Linker Information
General Information of This Linker
| Linker ID |
LIN0BHRGW
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| Linker Name |
DBCO-VC-PAB
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Unclear
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2023124537A1+ADC1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.112 nM
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Positive EGFR expression (EGFR+++/++) | ||
| Method Description |
Cells were cultured in a 5% CO2 cell incubator at 37°C for 24 hours. Cytotoxicity test contains about 10000 cells when 100uL is added to each well.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
WO2023124537A1+ADC2 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.126 nM
|
Positive EGFR expression (EGFR+++/++) | ||
| Method Description |
Cells were cultured in a 5% CO2 cell incubator at 37°C for 24 hours. Cytotoxicity test contains about 10000 cells when 101uL is added to each well.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
WO2023124537A1+ADC3 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.267 nM
|
Positive EGFR expression (EGFR+++/++) | ||
| Method Description |
Cells were cultured in a 5% CO2 cell incubator at 37°C for 24 hours. Cytotoxicity test contains about 10000 cells when 102uL is added to each well.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||