Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0PCGKN
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
hu5B1-TCO
|
|||||
| Synonyms |
hu5B1-TCO; hu5B1 TCO; hu5B1TCO
Click to Show/Hide
|
|||||
| Organization |
Memorial Sloan-Kettering Cancer Center
|
|||||
| Drug Status |
Phase 1
|
|||||
| Antibody Name |
hu5B1
|
Antibody Info | Antigen Name |
Undisclosed
|
||
| Payload Name |
Undisclosed
|
|||||
| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
|
Target Info | ||||
| Linker Name |
Undisclosed
|
|||||
The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic cancer |
1 Trials
|
General Information of The Activity Data Related to This ADC
Identified from the Human Clinical Data
Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Patients Enrolled |
Adults (≥18) with histologically confirmed pancreatic/bladder/GI tumors or imaging-suspected PDAC
|
||||
| Administration Dosage |
On study day 0, a single slow infusion of hu5B1-TCO will be administered intravenously. Subsequently, either 3 days (n = 3) or 5 days (n = 3) later, a single slow infusion of 64Cu-Tz-SarAr will be administered intravenously.
|
||||
| Related Clinical Trial | |||||
| NCT Number | NCT05737615 | Clinical Status | PHASE1 | ||
| Clinical Description | A Phase I Study of Pretargeted PET Imaging Using 64Cu-Tz-SarAr and a Trans-Cyclooctene-Modified Humanized 5B1 Immunoconjugate (hu5B1-TCO) in Patients With Pancreatic, Bladder Cancer, Gastrointestinal Malignancies or Solid Tumors With Elevated CA19-9 | ||||
| Primary Endpoint |
Primary endpoint is SUV mean measurement across multiple organs (heart, liver, spleen, kidney, lung, and other uptake sites) [Time Frame: 28 months].
|
||||
References