Linker Information
General Information of This Linker
| Linker ID |
LIN0LYNMC
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| Linker Name |
CN119317630A ADC-C10 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C20H32N4O7
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| Isosmiles |
CC([C@H](NC(CCCCCN1C(CCC1=O)=O)=O)C(N[C@@H](C)C(NCC(O)=O)=O)=O)C
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| InChI |
InChI=1S/C20H32N4O7/c1-12(2)18(20(31)22-13(3)19(30)21-11-17(28)29)23-14(25)7-5-4-6-10-24-15(26)8-9-16(24)27/h12-13,18H,4-11H2,1-3H3,(H,21,30)(H,22,31)(H,23,25)(H,28,29)/t13-,18-/m0/s1
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| InChIKey |
QFQDRGXDOQWWNN-UGSOOPFHSA-N
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| Pharmaceutical Properties |
Molecule Weight
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440.497
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Polar area
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161.98
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Complexity
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652.1518798
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xlogp Value
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-0.4579
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Heavy Count
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31
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Rot Bonds
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13
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Hbond acc
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6
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN119317630A ADC-C10 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
66 nM
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| Method Description |
Distribute the cell lines H358 (1E3/well), to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
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| In Vitro Model | Minimally invasive lung adenocarcinoma | H358 cells | CVCL_1559 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
96 nM
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| Method Description |
Distribute the cell lines H1048 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
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| In Vitro Model | Lung small cell carcinoma, Small cell lung cancer | H1048 cells | CVCL_1453 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
100 nM
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| Method Description |
Distribute the cell lines H441 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
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| In Vitro Model | Lung papillary adenocarcinoma | H441 cells | CVCL_1561 | ||