Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0TUHMP
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| ADC Name |
WO2023124537A1+ADC3
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| Synonyms |
WO2023124537A1+ADC3
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| Organization |
JENKEM TECHNOLOGY CO., LTD. (LIAONING)
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
2
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| Structure |
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| Antibody Name |
Anti-EGFR mAb
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Antibody Info | ||||
| Antigen Name |
Epidermal growth factor receptor (EGFR)
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Antigen Info | ||||
| Payload Name |
Active metabolite of irinotecan SN38
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
DBCO-VC-PAB
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Linker Info | ||||
| Conjugate Type |
DBCO-Azide Click Chemistry Conjugation
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| Combination Type |
DBCO-VC-PAB-SN38
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.267 nM | Positive EGFR expression (EGFR+++/++) | ||
| Method Description |
Cells were cultured in a 5% CO2 cell incubator at 37°C for 24 hours. Cytotoxicity test contains about 10000 cells when 102uL is added to each well.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||