Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0XAJRA
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| ADC Name |
RC88-Mc-Val-Cit-PAB-MMAE
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| Synonyms |
RC88-Mc-Val-Cit-PAB-MMAE
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| Organization |
REMEGEN, LTD.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.9
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| Structure |
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| Antibody Name |
RC88
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Antibody Info | ||||
| Antigen Name |
Mesothelin (MSLN)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Vedotin
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.0956۪.01 nM | Positive MSLN expression (MSLN+++/++) | ||
| Method Description |
Oval-Citar-3-MSLN cells with good growth state were added to 96-well cell culture plates (5×104 cells /mL, 100uL/ well) and incubated overnight in a CO2 incubator at 39°C.
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| In Vitro Model | High grade ovarian serous adenocarcinoma | Oval-Citar-3-MSLN cells | CVCL_0465 | ||