Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0YPCCO
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| ADC Name |
ROS-responsive SN38 ADC
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| Synonyms |
ROS-responsive-SN38-ADC
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
B-cell lymphoma [ICD11:2A86]
Investigative
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| Structure |
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| Antibody Name |
Rabbit derived VL single-domain Anti-ody
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Antibody Info | Antigen Name |
Undisclosed
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| Payload Name |
Active metabolite of irinotecan SN38
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
Mal-Cyc-PEG3-DAB
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Linker Info | ||||
| Conjugate Type |
Site-specific conjugating to the free sulfhydryl group of cysteine 82 on the VL single-domain antibody, Michael addition reaction.
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