Antibody Information
General Information of This Antibody
| Antibody ID | ANTI0BGQWC |
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| Antibody Name | RC88 |
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| Organization | REMEGEN, LTD. |
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| Synonyms |
RC88
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized lgG |
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| Antigen Name | Mesothelin (MSLN) |
Antigen Info | ||||
| Click to Show/Hide the Sequence Information of This Antibody | ||||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
RC88-Mc-Val-Cit-PAB-MMAD [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.0158۪.011 nM
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Positive MSLN expression (MSLN+++/++) | ||
| Method Description |
Oval-Citar-3-MSLN cells with good growth state were added to 96-well cell culture plates (5×104 cells /mL, 100uL/ well) and incubated overnight in a CO2 incubator at 40°C.
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| In Vitro Model | High grade ovarian serous adenocarcinoma | Oval-Citar-3-MSLN cells | CVCL_0465 | ||
RC88-Py-MAA-Val-Cit-PAB-MMAD [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.043۪.011 nM
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Positive MSLN expression (MSLN+++/++) | ||
| Method Description |
Oval-Citar-3-MSLN cells with good growth state were added to 96-well cell culture plates (5×104 cells /mL, 100uL/ well) and incubated overnight in a CO2 incubator at 38°C.
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| In Vitro Model | High grade ovarian serous adenocarcinoma | Oval-Citar-3-MSLN cells | CVCL_0465 | ||
RC88-Py-MAA-Val-Cit-PAB-MMAE [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.093۪.009 nM
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Positive MSLN expression (MSLN+++/++) | ||
| Method Description |
Oval-Citar-3-MSLN cells with good growth state were added to 96-well cell culture plates (5×104 cells /mL, 100uL/ well) and incubated overnight in a CO2 incubator at 37°C.
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| In Vitro Model | High grade ovarian serous adenocarcinoma | Oval-Citar-3-MSLN cells | CVCL_0465 | ||
RC88-Mc-Val-Cit-PAB-MMAE [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.0956۪.01 nM
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Positive MSLN expression (MSLN+++/++) | ||
| Method Description |
Oval-Citar-3-MSLN cells with good growth state were added to 96-well cell culture plates (5×104 cells /mL, 100uL/ well) and incubated overnight in a CO2 incubator at 39°C.
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| In Vitro Model | High grade ovarian serous adenocarcinoma | Oval-Citar-3-MSLN cells | CVCL_0465 | ||