|
Eribulin ADC (Jiangsu hengrui)
[207]
|
Eribulin |
Microtubule (MT) |
Undisclosed |
|
|
CBX-14
[200]
|
Multi-targetd DDR inhibitor |
Epithelial discoidin domain-containing receptor 1 (DDR1) |
Undisclosed |
|
|
Masked ADC (Adagene/ADC Therapeutics)
[208]
|
PBD dimer |
Human Deoxyribonucleic acid (hDNA) |
Undisclosed |
|
|
Spliceostatin-antibody-drug conjugate
[209]
|
Spliceostatin A |
Splicing factor 3B subunit 1 (SF3B1) |
Undisclosed |
|
|
XMT-2175
[210]
|
STING agonist |
Stimulator of interferon genes protein (STING1) |
Undisclosed |
|
|
XMT-2068
[210]
|
STING agonist |
Stimulator of interferon genes protein (STING1) |
Undisclosed |
|
|
STING agonist ADC
[211]
|
STING agonist |
Stimulator of interferon genes protein (STING1) |
Undisclosed |
|
|
EX108
[212]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC2313
[213]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC2154
[214]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC2231
[215]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC2335
[216]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC2317
[217]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BR-2202
[218]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BR-2102
[218]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BR-2003
[218]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BB-1708
[218]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BB-1706
[218]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BB-1710
[218]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MABS-01
[219]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MABS-02
[219]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PBX-002
[220]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SY-1700
[221]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SY-1274
[221]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SY-0831
[221]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SY-1330
[221]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SY-0833
[221]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SY-1211
[221]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SY-0625
[221]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BRKB-44
[222]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AMB-101
[223]
|
Topoisomerase I inhibitor |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
|
|
AMB-102
[224]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BP-A102
[225]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BP-A103
[225]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AU-011
[226]
|
IRDye 700DX |
Undisclosed |
Undisclosed |
|
|
IMB-202
[227]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
3-NAntC
[228]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIO105
[229]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CO-1003
[230]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CO-1023
[230]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BR107
[231]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BR109
[232]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BRY811
[233]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
OTV:CH2
[234]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
OTV:LF3
[234]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IN30728
[235]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
NW-001
[236]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
FG-B310
[237]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
FG-M131
[237]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC001 (Arbele)
[238]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC002 (Arbele)
[238]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADC003 (Arbele)
[238]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TST013
[239]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CS5005
[240]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CS5006
[240]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Monovalent Azymatic Antibody Drug Conjugate (Zymeworks)
[241]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate (University of Toronto/ImmunoBiochem)
[242]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate (University of Toronto/Advanced Proteome Therapeutics)
[243]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Multi-functional antibody drug conjugate combination therapeutics (Sutro Biopharma/Celgene)
[244]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MRG-009
[245]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MRG-008
[246]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MRG-007
[247]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MRG-005
[248]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LCB14-2nm
[249]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CYP-Ab
[250]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody drug conjugate (Sanofi)
[251]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody drug conjugate (Compugen)
[252]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate therapy (Neoantigenics)
[253]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody drug conjugate (Meditope Biosciences)
[254]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
LIN-003
[255]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
KSI-201
[256]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody drug conjugate (Intrexon)
[257]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CRC-02 targeting antibody-drug conjugate
[258]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate (Daiichi Sankyo)
[259]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody drug conjugate (Asana BioSciences)
[260]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIOO-7
[261]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIOO-6
[262]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BIOO-5
[263]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody-drug conjugate (Bristol-Myers Squibb)
[264]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Marine-derived cytotoxic payloads antibody-drug conjugation
[265]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Antibody drug conjugate (Five Prime cancer)
[266]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CBX-12
[267]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
|
|
DAN-222
[268]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CHB-111
[269]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
RG-7986
[270]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DS001
[271]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IgG2-ADC
[272]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Anti-0079b_AsnAsnPABC_MMAE
[273]
|
Monomethyl auristatin E |
Microtubule (MT) |
AsnAsnPABC |
|
|
FG-ADC (DAR 4)
[274]
|
Mertansine DM1 |
Microtubule (MT) |
MA-FG-P12 |
|
|
FG-ADC (DAR 8)
[274]
|
Mertansine DM1 |
Microtubule (MT) |
MA-FG-P12 |
|
|
VAG-ADC (DAR 4)
[274]
|
Mertansine DM1 |
Microtubule (MT) |
MA-VAG-P12 |
|
|
VAG-ADC (DAR 8)
[274]
|
Mertansine DM1 |
Microtubule (MT) |
MA-VAG-P12 |
|
|
Control to 8D302-MMAE
[275]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
Control to 8D302-DXd
[275]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
Isotype-SG3249
[52]
|
SG3199 |
Human Deoxyribonucleic acid (hDNA) |
Undisclosed |
|
|
Isotype-SG3376
[52]
|
SG3199 |
Human Deoxyribonucleic acid (hDNA) |
Undisclosed |
|
|
IgG-MMAE 8
[276]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
Control-MMAE-DAR3
[27]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
Control-DXd-DAR8
[27]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
39298786 ADC2 (DAR8)
[277]
|
AZ14170132 |
Undisclosed |
Val-Ala-PEG8 |
|
|
39298786 ADC2 (DAR4)
[277]
|
AZ14170132 |
Undisclosed |
Val-Ala-PEG8 |
|
|
38770747 ADC 1 (DAR 2)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 2 (DAR 2)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 3 (DAR 2)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 4 (DAR 2)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 5 (DAR 2)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 6 (DAR 2)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 7 (DAR 2)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 8 (DAR 2)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 1 (DAR 4)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 2 (DAR 4)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 3 (DAR 4)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 4 (DAR 4)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 5 (DAR 4)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 6 (DAR 4)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 7 (DAR 4)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
38770747 ADC 8 (DAR 4)
[278]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IgG-vedotin
[279]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
40300109 ADC 2
[280]
|
NLRP3 Agonist 2 |
Undisclosed |
Undisclosed |
|
|
40300109 ADC 4
[280]
|
NLRP3 Agonist 4 |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
40300109 ADC 5
[280]
|
NLRP3 Agonist 3 |
Undisclosed |
Undisclosed |
|
|
40300109 ADC 6
[280]
|
NLRP3 Agonist 3 |
Undisclosed |
Undisclosed |
|
|
40300109 ADC 7
[280]
|
NLRP3 Agonist 3 |
Undisclosed |
Undisclosed |
|
|
40300109 ADC 8
[280]
|
NLRP3 Agonist 3 |
Undisclosed |
Undisclosed |
|
|
IgG-NPLG-SN38
[281]
|
Active metabolite of irinotecan SN38 |
DNA topoisomerase 1 (TOP1) |
NPLG |
|
|
38679234 ADC1-FL
[282]
|
Fluorescein |
Undisclosed |
Undisclosed |
|
|
38679234 ADC1-FY
[282]
|
Eosin Y |
Undisclosed |
Undisclosed |
|
|
38679234 ADC1-MMAE
[282]
|
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
|
|
38679234 ADC1-DM1
[282]
|
Mertansine DM1 |
Microtubule (MT) |
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) |
|
|
38679234 ADC2
[282]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
39424599 ADC-10B
[283]
|
Undisclosed |
Undisclosed |
Electron-deficient sulfonamide-based cleavable linker 10 |
|
|
39424599 ADC-S32B
[283]
|
Undisclosed |
Undisclosed |
Electron-deficient Disulfide-based cleavable linker 32 |
|
|
39424599 ADC-S35B
[283]
|
Undisclosed |
Undisclosed |
S35 linker |
|
|
39948340 ADC 3 (nobinding)
[284]
|
TLR7 payload 1 |
Undisclosed |
39948340 Linker |
|
|
Isotype-MMAE (gylcan conjugation)
[23]
|
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
|
|
Isotype-MMAE (Lysine conjugation)
[23]
|
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
|
|
Control-STINGa
[285]
|
STINGa |
Undisclosed |
Undisclosed |
|
|
hIgGFc-DM1 (38127423)
[286]
|
Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
|
|
ASAK-22
[287]
|
KRM-1657 |
Undisclosed |
Mc-Val-Ala-PABC |
|
|
ASAC-01
[287]
|
KRM-1657 |
Undisclosed |
Undisclosed |
|
|
ASAC-02
[287]
|
KRM-1657 |
Undisclosed |
M6 Linker |
|
|
37788373 ADC24
[288]
|
(R)-Budesonide |
Undisclosed |
MP-Ala-Ala-RG-9 |
|
|
hIgG-MMAE
[289]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb-ZnPcGal4 conjugate
[290]
|
ZnPcGal4 |
Undisclosed |
Undisclosed |
|
|
38389885 ADC 21
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 22
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 23
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 24
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 25
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 26
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 27
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 28
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 29
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 30
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 31
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 32
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 33
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 34
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 35
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 36
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 37
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 38
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 39
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
38389885 ADC 40
[291]
|
GRM payload (38389885) |
Undisclosed |
DL1 linker |
|
|
Thio-1b
[292]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Thio-2b
[292]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IgG IB-Y
[293]
|
IB-Y |
Undisclosed |
Undisclosed |
|
|
hIgGFc-DM1 (36909522)
[294]
|
Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
|
|
scFv-PEG4-DM1
[295]
|
Mertansine DM1 |
Microtubule (MT) |
Undisclosed |
|
|
scFv-PEG4-DM4
[295]
|
Mertansine DM4 |
Microtubule (MT) |
Undisclosed |
|
|
TDC MMAE
[296]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
ProPBD-ADC
[297]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADCT-241
[298]
|
PL2202 |
Undisclosed |
Undisclosed |
|
|
Topo1i/PARPi dual-payload ADC
[299]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PA289 ADC
[300]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ThiOBI ADC
[301]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AMB304
[302]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CAB-ADC
[303]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
DKIF976 DAC
[304]
|
dKIF976 |
Undisclosed |
Undisclosed |
|
|
Control-AL1- LP1
[305]
|
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP1 LINKER |
|
|
Control-AL1- LP2
[305]
|
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP2 LINKER |
|
|
Control-AL1- LP20
[305]
|
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP20 LINKER |
|
|
Control-AL1- LP22
[305]
|
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP22 linker |
|
|
Control-AL1- LP23
[305]
|
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP23 linker |
|
|
Control-AL1- LP24
[305]
|
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP24 linker |
|
|
Control-ALl-LP1
[305]
|
US12209180B2 P3 |
Undisclosed |
Anti-Her2-AL1- LP1 LINKER |
|
|
Control-AL1- LP35
[305]
|
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP35 LINKER linker |
|
|
Control-AL1- LP32
[305]
|
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP32 linker |
|
|
Control-AL1- LP39
[305]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Control-AL1- LP38
[305]
|
Undisclosed |
Undisclosed |
Anti-Her2-AL1- LP38 linker |
|
|
WO2024043319A1 72-1
[306]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024043319A1 72-2
[306]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024043319A1 73
[306]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024043319A1 74
[306]
|
WO2024043319A1 74 payload |
Undisclosed |
Undisclosed |
|
|
WO2024043319A1 75-1
[306]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024043319A1 75-2
[306]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024043319A1 75-3
[306]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024043319A1 76
[306]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024043319A1 77
[306]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024043319A1 87
[306]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
deJ591-A
[307]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
deJ591-E
[307]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
deJ591-D
[307]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BI2-A
[307]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BI2-E
[307]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BI2-D
[307]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN108883196A 5F9-CDA-1
[308]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN108883196A 5F9-CDA-2
[308]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN108883196A 5F9-CDA-3
[308]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
hLL2-IgG1-Tap-18Hr1
[309]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
hLL2-IgG1-Tap-18Hr2
[309]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107614020A 1MB-101
[310]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107614020A 1MB-102
[310]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107614020A 1MB-991
[310]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107614020A 1MB-992
[310]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 19
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 20
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 21
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 22
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 23
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 24
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 25
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 26
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 27
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 28
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 29
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 30
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 31
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 32
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 33
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 34
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN107635405A CN107635405A 35
[311]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20200023071A1 Example 2
[312]
|
US20200023071A1 Example 2 payload |
Undisclosed |
Undisclosed |
|
|
US20200023071A1 Example 3
[312]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
anti-PanP-DM1
[313]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
BCN-B12 B12-v1a-145
[314]
|
Undisclosed |
Undisclosed |
linker145 |
|
|
WO2019126691A1 Conjugate No.138
[315]
|
Conjugate No.138 Payload |
Undisclosed |
Conjugate No.138 Linker |
|
|
WO2019126691A1 Conjugate No.139
[315]
|
undisclosed |
Undisclosed |
Conjugate No.138 Linker |
|
|
WO2019126691A1 Conjugate No.140
[315]
|
Conjugate No.140 Payload |
Undisclosed |
Conjugate No.138 Linker |
|
|
WO2019126691A1 Conjugate No.141
[315]
|
Conjugate No.141 Payload |
Undisclosed |
Conjugate No.138 Linker |
|
|
WO2019126691A1 Conjugate No.142
[315]
|
Conjugate No.136 Payload |
Undisclosed |
Conjugate No.57 Linker |
|
|
WO2019126691A1 Conjugate No.143
[315]
|
Conjugate No.136 Payload |
Undisclosed |
Conjugate No.71 Linker |
|
|
WO2019126691A1 Conjugate No.144
[315]
|
Conjugate No.136 Payload |
Undisclosed |
Conjugate No.67 Linker |
|
|
WO2019126691A1 Conjugate No.145
[315]
|
Conjugate No.136 Payload |
Undisclosed |
Conjugate No.73 Linker |
|
|
WO2019126691A1 Conjugate No.146
[315]
|
Conjugate No.136 Payload |
Undisclosed |
DL18 linker |
|
|
WO2019126691A1 Conjugate No.147
[315]
|
Conjugate No.94 Payload |
Undisclosed |
Conjugate No.147 Linker |
|
|
WO2019126691A1 Conjugate No.148
[315]
|
Conjugate No.148 Payload |
Undisclosed |
Conjugate No.147 Linker |
|
|
WO2019126691A1 Conjugate No.149
[315]
|
Conjugate No.94 Payload |
Undisclosed |
Conjugate No.147 Linker |
|
|
WO2019126691A1 Conjugate No.150
[315]
|
Conjugate No.112 Payload |
Undisclosed |
Conjugate No.112 Linker |
|
|
WO2019126691A1 Conjugate No.151
[315]
|
Conjugate No.112 Payload |
Undisclosed |
Conjugate No.151 Linker |
|
|
WO2019126691A1 Conjugate No.152
[315]
|
Conjugate No.94 Payload |
Undisclosed |
Conjugate No.152 Linker |
|
|
WO2019126691A1 Conjugate No.153
[315]
|
Conjugate No.94 Payload |
Undisclosed |
Conjugate No.119 Linker |
|
|
WO2019126691A1 Conjugate No.154
[315]
|
Conjugate No.137 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.155
[315]
|
Conjugate No.155 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.156
[315]
|
Conjugate No.156 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.157
[315]
|
Conjugate No.157 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.158
[315]
|
Conjugate No.158 Payload |
Undisclosed |
Conjugate No.94 Linker |
|
|
WO2019126691A1 Conjugate No.159
[315]
|
Conjugate No.159 Payload |
Undisclosed |
Conjugate No.94 Linker |
|
|
WO2019126691A1 Conjugate No.160
[315]
|
Conjugate No.160 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.161
[315]
|
Conjugate No.161 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.162
[315]
|
Conjugate No.162 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.163
[315]
|
Conjugate No.163 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.164
[315]
|
Conjugate No.164 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.165
[315]
|
Conjugate No.165 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.166
[315]
|
Conjugate No.166 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.167
[315]
|
Conjugate No.167 Payload |
Undisclosed |
Conjugate No.167 Linker |
|
|
WO2019126691A1 Conjugate No.168
[315]
|
Conjugate No.168 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.169
[315]
|
Conjugate No.169 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.170
[315]
|
Conjugate No.170 Payload |
Undisclosed |
Conjugate No.167 Linker |
|
|
WO2019126691A1 Conjugate No.171
[315]
|
Conjugate No.171 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.172
[315]
|
Conjugate No.172 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.173
[315]
|
Conjugate No.173 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.174
[315]
|
Conjugate No.174 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.175
[315]
|
Conjugate No.175 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.176
[315]
|
Conjugate No.176 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2019126691A1 Conjugate No.177
[315]
|
Conjugate No.177 Payload |
Undisclosed |
Conjugate No.105 Linker |
|
|
WO2024138000A1 FelD1 Ab
[316]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
FelD1- (AL11a)4
[316]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
FelD1- (AL2a)4
[316]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
FelD1- (AL3a)4
[316]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
FelD1- (AL7)4
[316]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
FelD1- (BL1)3.9
[316]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
FelD1- (BL3b)3.8
[316]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
FelD1- (AL7-LP1)3.9
[316]
|
aHer2- (AL6-LP1)3.6 Payload |
Undisclosed |
aHer2- (AL7-LP1)3.7 Linker |
|
|
FelD1- (AL7-LP13)7.3
[316]
|
aHer2- (AL6-LP1)3.6 Payload |
Undisclosed |
aHer2- (AL7-LP13)7.3 Linker |
|
|
FelD1- (AL7-LP2)3.80
[316]
|
aHer2- (AL7-LP2)3.83 Payload |
Undisclosed |
aHer2- (AL7-LP2)3.83 Linker |
|
|
FelD1- (AL7-LP3)3.82
[316]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
aHer2- (AL7-LP2)3.83 Linker |
|
|
FelD1- (AL7-LP4)3.82
[316]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
aHer2- (AL7-LP2)3.83 Linker |
|
|
FelD1- (AL7-LP5)3.69
[316]
|
aHer2- (AL7-LP5)3.80 Payload |
Undisclosed |
aHer2- (AL7-LP5)3.80 Linker |
|
|
FelD1- (AL7-LP7)3.68
[316]
|
aHer2- (AL7-LP7)3.70 Payload |
Undisclosed |
aHer2- (AL7-LP2)3.83 Linker |
|
|
FelD1- (AL7-LP9)3.89
[316]
|
undisclosed |
Undisclosed |
aHer2- (AL7-LP2)3.83 Linker |
|
|
FelD1- (AL7-LP12)3.83
[316]
|
aHer2- (AL7-LP12)3.82 Payload |
Undisclosed |
aHer2- (AL7-LP12)3.82 Linker |
|
|
FelD1- (AL4c-LP1B)3.45
[316]
|
aHer2- (AL4c-LP1B)3.49 Payload |
Undisclosed |
aHer2- (AL4c-LP1B)3.49 Linker |
|
|
FelD1- (AL11a-LP1)4
[316]
|
aHer2- (AL6-LP1)3.6 Payload |
Undisclosed |
aHer2- (AL7-LP2)3.83 Linker |
|
|
FelD1- (AL11a-LP13)7.3
[316]
|
aHer2- (AL6-LP1)3.6 Payload |
Undisclosed |
aHer2- (AL11a-LP13)7.8 Linker |
|
|
FelD1- (AL11a-LP15)7.0
[316]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
aHer2- (AL11a-LP15)7.6 Linker |
|
|
FelD1- (BL1-LP1)7.6
[316]
|
aHer2- (AL6-LP1)3.6 Payload |
Undisclosed |
aHer2- (BL1-LP1)7.7 Linker |
|
|
FelD1- (BL1-LP13)15.00
[316]
|
aHer2- (AL6-LP1)3.6 Payload |
Undisclosed |
aHer2- (BL1-LP13)14.88 Linker |
|
|
FelD1- (BL3b-LP1)7.1
[316]
|
aHer2- (AL4c-LP1B)3.49 Payload |
Undisclosed |
aHer2- (BL3b-LP1)7.5 Linker |
|
|
FelD1 1- (Mc-GGFG-DXD)7.5
[316]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
FelD1 2- (Mc-GGFG-DXD)7.5
[316]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
FelD1 3- (Mc-GGFG-DXD)7.5
[316]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
FelD1 1- (Mc-GGFG-DXD)7.0
[316]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
FelD1 2- (Mc-GGFG-DXD)7.0
[316]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
FelD1 3- (Mc-GGFG-DXD)7.0
[316]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
US20230022596A1 B-1
[317]
|
B-1 Payload |
Undisclosed |
B-1 Linker |
|
|
US20230022596A1 B-2
[317]
|
B-2 Payload |
Undisclosed |
B-1 Linker |
|
|
US20230022596A1 B-3
[317]
|
B-3 Payload |
Undisclosed |
B-1 Linker |
|
|
US20230022596A1 B-4
[317]
|
B-4 Payload |
Undisclosed |
B-1 Linker |
|
|
US20230022596A1 B-5
[317]
|
B-5 Payload |
Undisclosed |
B-1 Linker |
|
|
US20230022596A1 B-6
[317]
|
B-6 Payload |
Undisclosed |
B-1 Linker |
|
|
US20230022596A1 B-7
[317]
|
B-7 Payload |
Undisclosed |
B-1 Linker |
|
|
US20230022596A1 B-8
[317]
|
B-8 Payload |
Undisclosed |
B-1 Linker |
|
|
US20230022596A1 B-9
[317]
|
B-1 Payload |
Undisclosed |
B-9 Linker |
|
|
US20230022596A1 B-10
[317]
|
B-2 Payload |
Undisclosed |
B-9 Linker |
|
|
US20230022596A1 B-11
[317]
|
B-3 Payload |
Undisclosed |
B-9 Linker |
|
|
US20230022596A1 B-12
[317]
|
B-4 Payload |
Undisclosed |
B-9 Linker |
|
|
US20230022596A1 B-13
[317]
|
B-5 Payload |
Undisclosed |
B-9 Linker |
|
|
US20230022596A1 B-14
[317]
|
B-6 Payload |
Undisclosed |
B-9 Linker |
|
|
US20230022596A1 B-15
[317]
|
B-7 Payload |
Undisclosed |
B-9 Linker |
|
|
US20230022596A1 B-16
[317]
|
B-8 Payload |
Undisclosed |
B-9 Linker |
|
|
US20230022596A1 B-17
[317]
|
B-1 Payload |
Undisclosed |
B-17 Linker |
|
|
US20230022596A1 B-18
[317]
|
B-2 Payload |
Undisclosed |
B-17 Linker |
|
|
US20230022596A1 B-19
[317]
|
B-3 Payload |
Undisclosed |
B-17 Linker |
|
|
US20230022596A1 B-20
[317]
|
B-4 Payload |
Undisclosed |
B-17 Linker |
|
|
US20230022596A1 B-21
[317]
|
B-5 Payload |
Undisclosed |
B-17 Linker |
|
|
US20230022596A1 B-22
[317]
|
B-6 Payload |
Undisclosed |
B-17 Linker |
|
|
US20230022596A1 B-23
[317]
|
B-7 Payload |
Undisclosed |
B-17 Linker |
|
|
US20230022596A1 B-24
[317]
|
B-8 Payload |
Undisclosed |
B-17 Linker |
|
|
US20230022596A1 B-25
[317]
|
B-1 Payload |
Undisclosed |
B-25 Linker |
|
|
US20230022596A1 B-26
[317]
|
B-2 Payload |
Undisclosed |
B-25 Linker |
|
|
US20230022596A1 B-27
[317]
|
B-3 Payload |
Undisclosed |
B-25 Linker |
|
|
US20230022596A1 B-28
[317]
|
B-4 Payload |
Undisclosed |
B-25 Linker |
|
|
US20230022596A1 B-29
[317]
|
B-5 Payload |
Undisclosed |
B-25 Linker |
|
|
US20230022596A1 B-30
[317]
|
B-6 Payload |
Undisclosed |
B-25 Linker |
|
|
US20230022596A1 B-31
[317]
|
B-7 Payload |
Undisclosed |
B-25 Linker |
|
|
US20230022596A1 B-32
[317]
|
B-7 Payload |
Undisclosed |
B-25 Linker |
|
|
US20230022596A1 B-33
[317]
|
B-1 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-34
[317]
|
B-2 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-35
[317]
|
B-3 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-36
[317]
|
B-4 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-37
[317]
|
B-5 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-38
[317]
|
B-6 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-39
[317]
|
B-7 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-40
[317]
|
B-8 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-41
[317]
|
B-1 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-42
[317]
|
B-2 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-43
[317]
|
B-3 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-44
[317]
|
B-4 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-45
[317]
|
B-5 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-46
[317]
|
B-6 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-47
[317]
|
B-7 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-48
[317]
|
B-8 Payload |
Undisclosed |
B-33 Linker |
|
|
US20230022596A1 B-49
[317]
|
B-1 Payload |
Undisclosed |
B-49 Linker |
|
|
US20230022596A1 B-50
[317]
|
B-2 Payload |
Undisclosed |
B-49 Linker |
|
|
US20230022596A1 B-51
[317]
|
B-3 Payload |
Undisclosed |
B-49 Linker |
|
|
US20230022596A1 B-52
[317]
|
B-4 Payload |
Undisclosed |
B-49 Linker |
|
|
US20230022596A1 B-53
[317]
|
B-5 Payload |
Undisclosed |
B-49 Linker |
|
|
US20230022596A1 B-54
[317]
|
B-6 Payload |
Undisclosed |
B-49 Linker |
|
|
US20230022596A1 B-55
[317]
|
B-7 Payload |
Undisclosed |
B-49 Linker |
|
|
US20230022596A1 B-56
[317]
|
B-8 Payload |
Undisclosed |
B-49 Linker |
|
|
US20230022596A1 B-57
[317]
|
B-1 Payload |
Undisclosed |
B-57 Linker |
|
|
US20230022596A1 B-58
[317]
|
B-2 Payload |
Undisclosed |
B-57 Linker |
|
|
US20230022596A1 B-59
[317]
|
B-3 Payload |
Undisclosed |
B-57 Linker |
|
|
US20230022596A1 B-60
[317]
|
B-4 Payload |
Undisclosed |
B-57 Linker |
|
|
US20230022596A1 B-61
[317]
|
B-5 Payload |
Undisclosed |
B-57 Linker |
|
|
US20230022596A1 B-62
[317]
|
B-6 Payload |
Undisclosed |
B-57 Linker |
|
|
US20230022596A1 B-63
[317]
|
B-7 Payload |
Undisclosed |
B-57 Linker |
|
|
US20230022596A1 B-64
[317]
|
B-8 Payload |
Undisclosed |
B-57 Linker |
|
|
T-1-AB
[318]
|
T-1-AB Payload |
Undisclosed |
T-1-AB Linker |
|
|
T-3-AB 0.5
[318]
|
T-3-AB Payload |
Undisclosed |
T-3-AB Linker |
|
|
T-4-AB 0.42
[318]
|
T-4-AB Payload |
Undisclosed |
T-4-AB Linker |
|
|
AU2023281032A1 ADC-1
[319]
|
Monomethyl auristatin E |
Microtubule (MT) |
AU2023281032A1 ADC-1 linker |
|
|
IgG-P1-L12-P4
[320]
|
P4 payload |
Undisclosed |
L12 linker |
|
|
mAb2-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb3-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb4-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb5-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb6-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb7-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb8-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb9-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb10-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb11-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb12-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb13-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb14-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb15-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb16-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb17-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb18-MMAE
[321]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb2-MMAF
[321]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb3-MMAF
[321]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb17-MMAF
[321]
|
Monomethyl auristatin F |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
mAb2-DXd
[321]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
mAb3-DXd
[321]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
mAb17-DXd
[321]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
mAb2-MMAF+MMAE 1
[321]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
mAb1-MMAF+GGFG-DXd
[321]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
mAb1-MMAF+CL2A-SN38
[321]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
mAb2-MMAE+MMAF
[321]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
mAb2-MMAE+GGFG-DXd
[321]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
mAb2-MMAE+CL2A-SN38
[321]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
mAb2-MMAF+MMAE 2
[321]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
mAb2-MMAF+CL2A-SN38
[321]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
mAb3-MMAE+DXd
[321]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Isumab04-C5
[322]
|
compound 5 |
DNA topoisomerase I (TOP1) |
Undisclosed |
|
|
Isumab04-C6
[322]
|
WO2025015586A1, ADC24, Payload |
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8) |
Undisclosed |
|
|
MT-GGFG- Compound 104
[323]
|
TW202426058A+MT-GGFG-Compound 104+payload |
Undisclosed |
Undisclosed |
|
|
MT-GGFG- Compound 108
[323]
|
TW202426058A+MT-GGFG-Compound 108+payload |
Undisclosed |
Undisclosed |
|
|
MT-GGFG- Compound 127
[323]
|
TW202426058A+MT-GGFG-Compound 127+payload |
Undisclosed |
Undisclosed |
|
|
MT-GGFG-AM-Compound136
[323]
|
TW202426058A+MT-AM-GGFG-Compound 136+payload |
Undisclosed |
TW202426058A+MT-AM-GGFG-Compound 136+Linker |
|
|
MT-GGFG-AM-Compound139
[323]
|
TW202426058A+MT-AM-GGFG-Compound 136+payload |
Undisclosed |
TW202426058A+MT-AM-GGFG-Compound 139+Linker |
|
|
MT-GGFG-AM-Compound129
[323]
|
TW202426058A+MT-AM-GGFG-Compound 129+payload |
Undisclosed |
CN115160403A+B17+Linker |
|
|
MT-GGFG-AM-Compound113
[323]
|
TW202426058A+MT-AM-GGFG-Compound 113+payload |
Undisclosed |
Undisclosed |
|
|
MT-GGFG-AM-Compound141
[323]
|
TW202426058A+MT-AM-GGFG-Compound 141+payload |
Undisclosed |
Undisclosed |
|
|
MC-GGFG-AM-Compound141
[323]
|
TW202426058A+MC-GGFG-AM-Compound141+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
MT-GGFG-AM-Compound117
[323]
|
TW202426058A+MC-GGFG-AM-Compound117+payload |
Undisclosed |
TW202426058A+MT-GGFG-AM-Compound117+Linker |
|
|
MT-GGFG-AM-Compound118
[323]
|
TW202426058A+MT-GGFG-AM-Compound118+payload |
Undisclosed |
TW202426058A+MT-GGFG-AM-Compound118+Linker |
|
|
MC-GGFG-AM-Compound139
[323]
|
TW202426058A+MC-GGFG-AM-Compound139+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
DiS-Compound -145
[323]
|
FD6 |
DNA topoisomerase I (TOP1) |
TW202426058A+DiS-Compound -145+Linker |
|
|
MT-GGFG-Compound140
[323]
|
10NH2-11F-Camptothecin |
DNA topoisomerase I (TOP1) |
CN115160403A+B17+Linker |
|
|
MT-GGFG-Compound141
[323]
|
FD5 |
DNA topoisomerase I (TOP1) |
CN115160403A+B17+Linker |
|
|
MT-GGFG-Compound145
[323]
|
FD5 |
DNA topoisomerase I (TOP1) |
CN115160403A+B17+Linker |
|
|
MT-GGFG-Compound148
[323]
|
FD7 |
DNA topoisomerase I (TOP1) |
CN115160403A+B17+Linker |
|
|
MC-GGFG-Compound140
[323]
|
TW202426058A+MC-GGFG-Compound140+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
MT-GGFG-Compound142
[323]
|
TW202426058A+MT-GGFG-Compound142+payload |
Undisclosed |
CN115160403A+B17+Linker |
|
|
MC-GGFG-Compound141
[323]
|
TW202426058A+MC-GGFG-Compound141+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
MC-VA-Compound140
[323]
|
TW202426058A+MC-VA-Compound140+payload |
Undisclosed |
Mc-Val-Ala |
|
|
NHC-C-VA-Compound140
[323]
|
10NH2-11F-Camptothecin |
DNA topoisomerase I (TOP1) |
TW202426058A+NHC-C--VA-Compound140+Linker |
|
|
WO2024133815A1 Structure (4)
[324]
|
WO2024133815A1+structure (4)+payload |
Undisclosed |
WO2024133815A1+structure (4)+Linker |
|
|
CN118878620A ADC Drug linker 1
[325]
|
CN118878620A+Drug linker 1+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 2
[325]
|
CN118878620A+Drug linker 2+payload |
Undisclosed |
CN118878620A+Drug linker 2+Linker |
|
|
CN118878620A ADC Drug linker 3
[325]
|
CN118878620A+Drug linker 3+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 4
[325]
|
CN118878620A+Drug linker 4+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 5
[325]
|
CN118878620A+Drug linker 5+payload |
Undisclosed |
CN118878620A+Drug linker 5+Linker |
|
|
CN118878620A ADC Drug linker 6
[325]
|
CN118878620A+Drug linker 5+payload |
Undisclosed |
CN118878620A+Drug linker 6+Linker |
|
|
CN118878620A ADC Drug linker 7
[325]
|
CN118878620A+Drug linker 7+payload |
Undisclosed |
CN118878620A+Drug linker 7+Linker |
|
|
CN118878620A ADC Drug linker 8
[325]
|
CN118878620A+Drug linker 8+payload |
Undisclosed |
CN118878620A+Drug linker 8+Linker |
|
|
CN118878620A ADC Drug linker 9
[325]
|
CN118878620A+Drug linker 9+payload |
Undisclosed |
CN118878620A+Drug linker 7+Linker |
|
|
CN118878620A ADC Drug linker 10
[325]
|
CN118878620A+Drug linker 9+payload |
Undisclosed |
CN118878620A+Drug linker 10+Linker |
|
|
CN118878620A ADC Drug linker 11
[325]
|
CN118878620A+Drug linker 9+payload |
Undisclosed |
CN118878620A+Drug linker 11+Linker |
|
|
CN118878620A ADC Drug linker 12
[325]
|
CN118878620A+Drug linker 9+payload |
Undisclosed |
CN118878620A+Drug linker 12+Linker |
|
|
CN118878620A ADC Drug linker 13
[325]
|
CN118878620A+Drug linker 9+payload |
Undisclosed |
CN118878620A+Drug linker 11+Linker |
|
|
CN118878620A ADC Drug linker 14
[325]
|
CN118878620A+Drug linker 14+payload |
Undisclosed |
CN118878620A+Drug linker 14+Linker |
|
|
CN118878620A ADC Drug linker 16
[325]
|
CN118878620A+Drug linker 16+payload |
Undisclosed |
Undisclosed |
|
|
CN118878620A ADC Drug linker 15
[325]
|
CN118878620A+Drug linker 14+payload |
Undisclosed |
CN118878620A+Drug linker 11+Linker |
|
|
CN118878620A ADC Drug linker 17
[325]
|
CN118878620A+Drug linker 17+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 18
[325]
|
CN118878620A+Drug linker 18+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 19
[325]
|
CN118878620A+Drug linker 19+payload |
Undisclosed |
CN118878620A+Drug linker 19+Linker |
|
|
CN118878620A ADC Drug linker 20
[325]
|
CN118878620A+Drug linker 20+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 21
[325]
|
CN118878620A+Drug linker 21+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 22
[325]
|
CN118878620A+Drug linker 22+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 23
[325]
|
CN118878620A+Drug linker 23+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
CN118878620A ADC Drug linker 24
[325]
|
CN118878620A+Drug linker 24+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 25
[325]
|
CN118878620A+Drug linker 25+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN118878620A ADC Drug linker 26
[325]
|
CN118878620A+Drug linker 26+payload |
Undisclosed |
CN118878620A+Drug linker 1+Linker |
|
|
CN115160403A B1
[326]
|
CN115160403A+B1+payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
CN115160403A B2
[326]
|
CN115160403A+B2+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
CN115160403A B3
[326]
|
CN115160403A+B3+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
CN115160403A B4
[326]
|
CN115160403A+B4+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
CN115160403A B5
[326]
|
CN115160403A+B5+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
CN115160403A B6
[326]
|
CN115160403A+B6+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
CN115160403A B7
[326]
|
CN115160403A+B7+payload |
DNA topoisomerase I (TOP1) |
Mc-Gly-Gly-Phe-Gly |
|
|
CN115160403A B8
[326]
|
CN115160403A+B8+payload |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
|
|
CN115160403A B9
[326]
|
CN115160403A+B9+payload |
Undisclosed |
CN115160403A+B9+Linker |
|
|
CN115160403A B10
[326]
|
CN115160403A+B9+payload |
Undisclosed |
CN115160403A+B10+Linker |
|
|
CN115160403A B11
[326]
|
CN115160403A+B9+payload |
Undisclosed |
CN115160403A+B11+Linker |
|
|
CN115160403A B12
[326]
|
CN115160403A+B9+payload |
Undisclosed |
CN115160403A+B12+Linker |
|
|
CN115160403A B13
[326]
|
(4-NH2)-Exatecan |
DNA topoisomerase I (TOP1) |
CN115160403A+B11+Linker |
|
|
CN115160403A B14
[326]
|
CN115160403A+B1+payload |
DNA topoisomerase I (TOP1) |
CN115160403A+B14+Linker |
|
|
CN115160403A B15
[326]
|
CN115160403A+B1+payload |
DNA topoisomerase I (TOP1) |
CN115160403A+B15+Linker |
|
|
CN115160403A B16
[326]
|
CN115160403A+B7+payload |
DNA topoisomerase I (TOP1) |
CN115160403A+B11+Linker |
|
|
CN115160403A B17
[326]
|
CN115160403A+B7+payload |
DNA topoisomerase I (TOP1) |
CN115160403A+B17+Linker |
|
|
CN115160403A B18
[326]
|
CN115160403A+B7+payload |
DNA topoisomerase I (TOP1) |
CN115160403A+B18+Linker |
|
|
CN115160403A B19
[326]
|
CN115160403A+B19+payload |
Undisclosed |
CN115160403A+B19+Linker |
|
|
CN115160403A B20
[326]
|
CN115160403A+B20+payload |
Undisclosed |
CN115160403A+B20+Linker |
|
|
CN115160403A B21
[326]
|
CN115160403A+B20+payload |
Undisclosed |
CN115160403A+B19+Linker |
|
|
CN115160403A B22
[326]
|
CN115160403A+B20+payload |
Undisclosed |
CN115160403A+B22+Linker |
|
|
CN115160403A B23
[326]
|
CN115160403A+B19+payload |
Undisclosed |
CN115160403A+B22+Linker |
|
|
CN115160403A B24
[326]
|
CN115160403A+B19+payload |
Undisclosed |
CN115160403A+B24+Linker |
|
|
CN115160403A B25
[326]
|
CN115160403A+B20+payload |
Undisclosed |
CN115160403A+B24+Linker |
|
|
WO2022197877A1 compound 4
[327]
|
WO2022197877A1+compound 4+payload |
Undisclosed |
WO2022197877A1+compound 4+Linker |
|
|
WO2022197877A1 compound 5
[327]
|
WO2022197877A1+compound 5+payload |
Undisclosed |
WO2022197877A1+compound 4+Linker |
|
|
WO2022197877A1 compound 6
[327]
|
WO2022197877A1+compound 6+payload |
Undisclosed |
WO2022197877A1+compound 6+Linker |
|
|
WO2022197877A1 compound 7
[327]
|
WO2022197877A1+compound 7+payload |
Undisclosed |
WO2022197877A1+compound 6+Linker |
|
|
Synthesis Example 2
[327]
|
WO2022197877A1+Synthesis Example 2+payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
WO2022197877A1 compound 3
[327]
|
WO2022197877A1+compound 3+payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
WO2022197877A1 compound 10
[327]
|
WO2022197877A1+compound 10+payload |
Undisclosed |
WO2022197877A1+compound 10+Linker |
|
|
WO2022197877A1 compound 8
[327]
|
WO2022197877A1+compound 8+payload |
Undisclosed |
WO2022197877A1+compound 10+Linker |
|
|
WO2022197877A1 compound 9
[327]
|
WO2022197877A1+compound 9+payload |
Undisclosed |
WO2022197877A1+compound 10+Linker |
|
|
CN119072334A Formula 6
[328]
|
CN119072334A+Formula 6+payload |
Undisclosed |
Undisclosed |
|
|
CN119072334A Formula 7
[328]
|
CN119072334A+Formula 7+payload |
Undisclosed |
CN119072334A+Formula 7+Linker |
|
|
CN119072334A Formula 8
[328]
|
Topo1 inhibitor H |
DNA topoisomerase I (TOP1) |
CN119072334A+Formula 8+Linker |
|
|
MC-VaI-Cit-PAB-MMAE
[328]
|
Undisclosed |
Undisclosed |
CN119072334A+MC-VaI-Cit-PAB-MMAE+Linker |
|
|
ThioBridge-Glu- (Val-Cit-PAB-MMáE)-PEG (24u)
[328]
|
CN119072334A+ThioBridge⑪-Glu- (Val-Cit-PAB-MMáE)-PEG (24u)+payload |
Undisclosed |
CN119072334A+ThioBridge⑪-Glu- (Val-Cit-PAB-MMáE)-PEG (24u)+Linker |
|
|
ThioBridge-Glu-[ (Val-Cit-PAB-MMáE)]2-Glu-[PEG (24u)]2
[328]
|
Topo1 inhibitor H |
DNA topoisomerase I (TOP1) |
CN119072334A+ThioBridge⑪-Glu-[ (Val-Cit-PAB-MMáE)]2-Glu-[PEG (24u)]2+Linker |
|
|
US20240148883A1 Compound 18- Target 1
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 18- Target 2
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 18- Target 3
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 18- Target 4
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 18- Target 5
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 18- Target 6
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 18- Target 7
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 18- Target 8
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 18- Target 9
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 18- Target 10
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 1
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 2
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 3
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 4
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 5
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 6
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 7
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 8
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 9
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 36- Target 10
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 1
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 2
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 3
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 4
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 5
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 6
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 7
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 8
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 9
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US20240148883A1 Compound 32- Target 10
[329]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN118043080A ADC-4
[330]
|
CN118043080A+ADC-4+payload |
Undisclosed |
CN118043080A+ADC-4+Linker |
|
|
CN118043080A ADC-5
[330]
|
CN118043080A+ADC-5+payload |
Undisclosed |
CN118043080A+ADC-5+Linker |
|
|
CN118043080A ADC-6
[330]
|
CN118043080A+ADC-6+payload |
Undisclosed |
CN118043080A+ADC-6+Linker |
|
|
WO2024099368A1 Tra-CAST-MMAE
[331]
|
Monomethyl auristatin E |
Microtubule (MT) |
WO2024099368A1+Tra-CAST-MMAE+Linker |
|
|
IgG2a-Val-Cit-Pab-MMAE
[332]
|
Monomethyl auristatin E |
Microtubule (MT) |
WO2024102603A1+lgG2a-Val-Cit-Pab-MMAE+Linker |
|
|
CN110845480B ADC1
[333]
|
CN110845480B+ADC1+payload |
Undisclosed |
CN110845480B+ADC1+Linker |
|
|
CN110845480B ADC2
[333]
|
CN110845480B+ADC2+payload |
Undisclosed |
CN110845480B+ADC1+Linker |
|
|
CN110845480B ADC3
[333]
|
CN110845480B+ADC3+payload |
Undisclosed |
CN110845480B+ADC3+Linker |
|
|
CN110845480B ADC4
[333]
|
CN110845480B+ADC4+payload |
Undisclosed |
CN110845480B+ADC4+Linker |
|
|
WO2024118785A3 Lot22
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot23
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot24
[334]
|
P9 |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot34
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot36
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot38
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot49
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot50
[334]
|
P9 |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot57
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot61
[334]
|
P9 |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot62
[334]
|
P9 |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot70
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot71
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot77
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot78
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot79
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot80
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024118785A3 Lot91
[334]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP2024533562A ADC-1
[335]
|
JP2024533562A ADC-9 payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
JP2024533562A ADC-2
[335]
|
JP2024533562A ADC-10 payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
JP2024533562A ADC-3
[335]
|
JP2024533562A ADC-11 payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
JP2024533562A ADC-4
[335]
|
EP4494658A1 antibody-drug conjugate 1 payload |
DNA topoisomerase I (TOP1) |
Mc-Val-Cit-PABC |
|
|
JP2024533562A ADC-5
[335]
|
JP2024533562A ADC-13 payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
JP2024533562A ADC-6
[335]
|
JP2024533562A ADC-14 payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
JP2024533562A ADC-7
[335]
|
JP2024533562A ADC-15 payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
JP2024533562A ADC-8
[335]
|
JP2024533562A ADC-16 payload |
Undisclosed |
Mc-Val-Cit-PABC |
|
|
JP2024533562A ADC-9
[335]
|
JP2024533562A ADC-9 payload |
Undisclosed |
JP2024533562A ADC-16 linker |
|
|
JP2024533562A ADC-10
[335]
|
JP2024533562A ADC-10 payload |
Undisclosed |
JP2024533562A ADC-16 linker |
|
|
JP2024533562A ADC-11
[335]
|
JP2024533562A ADC-11 payload |
Undisclosed |
JP2024533562A ADC-16 linker |
|
|
JP2024533562A ADC-12
[335]
|
EP4494658A1 antibody-drug conjugate 1 payload |
DNA topoisomerase I (TOP1) |
JP2024533562A ADC-16 linker |
|
|
JP2024533562A ADC-13
[335]
|
JP2024533562A ADC-13 payload |
Undisclosed |
JP2024533562A ADC-16 linker |
|
|
JP2024533562A ADC-14
[335]
|
JP2024533562A ADC-14 payload |
Undisclosed |
JP2024533562A ADC-16 linker |
|
|
JP2024533562A ADC-15
[335]
|
JP2024533562A ADC-15 payload |
Undisclosed |
JP2024533562A ADC-16 linker |
|
|
JP2024533562A ADC-16
[335]
|
JP2024533562A ADC-16 payload |
Undisclosed |
JP2024533562A ADC-16 linker |
|
|
JP2024533562A ADC-17
[335]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Ab-TfR2-CIDE-BRM1-9
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Ab-TfR2-CIDE-BRM1-20
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Ab-TfR2-CIDE-BRM1-19
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Ab-TfR2-CIDE-BRM1-15
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
Ab-TfR2-CIDE-BRM1-13
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2023173132A1 ADC-12
[37]
|
P9 |
Undisclosed |
Undisclosed |
|
|
WO2023173132A1 ADC-13
[37]
|
P9 |
Undisclosed |
Undisclosed |
|
|
WO2023173132A1ADC-14
[37]
|
P9 |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-01
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-02
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-03
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-04
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-05
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-06
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-07
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-08
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-09
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-10
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-11
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-12
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-13
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-14
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-15
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-16
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-17
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-18
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-19
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-20
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-21
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-22
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-23
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-24
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-25
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC A-26
[336]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC-B-01
[336]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC-B-02
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC-B-03
[336]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC-B-04
[336]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC-B-05
[336]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC-B-06
[336]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024078586A9 ADC-C-01
[336]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula1
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula2
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula3
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula4
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula5
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula6
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula7
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula8
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula9
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula10
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula11
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula12
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula13
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula14
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula15
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
WO2024083953A1 Formula16
[337]
|
undisclosed |
Undisclosed |
Undisclosed |
|
|
US11833215B2 5A
[338]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11833215B2 5B
[338]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11833215B2 5C
[338]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11833215B2 5D
[338]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11833215B2 5E
[338]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11833215B2 5F
[338]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11833215B2 5G
[338]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11833215B2 5H
[338]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
US11833215B2 5I
[338]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
IGAC-2
[47]
|
IG-L-1 Payload |
Undisclosed |
IG-L-1 linker |
|
|
IGAC-4
[47]
|
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
MP-Ala-Ala-PAB |
|
|
IGAC-6
[47]
|
IG-L-2 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
|
|
IGAC-8
[47]
|
Smol006 |
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) |
MP-Ala-Ala-PAB |
|
|
IGAC-10
[47]
|
IG-L-1 Payload |
Undisclosed |
IG-L-1 linker |
|
|
IGAC-12
[47]
|
IG-L-3 Payload |
Undisclosed |
IG-L-3 linker |
|
|
IGAC-14
[47]
|
IG-L-7 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
|
|
IGAC-16
[47]
|
IG-L-4 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
|
|
IGAC-18
[47]
|
IG-L-5 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
|
|
IGAC-20
[47]
|
IG-L-9 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
|
|
IGAC-22
[47]
|
IG-L-10 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
|
|
IGAC-24
[47]
|
IG-L-11 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
|
|
IGAC-30
[47]
|
IG-L-12 Payload |
Undisclosed |
MP-Ala-Ala-PAB |
|
|
JP7560255B2 ControlADC1
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC2
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC3
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC4
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC5
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC59 8
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC7
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC8
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC9
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC10
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC11
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC12
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC13
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC14
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC15
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC16
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC17
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC18
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC19
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC20
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC21
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC22
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC23
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC24
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC25
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC26
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC27
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC28
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC29
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC30
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC31
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC32
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC33
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC34
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC35
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC36
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC37
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC38
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC39
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC40
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC41
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC42
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC43
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC44
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC60
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
JP7560255B2 ControlADC61
[339]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202506738A C-009
[340]
|
TW202506738A-C-009-PAYLOAD |
DNA topoisomerase I (TOP1) |
TW202506738A-C-009-LINKER |
|
|
TW202506738A C-020
[340]
|
TW202506738A-C-009-PAYLOAD |
DNA topoisomerase I (TOP1) |
TW202506738A-C-020-LINKER |
|
|
TW202506738A C-025
[340]
|
TW202506738A-C-025-PAYLOAD |
Undisclosed |
TW202506738A-C-025-LINKER |
|
|
TW202506738A C-027
[340]
|
TW202506738A-C-027-PAYLOAD |
Undisclosed |
TW202506738A-C-027-LINKER |
|
|
TW202506738A C-031
[340]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202506738A C-037
[340]
|
TW202506738A-C-037-PAYLOAD |
Undisclosed |
TW202506738A-C-009-LINKER |
|
|
TW202506738A C-038
[340]
|
TW202506738A-C-037-PAYLOAD |
Undisclosed |
TW202506738A-C-025-LINKER |
|
|
TW202506738A C-039
[340]
|
TW202506738A-C-037-PAYLOAD |
Undisclosed |
TW202506738A-C-039-LINKER |
|
|
TW202506738A C-043
[340]
|
TW202506738A-C-037-PAYLOAD |
Undisclosed |
TW202506738A-C-043-LINKER |
|
|
TW202506738A C-046
[340]
|
TW202506738A-C-046-PAYLOAD |
Undisclosed |
TW202506738A-C-046-LINKER |
|
|
TW202506738A C-052
[340]
|
TW202506738A-C-052-PAYLOAD |
Undisclosed |
TW202506738A-C-046-LINKER |
|
|
TW202506738A C-056
[340]
|
TW202506738A-C-056-PAYLOAD |
Undisclosed |
TW202506738A-C-056-LINKER |
|
|
TW202506738A C-059
[340]
|
TW202506738A-C-059-PAYLOAD |
Undisclosed |
TW202506738A-C-059-LINKER |
|
|
TW202506738A C-063
[340]
|
TW202506738A-C-063-PAYLOAD |
Undisclosed |
TW202506738A-C-063-LINKER |
|
|
TW202506738A C-066
[340]
|
TW202506738A-C-066-PAYLOAD |
Undisclosed |
TW202506738A-C-066-LINKER |
|
|
TW202506738A C-071
[340]
|
TW202506738A-C-071-PAYLOAD |
Undisclosed |
TW202506738A-C-071-LINKER |
|
|
TW202506738A C-079
[340]
|
TW202506738A-C-079-PAYLOAD |
Undisclosed |
TW202506738A-C-079-LINKER |
|
|
TW202506738A C-084
[340]
|
TW202506738A-C-084-PAYLOAD |
Undisclosed |
TW202506738A-C-084-LINKER |
|
|
TW202506738A C-087
[340]
|
TW202506738A-C-087-PAYLOAD |
Undisclosed |
TW202506738A-C-087-LINKER |
|
|
TW202506738A C-093
[340]
|
TW202506738A-C-093-PAYLOAD |
Undisclosed |
TW202506738A-C-093-LINKER |
|
|
TW202506738A C-096
[340]
|
Topo1 inhibitor E |
DNA topoisomerase I (TOP1) |
TW202506738A-C-096-LINKER |
|
|
TW202506738A C-102
[340]
|
TW202506738A-C-102-PAYLOAD |
Undisclosed |
TW202506738A-C-102-LINKER |
|
|
TW202506738A C-109
[340]
|
TW202506738A-C-102-PAYLOAD |
Undisclosed |
TW202506738A-C-109-LINKER |
|
|
TW202506738A C-111
[340]
|
Topo1 inhibitor E |
DNA topoisomerase I (TOP1) |
TW202506738A-C-111-LINKER |
|
|
TW202506738A C-118
[340]
|
TW202506738A-C-118-PAYLOAD |
Undisclosed |
TW202506738A-C-118-LINKER |
|
|
TW202506738A C-123
[340]
|
TW202506738A-C-123-PAYLOAD |
Undisclosed |
TW202506738A-C-123-LINKER |
|
|
TW202506738A C-133
[340]
|
Topo1 inhibitor E |
DNA topoisomerase I (TOP1) |
TW202506738A-C-133-LINKER |
|
|
TW202506738A C-155
[340]
|
Topo1 inhibitor E |
DNA topoisomerase I (TOP1) |
TW202506738A-C-155-LINKER |
|
|
TW202506738A C-168
[340]
|
Topo1 inhibitor E |
DNA topoisomerase I (TOP1) |
TW202506738A-C-168-LINKER |
|
|
TW202506738A C-172
[340]
|
Topo1 inhibitor E |
DNA topoisomerase I (TOP1) |
TW202506738A-C-172-LINKER |
|
|
TW202506738A C-182
[340]
|
Topo1 inhibitor G |
DNA topoisomerase I (TOP1) |
TW202506738A-C-182-LINKER |
|
|
TW202506738A C-186
[340]
|
Topo1 inhibitor G |
DNA topoisomerase I (TOP1) |
TW202506738A-C-186-LINKER |
|
|
TW202506738A C-208
[340]
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
TW202506738A-C-208-LINKER |
|
|
TW202506738A C-214
[340]
|
TW202506738A-C-214-PAYLOAD |
Undisclosed |
TW202506738A-C-214-LINKER |
|
|
TW202506738A C-215
[340]
|
TW202506738A-C-215-PAYLOAD |
Undisclosed |
TW202506738A-C-214-LINKER |
|
|
TW202506738A C-216
[340]
|
TW202506738A-C-216-PAYLOAD |
Undisclosed |
TW202506738A-C-214-LINKER |
|
|
TW202506738A C-217
[340]
|
TW202506738A-C-216-PAYLOAD |
Undisclosed |
TW202506738A-C-217-LINKER |
|
|
TW202506738A C-218
[340]
|
TW202506738A-C-218-PAYLOAD |
Undisclosed |
TW202506738A-C-217-LINKER |
|
|
TW202506738A C-226
[340]
|
TW202506738A-C-226-PAYLOAD |
Undisclosed |
TW202506738A-C-226-LINKER |
|
|
TW202506738A C-227
[340]
|
TW202506738A-C-227-PAYLOAD |
Undisclosed |
TW202506738A-C-226-LINKER |
|
|
TW202506738A C-231
[340]
|
TW202506738A-C-231-PAYLOAD |
Undisclosed |
TW202506738A-C-226-LINKER |
|
|
TW202506738A C-237
[340]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TW202506738A C-325
[340]
|
TW202506738A-C-325-PAYLOAD |
Undisclosed |
TW202506738A-C-325-LINKER |
|
|
TW202506738A C-326
[340]
|
TW202506738A-C-326-PAYLOAD |
Undisclosed |
TW202506738A-C-325-LINKER |
|
|
TW202506738A C-327
[340]
|
TW202506738A-C-327-PAYLOAD |
Undisclosed |
TW202506738A-C-327-LINKER |
|
|
TW202506738A C-328
[340]
|
TW202506738A-C-327-PAYLOAD |
Undisclosed |
TW202506738A-C-325-LINKER |
|
|
TW202506738A C-329
[340]
|
TW202506738A-C-329-PAYLOAD |
Undisclosed |
TW202506738A-C-327-LINKER |
|
|
TW202506738A C-330
[340]
|
TW202506738A-C-330-PAYLOAD |
Undisclosed |
TW202506738A-C-327-LINKER |
|
|
TW202506738A C-331
[340]
|
TW202506738A-C-331-PAYLOAD |
Undisclosed |
TW202506738A-C-327-LINKER |
|
|
TW202506738A C-332
[340]
|
TW202506738A-C-332-PAYLOAD |
Microtubule (MT) |
TW202506738A-C-327-LINKER |
|
|
TW202506738A C-333
[340]
|
TW202506738A-C-332-PAYLOAD |
Microtubule (MT) |
TW202506738A-C-333-LINKER |
|
|
TW202506738A C-334
[340]
|
TW202506738A-C-332-PAYLOAD |
Microtubule (MT) |
TW202506738A-C-333-LINKER |
|
|
TW202506738A C-335
[340]
|
TW202506738A-C-332-PAYLOAD |
Microtubule (MT) |
TW202506738A-C-335-LINKER |
|
|
TW202506738A C-353
[340]
|
TW202506738A-C-353-PAYLOAD |
Undisclosed |
TW202506738A-C-353-LINKER |
|
|
TW202506738A C-363
[340]
|
TW202506738A-C-363-PAYLOAD |
Undisclosed |
TW202506738A-C-353-LINKER |
|
|
TW202506738A C-397
[340]
|
TW202506738A-C-397-PAYLOAD |
Undisclosed |
TW202506738A-C-397-LINKER |
|
|
TW202506738A C-400
[340]
|
TW202506738A-C-400-PAYLOAD |
Undisclosed |
TW202506738A-C-400-LINKER |
|
|
CN113318238B ADC-1
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN113318238B ADC-2
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN113318238B ADC-3
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN113318238B ADC-4
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN113318238B ADC-5
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN113318238B ADC-6
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN113318238B ADC-7
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN113318238B ADC-8
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN113318238B ADC-9
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN113318238B ADC-10
[341]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
CN119630431A ADC-82
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
|
|
CN119630431A ADC-83
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
|
|
CN119630431A ADC-84
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-83-LINKER |
|
|
CN119630431A ADC-85
[5]
|
CN119630431A-ADC-84-PAYLOAD |
Undisclosed |
CN119630431A-ADC-67-LINKER |
|
|
CN119630431A ADC-86
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
|
|
CN119630431A ADC-87
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
|
|
CN119630431A ADC-88
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-83-LINKER |
|
|
CN119630431A ADC-89
[5]
|
CN119630431A-ADC-84-PAYLOAD |
Undisclosed |
CN119630431A-ADC-67-LINKER |
|
|
CN119630431A ADC-93
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
|
|
CN119630431A ADC-95
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
|
|
CN119630431A ADC-96
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
|
|
CN119630431A ADC-97
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
|
|
CN119630431A ADC-98
[5]
|
CN119630431A-ADC-82-PAYLOAD |
Undisclosed |
CN119630431A-ADC-82-LINKER |
|
|
MK-6204
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SLV-154
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ABBV-324
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
SLV-324
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
PHN-012
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MBRC-201
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
WEF-001
|
Monomethyl auristatin E |
Microtubule (MT) |
Undisclosed |
|
|
FS001
|
TOP1 inhibitor |
DNA topoisomerase 1 (TOP1) |
A cleavable linker |
|
|
BL-M24D1
|
WA-00 |
Microtubule (MT) |
Undisclosed |
|
|
ONA-255
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ABBV-901
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADCE-B05
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
AK0406
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
TORL-5-700
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG2002A
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG2001
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MG1901
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
tarcocimab tedromer
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
KSI-501
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
ADCX-020
|
TOP1 inhibitor |
DNA topoisomerase 1 (TOP1) |
A cleavable linker |
References